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| 1882 || ''{{w|Cordon sanitaire}}'' || {{w|Yellow fever}} || "in 1882, in response to a virulent outbreak of yellow fever in Brownsville, Texas, and in northern Mexico, a cordon sanitaire was established 180 miles north of the city, terminating at the Rio Grande to the west and the Gulf of Mexico to the east." ||
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| 1883 || || || Sterile gowns and caps are invented by German surgeon {{w|Gustav Adolf Neuber}} using a form of autoclave.<ref name="Rogers"/> || {{w|Germany}}
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| 1884 || || || French microbiologist {{w|Charles Chamberland}} invents the first autoclave.<ref name="Rogers"/> ||
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| 1933 || || || American Engineer Weeden Underwood makes notable advances in design of, and application of pressure steam sterilizers. This is considered the beginning of the era of scientific sterilization.<ref name="Rogers"/> || {{w|United States}}
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| 1933 || || || Schauffler documents the antimicrobial properties of chlorine dioxide solutions.<ref name="Rogers"/> ||
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| 1934 || || || Weeden Underwood writes an early textbook on sterilization called Textbook on Sterilization.<ref name="Rogers"/> || {{w|United States}}
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| 1935 || {{w|Disinfectant}} || || The use of quaternary ammonium compounds (QACs) as a germicide/disinfectant is formally recognized.<ref name="History and Evolution of Surface Disinfectants"/> ||
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| 1936 || || || Ernest Carr McCulloch publishes ''Disinfection and Sterilization''.<ref name="Rogers"/> ||
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| 1938 || || || Carl Walter describes the first rapid, safe mechanical process for routine cleaning and terminal sterilization, called the washer-sterilizer.<ref name="Rogers"/> ||
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| 1938 || || || Corona discharge is found to be a sterilizing agent.<ref name="Rogers"/> ||
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| 1939 || || || Nordgren reports on early work in regard to {{w|formaldehyde}} efficacy, poarticularly under deep vacuum.<ref name="Rogers"/> ||
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| 1941 || || || UK Control of Infection Officer<ref>{{cite book |last1=Weston |first1=Debbie |title=Infection Prevention and Control: Theory and Clinical Practice for Healthcare Professionals |url=https://books.google.com.ar/books?id=wHOkV16Xk8QC&pg=PA3&dq=1941+UK+Control+of+Infection+Officer&hl=en&sa=X&ved=0ahUKEwjn653aw8bpAhXxILkGHRSLDvAQ6AEIKDAA#v=onepage&q=1941%20UK%20Control%20of%20Infection%20Officer&f=false}}</ref> || {{w|United Kingdom}}
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| 1941 || || || Robertson, Bigg, Miller and Baker report on the {{w|aerosol}} disinfection of {{w|glycol}}s.<ref name="Rogers"/> ||
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| 1942 || || || {{w|Amidine}}s studied as antitrypanocidal drugs are shown to be antibacterial by Fuller.<ref name="Hugo"/> ||
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| 1942 || || || Underwood defines the first "flash sterilization" at 30 min at 121°C.<ref name="Rogers"/> ||
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| 1943 || || || First isolation ward in USA<ref>{{cite book |title=Navy Medicine, Volume 95, Issue 1 |url=https://books.google.com.ar/books?id=WtC6VUZ8XGgC&pg=PA32&lpg=PA32&dq=1943+First+isolation+ward+in+USA&source=bl&ots=jOy4TdbghP&sig=ACfU3U05uJpuL3bjg3fImCTZPdQE3g54yg&hl=en&sa=X&ved=2ahUKEwit-PiyxMbpAhXoIbkGHT-uCEUQ6AEwAHoECAgQAQ#v=onepage&q=1943%20First%20isolation%20ward%20in%20USA&f=false}}</ref> || {{w|United States}}
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| 1943 || || || Theodore Puck, Robertson and Henry Lemon report on the bactericidal activity of propylene glycol (hydrolysis by-product of propylene oxide) vapour.<ref name="Rogers"/> ||
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| 1944 || || || USA Infection Control Officer.<ref>{{cite journal |title=The organization of infection control in hospitals |doi=10.1016/0195-6701(80)90055-9 |url=https://www.journalofhospitalinfection.com/article/0195-6701(80)90055-9/pdf}}</ref> || {{w|United States}}
