Difference between revisions of "Timeline of lymphoma"
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| − | This is a '''timeline of [[lymphoma]]''', describing especially major discoveries and advances in treatment against the disease. | + | This is a '''timeline of [[wikipedia:lymphoma|lymphoma]]''', describing especially major discoveries and advances in treatment against the disease. |
==Big picture== | ==Big picture== | ||
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! Year/period !! Key developments | ! Year/period !! Key developments | ||
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| − | |19th Century||The presence of lymphoma in western medical literature is born after the works of people like [[Thomas Hodgkin]] and [[Samuel Wilks]]. [[Hodgkin's lymphoma]] is the first lymphoma to be described. | + | |19th Century||The presence of lymphoma in western medical literature is born after the works of people like [[wikipedia:Thomas Hodgkin|Thomas Hodgkin]] and [[wikipedia:Samuel Wilks|Samuel Wilks]]. [[wikipedia:Hodgkin's lymphoma|Hodgkin's lymphoma]] is the first lymphoma to be described. |
|- | |- | ||
| − | |1900–1950s||It is found that radiation therapy can cure some patients with Hodgkin lymphoma, one of two major classes of lymphomas. When it is discovered that radiating larger parts of the body improves cure rates, physicians begin increasing the size of the radiation fields. [[Radiotherapy]] starts to prove successful as a treatment against Hodgkin's lymphoma in the 1940s.<ref name="newsmedical" /> However, long-term effects of radiation to the chest (including cardiovascular disease and second cancers) are later recognized, and efforts start to be taken to reduce radiation exposure to healthy tissue.<ref name="cancerprogress">{{cite web|title=Progress & Timeline|url=http://cancerprogress.net/timeline/lymphoma|accessdate=23 August 2016}}</ref> | + | |1900–1950s||It is found that radiation therapy can cure some patients with Hodgkin lymphoma, one of two major classes of lymphomas. When it is discovered that radiating larger parts of the body improves cure rates, physicians begin increasing the size of the radiation fields. [[wikipedia:Radiotherapy|Radiotherapy]] starts to prove successful as a treatment against Hodgkin's lymphoma in the 1940s.<ref name="newsmedical" /> However, long-term effects of radiation to the chest (including cardiovascular disease and second cancers) are later recognized, and efforts start to be taken to reduce radiation exposure to healthy tissue.<ref name="cancerprogress">{{cite web|title=Progress & Timeline|url=http://cancerprogress.net/timeline/lymphoma|accessdate=23 August 2016}}</ref> |
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| − | |1960s–1970s||Very effective treatments for [[Hodgkin's lymphoma]] are developed in this period.<ref>{{cite web|title=Lymphoma - Hodgkin - Treatment Options|url=http://www.cancer.net/cancer-types/lymphoma-hodgkin/treatment-options|accessdate=25 August 2016}}</ref> Chemotherapeutic agents are combined into regimens capable of eradicating and even disseminating the disease.<ref name=ascopubs>{{cite web|title=Hodgkin’s Lymphoma: The Hazards of Success|url=http://jco.ascopubs.org/content/21/18/3388.full|accessdate=25 August 2016}}</ref> Combination of chemotherapy and high-energy radiation therapy are introduced.<ref>{{cite journal|title=Second Cancer Risk Up to 40 Years after Treatment for Hodgkin’s Lymphoma|doi=10.1056/NEJMoa1505949|url=http://www.nejm.org/doi/full/10.1056/NEJMoa1505949?rss=mostViewed#t=article | volume=373|journal=New England Journal of Medicine|pages=2499–2511}}</ref> | + | |1960s–1970s||Very effective treatments for [[wikipedia:Hodgkin's lymphoma|Hodgkin's lymphoma]] are developed in this period.<ref>{{cite web|title=Lymphoma - Hodgkin - Treatment Options|url=http://www.cancer.net/cancer-types/lymphoma-hodgkin/treatment-options|accessdate=25 August 2016}}</ref> Chemotherapeutic agents are combined into regimens capable of eradicating and even disseminating the disease.<ref name=ascopubs>{{cite web|title=Hodgkin’s Lymphoma: The Hazards of Success|url=http://jco.ascopubs.org/content/21/18/3388.full|accessdate=25 August 2016}}</ref> Combination of chemotherapy and high-energy radiation therapy are introduced.<ref>{{cite journal|title=Second Cancer Risk Up to 40 Years after Treatment for Hodgkin’s Lymphoma|doi=10.1056/NEJMoa1505949|url=http://www.nejm.org/doi/full/10.1056/NEJMoa1505949?rss=mostViewed#t=article | volume=373|journal=New England Journal of Medicine|pages=2499–2511}}</ref> |
|- | |- | ||
