Difference between revisions of "Timeline of liver cancer"

This is a '''timeline of [[liver cancer]]''', describing especially major discoveries and advances in treatment of the disease.

|1960s||[[Hepatitis B]] is found to be a leading cause of liver cancer.<ref name="Progress & Timeline" /> First liver transplant performed.

|2000s||The introduction of [[sorafenib]] in considered to mark a new era of liver cancer research and treatments.<ref name="Progress & Timeline" /> Obesity is linked to liver cancer deaths.  

|Recent years||As of 2010, liver cancer resulted in 754,000 deaths, up from 460,000 in 1990, making it the third leading cause of cancer death after lung and stomach.<ref name=Loz2012>{{cite journal|last=Lozano|first=R|title=Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010|journal=Lancet|date=Dec 15, 2012|volume=380|issue=9859|pages=2095–128|pmid=23245604|doi=10.1016/S0140-6736(12)61728-0|last2=Naghavi|first2=M|last3=Foreman|first3=K|last4=Lim|first4=S|last5=Shibuya|first5=K|last6=Aboyans|first6=V|last7=Abraham|first7=J|last8=Adair|first8=T|last9=Aggarwal|first9=R|last10=Ahn|first10=S. Y.|last11=Alvarado|first11=M|last12=Anderson|first12=H. R.|last13=Anderson|first13=L. M.|last14=Andrews|first14=K. G.|last15=Atkinson|first15=C|last16=Baddour|first16=L. M.|last17=Barker-Collo|first17=S|last18=Bartels|first18=D. H.|last19=Bell|first19=M. L.|last20=Benjamin|first20=E. J.|last21=Bennett|first21=D|last22=Bhalla|first22=K|last23=Bikbov|first23=B|last24=Bin Abdulhak|first24=A|last25=Birbeck|first25=G|last26=Blyth|first26=F|last27=Bolliger|first27=I|last28=Boufous|first28=S|last29=Bucello|first29=C|last30=Burch|first30=M|display-authors=29}}</ref> Current treatment options for liver cancer are surgery, tumor ablation, [[tumor embolization]], radiation therapy, targeted therapy and chemotherapy.<ref>{{cite web|title=Liver cancer treatment|url=http://www.cancer.org/cancer/livercancer/detailedguide/liver-cancer-treating-general-info|accessdate=1 October 2016}}</ref>

|1950||Organization||The [[American Association for the Study of Liver Diseases]] is founded as an organization of scientists and healthcare professionals committed to preventing and curing liver disease.<ref name="Related Societies">{{cite web|title=Related Societies|url=http://apasl.info/links-notices/related-societies|accessdate=30 September 2016}}</ref>||[[United States]]

|1956||Discovery||[[Fibrolamellar hepatocellular carcinoma]] (a rare form of [[hepatocellular carcinoma]] that typically affects young adults) is first described.<ref>{{cite journal|title=The genomic landscape of fibrolamellar hepatocellular carcinoma: whole genome sequencing of ten patients|doi=10.18632/oncotarget.2712|pmc=4359253 | pmid=25605237|volume=6|year=2015|journal=Oncotarget|pages=755–70 | last1 = Darcy | first1 = DG | last2 = Chiaroni-Clarke | first2 = R | last3 = Murphy | first3 = JM | last4 = Honeyman | first4 = JN | last5 = Bhanot | first5 = U | last6 = LaQuaglia | first6 = MP | last7 = Simon | first7 = SM}}</ref>||

|1965||Treatment||Radioactive isotope [[Yttrium-90]] (Y90) is first used for the treatment of inoperable liver cancer, for which previously there are no treatment options.<ref>{{cite journal|title=Treatment of Inoperable Primary Pancreatic and Liver Cancer by the Intra-Arterial Administration of Radioactive Isotopes (Y90 Radiating Microspheres|pmc=1476829 | pmid=14327011 | volume=162|year=1965|journal=Ann. Surg.|pages=267–78 | last1 = Ariel | first1 = IM | doi=10.1097/00000658-196508000-00018}}</ref>||

