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| Middle ages || Di-ethyl ether, the first agent to be demonstrated successfully in public, is originally synthesized (by the action of sulphuric acid on ethanol) in the 13th century, and there are early reports of both analgesic and soporific effects.<ref name="The History of Anaesthesiavvv">{{cite web |title=The History of Anaesthesia |url=https://www.rcoa.ac.uk/college-heritage/the-history-of-anaesthesia |website=rcoa.ac.uk |accessdate=21 August 2018}}</ref>
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| 19th century || "During most of the nineteenth century, the vast majority of notable advances in the science of anesthesiology were are achieved by basic scientists [10]. Among physiologists, {{w|Jean Pierre Jean Marie Flourens}}, {{w|François Magendie}}, and {{w|Claude Bernard }} are respected for their work on the effects and site of action of anesthetic gases. Pharmacologists and chemists, including {{w|Joseph Friedrich von Mering}}, Hans Meyer, and Charles Overton, synthesized synthesize novel drugs and investigated investigate the properties that enabled a chemical to function as an anesthetic. Surgeons, obstetricians, and dentists contributed contribute the bulk of clinical advances in the field [10]. Most of the practicing anesthetists functioned function primarily as technicians who made make meager contributions to advancing the scientific underpinnings of the discipline. But This would begin to change in the late nineteenth century, this would begin to change."<ref name="The History of Professionalism in Anesthesiology"/> In the 1980s, a movement opposing all types of human suffering is promoted by surgeon English physician {{w|Henry Hill Hickman}}.<ref name="The History of Professionalism in Anesthesiology"/>
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| 20th century || The anesthesia machine is introduced. By 1950 all of the elements of modern anaesthesia are in place. Very few of the drugs of that time are still in use, but their modern successors are really only improvements on the same theme.<ref name="The History of Anaesthesiavvv"/>