|1990s–present||Modern era of treatment for Hodgkin's lymphoma, focusing on reducing both toxicity and duration of chemotherapy.<ref name=ascopubs/> Lymphomas developed in 566,000 people in 2012 and caused 305,000 deaths worldwide.<ref>{{cite book|title=World Cancer Report 2014.|date=2014|publisher=World Health Organization|isbn=9283204298|pages=Chapter 5.13}}</ref> They comprise the seventh-most common form of cancers making up the 3–4% of them.<ref>{{cite book|last1=Marcus|first1=Robert|title=Lymphoma : pathology, diagnosis and treatment|date=2013|isbn=9781107010598|page=1|edition=Second|url=https://books.google.com/books?id=SX0LAgAAQBAJ&lpg=PP1}}</ref> | |1990s–present||Modern era of treatment for Hodgkin's lymphoma, focusing on reducing both toxicity and duration of chemotherapy.<ref name=ascopubs/> Lymphomas developed in 566,000 people in 2012 and caused 305,000 deaths worldwide.<ref>{{cite book|title=World Cancer Report 2014.|date=2014|publisher=World Health Organization|isbn=9283204298|pages=Chapter 5.13}}</ref> They comprise the seventh-most common form of cancers making up the 3–4% of them.<ref>{{cite book|last1=Marcus|first1=Robert|title=Lymphoma : pathology, diagnosis and treatment|date=2013|isbn=9781107010598|page=1|edition=Second|url=https://books.google.com/books?id=SX0LAgAAQBAJ&lpg=PP1}}</ref> | ||
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! Year/period !! Type of event !! Event !!Location | ! Year/period !! Type of event !! Event !!Location | ||
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| − | |1666||Development||Italian biologist [[Marcello Malpighi]] publishes ''De viscerum structuru exercitatio anatomica'', where he describes what later will be known as [[Hodgkin's lymphoma]].<ref name="Lakhtakia">{{cite journal|title=A Historical Tale of Two Lymphomas|pmc=4450782 | pmid=26052452 | volume=15|year=2015|journal=Sultan Qaboos Univ Med J|pages=e202–6 | last1 = Lakhtakia | first1 = R | last2 = Burney | first2 = I}}</ref>|| | + | |1666||Development||Italian biologist [[wikipedia:Marcello Malpighi|Marcello Malpighi]] publishes ''De viscerum structuru exercitatio anatomica'', where he describes what later will be known as [[wikipedia:Hodgkin's lymphoma|Hodgkin's lymphoma]].<ref name="Lakhtakia">{{cite journal|title=A Historical Tale of Two Lymphomas|pmc=4450782 | pmid=26052452 | volume=15|year=2015|journal=Sultan Qaboos Univ Med J|pages=e202–6 | last1 = Lakhtakia | first1 = R | last2 = Burney | first2 = I}}</ref>|| |
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| − | |1832||Development||British physician [[Thomas Hodgkin]] presents a paper describing seven patients with painless enlargement of the [[lymph node]]s, and including [[autopsy]] findings and illustrations from one of the patients.<ref name="Lakhtakia" />||[[London]], [[United Kingdom]] | + | |1832||Development||British physician [[wikipedia:Thomas Hodgkin|Thomas Hodgkin]] presents a paper describing seven patients with painless enlargement of the [[wikipedia:lymph node|lymph node]]s, and including [[wikipedia:autopsy|autopsy]] findings and illustrations from one of the patients.<ref name="Lakhtakia" />||[[wikipedia:London|London]], [[wikipedia:United Kingdom|United Kingdom]] |
|- | |- | ||
| − | |1856||Book||British physician [[Samuel Wilks]] publishes ''Cases of lardaceous diseases and some allied affections with remarks'', describing similar cases to those presented by [[Thomas Hodgkin]]. Wilks honors Hodgkin by [[eponym]]ously referring to this disease as ''Hodgkin's lymphoma''.<ref name="Lakhtakia" />|| | + | |1856||Book||British physician [[wikipedia:Samuel Wilks|Samuel Wilks]] publishes ''Cases of lardaceous diseases and some allied affections with remarks'', describing similar cases to those presented by [[wikipedia:Thomas Hodgkin|Thomas Hodgkin]]. Wilks honors Hodgkin by [[wikipedia:eponym|eponym]]ously referring to this disease as ''Hodgkin's lymphoma''.<ref name="Lakhtakia" />|| |
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| − | |1871||Development||Billroth reports the first case of [[non-Hodgkin's lymphoma]]<ref name=pollock>{{cite book|last1=Pollock|first1=Raphael|title=Advanced Therapy in Surgical Oncology|page=236|url=https://books.google.com.ar/books?id=_ZiBwOH_BS8C&pg=PA236&lpg=PA236&dq=%22billroth%22+%22lymphoma%22&source=bl&ots=5YByxfAQZc&sig=v40ua5NzyKFCXvBQftDC0qIBvmE&hl=en&sa=X&ved=0ahUKEwjGuOW5m9jOAhVFGZAKHZ70DZIQ6AEIKTAD#v=onepage&q=%22billroth%22%20%22lymphoma%22&f=false}}</ref> | + | |1871||Development||Billroth reports the first case of [[wikipedia:non-Hodgkin's lymphoma|non-Hodgkin's lymphoma]]<ref name=pollock>{{cite book|last1=Pollock|first1=Raphael|title=Advanced Therapy in Surgical Oncology|page=236|url=https://books.google.com.ar/books?id=_ZiBwOH_BS8C&pg=PA236&lpg=PA236&dq=%22billroth%22+%22lymphoma%22&source=bl&ots=5YByxfAQZc&sig=v40ua5NzyKFCXvBQftDC0qIBvmE&hl=en&sa=X&ved=0ahUKEwjGuOW5m9jOAhVFGZAKHZ70DZIQ6AEIKTAD#v=onepage&q=%22billroth%22%20%22lymphoma%22&f=false}}</ref> |
|- | |- | ||
