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Timeline of infection control

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| c.3000 BC || {{w|Disinfectant}} introduction || || Ancient Egyptians use palm wine and vinegar to rinse the abdominal cavities of human and animal cadavers prior to embalming.<ref name="oie.int">{{cite web |last1=BLANCOU |first1=J. |title=History of disinfection from early times until the end of the 18th century |url=https://www.oie.int/doc/ged/D8963.PDF |website=oie.int |accessdate=3 April 2020}}</ref> || {{w|Egypt}}
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| 800 BC || {{w|Disinfectant}} introduction || || The oldest reference to disinfection of premises with a chemical product seems to be that described by [[w:Homer (Homero)|Homer]] in book xii of the ''{{w|Odyssey}}'', where the hero, having killed his rivals, demands that sulphur be burnt in the house which they had occupied.<ref name="oie.int"/> ||
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| 1363 || {{w|Disinfectant}} introduction || Microbial pathogens || Alcohol as an {{w|antiseptic}} is recommended for wound treatment by French physician {{w|Guy de Chauliac}}.<ref name="Block">{{cite book |last1=Block |first1=Seymour Stanton |title=Disinfection, Sterilization, and Preservation |url=https://books.google.com.ar/books?id=3f-kPJ17_TYC&pg=PA229&lpg=PA229&dq=1363+++Alcohol+is+already+used+as+an+antiseptic.&source=bl&ots=KnIjEt4ON0&sig=ACfU3U19gDSSAKOZfh3tqGXdv6oIFH6fBQ&hl=en&sa=X&ved=2ahUKEwjF25rkucbpAhXwHrkGHSxCCB0Q6AEwDHoECAgQAQ#v=onepage&q=1363%20%20%20Alcohol%20is%20already%20used%20as%20an%20antiseptic.&f=false}}</ref> || {{w|France}}
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| 1523 || ''Protection (‘‘{{w|Cordon cordon sanitaire}}'' ’’) || {{w|Plague}} || During a plague outbreak in {{w|Birgu}}, {{w|Malta}}, the town is cordoned off by guards to prevent the disease from spreading to the rest of the island.<ref>{{cite book |last1=Luttrell |first1=Anthony |title=The Making of Christian Malta: From the Early Middle Ages to 1530 |url=https://books.google.com.ar/books?id=c3BQDwAAQBAJ&pg=PA56&lpg=PA56&dq=Birgu+1523+plague+cordon&source=bl&ots=9sNART0OXM&sig=ACfU3U0_1gDnIW6jrnPXQFSGqOenvf6O6A&hl=en&sa=X&ved=2ahUKEwi8gPTa6MfpAhWcGbkGHfUkAQsQ6AEwAHoECAsQAQ#v=onepage&q=Birgu%201523%20plague%20cordon&f=false}}</ref> || {{w|Malta}}
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| 1523 || Protection method || || English scholar {{w|Anthony Fitzherbert}} recommends removal of animals which have died from 'murrain' ({{w|anthrax}}), except the skin (which is sent to a tannery) and the head (which 'was to be placed on a pole to notify to others "that sickness existed in the township" ')<ref name="oie.int"/> || {{w|United Kingdom}}
| 1659 || {{w|Disinfectant}} introduction || || {{w|Potassium permanganate}} is first obtained by German-Dutch chemist {{w|Johann Rudolf Glauber}}.<ref>{{cite journal |last1=Ahmed |first1=Khalid Abdelazez Mohamed |title=Exploitation of KMnO4 material as precursors for the fabrication of manganese oxide nanomaterials |doi=10.1016/j.jtusci.2015.06.005 |url=https://www.sciencedirect.com/science/article/pii/S1658365515001132}}</ref><ref>{{cite book |title=Report of the ... Annual Proceedings of the Louisiana State Pharmaceutical Association |publisher=Louisiana State Pharmaceutical Association |url=https://books.google.com.ar/books?id=qd3qAAAAMAAJ&q=1659+Potassium+permanganate&dq=1659+Potassium+permanganate&hl=en&sa=X&ved=0ahUKEwifpMeZ6sfpAhUDJrkGHbxtB50Q6AEIKDAA}}</ref> || {{w|Netherlands}}
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| 1666 || ''Protection (‘‘{{w|Cordon cordon sanitaire}}'' ’’) || {{w|Plague}} || The English village of {{w|Eyam}} famously imposes a cordon sanitaire on itself after an outbreak of the {{w|bubonic plague}} in the community.<ref>{{cite book |last1=Brauer |first1=Fred |last2=Castillo-Chavez |first2=Carlos |last3=Feng |first3=Zhilan |title=Mathematical Models in Epidemiology |url=https://books.google.com.ar/books?id=Qm21DwAAQBAJ&pg=PA40&dq=%221666%22+%22eyam%22+%22plague%22&hl=en&sa=X&ved=0ahUKEwiC87WqkMjpAhX_F7kGHWvjBCYQ6AEIYzAH#v=onepage&q=%221666%22%20%22eyam%22%20%22plague%22&f=false}}</ref><ref>{{cite book |last1=Rhodes |first1=Ebenezer |title=Peak Scenery; Or, The Derbyshire Tourist |url=https://books.google.com.ar/books?id=RjhAAAAAIAAJ&pg=PA31&dq=%221666%22+%22eyam%22+%22plague%22&hl=en&sa=X&ved=0ahUKEwiC87WqkMjpAhX_F7kGHWvjBCYQ6AEIbjAI#v=onepage&q=%221666%22%20%22eyam%22%20%22plague%22&f=false}}</ref> || {{w|United Kingdom}}
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| 1675 || Scientific development || Microbial pathogens || {{w|Antonie Van Leuwenhoek}} discovers microorganisms.<ref name="History and Evolution of Surface Disinfectants">{{cite web |title=History and Evolution of Surface Disinfectants |url=http://blog.pdihc.com/blog/april-2018 |website=pdihc.com |accessdate=3 April 2020}}</ref> ||
| 1676 || || Microbial pathogens || Dutch scientist {{w|Antonie Van Leuwenhoek}} first sees bacteria.<ref name="Seymour"/> In the same year, he discovers that vinegar kills some microorganisms.<ref name="History and Evolution of Surface Disinfectants"/> Van Leuwenhoek provides the first scientific proof of the action of acids on 'animalcules', which he discovered using the microscope of his own invention.<ref name="oie.int"/> || {{w|Netherlands}}
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| 1708–1712 || ''Protection (‘‘{{w|Cordon cordon sanitaire}}'' ’’) || {{w|Plague}} || A broad cordon sanitaire is extended around the border of the former Duchy of Prussia during a plague outbreak. Those crossing into the exclave are quarantined.<ref>{{cite web |title=Great Northern War plague outbreak |url=https://alchetron.com/Great-Northern-War-plague-outbreak |website=alchetron.com |accessdate=7 July 2020}}</ref> || {{w|Russia}}
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| 1715 || Disinfection method || {{w|Cattle plague}} || Italian physician {{w|Giovanni Maria Lancisi}} recommends using {{w|vinegar}} (or vinegar water) for disinfecting objects (and even animals or persons) which have been in contact with cases of {{w|cattle plague}}.<ref>{{cite book |last1=Spinage |first1=Clive |title=Cattle Plague: A History |url=https://books.google.com.ar/books?id=uk3MBgAAQBAJ&pg=PT641&lpg=PT641&dq=Lancisi+1715+vinegar&source=bl&ots=xJkEP_KOfe&sig=ACfU3U0cgTPcyeMGkp9oB9dZF4GndknZEw&hl=en&sa=X&ved=2ahUKEwiToOnzlsjpAhVFD7kGHUUOAzYQ6AEwAHoECAoQAQ#v=onepage&q=Lancisi%201715%20vinegar&f=false}}</ref><ref>{{cite book |last1=Taylor |first1=William P. |title=Rinderpest and Peste des Petits Ruminants: Virus Plagues of Large and Small Ruminants |url=https://books.google.com.ar/books?id=Q70ffyHl2YAC&dq=Lancisi+1715+vinegar&source=gbs_navlinks_s}}</ref><ref name="oie.int"/> || {{w|Italy}}