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| 1943–1945 || || || Otto Rahn describes the logarithmic kinetics and temperature coefficient values of sterilants and antimicrobial agents.<ref name="Rogers"/> ||
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| 1946 || || || The Centers for Disease Control and Prevention (CDC) is founded.<ref name="Hewlett"/> || {{w|United States}}
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| 1946 || || || Ewell demonstrates that microbes are more readily killed by ozone in high humidity than at low humidity.<ref name="Rogers"/> ||
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| 1947 || || || Douglas Lea reports on the actions of radiation on living cells. In the main, ionizing radiation destroys microbes by direct hits of the radiations on or near the organism.<ref name="Rogers"/> ||
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| 1947 || {{w|Disinfectant}} || Fungus, {{w|HIV-1}} ({{w|AIDS}}), {{w|Hepatitis B}}, and {{w|Hepatitis C}} || The {{w|barbicide}} is invented by Maurice King and marketed heavily around the United States by his brother James.<ref name=SmithsonianArticle>{{cite web |url=https://query.nytimes.com/gst/fullpage.html?res=9D07E5DF113EF931A15755C0A961958260&pagewanted=all |title=The Smithsonian Celebrates Barbicide, A Barbershop Germ Killer Born in Brooklyn |accessdate=2 April 2020 |last=Martin |first=Douglas |date=1997-06-22 |format= |work={{w|The New York Times}} |publisher=The New York Times Company |pages=2 |doi= |archiveurl= |archivedate= |quote= }}</ref> || {{w|United States}}
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| 1947 || {{w|Disinfectant}} || || "It culminated in 12 papers by Jordan et al. (1947) on the dynamics of the disinfection of Escherichza cola by phenol and heat"<ref name="Hugo"/> ||
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| 1949 || || || Kolb and Schneiter show {{w|methyl bromide}} to be bactericidal for {{w|anthrax}} spores and its use is recommended for sterilization of improved wool.<ref name="Rogers"/> ||
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| 1949 || || || Hutchins and Xezones report {{w|peracetic acid}} to be highly germicide against spores of Bacillus thermoacidurans.<ref name="Rogers"/> ||
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| 1950 || {{w|Disinfectant}} || || "11 papers by Berry & Michaels (1950) on the bactericidal activity of ethylene glycol and its mono alkyl ethers on the same organism. These papers recorded in meticulous detail the time course of the disinfection process, the effect of temperature and other factors upon it and how loss of activity with dilution-the concentration exponent-is a variant property of antibacterial substances."<ref name="Hugo"/> ||
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| 1955 || {{w|Disinfectant}} || || Povidone-iodine comes into commercial use.<ref>{{cite book|last1=Sneader|first1=Walter|title=Drug Discovery: A History|date=2005|publisher=John Wiley & Sons|isbn=9780470015520|page=68|url=https://books.google.ca/books?id=jglFsz5EJR8C&pg=PA68|language=en|url-status=live|archiveurl=https://web.archive.org/web/20170113010552/https://books.google.ca/books?id=jglFsz5EJR8C&pg=PA68|archivedate=2017-01-13}}</ref> ||
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| Mid-1950s || || || "baby wipes most likely came in the mid-1950s as more people were travelling and needed a way to clean up on the go" ||
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| 1956 || {{w|Disinfectant}} || || {{w|Chlorine dioxide}} is introduced as a drinking water disinfectant on a large scale, when {{w|Brussels}}, Belgium, changes from chlorine to chlorine dioxide.<ref name="block2001">{{cite book | title = Disinfection, Sterilization, and Preservation | first= Seymour Stanton |last=Block | edition = 5th | publisher = Lippincott, Williams & Wilkins | year = 2001 | isbn = 0-683-30740-1 | page = 215}}</ref> || {{w|Belgium}}
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| 1956 || || || Glyoxal and related compounds are first used as potential blood sterilizing agents.<ref name="Rogers"/> ||
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| 1957 || {{w|Disinfectant}} || || Gluaraldehyde is introduced.<ref name="Hugo"/> ||
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| Mid-1950s 1957 || || || John Perkins publishes the first edition of Principals and Methods of Sterilization.<ref name="baby wipes most likely came in the midRogers"/> |||-1950s as more people were travelling | 1958 || || || G. Sykes publishes Disinfection and needed a way to clean up on the goSterilization.<ref name="Rogers" /> ||
