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Timeline of cardiovascular disease

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! Year/period !! Type of event !! Event !!Location
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|1628||DevelopmentScientific development ||[[wikipedia:English people|English]] physician [[wikipedia:William Harvey|William Harvey]] describes in detail the systemic circulation and properties of blood being pumped to the brain and body by the heart.<ref name=history-and-epidemiology/>||
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|1658||DevelopmentScientific development ||[[wikipedia:Swiss people|Swiss]] physician [[wikipedia:Jakob Wepfer|Jakob Wepfer]] describes for the first time [[wikipedia:Thrombosis|carotid thrombosis]], extracranially and intracranially, in a patient with a completely occluded and calcified right internal [[wikipedia:carotid artery|carotid artery]].<ref name=ahajournals>{{cite web|url=http://stroke.ahajournals.org/content/27/8/1427.full|title=The Evolution of Surgery for the Treatment and Prevention of Stroke |author=|date=|accessdate=28 July 2016}}</ref>||
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|1681–1742||DiscoveryScientific development ||[[wikipedia:German people|German]] physician [[wikipedia:Friedrich Hoffmann|Friedrich Hoffmann]] notes that coronary heart disease starts in the “reduced passage of the blood within the coronary arteries."<ref name=healthline/>||[[wikipedia:Martin Luther University of Halle-Wittenberg|Martin Luther University of Halle-Wittenberg]]
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|1733|Development| Medical development ||English clergyman and scientist [[wikipedia:Stephen Hales|Stephen Hales]] measures blood pressure.<ref>{{Cite journal|last=Lewis|first=O.|date=1994-12-01|title=Stephen Hales and the measurement of blood pressure|url=https://www.ncbi.nlm.nih.gov/pubmed/7884783|journal=Journal of Human Hypertension|volume=8|issue=12|pages=865–871|issn=0950-9240|pmid=7884783}}</ref>||[[wikipedia:Teddington|Teddington]], [[wikipedia:England|England]]
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|1768||DevelopmentScientific development ||English physician [[wikipedia:William Heberden|William Heberden]] describes [[wikipedia:angina|angina pectoris]] for the first time.<ref>{{cite web|url=http://rwjms1.umdnj.edu/shindler/heberden.html|title=Description of Angina Pectoris by William Heberden |author=|date=|accessdate=29 July 2016}}</ref>||[[wikipedia:Royal College of Physicians|Royal College of Physicians]], [[wikipedia:London|London]]
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|1785||DevelopmentMedical development ||English physician [[wikipedia:William Withering|William Withering]] publishes an account of medical use of [[wikipedia:digitalis|digitalis]], which are used for the treatment of heart conditions.<ref name=history-and-epidemiology/>||
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|1803||AchievementMedical development ||[[wikipedia:British people|British]] surgeon [[wikipedia:David Fleming (surgeon)|David Fleming]] performs the first successful ligation of a carotid artery.<ref name=ahajournals/>||
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| 1812 || DevelopmentScientific development || French physician {{w|César Julien Jean Legallois}} proposes the idea of artificial circulation.<ref name="Handbook of Polymer Applications in Medicine and Medical Devices: 8. Review of Research in Cardiovascular Devices">{{cite book|last1=Nawrat|first1=Zbigniew|title=Handbook of Polymer Applications in Medicine and Medical Devices: 8. Review of Research in Cardiovascular Devices|url=https://books.google.com.ar/books?id=QWt2DAAAQBAJ&pg=PT9&dq=%22in+1955%22+The+first+artificial+cardiac+pacemaker&hl=en&sa=X&ved=0ahUKEwid_8eBicrZAhUruVkKHeYKDOQQ6AEILTAB#v=onepage&q=%22in%201955%22%20The%20first%20artificial%20cardiac%20pacemaker&f=false}}</ref> ||
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| 1819 || Development || [[wikipedia:French people|French]] physician [[wikipedia:René Laennec|René Laennec]] invents the [[wikipedia:stethoscope|stethoscope]], an acoustic device for listening internal sounds of an animal or human body.<ref name=history-and-epidemiology/>||[[wikipedia:Necker-Enfants Malades Hospital|Necker-Enfants Malades Hospital]], [[wikipedia:Paris|Paris]]