| 1718 || Disinfection method introduction || || French naturalist {{w|Louis Joblot}} sterilizes a hay infusion by boiling it for 15 minutes and then sealing the container.<ref name="Rogers">{{cite book |last1=Rogers |first1=Wayne J |title=Healthcare Sterilisation: Introduction & Standard Practices, Volume 1, Volume 1 |url=https://books.google.com.ar/books?id=O_wlDwAAQBAJ&pg=PA47&dq=Joblot+1718++sterilise+an+infusion+of+hay+by+boiling+it+for+fifteen+minutes+and+then+sealing+the+container&hl=en&sa=X&ved=0ahUKEwipwPWKmcjpAhUcDrkGHdenD_UQ6AEIKDAA#v=onepage&q=Joblot%201718%20%20sterilise%20an%20infusion%20of%20hay%20by%20boiling%20it%20for%20fifteen%20minutes%20and%20then%20sealing%20the%20container&f=false}}</ref><ref>{{cite book |last1=Stanton Block |first1=Seymour |title=Disinfection, Sterilization, and Preservation |url=https://books.google.com.ar/books?id=3f-kPJ17_TYC&pg=PA16&dq=Joblot+1718++sterilise+an+infusion+of+hay+by+boiling+it+for+fifteen+minutes+and+then+sealing+the+container&hl=en&sa=X&ved=0ahUKEwipwPWKmcjpAhUcDrkGHdenD_UQ6AEIMTAB#v=onepage&q=Joblot%201718%20%20sterilise%20an%20infusion%20of%20hay%20by%20boiling%20it%20for%20fifteen%20minutes%20and%20then%20sealing%20the%20container&f=false}}</ref><ref name="oie.int"/> || {{w|France}}
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| 1719 || {{w|Disinfectant}} introduction || || {{w|Thymol}} is first isolated by the German chemist [[w:Caspar Neumann (chemist)|Caspar Neumann]].<ref>{{cite journal|first=Carolo |last=Neuman |date=1724 |title=De Camphora |journal=Philosophical Transactions of the Royal Society of London |volume=33 |issue=389 |pages=321–332 |url=http://rstl.royalsocietypublishing.org/content/33/381-391/321.full.pdf+html |doi=10.1098/rstl.1724.0061|doi-access=free }} On page 324, Neumann mentions that in 1719 (MDCCXIX) he distilled some essential oils from various herbs. On page 326, he mentions that during the course of these experiments, he obtained a crystalline substance from thyme oil, which he called "''Camphora Thymi''" ([[{{w|camphor]] }} of thyme). (Neumann gave the name "camphor" not only to the specific substance that today is called camphor, but to any crystalline substance that precipitated from a volatile, fragrant oil from some plant.)</ref> || {{w|Germany}}
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| 1730 || {{w|Disinfectant}} introduction || {{w|Glanders}} infection || {{w|Charles VI, Holy Roman Emperor}} decrees that stables which have housed glanderous horses should be plastered with {{w|quicklime}}. Such arrangements figure in numerous texts published in Europe around the time.<ref name="oie.int"/> || {{w|Europe}}
| 1745 || Policy || {{w|Plague}} || A decree in {{w|Oldenburg}} prescribes the cleaning with {{w|caustic soda}} of troughs from which cattle with plague have fed, and the cleaning of the woodwork and walls of their houses with lime-wash.<ref name="oie.int"/> || {{w|Germany}}
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| 1770 || ''Protection (‘‘{{w|Cordon cordon sanitaire}}'' ’’) || {{w|Plague}} || [[w:House of Habsburg|Habsburg]] {{w|Empress Maria Theresa}} sets up a {{w|cordon sanitaire}} between {{w|Austria}} and the {{w|Ottoman Empire}} to prevent people and goods infected with plague from crossing the border. Cotton and wool are held in storehouses for weeks, with peasants paid to sleep on the bales and monitored to see if they show signs of disease.<ref>{{cite web |title=Top 10 Historic Ways To Beat Plagues |url=https://listverse.com/2020/04/18/top-10-historic-ways-to-beat-plagues/ |website=listverse.com |accessdate=26 May 2020}}</ref> || {{w|Austrian Empire}} region
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| 1771 || Policy || Epizootic infection || Policy is introduced in France stipulating that animals killed or dead from epizootic disease may not be abandoned in forests, thrown into rivers or placed on rubbish dumps, nor may they be buried in stables, courtyards, gardens or elsewhere within the precincts of towns and villages.<ref name="oie.int"/> || {{w|France}}
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| 1774 || {{w|Disinfectant}} introduction || Microbial pathogens || [[w:Swedish people|Swedish]] chemist {{w|Carl Wilhelm Scheele}} discovers {{w|chlorine}}.<ref name="Hugo">{{cite journal |last1=Hugo |first1=W.B. |title=A brief history of heat and chemical preservation and disinfect ion |journal=Journal of Applied Bacteriology |url=https://sfamjournals.onlinelibrary.wiley.com/doi/pdf/10.1111/j.1365-2672.1991.tb04657.x |accessdate=3 April 2020}}</ref> ||
| 1789 || {{w|Disinfectant}} introduction || || Scottish chemist {{w|Charles Tennant}} prepares a bleaching powder, as distinct from a liquid, by passing chlorine gas into a slurry of slaked lime.<ref>{{cite book |title=Britain in the Hanoverian Age, 1714-1837: An Encyclopedia |edition=Gerald Newman, Leslie Ellen Brown, A. J. Graham Cummings, Jack Fruchtman (Jr.).), Peter A. Tasch |url=https://books.google.com.ar/books?id=ZhaBz_5OZiUC&pg=RA4-PA693-IA5&lpg=RA4-PA693-IA5&dq=Tennant+1789+bleach&source=bl&ots=z0UgHGAXHI&sig=ACfU3U0YGLnvzILTx-8Apg0x7m3g9WXZBw&hl=en&sa=X&ved=2ahUKEwjXu7_MwLvqAhUSIrkGHZJ0DkQQ6AEwAHoECAgQAQ#v=onepage&q=Tennant%201789%20bleach&f=false}}</ref><ref>{{cite book |title=Materials and Expertise in Early Modern Europe: Between Market and Laboratory |edition=Ursula Klein, E. C. Spary |url=https://books.google.com.ar/books?id=0TBhqoUJjo8C&pg=PA340&lpg=PA340&dq=Tennant+1789+bleach&source=bl&ots=q5OIcMsy41&sig=ACfU3U1I_YkLy0rZznvOtScBUpzOy9_HNQ&hl=en&sa=X&ved=2ahUKEwjXu7_MwLvqAhUSIrkGHZJ0DkQQ6AEwC3oECAwQAQ#v=onepage&q&f=false}}</ref><ref name="Hugo"/> || {{w|United Kingdom}}
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| 1793 || ''Protection (‘‘{{w|Cordon cordon sanitaire}}'' ’’) || {{w|Yellow fever}} || During a yellow fever epidemic in {{w|Philadelphia}}, roads and bridges leading to the city are blocked off by soldiers from the local militia to prevent the illness from spreading.<ref>{{cite journal |last1=Cohn |first1=Samuel K. |title=Yellow Fever |doi=10.1093/oso/9780198819660.003.0018 |url=https://www.oxfordscholarship.com/view/10.1093/oso/9780198819660.001.0001/oso-9780198819660-chapter-18}}</ref> || {{w|United States}}
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| 1794 || Protection method || {{w|Plague}} || English physician {{w|Erasmus Darwin}} recommends that if cattle plague are introduced into England, all cattle within a five mile radius of any confirmed outbreak should be 'immediately slaughtered, and consumed within the circumscribed district; and their hides put into quicklime before proper inspectors'.<ref name="oie.int"/> || {{w|United Kingdom}}
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| 1800 || Infrastructure || {{w|Hospital-acquired infection}}, communicable infection || A Hospital for Sick Children is established in {{w|Paris}}, initially admitting infectious cases, with consequent high mortality from cross-infection.<ref name="Wright">{{cite journal |last1=Wright |first1=David |title=Infection control throughout history |doi=10.1016/S1473-3099(14)70726-1 |url=https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(14)70726-1/fulltext}}</ref> || {{w|France}}