|1872–1878||Development||Microscopic descriptions of Hodgkin's lymphoma are first described.<ref name="Lakhtakia" />|| | |1872–1878||Development||Microscopic descriptions of Hodgkin's lymphoma are first described.<ref name="Lakhtakia" />|| | ||
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| − | |1878||Development||W. S. Greenfield first publishes drawings of the [[pathognomonic]] giant cells, later called [[Reed–Sternberg cell]]s.<ref>{{cite book|last1=Hoffman|first1=Ronald|title=Hematology: Basic Principles and Practice, Expert Consult Premium Edition|page=1138|pages=|url=https://books.google.com.ar/books?id=M5fD7gZSDYMC&pg=PA1138&lpg=PA1138&dq=%221878%22+%22Greenfield%22+Hodgkin%22&source=bl&ots=DATR_dxEi7&sig=e0YVRIaenfqKBhmLOehGsuxPh3E&hl=en&sa=X&ved=0ahUKEwjtooOqk9bOAhVLgpAKHVBNDTIQ6AEIKTAD#v=onepage&q=%221878%22%20%22Greenfield%22%20Hodgkin%22&f=false}}</ref>|| | + | |1878||Development||W. S. Greenfield first publishes drawings of the [[wikipedia:pathognomonic|pathognomonic]] giant cells, later called [[wikipedia:Reed–Sternberg cell|Reed–Sternberg cell]]s.<ref>{{cite book|last1=Hoffman|first1=Ronald|title=Hematology: Basic Principles and Practice, Expert Consult Premium Edition|page=1138|pages=|url=https://books.google.com.ar/books?id=M5fD7gZSDYMC&pg=PA1138&lpg=PA1138&dq=%221878%22+%22Greenfield%22+Hodgkin%22&source=bl&ots=DATR_dxEi7&sig=e0YVRIaenfqKBhmLOehGsuxPh3E&hl=en&sa=X&ved=0ahUKEwjtooOqk9bOAhVLgpAKHVBNDTIQ6AEIKTAD#v=onepage&q=%221878%22%20%22Greenfield%22%20Hodgkin%22&f=false}}</ref>|| |
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| − | |1894||Development||Osler first mentions use of [[chemotherapy]] for lymphoma in his work ''Textbook of Medicine''.<ref>{{cite book|last1=Specht|first1=Lena|title=Radiotherapy for Hodgkin Lymphoma|page=45|url=https://books.google.com.ar/books?id=NJqVQVVd7dQC&pg=PA45&lpg=PA45&dq=%221894%22+%22Osler%22+%22lymphoma%22&source=bl&ots=kn7WK52u11&sig=GYdAvlDu8Qwkd6yzv42lWWYztKY&hl=en&sa=X&ved=0ahUKEwiHmpipmNbOAhVHlpAKHcTsDrkQ6AEIIzAB#v=onepage&q=%221894%22%20%22Osler%22%20%22lymphoma%22&f=false}}</ref>|| | + | |1894||Development||Osler first mentions use of [[wikipedia:chemotherapy|chemotherapy]] for lymphoma in his work ''Textbook of Medicine''.<ref>{{cite book|last1=Specht|first1=Lena|title=Radiotherapy for Hodgkin Lymphoma|page=45|url=https://books.google.com.ar/books?id=NJqVQVVd7dQC&pg=PA45&lpg=PA45&dq=%221894%22+%22Osler%22+%22lymphoma%22&source=bl&ots=kn7WK52u11&sig=GYdAvlDu8Qwkd6yzv42lWWYztKY&hl=en&sa=X&ved=0ahUKEwiHmpipmNbOAhVHlpAKHcTsDrkQ6AEIIzAB#v=onepage&q=%221894%22%20%22Osler%22%20%22lymphoma%22&f=false}}</ref>|| |
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| − | |1898||Development||Austrian pathologist [[Carl Sternberg]] first describes in detail giant cells ([[Reed–Sternberg cell]]s).<ref name="lymphomainfo">{{cite web|title=Hodgkin's Disease - Historical Timeline|url=http://www.lymphomainfo.net/hodgkins/timeline.html|accessdate=22 August 2016}}</ref>||[[Germany]] | + | |1898||Development||Austrian pathologist [[wikipedia:Carl Sternberg|Carl Sternberg]] first describes in detail giant cells ([[wikipedia:Reed–Sternberg cell|Reed–Sternberg cell]]s).<ref name="lymphomainfo">{{cite web|title=Hodgkin's Disease - Historical Timeline|url=http://www.lymphomainfo.net/hodgkins/timeline.html|accessdate=22 August 2016}}</ref>||[[wikipedia:Germany|Germany]] |
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| − | |1902||Development||American physician [[Dorothy Reed Mendenhall]] independently describes Reed-Sternberg cells.<ref name="lymphomainfo" />||[[United States]] | + | |1902||Development||American physician [[wikipedia:Dorothy Reed Mendenhall|Dorothy Reed Mendenhall]] independently describes Reed-Sternberg cells.<ref name="lymphomainfo" />||[[wikipedia:United States|United States]] |
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| − | |1910||Discovery||Albert Cook, a missionary doctor in [[Africa]], reports a child with a large jaw tumor, in what becomes the first description of [[Burkitt lymphoma]].<ref>{{cite book|last1=Robertson|first1=Erle S.|title=Burkitt’s Lymphoma|page=1|url=https://books.google.com.ar/books?id=qgPl0rdoE8UC&pg=PA1&lpg=PA1&dq=%22lymphoma%22+%22first+description%22&source=bl&ots=LWWKA-shQ3&sig=RVeNerpiYqlzYqZyEPyIbJsutm8&hl=en&sa=X&ved=0ahUKEwiO-9qjpt3OAhWLHZAKHTOlCdYQ6AEIPjAE#v=onepage&q=%22lymphoma%22%20%22first%20description%22&f=false}}</ref>||[[Uganda]] | + | |1910||Discovery||Albert Cook, a missionary doctor in [[wikipedia:Africa|Africa]], reports a child with a large jaw tumor, in what becomes the first description of [[wikipedia:Burkitt lymphoma|Burkitt lymphoma]].<ref>{{cite book|last1=Robertson|first1=Erle S.|title=Burkitt’s Lymphoma|page=1|url=https://books.google.com.ar/books?id=qgPl0rdoE8UC&pg=PA1&lpg=PA1&dq=%22lymphoma%22+%22first+description%22&source=bl&ots=LWWKA-shQ3&sig=RVeNerpiYqlzYqZyEPyIbJsutm8&hl=en&sa=X&ved=0ahUKEwiO-9qjpt3OAhWLHZAKHTOlCdYQ6AEIPjAE#v=onepage&q=%22lymphoma%22%20%22first%20description%22&f=false}}</ref>||[[wikipedia:Uganda|Uganda]] |