|1960||Achievement||The first successful coronary artery bypass operation (anastomosis) is performed by German surgeon [[wikipedia:Robert H. Goetz|Robert H. Goetz]].<ref name=greatest-discoveries>{{cite journal |author=Jordan D. Haller, Andrew S. Olearchyk |date= |title=Cardiology's 10 Greatest Discoveries |journal= Tex Heart Inst J|publisher= National Center for Biotechnology Information |volume= 29|issue= |pages= 342–4|doi= |pmc=140304 |pmid= 12484626 |year=2002}}</ref>||[[wikipedia:Albert Einstein College of Medicine|Albert Einstein College of Medicine]], [[wikipedia:New York City|New York City]]
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|1961||DiscoveryScientific development ||[[wikipedia:Cholesterol|Cholesterol]] level, [[wikipedia:blood pressure|blood pressure]], and [[wikipedia:Electrocardiography|electrocardiogram]] abnormalities are found to increase the risk of heart disease.<ref name=framinghamheartstudy/>||[[wikipedia:U.S.A|U.S.A]]
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|1961||Organization||The [[wikipedia:British Heart Foundation|British Heart Foundation]] (BHF) is established as a charity organization in order to fund research on cardiovascular disease.<ref>{{cite web|url=https://www.bhf.org.uk/|title=British Heart Foundation|author=|date=|accessdate=31 July 2016}}</ref>||[[wikipedia:London|London]]
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|1963||Organization||[[wikipedia:Instituto do Coração da Universidade de São Paulo|Instituto do Coração da Universidade de São Paulo]] is founded as a center specializing in [[wikipedia:cardiology|cardiology]], [[wikipedia:cardiovascular medicine|cardiovascular medicine]] and [[wikipedia:cardiovascular surgery|cardiovascular surgery]].<ref>{{cite web|url=http://www.incor.usp.br/sites/incor2013/|title=incor|author=|date=|accessdate=31 July 2016}}</ref>||[[wikipedia:Sao Paulo|Sao Paulo]]
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|1964||AchievementMedical development ||[[wikipedia:Russians|Russian]] cardiac surgeon [[wikipedia:Vasiliy Kolesov|Vasiliy Kolesov]] performs the first successful coronary bypass using a standard suture technique.<ref name=greatest-discoveries/>||
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|1964||DevelopmentMedical development ||American [[wikipedia:interventional radiologist|interventional radiologist]] [[wikipedia:Charles Dotter|Charles Dotter]] describes [[wikipedia:angioplasty|angioplasty]] for the first time.<ref>{{cite journal |vauthors =Dotter CT, Judkins MP |title=Transluminal treatment of arteriosclerotic obstruction |journal=Circulation |volume=30 |pages=654–70 |date=November 1964 |pmid=14226164 |url=http://circ.ahajournals.org/cgi/pmidlookup?view=long&pmid=14226164 |doi=10.1161/01.CIR.30.5.654 |issue=5 }}</ref>||
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|1967||AchievementMedical development ||[[wikipedia:South African people|South African]] cardiac surgeon [[wikipedia:Christiaan Barnard|Christiaan Barnard]] performs the first successful human-to-human heart transplant.<ref name=history-and-epidemiology/>||[[wikipedia:Groote Schuur Hospital|Groote Schuur Hospital]], [[wikipedia:Cape Town|Cape Town]]
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|1967||AchievementMedical development ||[[wikipedia:Argentine|Argentine]] [[wikipedia:cardiac surgeon|cardiac surgeon]] [[wikipedia:René Favaloro|René Favaloro]] performs the first documented [[wikipedia:Coronary artery bypass surgery|saphenous aortocoronary bypass]].<ref>{{cite journal |author=Denton A. Cooley |date= |title=In Memoriam: Tribute to René Favaloro, Pioneer of Coronary Bypass |journal= Tex Heart Inst J|publisher= |volume= 27|issue= |pages= 231–2|doi= |pmc=101069 |pmid= 11225585 |year=2000}}</ref>||[[wikipedia:Cleveland Clinic|Cleveland Clinic]], [[wikipedia:Ohio|Ohio]]
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|1967||DiscoveryDcientific development ||[[wikipedia:Sedentary lifestyle|Physical inactivity]] and [[wikipedia:obesity|obesity]] are found to increase the risk of heart disease.<ref name=cardiovascular_diseases>{{cite web|url=http://www.who.int/cardiovascular_diseases/en/cvd_atlas_27_MILS_1856_1967.pdf|title=who cardiovascular diseases|author=|date=|accessdate=31 July 2016}}</ref>||[[wikipedia:U.S.A.|U.S.A.]]