| 1811 || {{w|Disinfectant}} introduction || Microbial pathogens || {{w|Chlorine dioxide}} is discovered.<ref>{{cite web |title=OVERVIEW OF CHLORINE DIOXIDE (CLO2) |url=http://www.afinitica.com/arnews/?q=node/92 |website=afinitica.com |accessdate=26 May 2020}}</ref><ref>{{cite book |last1=Wilson |first1=Charles L. |last2=Droby |first2=Samir |title=Microbial Food Contamination |url=https://books.google.com.ar/books?id=2vN64QtjI2UC&pg=PA6&lpg=PA6&dq=1811+Chlorine+dioxide+is+discovered&source=bl&ots=I7jW8ehJRe&sig=ACfU3U06z_UEtmrnhJ3Lo_KI_aw1KU5OKw&hl=en&sa=X&ved=2ahUKEwiqrOOBzNLpAhXSHLkGHeEKC6kQ6AEwC3oECAwQAQ#v=onepage&q=1811%20Chlorine%20dioxide%20is%20discovered&f=false}}</ref><ref>{{cite book |last1=Schmidt |first1=Ronald H. |last2=Rodrick |first2=Gary E. |title=Food Safety Handbook |url=https://books.google.com.ar/books?id=87Eimlt7dMMC&pg=PA396&lpg=PA396&dq=1811+Chlorine+dioxide+is+discovered&source=bl&ots=p035rVGjJY&sig=ACfU3U2qE0ue-H03gu9_h-qWuMZN2hlkCQ&hl=en&sa=X&ved=2ahUKEwiqrOOBzNLpAhXSHLkGHeEKC6kQ6AEwDHoECA0QAQ#v=onepage&q=1811%20Chlorine%20dioxide%20is%20discovered&f=false}}</ref> ||
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| 1813–1814 || ''Protection (‘‘{{w|Cordon cordon sanitaire}}'' ’’) || {{w|Plague}} || During the {{w|1813–1814 Malta plague epidemic}}, cordon sanitaires are implemented in the main urban settlements and rural settlements with a high mortality rate. People are prevented from entering or leaving.<ref>{{cite web |title=Inspector of Hospitals Ralph Green – Introduction |url=http://www.maltaramc.com/articles/contents/plague1813.html |website=maltaramc.com |accessdate=7 July 2020}}</ref><ref>{{cite web |title=Aspects of the demography of modern Malta.: a study of the human geography of the Maltese Islands |url=http://etheses.dur.ac.uk/9175/2/6106-vol2.pdf?UkUDh:CyT |website=etheses.dur.ac.uk |accessdate=7 July 2020}}</ref> || {{w|Malta}}
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| 1818 || {{w|Disinfectant}} introduction || || {{w|Louis Jacques Thénard}} first produces {{w|hydrogen peroxide}} by reacting {{w|barium peroxide}} with {{w|nitric acid}}.<ref>{{Cite journal
| url = https://books.google.com/?id=-N43AAAAMAAJ&pg=PA306#v=onepage}}</ref> || {{w|France}}
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| 1821 || ''Protection (‘‘{{w|Cordon cordon sanitaire}}'' ’’) || Concept development || The term {{w|cordon sanitaire}} dates to this year.<ref>{{cite book |last1=Smart |first1=William |title=Economic Annals of the Nineteenth Century ...: 1821-1830 |url=https://books.google.com.ar/books?id=vgjRAAAAMAAJ&q=cordon+sanitaire+1821&dq=cordon+sanitaire+1821&hl=en&sa=X&ved=0ahUKEwjHp6-z983pAhXCILkGHesIDB8Q6AEIVDAF}}</ref><ref>{{cite book |last1=Bourgon |first1=Jean Ignace Joseph |title=Abrégé de l'histoire de France, Volume 2 |url=https://books.google.com.ar/books?id=KVEvAAAAMAAJ&pg=PA826&dq=cordon+sanitaire+1821&hl=en&sa=X&ved=0ahUKEwjHp6-z983pAhXCILkGHesIDB8Q6AEIdzAJ#v=onepage&q=cordon%20sanitaire%201821&f=false}}</ref><ref>{{cite journal |last1=Salas-Vives |first1=Pere |last2=Pujadas-Mora |first2=Joana-Maria |title=Cordons Sanitaires and the Rationalisation Process in Southern Europe (Nineteenth-Century Majorca) |doi=10.1017/mdh.2018.25 |pmid=29886862 |url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6113753/}}</ref> || {{w|France}}
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| 1823 || {{w|Disinfectant}} introduction || || French chemist {{w|Antoine Germain Labarraque}} uses {{w|hypochlorite}} as a deodorant and disinfectant in a cat-gut factory.<ref name="Hugo"/> || {{w|France}}
| 1827 || {{w|Disinfectant}} introduction || || English surgeon [[w:Thomas Alcock (surgeon)|Thomas Alcock]] shows the possibility to use {{w|hypochlorite}} for disinfection.<ref name="Rogers"/> || {{w|United Kingdom}}
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| 1829 || {{w|Disinfectant}} introduction || || {{w|Lugol's iodine}} is first made by French physician {{w|Jean Guillaume Auguste Lugol}}.<ref name=Pre2009>{{cite book|last1=Preedy|first1=Victor R.|last2=Burrow|first2=Gerard N.|last3=Watson|first3=Ronald Ross|title=Comprehensive Handbook of Iodine: Nutritional, Biochemical, Pathological and Therapeutic Aspects|date=2009|publisher=Academic Press|isbn=9780080920863|page=135|language=en|url=https://web.archive.org/web/20170812100039/https://books.google.ca/books?id=7v7g5XoCQQwC&pg=PA135}}</ref><ref name=Sn2005>{{cite book|last1=Sneader|first1=Walter|title=Drug Discovery: A History|date=2005|publisher=John Wiley & Sons|isbn=9780471899792|page=67|language=en|url=https://web.archive.org/web/20170826071343/https://books.google.ca/books?id=Cb6BOkj9fK4C&pg=PA67}}</ref> || {{w|France}}
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| 1831 || Disinfection method introduction || || English chemist {{w|William Henry}} investigates the disinfection of infected clothing using heat rendered them harmless. Henry devises a jacketed dry heat (hot air) steriliser.<ref name="Rogers"/> || {{w|United Kingdom}}
| 1854 || {{w|Disinfectant}} introduction || || {{w|Chlorinated lime}} is applied in the tratment of sewage in {{w|London}}.<ref name="Rogers"/> || {{w|United Kingdom}}
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| 1856 || ''Protection (‘‘{{w|Cordon cordon sanitaire}}'' ’’) || {{w|Yellow fever}} || A cordon sanitaire is implemented in several cities during the yellow fever epidemic. ||
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| 1858 || {{w|Disinfectant}} introduction || || British physician {{w|Benjamin Ward Richardson}} takes note of the capacity of {{w|hydrogen peroxide}} to remove foul odours and subsequently proposes its use as disinfectant.<ref name="Rogers"/> || {{w|United Kingdom}}
| 1867 || {{w|Disinfectant}} introduction || || The first reasoned attempt to sterilize air is made by {{w|Joseph Lister}} in his pursuit of antiseptic surgery.<ref name="Hugo"/> || {{w|United Kingdom}}
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| 1869 || ''Protection (‘‘{{w|Cordon cordon sanitaire}}'' ’’) || {{w|Cholera}} || French epidemiologist {{w|Achille Adrien Proust}} (father of novelist {{w|Marcel Proust}}) proposes the use of an international {{w|cordon sanitaire}} to control the spread of {{w|cholera}}, which emerged from {{w|India}} and, and threatening Europe and Africa at the time. Proust proposes that all ships bound for Europe from India and Southeast Asia be quarantined at {{w|Suez}}, however his ideas would not be generally embraced.<ref>{{cite web |title=Böses Komma |url=https://www.sueddeutsche.de/kultur/literatur-und-seuchengeschichte-boeses-komma-1.4914831 |website=sueddeutsche.de |accessdate=26 May 2020}}</ref><ref>{{cite web |title=MARCEL PROUST and the medicine of the Belle Epoque |url=https://www.rsm.ac.uk/media/2060/marcel-proust-exhibition-booklet.pdf |website=rsm.ac.uk |accessdate=26 May 2020}}</ref><ref>{{cite journal |last1=Chantre |first1=Luc |title=Entre pandémie et panislamisme |doi=10.4000/assr.25258 |url=https://journals.openedition.org/assr/25258?lang=it}}</ref> || {{w|France}}