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| − | |1925||Discovery||[[Follicular lymphoma]] is first described.<ref>{{cite journal|title=Follicular lymphoma: a historical overview.|doi=10.1080/10428190601059746|pmid=17325883 | volume=48|journal=Leuk Lymphoma|pages=232-43 | last1 = van Besien | first1 = K | last2 = Schouten | first2 = H}}</ref>|| | + | |1925||Discovery||[[wikipedia:Follicular lymphoma|Follicular lymphoma]] is first described.<ref>{{cite journal|title=Follicular lymphoma: a historical overview.|doi=10.1080/10428190601059746|pmid=17325883 | volume=48|journal=Leuk Lymphoma|pages=232-43 | last1 = van Besien | first1 = K | last2 = Schouten | first2 = H}}</ref>|| |
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| − | |1932||Development||Chevalier and Bernard describe the use of [[radiation therapy]] to treat Hodgkin's disease.<ref name="newsmedical">{{cite web|title=Hodgkin's Lymphoma History|url=http://www.news-medical.net/health/Hodgkins-Lymphoma-History.aspx|accessdate=22 August 2016}}</ref>|| | + | |1932||Development||Chevalier and Bernard describe the use of [[wikipedia:radiation therapy|radiation therapy]] to treat Hodgkin's disease.<ref name="newsmedical">{{cite web|title=Hodgkin's Lymphoma History|url=http://www.news-medical.net/health/Hodgkins-Lymphoma-History.aspx|accessdate=22 August 2016}}</ref>|| |
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|1939||Development||E. Epstein reports better survival prognosis for women against Hodgkin's lymphoma in his book ''Sex as factor in the prognosis of Hodgkins disease''.<ref name="lymphomainfo" />|| | |1939||Development||E. Epstein reports better survival prognosis for women against Hodgkin's lymphoma in his book ''Sex as factor in the prognosis of Hodgkins disease''.<ref name="lymphomainfo" />|| | ||
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|1942||Development||Gall and Mallory propose the first morphological classification for lymphoma.<ref name="pollock" />|| | |1942||Development||Gall and Mallory propose the first morphological classification for lymphoma.<ref name="pollock" />|| | ||
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| − | |1944||Discovery||[[Lymphoplasmacytic lymphoma]], also known as Waldenström's macroglobulinemia, is first described by Swedish oncologist [[Jan G. Waldenström]].<ref>{{cite journal|title=Waldenström's Macroglobulinemia — Clinical and Pathological Report of a Case Resembling Multiple Myeloma|doi=10.1056/NEJM195806262582604|url=http://www.nejm.org/doi/full/10.1056/NEJM195806262582604 | volume=258|journal=New England Journal of Medicine|pages=1293–1296}}</ref>||[[Sweden]] | + | |1944||Discovery||[[wikipedia:Lymphoplasmacytic lymphoma|Lymphoplasmacytic lymphoma]], also known as Waldenström's macroglobulinemia, is first described by Swedish oncologist [[wikipedia:Jan G. Waldenström|Jan G. Waldenström]].<ref>{{cite journal|title=Waldenström's Macroglobulinemia — Clinical and Pathological Report of a Case Resembling Multiple Myeloma|doi=10.1056/NEJM195806262582604|url=http://www.nejm.org/doi/full/10.1056/NEJM195806262582604 | volume=258|journal=New England Journal of Medicine|pages=1293–1296}}</ref>||[[wikipedia:Sweden|Sweden]] |
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| − | |1949||Treatment||First [[chemotherapy]] drug ([[nitrogen mustard]]) is approved by the [[Food and Drug Administration]] (FDA) for the treatment of Hodgkin's lymphoma.<ref name="cancerprogress" />||United States | + | |1949||Treatment||First [[wikipedia:chemotherapy|chemotherapy]] drug ([[wikipedia:nitrogen mustard|nitrogen mustard]]) is approved by the [[wikipedia:Food and Drug Administration|Food and Drug Administration]] (FDA) for the treatment of Hodgkin's lymphoma.<ref name="cancerprogress" />||United States |
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| − | |1949–1956||Discovery||After shielding a mouse's [[spleen]], researchers discover that the body recruits [[stem cell]]s, which are found in the spleen and [[bone marrow]], to protect and heal itself from [[radiation damage]].<ref name="cancerprogress" />|| | + | |1949–1956||Discovery||After shielding a mouse's [[wikipedia:spleen|spleen]], researchers discover that the body recruits [[wikipedia:stem cell|stem cell]]s, which are found in the spleen and [[wikipedia:bone marrow|bone marrow]], to protect and heal itself from [[wikipedia:radiation damage|radiation damage]].<ref name="cancerprogress" />|| |