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| 1968 || Medical development (device) || A. Kantrowitz et al. perform the first clinical trial in a man with intra-aortic balloon pumping.<ref name="Handbook of Polymer Applications in Medicine and Medical Devices: 8. Review of Research in Cardiovascular Devices"/> ||
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| 1969 || Organization || The [[wikipedia:World Heart Federation|International Cardiology Foundation]] (ICF) is established.<ref>{{cite web|url=http://www.epi.umn.edu/cvdepi/essay/the-international-society-of-cardiology-isc-and-cvd-epidemiology/|title=The International Society of Cardiology (ISC) and CVD Epidemiology|author=|date=|accessdate=29 July 2016}}</ref> || [[wikipedia:Geneva|Geneva]]
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| 1969|| AchievementMedical development (device) ||Argentine [[wikipedia:cardiac surgeon|cardiac surgeon]] [[wikipedia:Domingo Liotta|Domingo Liotta]] and [[wikipedia:Americans|American]] [[wikipedia:cardiac surgeon|cardiac surgeon]] [[wikipedia:Denton Cooley|Denton Cooley]] perform the first clinical implantation of a total [[wikipedia:artificial heart|artificial heart]] (TAH).<ref>{{cite web|url=http://www.fdliotta.org/biography.htm|title=Professor Domingo Santo Liotta|author=|date=|accessdate=28 July 2016}}</ref>||[[wikipedia:The Texas Heart Institute|The Texas Heart Institute]], [[wikipedia:Houston|Houston]]
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|1970||Organization||The Sixth [[wikipedia:World Congress of Cardiology|World Congress of Cardiology]] is held. During this congress, the [[wikipedia:World Congress of Cardiology|International Cardiology Federation]] (ICF) is created.<ref name=world-heart-federation/>||[[wikipedia:London|London]]
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|1970||DiscoveryScientific development ||[[wikipedia:Atrial fibrillation|Atrial fibrillation]] is found to increase stroke risk 5-fold.<ref name=framinghamheartstudy/>||U.S.A
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| 1971 || Medical development (device) || White– Extracorporeal Membrane Oxygenation (ECMO) are implemented on newborn babies using veno-venous bypass for up to 9 days.<ref name="Handbook of Polymer Applications in Medicine and Medical Devices: 8. Review of Research in Cardiovascular Devices"/> ||
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|1975||Organization||The [[wikipedia:Philippine Heart Center|Philippine Heart Center]] is founded.<ref>{{cite web|url=http://www.phc.gov.ph/|title=Philippine Heart Center|author=|date=|accessdate=31 July 2016}}</ref>||[[wikipedia:Quezón City|Quezón City]], [[wikipedia:Philippines|Philippines]]
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|1976||DiscoveryScientific development ||[[wikipedia:Menopause|Menopause]] is found to increase the risk of heart disease<ref name=framinghamheartstudy/>||U.S.A
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|1977||DevelopmentMedical development ||German [[wikipedia:radiology|radiologist]] [[wikipedia:Andreas Gruentzig|Andreas Gruentzig]] first develops [[wikipedia:coronary angioplasty|coronary angioplasty]] for treatment of [[wikipedia:coronary artery disease|coronary artery disease]].<ref>{{cite journal |author= Bernhard Meier, Dölf Bachmann, Thomas F Lüscher |date= February 2003|title=25 years of coronary angioplasty: almost a fairy tale|url=http://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2803%2912470-1/fulltext|journal= The Lancet|publisher= |volume= 361|issue= |pages= 527|doi=10.1016/S0140-6736(03)12470-1|pmc= |pmid= 12583964}}</ref>||[[wikipedia:Zurich|Zurich]], [[wikipedia:Switzerland|Switzerland]]
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|1978||DiscoveryScientific development ||Psychosocial factors are found to affect heart disease.<ref name=framinghamheartstudy/>||[[wikipedia:U.S.A|U.S.A]]