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| 1871 || {{w|Disinfectant}} introduction || || Soap is used with {{w|coal tar}} to make an antiseptic preparation. This formulation is patented.<ref name="Hugo"/> ||
| 1881 || Disinfectant research || {{w|Diphtheria}} || There is evidence of the use of {{w|ozone}} as a disinfectant, mentioned by Kellogg in his book on {{w|diphtheria}}.<ref name="Rogers"/> ||
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| 1882 || ''Protection (‘‘{{w|Cordon cordon sanitaire}}'' ’’) || {{w|Yellow fever}} || In response to a virulent outbreak of {{w|yellow fever}} in {{w|Brownsville, Texas}}, and in northern Mexico, a {{w|cordon sanitaire}} is established 180 miles north of the city, terminating at the Rio Grande to the west and the Gulf of Mexico to the east.<ref>{{cite web |title=Part II: Yellow Fever Comes to the Valley |url=https://www.valleymorningstar.com/2016/08/07/part-ii-yellow-fever-comes-to-the-valley/ |website=valleymorningstar.com |accessdate=27 May 2020}}</ref><ref>{{cite web |title=Encyclopedia of Pestilence, Pandemics, and Plagues |url=https://www.academia.dk/MedHist/Sygdomme/PDF/Encyclopedia_of_Pestilence_Pandemics_and_Plagues.pdf |website=academia.dk |accessdate=27 May 2020}}</ref> || {{w|United States}}
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| 1882 || {{w|Disinfectant}} introduction || || {{w|Hydrogen peroxide}} is first used for bleaching.<ref>{{cite book|url=https://www.scribd.com/doc/90597292/9/History-of-bleaching-with-hydrogen-peroxide|title=Catalytic Bleaching of Cotton: Molecular and Macroscopic Aspects p 16|author=Tatjana Topalović|publisher=Thesis, University of Twente, the Netherlands |accessdate=8 May 2012|year=2007}}</ref> ||
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| 1883 || Protection method || || Sterile gowns and caps are invented by German surgeon {{w|Gustav Adolf Neuber}} using a form of autoclave.<ref name="Rogers"/> || {{w|Germany}}
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| 1884 || Disinfection method introduction || || French microbiologist {{w|Charles Chamberland}} invents the first {{w|autoclave}}.<ref name="Rogers"/> ||
| 1887 || {{w|Disinfectant}} introduction || || Rosahegyi notes that dyes are inhibitory to {{w|bacteria}}.<ref name="Hugo"/> ||
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| 1888 || ''Protection (‘‘{{w|Cordon cordon sanitaire}}'' ’’) || || During a yellow fever epidemic, the city of {{w|Jacksonville}}, {{w|Florida}}, is surrounded by an armed cordon sanitaire by order of Governor Edward A. Perry.<ref>{{cite web |title=1888 Epidemic in Jacksonville |url=http://exhibits.lib.usf.edu/exhibits/show/discovering-florida/disease/1888-epidemic-in-jacksonville |website=exhibits.lib.usf.edu |accessdate=22 May 2020}}</ref><ref>{{cite book |title=Annual report of the Surgeon General |url=https://books.google.com.ar/books?id=YCr5AAAAIAAJ&pg=PA40&dq=1888+Cordon+sanitaire++yellow+fever+Jacksonville&hl=en&sa=X&ved=0ahUKEwi4_c7hlMjpAhXJF7kGHUWzAeYQ6AEIKDAA#v=onepage&q=1888%20Cordon%20sanitaire%20%20yellow%20fever%20Jacksonville&f=false}}</ref> || {{w|United States}}
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| 1888 || Publication || || Fred Kilmer publishes Modern Methods of Antiseptic Wound Treatment, which helps spread the adoption of antiseptic surgery.<ref name="Rogers"/> ||
| 1893 || Disinfection method introduction || || British botanist {{w|Harry Marshall Ward}} experiments on the bactericidal effects of different coloured lights.<ref>{{cite book |title=Disinfection, Sterilization, and Preservation |publisher=Seymour Stanton Block |url=https://books.google.com.ar/books?id=3f-kPJ17_TYC&pg=PA16&lpg=PA16&dq=1893+Ward+experiments+on+the+bactericidal+effects+of+different+coloured+lights&source=bl&ots=KnIjGx0NI-&sig=ACfU3U1k4NP-7Aqal_F1gi5veBhfs_h1Zw&hl=en&sa=X&ved=2ahUKEwi8l8qxqM3pAhUlHLkGHcKpDLsQ6AEwAnoECAgQAQ#v=onepage&q=1893%20Ward%20experiments%20on%20the%20bactericidal%20effects%20of%20different%20coloured%20lights&f=false}}</ref><ref>{{cite journal |last1=Clark |first1=Janet H. |title=THE PHYSIOLOGICAL ACTION OF LIGHT |doi=10.1152/physrev.1922.2.2.277 |url=https://journals.physiology.org/doi/abs/10.1152/physrev.1922.2.2.277?journalCode=physrev}}</ref> Ward demonstrates that it is primarily the ultraviolet portion of the spectrum that has the bactericidal action.<ref>{{cite web |title=Ultraviolet (UV) Light |url=http://www.spectralinnovations.com/reference/ultraviolet_light.htm |website=spectralinnovations.com |accessdate=24 May 2020}}</ref> || {{w|United Kingdom}}
|-
| 1894 || {{w|Disinfectant}} introduction || || English industrialist {{w|William Lever, 1st Viscount Leverhulme}} introduces the first mass-produced {{w|carbolic soap}} to the market, [[w:Lifebuoy (soap)|Lifebuoy]].<ref>{{cite web |url=http://www.lifebuoy.com/about-us/history-of-health/ |title=Country Selector |accessdate=2014-10-16 |url-status=dead |archiveurl=https://web.archive.org/web/20141006155150/http://www.lifebuoy.com/about-us/history-of-health/ |archivedate=2014-10-06 }} A History of Health, lifebuoy.com</ref> || {{w|United Kingdom}}
|-
| 1896 || Disinfection method introduction || || German physicist {{w|Wilhelm Röntgen}} discovers X-rays, which soon become known for their ability to destroy microbes.<ref name="Rogers"/> ||
| 1897 || Disinfection method introduction || || Kronig and Paul in Germany publish paper examining the kinetics or dynamics of the course of the disinfection process.<ref name="Hugo"/><ref>{{cite journal |last1=FALK |first1=S. |last2=WINSLOW |first2=E. A. |title=A CONTRIBUTION TO THE DYNAMICS OF TOXICITY AND THE THEORY OF DISINFECTION |url=https://jb.asm.org/content/jb/11/1/1.full.pdf}}</ref><ref>{{cite journal |title=Handbook of water and wastewater microbiology |url=https://www.researchgate.net/publication/230887820_Handbook_of_water_and_wastewater_microbiology}}</ref> || {{w|Germany}}
|-
| 1897 || Protection method || || Kilmer publishes a classical paper entitled ''Modern Surgical Dressings''.<ref name="Rogers"/> ||
|-
| 1897 || Concept development || {{w|Microbes}} || The adjective ''microbiocidal'' appears.<ref name="Seymour"/> ||
| 1898 || Disinfection method introduction || Bacterial infection || H. Rieder describes the bactericidal activity of {{w|X-rays}}, achieving almost complete sterilization of agar and gelatin plates of {{w|cholera}}, {{w|diphtheria}}, {{w|typhoid}}, and colon organisms, with exposure for about 1 hour.<ref name="Rogers"/><ref>{{cite web |title=BACTERICIDAL FLUORESCENCE EXCITED BY X-RAYS. |url=https://core.ac.uk/download/pdf/7827129.pdf |website=core.ac.uk |accessdate=9 July 2020}}</ref> ||
