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| 1523 || Protection (‘‘{{w|cordon sanitaire}}’’) || {{w|Plague}} || During a plague outbreak in {{w|Birgu}}, {{w|Malta}}, the town is cordoned off by guards to prevent the disease from spreading to the rest of the island.<ref>{{cite book |last1=Luttrell |first1=Anthony |title=The Making of Christian Malta: From the Early Middle Ages to 1530 |url=https://books.google.com.ar/books?id=c3BQDwAAQBAJ&pg=PA56&lpg=PA56&dq=Birgu+1523+plague+cordon&source=bl&ots=9sNART0OXM&sig=ACfU3U0_1gDnIW6jrnPXQFSGqOenvf6O6A&hl=en&sa=X&ved=2ahUKEwi8gPTa6MfpAhWcGbkGHfUkAQsQ6AEwAHoECAsQAQ#v=onepage&q=Birgu%201523%20plague%20cordon&f=false}}</ref> || {{w|Malta}}
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| 1523 || Protection method || {{w|Anthrax}} || English scholar {{w|Anthony Fitzherbert}} recommends removal of animals which have died from 'murrain' ({{w|anthrax}}), except the skin (which is sent to a tannery) and the head (which 'was to be placed on a pole to notify to others "that sickness existed in the township" ')<ref name="oie.int"/> || {{w|United Kingdom}}
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| 1598 || Concept development || || The word ''disinfectant'' is first recorded in writing, with the meaning "to cure, to heale".<ref name="Seymour"/> ||