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|1978||Organization||The [[wikipedia:World Congress of Cardiology|International Society of Cardiology]] and the [[wikipedia:World Congress of Cardiology|International Cardiology Federation]] merge to become the [[wikipedia:World Congress of Cardiology|International Society and Federation of Cardiology]].<ref name=world-heart-federation/>||
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|1979||Organization||The [[wikipedia:Heart Rhythm Society|Heart Rhythm Society]] (HRS) is founded as an international non-profit organization in order to promote education and advocacy for cardiac arrhythmia professionals and patients.<ref>{{cite web|url=http://www.hrsonline.org/About-HRS/|title=Heart Rhythm Society|author=|date=|accessdate=31 July 2016}}</ref>||[[wikipedia:Washington, D.C.|Washington, D.C.]]
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|1982||DevelopmentMedical development (device) ||The [[wikipedia:Jarvik 7|Jarvik 7]] total [[wikipedia:artificial heart|artificial heart]], named for its designer, Dr. [[wikipedia:Robert Jarvik|Robert Jarvik]], is implanted in a patient.<ref>{{cite web|url=http://www.texasheart.org/Research/Devices/j7tah.cfm|title=Jarvik 7|author=|date=|accessdate=31 July 2016}}</ref>||[[wikipedia:University of Utah|University of Utah]]
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| 1984 || Medical development || American surgeon {{w|Leonard L Bailey}} transplants a baboon heart into {{w|Baby Fae}}, at Loma Linda Medical Center. The baby survives for three weeks.<ref name="Handbook of Polymer Applications in Medicine and Medical Devices: 8. Review of Research in Cardiovascular Devices"/> || {{w|United States}}
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| 1984 || Medical development (device) || Oyer and Portner use the Novacor electronically powered implantable left ventricular assist device as the first successful bridge to transplant.<ref>{{cite book|title=Textbook of Organ Transplantation Set|edition=Allan D. Kirk, Stuart J. Knechtle, Christian P. Larsen, Joren C. Madsen, Thomas C. Pearson, Steven A. Webber|url=https://books.google.com.ar/books?id=GzMWBAAAQBAJ&pg=PA555&dq=%22in+1984%22+%22novacor%22+%22transplant%22&hl=en&sa=X&ved=0ahUKEwj3n6nkm8rZAhVPrVkKHasDCg0Q6AEILDAB#v=onepage&q=%22in%201984%22%20%22novacor%22%20%22transplant%22&f=false}}</ref><ref name="Handbook of Polymer Applications in Medicine and Medical Devices: 8. Review of Research in Cardiovascular Devices"/> ||
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|1986||DevelopmentMedical development (device) ||French physician [[wikipedia:Jacques Puel|Jacques Puel]] and German [[wikipedia:cardiologist|cardiologist]] [[wikipedia:Ulrich Sigwart|Ulrich Sigwart]] are attributed to be the first to use the [[wikipedia:coronary stent|coronary stent]].<ref>{{cite journal|last1=Roguin|first1=Ariel|title=Historical Perspectives in Cardiology|journal=Circulation: Cardiovascular Interventsions|date=2011|volume=4|pages=206–209|doi=10.1161/CIRCINTERVENTIONS.110.960872|url=http://circinterventions.ahajournals.org/content/4/2/206.full|issue=2}}</ref>||[[wikipedia:Toulouse|Toulouse]], [[wikipedia:France|France]]
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| 1986 || Medical development (device) || The first atherectomy devices that remove material from the vessel wall are introduced.<ref name="Handbook of Polymer Applications in Medicine and Medical Devices: 8. Review of Research in Cardiovascular Devices"/> ||
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| 1987 || Discovery Medical development || Study done by [[wikipedia:Cooperative North Scandinavian Enalapril Survival Study|Cooperative North Scandinavian Enalapril Survival Study]] (CONSENSUS), shows unequivocal survival benefit of [[wikipedia:angiotensin|angiotensin]] converting enzyme inhibitors in severe heart failure.<ref name=history-and-epidemiology/> ||