|-
| 1899 || ''Protection (‘‘{{w|Cordon cordon sanitaire}}'' ’’) || {{w|Plague}} || An outbreak of {{w|plague}} in {{w|Honolulu}} is managed by a cordon sanitaire around the Chinatown district. In an attempt to control the infection, a barbed wire perimeter is created and people's belongings and homes are burned.<ref>{{cite web |title=Plague in San Francisco: 1900, the Year of the Rat |url=https://www.niaid.nih.gov/about/joseph-kinyoun-indispensable-man-plague-san-francisco |website=niaid.nih.gov |accessdate=26 May 2020}}</ref><ref>{{cite web |title=When epidemics change the world: Can we learn anything from the third plague pandemic? |url=https://sciencenordic.com/denmark-epidemic-history/when-epidemics-change-the-world-can-we-learn-anything-from-the-third-plague-pandemic/1685595 |website=sciencenordic.com |accessdate=26 May 2020}}</ref> || {{w|United States}}
|-
| 1900 || Disinfection research || || Strebel demonstrates the inhibitory action of radioactive substances (radium).<ref name="Rogers"/><ref>{{cite book |last1=Block |first1=Seymour Stanton |title=Disinfection, Sterilization, and Preservation |url=https://books.google.com.ar/books?id=3f-kPJ17_TYC&pg=PA16&lpg=PA16&dq=1900+Strebel+demonstrates+the+inhibitory+action+of+radioactive+substances+(radium)&source=bl&ots=KnIjGx2QJ4&sig=ACfU3U3f3OdZ0aeBW7LRTX8K7FSjqoTKXA&hl=en&sa=X&ved=2ahUKEwj7xtiBsc3pAhU2ILkGHfIfCmYQ6AEwCXoECAkQAQ#v=onepage&q=1900%20Strebel%20demonstrates%20the%20inhibitory%20action%20of%20radioactive%20substances%20(radium)&f=false}}</ref> ||
|-
| 1900–1904 || ''Protection (‘‘{{w|Cordon cordon sanitaire}}'' ’’) || {{w|Plague}} || "During the San Francisco plague of 1900–1904 San Francisco's Chinatown was subjected to a cordon sanitaire" ||
|-
| 1901 || {{w|Disinfectant}} introduction || || Meyer conducts the first systematic experiment on the nature of the antibacterial action of {{w|phenol}}s. Meyer shows that the antibacterial action of phenols is paralleled by their distribution between protein and water, suggesting that protein is the prime target.<ref name="Hugo"/> ||
| 1903 || {{w|Disinfectant}} introduction || || "The Rideal-Walker test was introduced to evaluate the performance of phenolic disinfectants against Salmonella typhi. It was published in 1903"<ref name="Hugo"/> Rideal Walker proposes the phenol coefficient test.<ref name="Rogers"/> ||
|-
| 1903–1914 || ''Protection (‘‘{{w|Cordon cordon sanitaire}}'' ’’) || {{w|Trypanosomiasis}} || The Belgian colonial government imposes a cordon sanitaire on Uele Province in the {{w|Belgian Congo}} to control outbreaks of {{w|trypanosomiasis}} (sleeping sickness).<ref>{{cite journal |last1=Lyons |first1=Maryinez |title=From ‘Death Camps’ to Cordon Sanitaire: The Development of Sleeping Sickness Policy in the Uele District of the Belgian Congo, 1903–19141 |doi=10.1017/S0021853700023094 |url=https://www.cambridge.org/core/journals/journal-of-african-history/article/from-death-camps-to-cordon-sanitaire-the-development-of-sleeping-sickness-policy-in-the-uele-district-of-the-belgian-congo-190319141/5219FA5E652897DD974E3B86E546C8A5}}</ref> || {{w|Congo D.R}}
|-
| 1909 || {{w|Disinfectant}} introduction || Airborne bacteria || "A modification of this method was adopted by the American Public Health Association in 1909 as a standard for determining airborne bacteria."<ref name="Hugo"/> ||
| 1916 || Publication || || The United States Pharmacopeia (USP) publishes its first chapteron sterilization in USP Volume 9.<ref name="Rogers"/> || {{w|United States}}
|-
| 1918 || ''Protection (‘‘{{w|Cordon cordon sanitaire}}'' ’’) || Influenza || "The 1918 flu pandemic spread so rapidly that, in general, there was no time to implement cordons sanitaires. However, to prevent an introduction of the infection, residents of Gunnison, Colorado isolated themselves from the surrounding area for two months at the end of 1918. All highways were barricaded near the county lines" ||
|-
| 1918 || ''Protection (‘‘{{w|Cordon cordon sanitaire}}'' ’’) || Influenza || In the [[w:South Pacific Ocean|South Pacific]], the [[w:List of governors of American Samoa|Governor of]] {{w|American Samoa}}, {{w|John Martin Poyer}}, imposed a reverse ''{{w|cordon sanitaire}}'' of the islands from all incoming ships, successfully achieving zero deaths within the territory during the influenza epidemic.<ref>[https://scholarcommons.usf.edu/cgi/viewcontent.cgi?article=5386&context=etd Peter Oliver Okin, ''The Yellow Flag of Quarantine: An Analysis of the Historical and Prospective Impacts of Socio-Legal Controls Over Contagion'', doctoral dissertation, University of South Florida, January 2012; p. 232]</ref> In contrast, the neighboring [[w:Occupation of German Samoa|New Zealand-controlled]] [[w:Western Samoa Trust Territory|Western Samoa]] is among the hardest hit, with a 90% infection rate and over 20% of its adults dying from the disease.<ref>[http://www.arlingtoncemetery.net/jmpoyer.htm John Poyer, Commander, US Navy, Navy Cross citation]</ref> || {{w|American Samoa}}, [[w:Western Samoa Trust Territory|Western Samoa]]
|-
| 1918 || Crisis || {{w|Influenza}} || In late year, {{w|Spain}} attempts unsuccessfully to prevent the spread of the {{w|Spanish flu}} by imposing border controls, roadblocks, restricting rail travel, and a maritime ''cordon sanitaire'' prohibiting ships with sick passengers from landing, but by then the epidemic is already in progress in the country.<ref>[https://books.google.com/books?id=taEhAQAAQBAJ&pg R. Davis, ''The Spanish Flu: Narrative and Cultural Identity in Spain, 1918'', Springer, 2013.] {{ISBN|1137339217}}</ref> || {{w|Spain}}
| 1933 || {{w|Disinfectant}} introduction || || Gross and Dixon patent use of {{w|ethylene oxide}} as a sterilizing agent.<ref name="Rogers"/> ||
|-
| 1933 || {{w|Disinfectant}} introduction || || Soap-solubilized formulation containing {{w|chloroxylenol }} and {{w|terpineol }} is introduced by Colebrook and Maxted.<ref name="Hugo"/> ||
|-
| 1933 || Disinfection method introduction || || American Engineer Weeden Underwood makes notable advances in design of, and application of pressure steam sterilizers. This is considered the beginning of the era of scientific sterilization.<ref name="Rogers"/> || {{w|United States}}
| 1933 || Disinfectant research || || Schauffler documents the antimicrobial properties of chlorine dioxide solutions.<ref name="Rogers"/> ||
|-
| 1934 || Literature Publication || || Weeden Underwood writes an early textbook on sterilization called Textbook on Sterilization.<ref name="Rogers"/> || {{w|United States}}
|-
| 1935 || {{w|Disinfectant}} introduction || Germ infection || The use of quaternary ammonium compounds (QACs) as a germicide/disinfectant is formally recognized.<ref name="History and Evolution of Surface Disinfectants"/> ||