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| − | |1956||Development||American chemist [[Henry Rapoport]] proposes the first classification of [[non-Hodgkin's lymphoma]] based on cellular morphology.<ref name="pollock" />|| | + | |1956||Development||American chemist [[wikipedia:Henry Rapoport|Henry Rapoport]] proposes the first classification of [[wikipedia:non-Hodgkin's lymphoma|non-Hodgkin's lymphoma]] based on cellular morphology.<ref name="pollock" />|| |
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| − | |1963||Treatment||First program for combination of chemotherapy agents against Hodgkin's lymphoma is designed, combining [[cyclophosphamide]], [[vincristine]], [[methotrexate]], and [[prednisone]] (MOMP).<ref>{{cite book|last1=Heinz|first1=Beverley|title=Trends in Hodgkin's Disease Research|url=https://books.google.com.ar/books?id=wDS_iYHWq40C&pg=PA77&lpg=PA77&dq=%221963%22+%22cyclophosphamide%22+%22vincristine%22+%22methotrexate%22&source=bl&ots=zZO1VRAwCt&sig=Tx1v6h_zPHEbpgjkHuW6iXB5CRY&hl=en&sa=X&ved=0ahUKEwjz9r2_qdbOAhXHi5AKHXzFAN0Q6AEIJzAB#v=onepage&q=%221963%22%20%22cyclophosphamide%22%20%22vincristine%22%20%22methotrexate%22&f=false}}</ref>|| | + | |1963||Treatment||First program for combination of chemotherapy agents against Hodgkin's lymphoma is designed, combining [[wikipedia:cyclophosphamide|cyclophosphamide]], [[wikipedia:vincristine|vincristine]], [[wikipedia:methotrexate|methotrexate]], and [[wikipedia:prednisone|prednisone]] (MOMP).<ref>{{cite book|last1=Heinz|first1=Beverley|title=Trends in Hodgkin's Disease Research|url=https://books.google.com.ar/books?id=wDS_iYHWq40C&pg=PA77&lpg=PA77&dq=%221963%22+%22cyclophosphamide%22+%22vincristine%22+%22methotrexate%22&source=bl&ots=zZO1VRAwCt&sig=Tx1v6h_zPHEbpgjkHuW6iXB5CRY&hl=en&sa=X&ved=0ahUKEwjz9r2_qdbOAhXHi5AKHXzFAN0Q6AEIJzAB#v=onepage&q=%221963%22%20%22cyclophosphamide%22%20%22vincristine%22%20%22methotrexate%22&f=false}}</ref>|| |
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| − | |1965||Organization||The [[International Agency for Research on Cancer]] (IARC) is founded as an intergovernmental agency forming part of the [[World Health Organization]] of the [[United Nations]]. Its role is to conduct and coordinate research into the causes of cancer.<ref>{{cite web|title=International Agency for Research on Cancer|url=http://www-dep.iarc.fr/|accessdate=28 August 2016}}</ref>||[[Lyon]], [[France]] | + | |1965||Organization||The [[wikipedia:International Agency for Research on Cancer|International Agency for Research on Cancer]] (IARC) is founded as an intergovernmental agency forming part of the [[wikipedia:World Health Organization|World Health Organization]] of the [[wikipedia:United Nations|United Nations]]. Its role is to conduct and coordinate research into the causes of cancer.<ref>{{cite web|title=International Agency for Research on Cancer|url=http://www-dep.iarc.fr/|accessdate=28 August 2016}}</ref>||[[wikipedia:Lyon|Lyon]], [[wikipedia:France|France]] |
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| − | |1966||Discovery||It is discovered that Hodgkin's lymphoma spreads through the body in an orderly and somewhat predictable way. This implies that [[prognosis]] and appropriate treatment can be determined based on the extent of the spread.<ref name="cancerprogress" />|| | + | |1966||Discovery||It is discovered that Hodgkin's lymphoma spreads through the body in an orderly and somewhat predictable way. This implies that [[wikipedia:prognosis|prognosis]] and appropriate treatment can be determined based on the extent of the spread.<ref name="cancerprogress" />|| |
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| − | |1967||Treatment||New chemotherapy regimen called MOPP ([[mechlorethamine]], [[vincristine]], [[procarbazine]] and [[prednisone]]) is found to cure more than 50 percent of patients with advanced [[Hodgkin's lymphoma]].<ref name="cancerprogress" />|| | + | |1967||Treatment||New chemotherapy regimen called MOPP ([[wikipedia:mechlorethamine|mechlorethamine]], [[wikipedia:vincristine|vincristine]], [[wikipedia:procarbazine|procarbazine]] and [[wikipedia:prednisone|prednisone]]) is found to cure more than 50 percent of patients with advanced [[wikipedia:Hodgkin's lymphoma|Hodgkin's lymphoma]].<ref name="cancerprogress" />|| |
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| − | |1974||Treatment||Antibiotic [[doxorubicin]] is approved by [[FDA]] as part of combination chemotherapy against [[Hodgkin's lymphoma]].<ref name="cancerprogress" />||United States | + | |1974||Treatment||Antibiotic [[wikipedia:doxorubicin|doxorubicin]] is approved by [[wikipedia:FDA|FDA]] as part of combination chemotherapy against [[wikipedia:Hodgkin's lymphoma|Hodgkin's lymphoma]].<ref name="cancerprogress" />||United States |