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|1988||DevelopmentMedical development (device) ||[[wikipedia:Hemopump|Hemopump]], a temporary left ventricular assist blood pump, is put to clinical use. It is designed to allow for temporary support of a failing heart.<ref>{{cite web|url=http://www.texasheart.org/Research/Devices/hemopump.cfm|title=Hemopump|author=|date=|accessdate=31 July 2016}}</ref>||[[wikipedia:The Texas Heart Institute|The Texas Heart Institute]], [[wikipedia:Houston|Houston]]
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|1988||AchievementMedical development (device) ||The first successful long-term implantation of an artificial [[wikipedia:Ventricular assist device|Ventricular assist device]] LVAD is conducted by Dr. [[wikipedia:William F. Bernhard|William F. Bernhard]].<ref>{{cite web|url=https://www.joomag.com/magazine/lvad-living-august-2014/0872428001402630896?page=10|title=LVAD |author=|date=|accessdate=31 July 2016}}</ref>||[[wikipedia:Boston Children's Hospital|Boston Children's Hospital]]
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|1993||Organization||the [[wikipedia:American Society of Nuclear Cardiology|American Society of Nuclear Cardiology]] (ASNC) is founded.<ref>{{cite web|url=http://www.asnc.org/|title=ASNC|author=|date=|accessdate=31 July 2016}}</ref>||
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|1994||DiscoveryScientific development ||Enlarged left [[wikipedia:Ventricle (heart)|ventricle]] (one of two lower chambers of the heart) is shown to increase the risk of stroke.<ref name=framinghamheartstudy/>||[[wikipedia:U.S.A|U.S.A]]
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|1995||DevelopmentPublication ||The [[wikipedia:European Society of Cardiology|European Society of Cardiology]] publishes guidelines for diagnosing [[wikipedia:heart failure|heart failure]].<ref name=history-and-epidemiology/>||
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|1996||DevelopmentScientific development ||Progression from hypertension to heart failure is described.<ref name=framinghamheartstudy/>||[[wikipedia:U.S.A|U.S.A]]
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|1997||DevelopmentMedical development (device) ||The [[wikipedia:Thoratec|Thoratec]] [[wikipedia:Ventricular Assist Device|Ventricular Assist Device]] (VAD) is put to clinical use to support patients with acute and chronic heart failure.<ref>{{cite web|url=http://www.texasheart.org/Research/Devices/thoratec.cfm|title=Thoratec VAD|author=|date=|accessdate=31 July 2016}}</ref>||[[wikipedia:The Texas Heart Institute|The Texas Heart Institute]], [[wikipedia:Houston|Houston]]
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|1998||DiscoveryScientific development ||[[wikipedia:Framingham Study|Framingham Study]]: [[wikipedia:Atrial fibrillation|Atrial fibrillation]] is found to be associated with an increased risk of all-cause mortality.<ref name=framinghamheartstudy/>||U.S.A
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|1998||Organization||The [[wikipedia:World Congress of Cardiology|International Society and Federation of Cardiology]] board approves the change of name to [[wikipedia:World Heart Federation|World Heart Federation]] (WHF).<ref name=world-heart-federation/>||
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|1999||DiscoveryScientific development ||Lifetime risk at age 40 years of developing coronary heart disease is found to be one in two for men and one in three for women.<ref name=framinghamheartstudy/>||[[wikipedia:U.S.A|U.S.A]]