|-
| 1936 || Literature Publication || || Ernest Carr McCulloch publishes ''Disinfection and Sterilization''.<ref name="Rogers"/> ||
|-
| 1938 || Disinfection method introduction || || Carl Walter describes the first rapid, safe mechanical process for routine cleaning and terminal sterilization, called the washer-sterilizer.<ref name="Rogers"/> ||
| 1941 || Disinfectant research || || Robertson, Bigg, Miller and Baker report on the {{w|aerosol}} disinfection of {{w|glycol}}s.<ref name="Rogers"/> ||
|-
| 1942 || Disinfectant research || Bacterial infection || {{w|Amidine}}s are studied as antitrypanocidal drugs are shown to be antibacterial by Fuller.<ref name="Hugo"/><ref>{{cite journal |last1=DAWES |first1=G. S. |author1=Department of Pharmacology, Oxford |title=AMIDINES, GUANIDINES AND ADRENALINE INACTIVATION IN THE LIVER |url=https://bpspubs.onlinelibrary.wiley.com/doi/pdf/10.1111/j.1476-5381.1946.tb00024.x}}</ref><ref>{{cite web |title=Antibacterial Action of Some Aromatic Amines, Amidines, Amidoximes, Guanidines and Diguanides |url=https://watermark.silverchair.com/bj0410403.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAA3QwggNwBgkqhkiG9w0BBwagggNhMIIDXQIBADCCA1YGCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQM4oPUaMtlnrs5J5GbAgEQgIIDJ5LZfG93ZAjy_m9tqiZXM3u_pUpIMoEQY0qTZYWLoOeQb2BOqaNTRE8PG_M_uWktdL-_Eor0Ghahs3ccffmC-LHss0zGOYuJNx-suepvjNNGySjg9dF_qPufa6vxjFc0BZ6hnm2RPDacOZh3-XLcS45yM__HENxwXZTEf6I9_W219DrktG1M9-DGjBYVx9qURZ2Wf49JEajvIhUYd3FGZOXWypAUktp65y0sjkF7e9AiB88nUTMjVq2qT4sEuEIfkiVnVmA3lq6Q9fw2hcO2hmqiXOot37TLoBrg4AMhjKZbyjibmrdwC-1sUfgEQBOf-25Sc2IAMGdZn96P1eUoOky-LuxAPiVCketI2j2klvQGBBFI70JpeST58DtkSwbR6CzvNvaSf-HCB75SjSoyn0pvjYw-bOWV7CvfdZA878G0z-kSxXNukzqqhf2Q4N3oQUy2GFkf_JPLFBOZNhV4tfUlBztCdhifpEQDmdoC0evUTrva0zfuJPH4_CqU4oZsYFQpHauPf5ymyO_vFuuk9bXlIBgM0nq6PIzuiSSzwXJbElIQpUm-Ty0kcarMgEhL1CF0barAURFZLzsaLo8yyzMegASCAoe2cNUrUCyGtCKY0UeLlracD1T4vqEsZV9Tk1trjcEDSSv11QD52tf3FzS6nHMQRyhKfRhCubL7iCXAWkvCK68osHFoF-abmYUz5NKj2GdHiqWegtDoqLHmrYpIQ2bRXEBG6991YpcgtFrZTt7lOxK_R5E5w9BeXv0yf7n9cAuQ9bF9ABGebOZqKSZYrhCrLNul6KksyRUl5970_8dh8sKrlpw4Zt68eteTpn8QygYsczMcm2-5rvjw4MeK_9oF0QyKPwnyMvDecYOMbLFoX9_6oL8oSAsz58wsPjfroTXF38k_7WGJVeEdTLxqMoDGeEWeO92avE4MHQ9EJfsuCRZGdSfyB_GwTZ1be32Am3m3IPJGOIn38mV28Pkgj6GEXaNJRizIwwkgmhSpkicHgfFTOR3t2AxMmqdRA_qLMeQ8eIUpJTAfh7Jbep3-Mq8OKI7XFOYNZHNN_bDVoayqBrue3g |website=watermark.silverchair.com |accessdate=26 May 2020}}</ref> ||
|-
| 1942 || Disinfection method introduction || || Underwood defines the first "flash sterilization" at 30 min at 121°C.<ref name="Rogers"/> ||
| 1950s || {{w|Disinfectant}} introduction || || {{w|Chlorhexidine}} comes into medical use.<ref>{{cite book|last1=Schmalz|first1=Gottfried|last2=Bindslev|first2=Dorthe Arenholt|title=Biocompatibility of Dental Materials|date=2008|publisher=Springer Science & Business Media|isbn=9783540777823|page=351|language=en|url=https://web.archive.org/web/20170113080904/https://books.google.ca/books?id=mrreTHuo54wC&pg=PA351}}</ref> ||
|-
| 1959 || Medical development || || {{w|Exeter}} microbiologist Brendan Moore becomes the first appointed Infection Control Nurse.<ref>{{cite book |last1=Wilson |first1=Jennie |title=Infection Control in Clinical Practice Updated Edition E-Book |url=https://books.google.com.ar/books?id=hol-DwAAQBAJ&pg=PA75&lpg=PA75&dq=1959+The+first+Infection+Control+Nurse&source=bl&ots=EIfEmcPzM_&sig=ACfU3U0OvfzYJWMJmZKsXGnmXlwEY3PZqA&hl=en&sa=X&ved=2ahUKEwir3pPS2c3pAhWtLLkGHXDNAb4Q6AEwBXoECAoQAQ#v=onepage&q=1959%20The%20first%20Infection%20Control%20Nurse&f=false}}</ref><ref>{{cite web |title=The 'Rediscovery' of Infection, 1957-1970 |url=https://kingscollections.org/exhibitions/archives/from-microbes-to-matrons/chronology/the-rediscovery-of-infection |website=kingscollections.org |accessdate=24 May 2020}}</ref><ref>{{cite web |title=Infection Prevention and Control |url=https://www.worldcat.org/wcpa/servlet/DCARead?standardNo=9780470059074&standardNoType=1&excerpt=true |website=worldcat.org |accessdate=24 May 2020}}</ref> || {{w|United Kingdom}}
|-
| 1960 || Disinfection method || || It is found that conveyor ovens can provide continuous sterilization of syringes.<ref name="Rogers"/> ||
| 1962 || Disinfection research || Bacterial infection || It is found that the rate of bacterial spore destruction improves with simultaneous applied ionizing and thermal processing.<ref name="Rogers"/> ||
|-
| 1962 || Disinfection method introduction || || Robert McDonald invents the prehumidification step for effective ethylene oxide sterilization.<ref name="Rogers"/> ||
|-
| 1962 || Disinfectant research || || The first antimicrobial indications of dialdehydes, e.g., {{w|glutaldehyde}}, are described by Pepper and Liebermann.<ref name="Rogers"/> ||
|-
| 1963 || Disinfection method introduction || || The first gamma irradiator is used in the United States for sterilization of medical devices.<ref name="Rogers"/> ||
|-
| 1963 || {{w|Disinfectant}} introduction || || Gaseous {{w|propylene oxide}} is used to sterilize and de-infest food products.<ref name="Rogers"/> ||
|-
| 1963 || Scientific development || Microbial infection || Guerin shows that desiccated microbes are more resistant to ozone than hydrated cells.<ref name="Rogers"/> ||
|-
| 1964 || Disinfection method introduction || || {{w|Johnson and Johnson}} provides commercial {{w|gamma irradiation}}.<ref name="Rogers"/> ||
|-
| 1964 || Disinfection method introduction || || Armstrong discovers a gaseous ozone sterilization process.<ref name="Rogers"/> ||
|-
| 1965 || Disinfectant research || || Sydney Rubbo and Joan Gardner show that {{w|glutaraldehyde }} is not only more effective than {{w|formaldehyde }} but also less irritating.<ref name="Rogers"/> ||
|-
| 1966 || {{w|Disinfectant}} introduction || || Hand sanitizers are first introduced.<ref>{{cite web |title=Lupe Hernandez and the Invention of Hand Sanitizer |url=https://invention.si.edu/lupe-hernandez-and-invention-hand-sanitizer |website=invention.si.edu |accessdate=25 May 2020}}</ref> ||
|-
| 1966 || Disinfection method introduction || || Alder and co-workers develop a low temperature steam and {{w|formaldehyde }} system similar to high vacuum steam sterilization but operating at 65-80°C.<ref name="Rogers"/> ||
|-
| 1967 || Disinfectant research || || Saul Kaye demonstrates that formic acid is microcidal synergistic with {{w|ethylene oxide}} and other epoxides.<ref name="Rogers"/> ||
|-
| 1968 || Concept development || || Paul Borick describes and defines chemosterilizers{{w|chemosterilizer}}s.<ref>{{cite journal |last1=Borick |first1=Paul M. |title=Chemical Sterilizers (Chemosterilizers). |doi=10.1016/S0065-2164(08)70195-3 |url=https://www.sciencedirect.com/science/article/pii/S0065216408701953 |accessdate=25 May 2020}}</ref><ref>{{cite journal |last1=Thomas |first1=Sonyja |last2=Russell |first2=A. Denver |title=Temperature-induced changes in the sporicidal activity and chemical properties of glutaraldehyde. |doi=10.1128/aem.28.3.331-335.1974 |url=https://www.semanticscholar.org/paper/Temperature-induced-changes-in-the-sporicidal-and-Thomas-Russell/88a8b63039102e2ad6fb7a4b24521213294fc74d}}</ref> ||
