289
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| 1581 || {{W|Tycho Brahe}} builds large scale research facility, {{W|Stjerneborg}} dedicated to obtaining high precision measurements of the planets.
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| 1595 || {{W|Microscope}} invented in the {{W|Netherlands}}\
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| 1600 || First dedicated {{W|laboratory}}
| 1897 || {{W|Thomas Chrowder Chamberlin}} proposes the use of multiple hypotheses to assist in the design of experiments.
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| 1905 || {{W|Albert Einstein}} proposes the {{W|Theory of Relativity}}\<!-- *1908 — Three kinds of logical reasoning, {{W|Abductive reasoning|Abduction}}, {{W|Deductive reasoning|Deduction}} and {{W|Inductive reasoning|Induction}} identified by {{W|Charles Sanders Peirce}} (1839-1914) -->
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| 1926 || {{W|Completely Randomized Design|Randomized design}} popularized and analyzed by {{W|Ronald Fisher}} (following {{W|Charles Sanders Peirce|Peirce}})