|1966||Organization||The [[European Association for the Study of Liver Diseases]] is founded.<ref>{{cite web|title=EASL|url=http://www.easl.eu/discover/what-is-easl/easl-history|accessdate=30 September 2016}}</ref>||[[Marburg]], [[Germany]]

|1968||Organization||The [[Latin American Association for the Study of the Liver]] (ALEH) is founded.<ref name="Related Societies" />||[[Sao Paulo]], [[Brazil]]

|1973||Development||[[Child-Pugh score]] system develops as a method used to assess the prognosis of chronic liver disease. The system, which remains in use today, considers the results of three specific blood tests, the presence of fluid in the abdomen and cognitive function.<ref>{{cite web|title=The Child-Pugh score: Prognosis in chronic liver disease and cirrhosis|url=http://www.2minutemedicine.com/the-child-pugh-score-prognosis-in-chronic-liver-disease-and-cirrhosis-classics-series/|accessdate=1 October 2016}}</ref>||

|1975||Treatment||Research shows that advanced liver cancers respond to single-drug treatment with [[doxorubicin]] ([[Adriamycin]]).<ref>{{cite journal|title=Treatment of hepatocellular carcinoma with adriamycin. Preliminary communication|doi=10.1002/1097-0142(197510)36:4<1250::AID-CNCR2820360410>3.0.CO;2-X|url=http://onlinelibrary.wiley.com/doi/10.1002/1097-0142%28197510%2936:4%3C1250::AID-CNCR2820360410%3E3.0.CO;2-X/abstract | volume=36|journal=Cancer|pages=1250–1257}}</ref>||

|1981||Treatment||United States [[FDA]] approves the first vaccine against [[hepatitis B]], one of the primary causes of liver cancer.<ref>{{cite web|title=Hepatitis B VIS|url=http://www.cdc.gov/vaccines/hcp/vis/vis-statements/hep-b.html|accessdate=1 October 2016}}</ref>||[[United States]]

|1983||Treatment||A new technique called [[tumor ablation]] helps patients who cannot undergo surgery by shrinking and, in some cases, destroying smaller liver tumors.<ref name="Tumor Ablation: Principles and Practice">{{cite book|last1=van Sonnenberg|first1=Eric|last2=McMullen|first2=William|last3=Solbiati|first3=Luigi|title=Tumor Ablation: Principles and Practice|url=https://books.google.com.ar/books?id=2aT0eMPpArMC&pg=PA159&lpg=PA159&dq=%22tumor+ablation%22+%221983%22&source=bl&ots=JVsLAm3giX&sig=vo_S_ofGG8f6V3LQ8m9WS0XZrKo&hl=en&sa=X&ved=0ahUKEwjdr4GEvbjPAhVKOZAKHVybCusQ6AEINTAD#v=onepage&q=%22tumor%20ablation%22%20%221983%22&f=false}}</ref>||

|1989||Treatment||[[Interstitial laser photocoagulation]] (ILP) for metastatic liver lesions is described. Since then, lasers are used to deliver local, controlled heat deposition in multiple organs.<ref name="Tumor Ablation: Principles and Practice" />||

|1991||Discovery||[[Hepatitis C]] virus is first associated with [[hepatocellular carcinoma]].<ref name="Risk Factors for the Rising Rates of Primary Liver Cancer in the United States">{{cite web|title=Risk Factors for the Rising Rates of Primary Liver Cancer in the United States|url=http://archinte.jamanetwork.com/article.aspx?articleid=485560|accessdate=30 September 2016}}</ref>||

|1994||Development||Researchers describe the infectious agent [[Helicobacter hepaticus]] and its role in causing active hepatitis and associated liver tumors in mice.<ref>{{cite journal|title=Helicobacter pylori and Liver – Detection of Bacteria in Liver Tissue from Patients with Hepatocellular Carcinoma Using Laser Capture Microdissection Technique (LCM)|doi=10.5772/57080|url=http://www.intechopen.com/books/trends-in-helicobacter-pylori-infection/helicobacter-pylori-and-liver-detection-of-bacteria-in-liver-tissue-from-patients-with-hepatocellula}}</ref>||  