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| 1950s || {{w|Disinfectant}} || || {{w|Chlorhexidine}} comes into medical use.<ref>{{cite book|last1=Schmalz|first1=Gottfried|last2=Bindslev|first2=Dorthe Arenholt|title=Biocompatibility of Dental Materials|date=2008|publisher=Springer Science & Business Media|isbn=9783540777823|page=351|url=https://books.google.ca/books?id=mrreTHuo54wC&pg=PA351|language=en|url-status=live|archiveurl=https://web.archive.org/web/20170113080904/https://books.google.ca/books?id=mrreTHuo54wC&pg=PA351|archivedate=2017-01-13}}</ref> ||
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| 1959 || || || The first Infection Control Nurse ||
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| 1960 || || || It is found that conveyor ovens can provide continuous sterilization of syringes.<ref name="Rogers"/> ||
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| 1960 || || || Alkalinized {{w|glutaraldehyde}} is found to be effective as a sterilant.<ref name="Rogers"/> ||
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| 1961 || || || High vacuum infrared ovens become available for batch sterilization.<ref name="Rogers"/> ||
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| 1961 || || || Propylene oxide is demonstrated to have microbicidal activity within powered or flaked food.<ref name="Rogers"/> ||
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| 1961 || || || Robert Ernst shows that the use of {{w|iodophor}}es at elevated temperature (e.g., 50-60°C) in combination with ultrasonics could be an effective sterilizing agent for surgical and dental instruments.<ref name="Rogers"/> ||
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| 1962 || || || The rate of bacterial spore destruction improves with simultaneous applied ionizing and thermal processing.<ref name="Rogers"/> ||
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| 1962 || || || Robert McDonald invents the prehumidification step for effective ethylene oxide sterilization.<ref name="Rogers"/> ||
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| 1962 || || || The first antimicrobial indications of dialdehydes, e.g., {{w|glutaldehyde}}, are described by Pepper and Liebermann.<ref name="Rogers"/> ||
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| 1963 || || || The first gamma irradiator is used in the United States for sterilization of medical devices.<ref name="Rogers"/> ||
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| 1963 || || || Gaseous {{w|propylene oxide}} is used to sterilize and de-infest food products.<ref name="Rogers"/> ||
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| 1963 || || || Guerin shows that desiccated microbes are more resistant to ozone than hydrated cells.<ref name="Rogers"/> ||
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| 1964 || || || {{w|Johnson and Johnson}} provides commercial gamma irradiation.<ref name="Rogers"/> ||
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| 1964 || || || Armstrong discovers a gaseous ozone sterilization process.<ref name="Rogers"/> ||
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| 1965 || || || Sydney Rubbo and Joan Gardner show that glutaraldehyde is not only more effective than formaldehyde but also less irritating.<ref name="Rogers"/> ||
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| 1966 || {{w|Disinfectant}} || || Hand sanitizers are first introduced. ||
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| 1966 || || || Alder and co-workers develop a low temperature steam and formaldehyde system similar to high vacuum steam sterilization but operating at 65-80°C.<ref name="Rogers"/> ||
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| 1967 || || || Saul Kaye demonstrates that formic acid is microcidal synergistic with {{w|ethylene oxide}} and other epoxides.<ref name="Rogers"/> ||
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| 1968 || || || Paul Borick describes and defines chemosterilizers.<ref name="Rogers"/> ||
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| 1968 || || || Earle H. Spaulding devises a rational approach of disinfection and classification for patient care items and equipment – non-critical items, semi-critical items, and critical items.<ref name="Rogers"/> ||
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| 1969 || || || Marcel Reynolds discovers the feasibility of using thermo-irradiation as sterilization of spacecraft.<ref name="Rogers"/> ||
