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| 1827 || || || "In 1827, Scottish scientist Robert Brown discovered "Brownian motion," which theoretically proved the protective effect of masks on dust."<ref name="globaltimes.cn"/> ". In 1827, the Scottish botanist Robert Brown discovered the phenomenon known as the Brownian movement – the theory that collisions of rapidly moving gas molecules causes the random bouncing motion of extremely small particles. Understanding the behavior of small particles, the properties of filter media and their interactions led to the first particulate respirator."<ref name="cdc.govi"/> || {{w|Middle East}}
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| 1848 || Mining pollution || || Lewis Hassley in the United States develops a mask for miners, obtaining the first patent for a protective mask.<ref name="globaltimes.cn"/> |||-| 1849 || || || "In 1848, the mask made by American Lewis Hassley for miners obtained the first patent for a protective mask, which was a milestone in the history of face masks. Masks at this stage were closer to gas masks. Hassley applied for the patent in 1849 with the patent number 6529, which is still available in the archives in the US."<ref name="globaltimes.cn"/> ||{{w|United States}}
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| 1861 || || || French scientist {{w|Louis Pasteur}} proves the presence of {{w|bacteria}} in the air. This makes more people pay attention to the design of modern masks.<ref name="globaltimes.cn"/> || {{w|France}}
| 1877 || || || The Nealy Smoke Mask is invented and patented in {{w|England}}. It users a series of water-saturated sponges and a bag of water attached to a neck strap. The wearer could squeeze the bag of water to re-saturate the sponges to filter out some of the smoke.<ref name="cdc.govi"/> || {{w|United Kingdom}}
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| 1879 || || || One of the first domestically produced masks is advertised in newspapersin Japan.<ref name="japantimes.co.jp">{{cite web |title=The history behind Japan’s love of face masks |url=https://www.japantimes.co.jp/news/2020/07/04/national/science-health/japans-history-wearing-masks-coronavirus/ |website=japantimes.co.jp |accessdate=10 September 2020}}</ref> || {{w|Japan}}
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| 1895 || Noxious fumes || || Henrot suggests equipping the privates in Madagascar with face masks to protect them from noxious fumes. By this time this idea is considered comical if not downright ridiculous.<ref name="newseye.euv"/> || {{w|Madagascar}}
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| 1897 || || || Polish surgeon {{w|Jan Mikulicz-Radecki}} describes a surgical mask composed on one layer of gauze.<ref name="History of Surgical Face Masks">{{cite journal |last1=Spooner |first1=John L. |title=History of Surgical Face Masks |doi=10.1016/S0001-2092(08)71359-0 |url=Johann Von Mikulicz Radecki describes a surgical mask composed on one layer of gauze.}}</ref> The practice of using face masks is considered to be introduced by him.<ref name="bloomberg.comss"/> || {{w|Poland}} || [[File:Jan Mikulicz-Radecki (c. 1878).jpg|thumb|center|150px|Jan Mikulicz-Radecki]]