|1998||Discovery||Research links non-alcoholic [[steatohepatitis]] (NASH) to increased liver cancer risk.<ref>{{cite journal|title=Hepatitis G infection: role in cryptogenic chronic liver disease and primary liver cell cancer in the UK. Trent Hepatitis C virus Study Group.|pmid=9658369 | volume=5 | journal=J Viral Hepat|pages=165–9 | last1 = Hollingsworth | first1 = RC | last2 = Minton | first2 = EJ | last3 = Fraser-Moodie | first3 = C | last4 = Metivier | first4 = E | last5 = Rizzi | first5 = PM | last6 = Irving | first6 = WL | last7 = Jenkins | first7 = D | last8 = Ryder | first8 = SD | doi=10.1046/j.1365-2893.1998.00102.x}}</ref>||

|2003||Discovery||Study links [[obesity]] to higher risk of death from liver cancer, along with several other cancer types.<ref>{{cite journal|title=Overweight, Obesity, and Mortality from Cancer in a Prospectively Studied Cohort of U.S. Adults|doi=10.1056/NEJMoa021423|url=http://www.nejm.org/doi/full/10.1056/NEJMoa021423#t=article | pmid=12711737|volume=348|date=April 2003|journal=N. Engl. J. Med.|pages=1625–38 | last1 = Calle | first1 = EE | last2 = Rodriguez | first2 = C | last3 = Walker-Thurmond | first3 = K | last4 = Thun | first4 = MJ}}</ref>||[[United States]]  

|2006||Organization||The [[International Liver Cancer Association]] (ILCA) is established. It is the only international organization devoted exclusively to liver cancer research for experts from all related disciplines.<ref>{{cite web|title=ILCA|url=http://www.prnewswire.com/news-releases/the-international-liver-cancer-association-ilca-celebrates-10-years-of-promoting-novel-pathogenic-diagnostic-and-therapeutic-interventions-for-liver-cancer-at-the-10th-ilca-annual-conference-590904481.html|accessdate=1 October 2016}}</ref>||

|2007||Treatment||Study shows that drug [[sorafenib]] ([[Nexavar]]), extends the lives of patients with advanced, inoperable [[hepatocellular carcinoma]], the most common form of liver cancer.<ref>{{cite journal|title=Sorafenib in Advanced Hepatocellular Carcinoma|doi=10.1056/NEJMoa0708857|url=http://www.nejm.org/doi/full/10.1056/NEJMoa0708857 | volume=359|journal=New England Journal of Medicine|pages=378–390|pmid=18650514|date=July 2008 | last1 = Llovet | first1 = JM | last2 = Ricci | first2 = S | last3 = Mazzaferro | first3 = V | display-authors = 3 | last4 = et al}}</ref>||

|2012||Organization||The [[South Asian Association for the Study of the Liver]] is founded.<ref name="Related Societies" />||[[Dhaka]], [[Bangladesh]]

|2016||Discovery||Study shows that liver cancer risk rises up to 10 times with low [[selenium]] levels in the [[blood]].<ref>{{cite news|title=Liver cancer risk influenced by blood selenium levels|url=http://www.medicalnewstoday.com/articles/312692.php|accessdate=30 September 2016|publisher=Medical News Today}}</ref>||[[United States]]

|2016||Treatment||[[Bayer]]’s [[Stivarga]] is found to improve liver cancer survival rates after trial.<ref>{{cite news|title=Bayer’s Stivarga improves liver cancer survival rates, trial shows|url=http://www.thepharmaletter.com/article/bayer-s-stivarga-improves-liver-cancer-survival-rates-trial-shows|accessdate=30 September 2016}}</ref>||[[Germany]]

* [[Timeline of lung cancer]]

* [[Timeline of brain cancer]]

* [[Timeline of colorectal cancer]]

* [[Timeline of pancreatic cancer]]

* [[Timeline of cervical cancer]]

* [[Timeline of kidney cancer]]

[[Category:Health-related timelines|Cancer, liver]]

[[Category:Hepatology]]

[[Category:Digestive system neoplasia]]

[[Category:Diseases of liver|C]]