|-
| 1968 || Disinfection method introduction || || Earle H. Spaulding devises a rational approach of disinfection and classification for patient care items and equipment – non-critical items, semi-critical items, and critical items.<ref name="Rogers"/> ||
|-
| 1969 || Disinfection research || || Marcel Reynolds discovers the feasibility of using thermo-irradiation as sterilization of {{w|spacecraft}}.<ref name="Rogers"/> ||
|-
| 1960s || {{w|Disinfectant}} introduction || || {{w|Glutaraldehyde}} comes into medical use.<ref>{{cite book|last1=Booth|first1=Anne|title=Sterilization of Medical Devices|date=1998|publisher=CRC Press|isbn=9781574910872|page=8|language=en|url=https://web.archive.org/web/20170923210311/https://books.google.com/books?id=a-HfyG5XuM8C&pg=PA8}}</ref> ||
| 1991 || Disinfection method introduction || || Karlson patents a gaseous ozone sterilization process.<ref name="Rogers"/> ||
|-
| 1995 || ''Protection (‘‘{{w|Cordon cordon sanitaire}}'' ’’) || {{w|Ebola}} || A {{w|cordon sanitaire}} is used to control an outbreak of {{w|Ebola}} virus disease in {{w|Kikwit}}, Zaire.<ref>{{cite web |title=ETHICAL CONSIDERATIONS IN THE USE OF CORDONS SANITAIRES |url=https://www.clinicalcorrelations.org/2015/02/19/ethical-considerations-in-the-use-of-cordons-sanitaires/ |website=clinicalcorrelations.org |accessdate=25 May 2020}}</ref><ref>{{cite journal |last1=Muyembe-Tamfum |first1=J J |last2=Kipasa |first2=M |last3=Kiyungu |first3=C |last4=Colebunders |first4=R |title=Ebola Outbreak in Kikwit, Democratic Republic of the Congo: Discovery and Control Measures |doi=10.1086/514302 |pmid=9988192 |url=https://pubmed.ncbi.nlm.nih.gov/9988192/ |accessdate=25 May 2020}}</ref> || {{w|Congo D.R.}}
|-
| 1995 || Statistics || {{w|Hospital-acquired infection}} || || The {{w|Centers for Disease Control and Prevention}} estimates that approximately 1.9 million cases of {{w|hospital-acquired infection}} occurred in the United States.<ref>{{cite web |title=Frequently Asked Questions |url=https://www.ncsl.org/research/health/hospital-acquired-infections-faq.aspx |website=ncsl.org |accessdate=2 April 2020}}</ref> || {{w|United States}}
|-
| 1998 || Statistics || {{w|Hospital-acquired infection}} || According to {{w|CDC}}, approximately one third of healthcare acquired infections are preventable.<ref>{{cite journal | vauthors = Weinstein RA | title = Nosocomial infection update | journal = Emerging Infectious Diseases | volume = 4 | issue = 3 | pages = 416–20 | date = September 1998 | pmid = 9716961 | pmc = 2640303 | doi = 10.3201/eid0403.980320 | url = http://wwwnc.cdc.gov/eid/article/4/3/98-0320 | publisher = CDC }}</ref> ||
| 2001 || Disinfectant research || General || Disinfection with performic acid is noted.<ref name="Rogers"/> ||
|-
| 2002 2001 || Publication Protection ({{w|hand washing}}) || || The {{w|Royal Australian College Global Handwashing Partnership (GHP) is established as a coalition of General Practitioners}} publishes international stakeholders "working to promote handwashing with soap and recognize hygiene as a revised standard for office-based infection control which covers the sections pillar of managing immunization, sterilization international development and disease surveillancepublic health."<ref name=racgp>{{cite web| last =The Royal Australian College of General Practitioners| title =RACGP Infection Control Standards for Office-based Practices (4th Edition)Global Handwashing Partnership | url =httphttps://www.racgpglobalhandwashing.org.au/infectioncontrol| accessabout-date =8 November 2008| url-status =dead| archive-url =httpsus/#://web.archive.org/web/20081220163900/http~://www.racgp.org.au/infectioncontrol| archive-date text=The%20Global%20Handwashing%20Partnership%20 December 2008| df =dmy-all}}</ref><ref name=sracgp>{{cite web| last =The Royal Australian College of General Practitioners| title =Slides - RACGP Infection Control Standards for Office-based Practices (4th Edition)| url =http://www.racgp.org.au/Content/NavigationMenu/PracticeSupport/StandardsforGeneralPractices/200708RACGP_Infection_Control_StandardsGHP,knowledge%20to%20strengthen%20handwashing%20implementation.pdf| access-date =8 November 2008| url-status =dead| archive-url website=https://web.archiveglobalhandwashing.org/web/20081217113407/http://www.racgp.org.au/Content/NavigationMenu/PracticeSupport/StandardsforGeneralPractices/200708RACGP_Infection_Control_Standards.pdf| archive-date =17 December 2008| df accessdate=dmy-all10 July 2020}}</ref> || {{w|Australia}}
|-
| 2003 2002 || ''{{wPublication ||Cordon sanitaire}}'' || The {{w|Severe acute respiratory syndromeRoyal Australian College of General Practitioners}} || During publishes a revised standard for office-based infection control which covers the [[w:Timeline sections of the SARS outbreak|2003 SARS outbreak]] in Canadamanaging immunization, "community quarantine" is used to successfully reduce transmission of the sterilization and diseasesurveillance.<refname=racgp>{{cite journalweb| pmidlast =20034405 The Royal Australian College of General Practitioners| doititle =10.1186/1471-2458-9RACGP Infection Control Standards for Office-488 based Practices (4th Edition)| pmcurl =2808319 | volumehttps://web.archive.org/web/20081220163900/http://www.racgp.org.au/infectioncontrol}}</ref><ref name=9 sracgp>{{cite web| titlelast =Quantifying the impact of community quarantine on SARS transmission in Ontario: estimation The Royal Australian College of secondary case count difference and number needed to quarantine General Practitioners| yeartitle =2009 Slides - RACGP Infection Control Standards for Office-based Practices (4th Edition)| journalurl =BMC Public Health http://www.racgp.org.au/Content/NavigationMenu/PracticeSupport/StandardsforGeneralPractices/200708RACGP_Infection_Control_Standards.pdf| pageurl =488 | last1 = Bondy | first1 = SJ | last2 = Russell | first2 = ML | last3 = Laflèche | first3 = JM | last4 = Rea | first4 = Ehttps://web.archive.org/web/20081217113407/http://www.racgp.org.au/Content/NavigationMenu/PracticeSupport/StandardsforGeneralPractices/200708RACGP_Infection_Control_Standards.pdf}}</ref> || {{w|CanadaAustralia}}
|-