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|2000||Organization||The World Heart Federation launches '''World Heart Day''' as an annual event on the last Sunday of each September.<ref name=world-heart-federation/>||
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|2000||Organization||The [[wikipedia:Krishna Heart Institute|Krishna Heart Institute]] is founded as a high-end medical facility, specializing in [[wikipedia:heart diseases|heart diseases]].<ref>{{cite web|url=http://www.indiaheartbeat.com/hospital/profile/30849/KRISHNA-HEART-SUPER-SPECIALTY-INSTITUTE.html|title=Krishna Heart Institute|author=|date=|accessdate=31 July 2016}}</ref>||[[wikipedia:Ahmedabad|Ahmedabad]], [[wikipedia:India|India]]
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|2000||Organization||The [[wikipedia:Blood Pressure Association|Blood Pressure Association]] is founded as a [[wikipedia:charitable organization|charitable organization]] to provide information and support to people with [[wikipedia:hypertension|hypertension]].<ref>{{cite web|url=http://www.blood-pressure-monitoring.org/|title=Blood Pressure Association|author=|date=|accessdate=31 July 2016}}</ref>||[[wikipedia:London|London]]
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|2001||DiscoveryScientific development ||High-normal [[wikipedia:blood pressure|blood pressure]] is found to be associated with an increased risk of cardiovascular disease, emphasizing the need to determine whether lowering high-normal blood pressure can reduce the risk of cardiovascular disease.<ref name=framinghamheartstudy/>||[[wikipedia:U.S.A|U.S.A]]
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|2001||DevelopmentMedical development (device) ||[[wikipedia:AbioCor|AbioCor]] total [[wikipedia:artificial heart|artificial heart]] is implanted in a 59-year-old man. The TAH is developed by company [[wikipedia:AbioMed|AbioMed]].<ref>{{cite web|url=http://www.texasheart.org/Research/Devices/abiocor.cfm|title=AbioCor|author=|date=|accessdate=31 July 2016}}</ref>||[[wikipedia:Jewish Hospital (Louisville, Kentucky)|Jewish Hospital]], [[wikipedia:Louisville, Kentucky|Louisville]], [[wikipedia:Kentucky|Kentucky]]
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|2004||DiscoveryScientific development ||Serum [[wikipedia:aldosterone|aldosterone]] levels are found to predict future risk of hypertension in non-hypertensive individuals.<ref name=framinghamheartstudy/><ref>{{cite journal |author=Ramachandran S. Vasan, M.D., Jane C. Evans, D.Sc., Martin G. Larson, Sc.D., Peter W.F. Wilson, M.D., James B. Meigs, M.D., M.P.H., Nader Rifai, Ph.D., Emelia J. Benjamin, M.D., Daniel Levy, M.D. |date= |title=Serum Aldosterone and the Incidence of Hypertension in Nonhypertensive Persons|url=http://www.nejm.org/doi/full/10.1056/NEJMoa033263#t=article|journal= New England Journal of Medicine|publisher= |volume= 351|issue= |pages= 33–41|doi=10.1056/NEJMoa033263 |pmc= |pmid= }}</ref>||[[wikipedia:Boston Medical Center|Boston Medical Center]], [[wikipedia:U.S.A|U.S.A]]
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|2006||Organization||The [[wikipedia:Multan Institute of Cardiology|Multan Institute of Cardiology]] is founded.<ref>{{cite web|url=http://cpeic.gop.pk/|title=Multan Institute of Cardiology|author=|date=|accessdate=31 July 2016}}</ref>||[[wikipedia:Multan|Multan]], [[wikipedia:Pakistan|Pakistan]]
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|2007||Organization||[[wikipedia:Atrial Fibrillation Association|Atrial Fibrillation Association]] is established as an international charity that provides information and support for patients with [[wikipedia:atrial fibrillation|atrial fibrillation]].<ref>{{cite web|url=http://www.heartrhythmalliance.org/afa/uk/about|title=Atrial Fibrillation Association|author=|date=|accessdate=31 July 2016}}</ref>||[[wikipedia:Shipston-on-Stour|Shipston-on-Stour]], [[wikipedia:United Kingdom|United Kingdom]]