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| 1960s || {{w|Disinfectant}} || || {{w|Glutaraldehyde}} comes into medical use.<ref>{{cite book|last1=Booth|first1=Anne|title=Sterilization of Medical Devices|date=1998|publisher=CRC Press|isbn=9781574910872|page=8|url=https://books.google.com/books?id=a-HfyG5XuM8C&pg=PA8|language=en|url-status=live|archiveurl=https://web.archive.org/web/20170923210311/https://books.google.com/books?id=a-HfyG5XuM8C&pg=PA8|archivedate=2017-09-23}}</ref> ||
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| 1970 || || || {{w|Trimethylene oxide}} (oxetane) is patented for its disinfecting capabilities, and possible use in sterilization processes.<ref name="Rogers"/> |||-| 1970 || || || Russian scientists pubish a method detailing using a gas mixture of methyl bromide and ethylene oxide for sterilization of a space lander in a plastic bag.<ref name="Rogers"/> || {{w|Russia}}|-| 1970 || || || Continuous ethylene oxide sterilization process is developed.<ref name="Rogers"/> |||-| 1971 || || || D.A. Gunther patents a balance pressure process for use with {{w|ethylene oxide}} sterilization.<ref name="Rogers"/> |||-| 1972 || ''{{w|Cordon sanitaire}}'' || {{w|Smallpox}} || "During the 1972 Yugoslav smallpox outbreak, over 10,000 people were sequestered in cordons sanitaires of villages and neighborhoods using roadblocks, and there was a general prohibition of public meetings, a closure of all borders and a prohibition of all non-essential travel." ||
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| 1972 || || || APIC first meeting ||
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| 1972 || || || Leland Ashman and Wilson Menashi use low temperature gas plasma for sterilization of contaminated surfaces.<ref name="Rogers"/> ||
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| 1976 || || || SENIC 1 ICP:250 beds, importance of surveillance ||
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| 1976 || || || A method of cold sterilization using frozen dimethyl dicarbonate is developed.<ref name="Rogers"/> ||
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| 1976 || || || Lowell Tensmeyer devises a method of killing micro-organisms in the inside of a container utilizing a plasma initiated by a focused laser beam and sustained by an electromagnetic field.<ref name="Rogers"/> ||
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| 1976 || || || CHICA is incorporated ||
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| 1979 || || || Francis C. Moore and Leon R. Perkinson devise a hydrogen peroxide vapour sterilization method.<ref name="Rogers"/> ||
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| 1980 || || || A seeded (dialdehyde) gas plasma sterilization method is patented by G. Boucher.<ref name="Rogers"/> ||
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| 1984 || || {{w|Hospital-acquired infection}} || A survey in Australia documents that 6.3% of 28,643 hospitalized patients in the country have a hospital-acquired infection, with the highest rates in larger hospitals.<ref>{{cite journal |last1=Spelman |first1=Denis W |title=2: Hospital-acquired infections |doi=10.5694/j.1326-5377.2002.tb04412.x |url=https://www.mja.com.au/journal/2002/176/6/2-hospital-acquired-infections}}</ref> || {{w|Australia}}
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| 1985 || || || Rosenblatt, Rosenblatt and Knapp find chlorine to be a sterilant in a gaseous phase.<ref name="Rogers"/> ||
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| 1986 || || || Pulsed laser sterilization is described.<ref name="Rogers"/> ||
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| 1988 || || || Joslyn introduces a post-steam sterilization process for removing EO residuals more effectively, than mere heated aeration.<ref name="Rogers"/> ||
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| 1989 || || || The use of the vapor phase of hydrogen peroxide as a surface decontaminant and sterilant is discovered.<ref name="Rogers"/> ||
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| 1980s || {{w|Disinfectant}} || || Alcohol-based hand sanitizer starts being commonly used in Europe.<ref>{{cite book|last1=Miller|first1=Chris H.|last2=Palenik|first2=Charles John|title=Infection Control and Management of Hazardous Materials for the Dental Team|date=2016|publisher=Elsevier Health Sciences|isbn=9780323476577|page=269|edition=5|url=https://books.google.com/books?id=oySKCwAAQBAJ&pg=PA269|language=en|url-status=live|archiveurl=https://web.archive.org/web/20170918190157/https://books.google.com/books?id=oySKCwAAQBAJ&pg=PA269|archivedate=2017-09-18}}</ref> ||