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| − | |1975||Discovery||Researchers first identify [[lymphoblastic lymphoma]].<ref name="onlinelibrary.wiley.com">{{cite web|title=Historical review of lymphomas|url=http://onlinelibrary.wiley.com/doi/10.1046/j.1365-2141.2000.01988.x/full|accessdate=23 August 2016}}</ref>|| | + | |1975||Discovery||Researchers first identify [[wikipedia:lymphoblastic lymphoma|lymphoblastic lymphoma]].<ref name="onlinelibrary.wiley.com">{{cite web|title=Historical review of lymphomas|url=http://onlinelibrary.wiley.com/doi/10.1046/j.1365-2141.2000.01988.x/full|accessdate=23 August 2016}}</ref>|| |
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| − | |1975||Treatment||New chemotherapy combination of [[doxorubicin]], [[bleomycin]], [[vinblastine]], and [[dacarbazine]] (known as ABVD) is found to be more effective than the older MOPP combination regimen, and causes fewer side effects.<ref name="cancerprogress" />|| | + | |1975||Treatment||New chemotherapy combination of [[wikipedia:doxorubicin|doxorubicin]], [[wikipedia:bleomycin|bleomycin]], [[wikipedia:vinblastine|vinblastine]], and [[wikipedia:dacarbazine|dacarbazine]] (known as ABVD) is found to be more effective than the older MOPP combination regimen, and causes fewer side effects.<ref name="cancerprogress" />|| |
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| − | |1977||Discovery||[[Adult T-cell leukemia/lymphoma]], a distinct subtype of lymphoma, is reported.<ref name="onlinelibrary.wiley.com" />||[[Japan]] | + | |1977||Discovery||[[wikipedia:Adult T-cell leukemia/lymphoma|Adult T-cell leukemia/lymphoma]], a distinct subtype of lymphoma, is reported.<ref name="onlinelibrary.wiley.com" />||[[wikipedia:Japan|Japan]] |
|- | |- | ||
| − | |1983||Discovery||[[MALT lymphoma]] is first described by Isaacson and Wright.<ref>{{cite journal|title=Molecular Pathogenesis of MALT Lymphoma|pmc=4397421|pmid=25922601|doi=10.1155/2015/102656|volume=2015|year=2015|journal=Gastroenterol Res Pract|pages=102656 | last1 = Troppan | first1 = K | last2 = Wenzl | first2 = K | last3 = Neumeister | first3 = P | last4 = Deutsch | first4 = A}}</ref>|| | + | |1983||Discovery||[[wikipedia:MALT lymphoma|MALT lymphoma]] is first described by Isaacson and Wright.<ref>{{cite journal|title=Molecular Pathogenesis of MALT Lymphoma|pmc=4397421|pmid=25922601|doi=10.1155/2015/102656|volume=2015|year=2015|journal=Gastroenterol Res Pract|pages=102656 | last1 = Troppan | first1 = K | last2 = Wenzl | first2 = K | last3 = Neumeister | first3 = P | last4 = Deutsch | first4 = A}}</ref>|| |
|- | |- | ||
| − | |1985||Treatment||[[Bone marrow]] transplantation is successfully used to cure lymphoma.<ref name="cancerprogress" />|| | + | |1985||Treatment||[[wikipedia:Bone marrow|Bone marrow]] transplantation is successfully used to cure lymphoma.<ref name="cancerprogress" />|| |
|- | |- | ||
| − | |1987||Discovery||[[Epstein-Barr virus]] (EBV) [[DNA]] is first reported in [[Reed–Sternberg cell]]s of a proportion of [[Hodgkin's lymphoma]] cases.<ref name="Lakhtakia"/>|| | + | |1987||Discovery||[[wikipedia:Epstein-Barr virus|Epstein-Barr virus]] (EBV) [[wikipedia:DNA|DNA]] is first reported in [[wikipedia:Reed–Sternberg cell|Reed–Sternberg cell]]s of a proportion of [[wikipedia:Hodgkin's lymphoma|Hodgkin's lymphoma]] cases.<ref name="Lakhtakia"/>|| |
|- | |- | ||
| − | |1990||Organization||The [[International Lymphoma Study Group]] is founded.<ref name="Lakhtakia"/>|| | + | |1990||Organization||The [[wikipedia:International Lymphoma Study Group|International Lymphoma Study Group]] is founded.<ref name="Lakhtakia"/>|| |
|- | |- | ||
| − | |1991||Organization||[[Lymphoma Research Foundation of America]] (LRFA) is founded.<ref name="lymphomainfo"/>||[[Los Angeles]], United States | + | |1991||Organization||[[wikipedia:Lymphoma Research Foundation of America|Lymphoma Research Foundation of America]] (LRFA) is founded.<ref name="lymphomainfo"/>||[[wikipedia:Los Angeles|Los Angeles]], United States |
|- | |- | ||
| − | |1992||Discovery||[[Mantle cell lymphoma]] subtype is first recognized.<ref>{{cite web|title=Aggressive Non-Hodgkin's Lymphoma (Mantle Cell Lymphoma) On The Rise|url=https://www.sciencedaily.com/releases/2008/07/080707081821.htm|accessdate=25 August 2016}}</ref>|| | + | |1992||Discovery||[[wikipedia:Mantle cell lymphoma|Mantle cell lymphoma]] subtype is first recognized.<ref>{{cite web|title=Aggressive Non-Hodgkin's Lymphoma (Mantle Cell Lymphoma) On The Rise|url=https://www.sciencedaily.com/releases/2008/07/080707081821.htm|accessdate=25 August 2016}}</ref>|| |
|- | |- | ||