| 2003 || ''Protection (‘‘{{w|Cordon cordon sanitaire}}'' ’’) || {{w|Severe acute respiratory syndrome}} || During the [[w:Timeline of the SARS outbreak|2003 SARS outbreak]] in Canada, "community quarantine" is used to successfully reduce transmission of the disease.<ref>{{cite journal| pmid=20034405 | doi=10.1186/1471-2458-9-488 | pmc=2808319 | volume=9 | title=Quantifying the impact of community quarantine on SARS transmission in Ontario: estimation of secondary case count difference and number needed to quarantine | year=2009 | journal=BMC Public Health | page=488 | last1 = Bondy | first1 = SJ | last2 = Russell | first2 = ML | last3 = Laflèche | first3 = JM | last4 = Rea | first4 = E}}</ref> || {{w|Canada}}|-| 2003 || Protection (‘‘{{w|cordon sanitaire}}’’) || {{w|Severe acute respiratory syndrome}} || During the 2003 SARS outbreak in mainland {{w|China}}, {{w|Hong Kong}}, {{w|Taiwan}}, and {{w|Singapore}}, large-scale quarantine is imposed on travelers arriving from other SARS areas, work and school contacts of suspected cases, and, in a few instances, entire apartment complexes where high attack rates of SARS were occurring.<ref>{{cite journal |last1=Cetron |first1=Martin |last2=Maloney |first2=Susan |last3=Koppaka |first3=Ram |last4=Simone |first4=Patricia |title=ISOLATION AND QUARANTINE: CONTAINMENT STRATEGIES FOR SARS 2003 |url=https://www.ncbi.nlm.nih.gov/books/NBK92450/}}</ref> || {{w|China}}, {{w|Hong Kong}}, {{w|Taiwan}}, {{w|Singapore}}
|-
| 2004 || Publication || Microbial infection || Ferric Fang publishes a paper on antimicrobial reactive oxygen and nitrogen species.<ref>{{cite journal |last1=Fang |first1=Ferric C. |title=Antimicrobial reactive oxygen and nitrogen species: concepts and controversies |journal=Nature Reviews Microbiology |url=https://www.nature.com/articles/nrmicro1004?proof=true}}</ref> ||
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| 2004 || ''Protection (‘‘{{w|Cordon cordon sanitaire}}'' ’’) || {{w|Ebola}} || A ''cordon sanitaire'' is established around some of the most affected areas of the {{w|2014 West Africa Ebola virus outbreak}}.<ref>[https://www.cdc.gov/mmwr/preview/mmwrhtml/mm6407a4.htm "Community Quarantine to Interrupt Ebola Virus Transmission – Mawah Village, Bong County, Liberia, August–October, 2014," ''Morbidity and Mortality Weekly Report,'' February 27, 2015 / 64(07); 179–182.]</ref><ref>{{Cite news|url=https://www.nytimes.com/2014/08/13/science/using-a-tactic-unseen-in-a-century-countries-cordon-off-ebola-racked-areas.html?_r=0|author=Donald G. McNeil Jr.|newspaper={{w|The New York Times}}|date=August 13, 2014|title=Using a Tactic Unseen in a Century, Countries Cordon Off Ebola-Racked Areas}}</ref> On 19 August, the Liberian government quarantines the entirety of {{w|West Point, Monrovia}} and issued a curfew statewide.<ref name="nbcnews1">{{cite web |url=http://www.nbcnews.com/storyline/ebola-virus-outbreak/liberian-soldiers-seal-slum-halt-ebola-n185046 |title=Liberian Soldiers Seal Slum to Halt Ebola |publisher=NBC News |date=2014-08-09 |accessdate=2014-08-23}}</ref> || {{w|Liberia}}
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| 2005 || Publication || {{w|Hospital-acquired infection}} || || The {{w|American Thoracic Society}} and {{w|Infectious Diseases Society of America}} publish guidelines suggesting antibiotics specifically for {{w|hospital-acquired pneumonia}}.<ref name="guidelines">{{cite journal |author=American Thoracic Society |author2=Infectious Diseases Society of America |title=Guidelines for the management of adults with hospital-acquired, ventilator-associated, and healthcare-associated pneumonia |journal=Am. J. Respir. Crit. Care Med. |volume=171 |issue=4 |pages=388–416 |year=2005 |pmid=15699079 |doi=10.1164/rccm.200405-644ST|url=https://semanticscholar.org/paper/c1e3c150b88a50d40302f15a5533bdd6b0da5885 }}</ref> || {{w|United States}}
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| 2008 (February) || Disinfection method introduction || || The {{w|United States Environmental Protection Agency}} (EPA) approves the registrations of five different groups of copper alloys as "{{w|antimicrobial}} materials" with public health benefits.<ref>{{cite web |title=Antimicrobial Copper Surfaces for the Reduction of Health Care–Associated Infections in Intensive Care Settings |url=https://www.cadth.ca/sites/default/files/pdf/EH0021_Copper_Surfaces_e.pdf |website=cadth.ca |accessdate=26 June 2020}}</ref> || {{w|United States}}
| 2014 || Organization || General || The {{w|Global Health Security Agenda}} (GHSA) is launched as global partnership devoted to the purpose of strengthening the world’s ability to prevent, detect, and respond to infectious disease threats. As of 2020 it has 67 member countries.<ref>{{cite web |title=FACT SHEET: Global Health Security Agenda: Getting Ahead of the Curve on Epidemic Threats |url=https://obamawhitehouse.archives.gov/the-press-office/2014/09/26/fact-sheet-global-health-security-agenda-getting-ahead-curve-epidemic-th |website=obamawhitehouse.archives.gov |accessdate=1 July 2020}}</ref> ||
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| 2014 || Protection method ({{w|hand washing}}) || || A study shows that {{w|Saudi Arabia}} has the highest rate of hand washing with soap, with 97 percent; the United States near the middle with 77 percent; and China with the lowest rate of 23 percent.<ref>{{Cite web|url=https://www.bva-group.com/sondages/les-francais-et-le-savonnage-des-mains-apres-etre-alle-aux-toilettes/|title=Les Français et le savonnage des mains après être allé aux toilettes|last=BreakingWeb|website=BVA Group|language=fr-FR|access-date=3 April 2020}}</ref> ||
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| 2015 || Protection method ({{w|hand washing}}) || || A study of hand washing in 54 countries finds that on average, 38.7% of households practice hand washing with soap. ||
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| 2019 || Disinfection research || || A number of studies find that {{w|copper}} surfaces may help prevent infection in the healthcare environment.<ref>{{cite journal |last1=Arendsen |first1=LP |last2=Thakar |first2=R |last3=Sultan |first3=AH |title=The Use of Copper as an Antimicrobial Agent in Health Care, Including Obstetrics and Gynecology. |journal=Clinical Microbiology Reviews |date=18 September 2019 |volume=32 |issue=4 |doi=10.1128/CMR.00125-18 |pmid=31413046|pmc=6730497 }}</ref> ||
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| 2020 || ''Protection (‘‘{{w|Cordon cordon sanitaire}}'' ’’) || {{w|Coronavirus disease 2019}} || A multiple number of lockdowns are imposed worldwide in response to the {{w|2019–20 coronavirus pandemic}}. || Worldwide
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| 2020 (April 22) || Publication || || The {{w|World Health Organization}} publishes ''How To Pun On And Take Off Personal Protective Equipment (PPE)'', a series of posters on emergencies preparedness and response.<ref>{{cite web |title=HOW TO PUT ON AND TAKE OFF Personal Protective Equipment (PPE) |url=https://www.who.int/csr/resources/publications/putontakeoffPPE/en/ |website=who.int |accessdate=19 May 2020}}</ref> ||
* {{w|Disinfectant}}
* {{w|Category:Medical hygiene}}
* [https://cha.com/brief-modern-era-history-of-infection-prevention/]
* [https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(14)70726-1/fulltext]
===Timeline update strategy===
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