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| 1991 || || || Karlson patents a gaseous ozone sterilization process.<ref name="Rogers"/> ||
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| 1995 || ''{{w|Cordon sanitaire}}'' || {{w|Ebola}} || "In 1995 a cordon sanitaire was used to control an outbreak of Ebola virus disease in Kikwit, Zaire" ||
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| 1995 || || {{w|Hospital-acquired infection}} || The {{w|Centers for Disease Control and Prevention}} estimates that approximately 1.9 million cases of {{w|hospital-acquired infection}} occurred in the United States.<ref>{{cite web |title=Frequently Asked Questions |url=https://www.ncsl.org/research/health/hospital-acquired-infections-faq.aspx |website=ncsl.org |accessdate=2 April 2020}}</ref> || {{w|United States}}
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| 1999 || || || A new plasma sterilizer is approved by the FDA.<ref name="Rogers"/> ||
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| 1990s || {{w|Disinfectant}} || || [[w:NAV-CO2 System|Non-flammable Alcohol Vapor in Carbon Dioxide systems]] (NAV-CO2 System) are developed in Japan in the 1990s to sanitize hospitals and ambulances. || {{w|Japan}}
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| 2001 || || || Disinfection with performic acid is noted.<ref name="Rogers"/> ||
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| 2003 || ''{{w|Cordon sanitaire}}'' || {{w|Severe acute respiratory syndrome}} || During the [[w:Timeline of the SARS outbreak|2003 SARS outbreak]] in Canada, "community quarantine" is used to successfully reduce transmission of the disease.<ref>{{cite journal| pmid=20034405 | doi=10.1186/1471-2458-9-488 | pmc=2808319 | volume=9 | title=Quantifying the impact of community quarantine on SARS transmission in Ontario: estimation of secondary case count difference and number needed to quarantine | year=2009 | journal=BMC Public Health | page=488 | last1 = Bondy | first1 = SJ | last2 = Russell | first2 = ML | last3 = Laflèche | first3 = JM | last4 = Rea | first4 = E}}</ref> || {{w|Canada}}
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| 2003 || ''{{w|Cordon sanitaire}}'' || {{w|Severe acute respiratory syndrome}} || During the 2003 SARS outbreak in mainland {{w|China}}, {{w|Hong Kong}}, {{w|Taiwan}}, and {{w|Singapore}}, large-scale quarantine is imposed on travelers arriving from other SARS areas, work and school contacts of suspected cases, and, in a few instances, entire apartment complexes where high attack rates of SARS were occurring.<ref>[https://www.ncbi.nlm.nih.gov/books/NBK92450/ Martin Cetron, et al. "Isolation and Quarantine: Containment Strategies for SARS, 2003." From ''Learning from SARS: Preparing for the Next Disease Outbreak,'' National Academy of Sciences, 2004.] {{ISBN|0309594332}}</ref> || {{w|China}}, {{w|Hong Kong}}, {{w|Taiwan}}, {{w|Singapore}}
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| 2004 || || || Ferric Fang publishes a paper on antimicrobial reactive oxygen and nitrogen species.<ref name="Rogers"/> ||
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| 2004 || ''{{w|Cordon sanitaire}}'' || {{w|Ebola}} || A ''cordon sanitaire'' is established around some of the most affected areas of the {{w|2014 West Africa Ebola virus outbreak}}.<ref>[https://www.cdc.gov/mmwr/preview/mmwrhtml/mm6407a4.htm "Community Quarantine to Interrupt Ebola Virus Transmission – Mawah Village, Bong County, Liberia, August–October, 2014," ''Morbidity and Mortality Weekly Report,'' February 27, 2015 / 64(07); 179–182.]</ref><ref>{{Cite news|url=https://www.nytimes.com/2014/08/13/science/using-a-tactic-unseen-in-a-century-countries-cordon-off-ebola-racked-areas.html?_r=0|author=Donald G. McNeil Jr.|newspaper={{w|The New York Times}}|date=August 13, 2014|title=Using a Tactic Unseen in a Century, Countries Cordon Off Ebola-Racked Areas}}</ref> On 19 August, the Liberian government quarantined the entirety of [[West Point, Monrovia]] and issued a curfew statewide.<ref name="nbcnews1">{{cite web |url=http://www.nbcnews.com/storyline/ebola-virus-outbreak/liberian-soldiers-seal-slum-halt-ebola-n185046 |title=Liberian Soldiers Seal Slum to Halt Ebola |publisher=NBC News |date=2014-08-09 |accessdate=2014-08-23}}</ref> || {{w|Liberia}}