| − | |1992||Treatment||German Hodgkin Study Group (GHSG) develops the BEACOPP regimen for patients with advanced Hodgkin's lymphoma, involving the use of chemotherapy agents [[bleomycin]], [[etoposide]], [[adriamycin]], [[cyclophosphamide]], [[oncovin]], [[procarbazine]] and [[prednisone]].<ref name="newsmedical" /><ref>{{cite journal|last1=Diehl|first1=V|title=Could BEACOPP be the new standard for the treatment of advanced Hodgkin's lymphoma (HL)?|doi=10.1080/07357900600981380|pmid=17118782|volume=24|journal=Cancer Invest|pages=713-7}}</ref>||[[Germany]] | + | |1992||Treatment||German Hodgkin Study Group (GHSG) develops the BEACOPP regimen for patients with advanced Hodgkin's lymphoma, involving the use of chemotherapy agents [[wikipedia:bleomycin|bleomycin]], [[wikipedia:etoposide|etoposide]], [[wikipedia:adriamycin|adriamycin]], [[wikipedia:cyclophosphamide|cyclophosphamide]], [[wikipedia:oncovin|oncovin]], [[wikipedia:procarbazine|procarbazine]] and [[wikipedia:prednisone|prednisone]].<ref name="newsmedical" /><ref>{{cite journal|last1=Diehl|first1=V|title=Could BEACOPP be the new standard for the treatment of advanced Hodgkin's lymphoma (HL)?|doi=10.1080/07357900600981380|pmid=17118782|volume=24|journal=Cancer Invest|pages=713-7}}</ref>||[[wikipedia:Germany|Germany]] |
|- | |- | ||
| − | |1994||Development||The Revised European-American Classification of Lymphoid Neoplasms (REAL) is proposed as a new classification for [[non Hodgkin's lymphoma]], taking into account immunologic, genetic and clinical characteristics of the disorders in addition to [[histopathologic]] characteristics of the tumor cells.<ref name="non-hodgkin">{{cite web|title=Non-Hodgkin Lymphoma History|url=http://www.news-medical.net/health/Non-Hodgkin-Lymphoma-History.aspx|accessdate=23 August 2016}}</ref>|| | + | |1994||Development||The Revised European-American Classification of Lymphoid Neoplasms (REAL) is proposed as a new classification for [[wikipedia:non Hodgkin's lymphoma|non Hodgkin's lymphoma]], taking into account immunologic, genetic and clinical characteristics of the disorders in addition to [[wikipedia:histopathologic|histopathologic]] characteristics of the tumor cells.<ref name="non-hodgkin">{{cite web|title=Non-Hodgkin Lymphoma History|url=http://www.news-medical.net/health/Non-Hodgkin-Lymphoma-History.aspx|accessdate=23 August 2016}}</ref>|| |
|- | |- | ||
| − | |1994||Organization||[[Cure for Lymphoma Foundation]] is established.<ref name="lymphomainfo"/>||[[New York City]], United States | + | |1994||Organization||[[wikipedia:Cure for Lymphoma Foundation|Cure for Lymphoma Foundation]] is established.<ref name="lymphomainfo"/>||[[wikipedia:New York City|New York City]], United States |
|- | |- | ||
| − | |1994||Discovery||[[Primary effusion lymphoma]] type is first recognized.<ref>{{cite web|title=Primary Effusion Lymphoma|url=http://www.knowcancer.com/oncology/primary-effusion-lymphoma/|accessdate=25 August 2016}}</ref>|| | + | |1994||Discovery||[[wikipedia:Primary effusion lymphoma|Primary effusion lymphoma]] type is first recognized.<ref>{{cite web|title=Primary Effusion Lymphoma|url=http://www.knowcancer.com/oncology/primary-effusion-lymphoma/|accessdate=25 August 2016}}</ref>|| |
|- | |- | ||
| − | |1995||Discovery||Researchers discover that [[lymphocyte]] transfusion from a biologically matched, healthy donor to a patient with [[chronic myelogenous leukemia]] can induce the disease into remission.<ref name="cancerprogress"/>|| | + | |1995||Discovery||Researchers discover that [[wikipedia:lymphocyte|lymphocyte]] transfusion from a biologically matched, healthy donor to a patient with [[wikipedia:chronic myelogenous leukemia|chronic myelogenous leukemia]] can induce the disease into remission.<ref name="cancerprogress"/>|| |
|- | |- | ||
| − | |1997||Treatment||[[FDA]] approves [[rituximab]], the first molecularly targeted cancer drug, to treat patients with B-cell non-Hodgkin lymphoma that no longer responds to other treatments<ref>{{cite journal|title=Rituximab|pmid=11467356 | volume=1 | journal=Curr Pharm Biotechnol|pages=1-9 | last1 = Grillo-López | first1 = AJ | last2 = White | first2 = CA | last3 = Dallaire | first3 = BK | last4 = Varns | first4 = CL | last5 = Shen | first5 = CD | last6 = Wei | first6 = A | last7 = Leonard | first7 = JE | last8 = McClure | first8 = A | last9 = Weaver | first9 = R | last10 = Cairelli | first10 = S | last11 = Rosenberg | first11 = J}}</ref>||United States | + | |1997||Treatment||[[wikipedia:FDA|FDA]] approves [[wikipedia:rituximab|rituximab]], the first molecularly targeted cancer drug, to treat patients with B-cell non-Hodgkin lymphoma that no longer responds to other treatments<ref>{{cite journal|title=Rituximab|pmid=11467356 | volume=1 | journal=Curr Pharm Biotechnol|pages=1-9 | last1 = Grillo-López | first1 = AJ | last2 = White | first2 = CA | last3 = Dallaire | first3 = BK | last4 = Varns | first4 = CL | last5 = Shen | first5 = CD | last6 = Wei | first6 = A | last7 = Leonard | first7 = JE | last8 = McClure | first8 = A | last9 = Weaver | first9 = R | last10 = Cairelli | first10 = S | last11 = Rosenberg | first11 = J}}</ref>||United States |