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|2008||ReportEpidemiology ||The total number of deaths due to cardiovascular disease reads 17.3 million worldwide a year according to the [[wikipedia:World Health Organization|WHO]].<ref>{{cite web|url=http://www.world-heart-federation.org/cardiovascular-health/global-facts-map/|title=Deaths due to cardiovascular disease|author=|date=|accessdate=1 July 2016}}</ref>||
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|2008||Organization||The Sixteenth [[wikipedia:World Congress of Cardiology|World Congress of Cardiology]] is held. From then on, the WCC moves from a 4-year to a 2-year cycle.<ref name=world-heart-federation/>||[[wikipedia:Buenos Aires|Buenos Aires]]
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|2010||DiscoveryScientific development ||[[wikipedia:Sleep apnea|Sleep apnea]] is found to be tied to increased risk of stroke.<ref name=framinghamheartstudy/><ref>{{cite web|url=http://www.nhlbi.nih.gov/news/press-releases/2010/sleep-apnea-tied-to-increased-risk-of-stroke|title=Sleep apnea tied to increased risk of stroke|author=|date=|accessdate=1 July 2016}}</ref>||[[wikipedia:National Heart, Lung, and Blood Institute|National Heart, Lung, and Blood Institute]], [[wikipedia:Maryland|Maryland]], [[wikipedia:U.S.A|U.S.A]]
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|2011||DevelopmentMedical development (drug) ||pCMV-''vegf165'' is registered in [[wikipedia:Russia|Russia]] as the first-in-class gene therapy drug for treatment of [[wikipedia:peripheral artery disease|peripheral artery disease]], including the advanced stage of [[wikipedia:critical limb ischemia|critical limb ischemia]].<ref>{{cite news|title=Gene Therapy for PAD Approved|url=http://www.dddmag.com/news/2011/12/gene-therapy-pad-approved|accessdate=28 July 2016|date=6 December 2011}}</ref><ref>{{cite journal|last1=Deev|first1=R.|last2=Bozo|first2=I.|last3=Mzhavanadze|first3=N.|last4=Voronov|first4=D.|last5=Gavrilenko|first5=A.|last6=Chervyakov|first6=Yu.|last7=Staroverov|first7=I.|last8=Kalinin|first8=R.|last9=Shvalb|first9=P.|last10=Isaev|first10=A.|title=pCMV-vegf165 Intramuscular Gene Transfer is an Effective Method of Treatment for Patients With Chronic Lower Limb Ischemia|journal=Journal of cardiovascular pharmacology and therapeutics|date=13 March 2015|doi=10.1177/1074248415574336|url=http://cpt.sagepub.com/content/early/2015/03/12/1074248415574336.abstract|accessdate=28 July 2016|pmid=25770117|volume=20|pages=473–82}}</ref>||[[wikipedia:Russia|Russia]]
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|2011||CampaignUpdate ||The [[wikipedia:United Nations|UN]] declaration on [[wikipedia:Non-communicable disease|Non-communicable disease]]s change the global approach to NCD’s of which cardiovascular disease is the greatest contributor.<ref name=world-heart-federation/>||
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|2012||ReportEpidemiology ||[[wikipedia:Ischemic heart disease|Ischemic heart disease]] and [[wikipedia:stroke|stroke]] are found to be the leading causes of death worldwide, with 7.4 million deaths due to ischemic heart disease and 6.7 million deaths for stroke.<ref name=factsheets>{{cite web|url=http://who.int/mediacentre/factsheets/fs310/en/|title=The top 10 causes of death|author=|date=|accessdate=1 July 2016}}</ref>||
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|2013||CampaignProgram ||World Heart Federation board adopts the [[wikipedia:United Nations|United Nations]] and [[wikipedia:World Health Organization|World Health Organization]] targets for cardiovascular disease, launching the '''25 x 25 campaign''' to reduce premature death from CVD by 25% by 2025.<ref name=world-heart-federation/>||
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