|- | |- | ||
| − | |1997||Discovery||[[ALK+ large B-cell lymphoma]] is first reported.<ref>{{cite journal |authors=Morgan EA, Nascimento AF |title=Anaplastic lymphoma kinase-positive large B-cell lymphoma: an underrecognized aggressive lymphoma |journal=Adv Hematol |volume=2012 |issue= |pages=529572 |year=2012 |pmid=22474449 |pmc=3299366 |doi=10.1155/2012/529572 }}</ref>|| | + | |1997||Discovery||[[wikipedia:ALK+ large B-cell lymphoma|ALK+ large B-cell lymphoma]] is first reported.<ref>{{cite journal |authors=Morgan EA, Nascimento AF |title=Anaplastic lymphoma kinase-positive large B-cell lymphoma: an underrecognized aggressive lymphoma |journal=Adv Hematol |volume=2012 |issue= |pages=529572 |year=2012 |pmid=22474449 |pmc=3299366 |doi=10.1155/2012/529572 }}</ref>|| |
|- | |- | ||
|2001||Discovery||Scientists discover that diffuse large B-cell lymphoma – the most common form of non-Hodgkin lymphoma – is actually two distinct diseases, each with its own genetic profile.<ref name="cancerprogress" />|| | |2001||Discovery||Scientists discover that diffuse large B-cell lymphoma – the most common form of non-Hodgkin lymphoma – is actually two distinct diseases, each with its own genetic profile.<ref name="cancerprogress" />|| | ||
|- | |- | ||
| − | |2002||Treatment||[[FDA]] approves [[ibritumomab tiuxetan]], which combines radioactive material with a specific [[protein]]. The radioactive material kills the cells with which it comes in contact, while sparing the healthy surrounding tissue. It is the first [[radioimmunotherapy]] introduced to treat lymphoma.<ref name="cancerprogress" />||United States | + | |2002||Treatment||[[wikipedia:FDA|FDA]] approves [[wikipedia:ibritumomab tiuxetan|ibritumomab tiuxetan]], which combines radioactive material with a specific [[wikipedia:protein|protein]]. The radioactive material kills the cells with which it comes in contact, while sparing the healthy surrounding tissue. It is the first [[wikipedia:radioimmunotherapy|radioimmunotherapy]] introduced to treat lymphoma.<ref name="cancerprogress" />||United States |
|- | |- | ||
| − | |2008||Discovery||WHO classification recognizes [[primary mediastinal (thymic) large B cell lymphoma]] type.<ref>{{cite book |first1=Steven H. |last1=Swerdlow |author2=International Agency for Research on Cancer |author3=World Health Organization |title=WHO classification of tumours of haematopoietic and lymphoid tissues |url=http://apps.who.int/bookorders/anglais/detart1.jsp?codlan=1&codcol=70&codcch=4002 |year=2008 |publisher=International Agency for Research on Cancer |edition=4th | volume=2 |series=World Health Organization classification of tumours |isbn=9789283224310}}</ref><ref>{{Cite book | last=Jaffe | first=ES | author2=Harris NL | author3=Vardiman JW | author4=Campo E | author5= Arber DA|title=Hematopathology | publisher=Elsevier Saunders| year=2011 | chapter=|edition=1st |isbn= 9780721600406}}</ref>|| | + | |2008||Discovery||WHO classification recognizes [[wikipedia:primary mediastinal (thymic) large B cell lymphoma|primary mediastinal (thymic) large B cell lymphoma]] type.<ref>{{cite book |first1=Steven H. |last1=Swerdlow |author2=International Agency for Research on Cancer |author3=World Health Organization |title=WHO classification of tumours of haematopoietic and lymphoid tissues |url=http://apps.who.int/bookorders/anglais/detart1.jsp?codlan=1&codcol=70&codcch=4002 |year=2008 |publisher=International Agency for Research on Cancer |edition=4th | volume=2 |series=World Health Organization classification of tumours |isbn=9789283224310}}</ref><ref>{{Cite book | last=Jaffe | first=ES | author2=Harris NL | author3=Vardiman JW | author4=Campo E | author5= Arber DA|title=Hematopathology | publisher=Elsevier Saunders| year=2011 | chapter=|edition=1st |isbn= 9780721600406}}</ref>|| |
|- | |- | ||
| − | |2013–2014||Drug||[[Ibrutinib]] is approved by the [[FDA]] for patients with [[mantle cell lymphoma]] or [[chronic lymphocytic leukemia]] that progresses despite other standard therapies.<ref name="cancerprogress" />||United States | + | |2013–2014||Drug||[[wikipedia:Ibrutinib|Ibrutinib]] is approved by the [[wikipedia:FDA|FDA]] for patients with [[wikipedia:mantle cell lymphoma|mantle cell lymphoma]] or [[wikipedia:chronic lymphocytic leukemia|chronic lymphocytic leukemia]] that progresses despite other standard therapies.<ref name="cancerprogress" />||United States |
|- | |- | ||
|} | |} | ||
| + | |||
| + | == Numerical and visual data == | ||
| + | |||
| + | === Google Scholar === | ||
| + | |||
| + | The following table summarizes per-year mentions on Google Scholar as of August 10, 2021. | ||
| + | |||
| + | {| class="sortable wikitable" | ||
| + | ! Year | ||
| + | ! leukemia | ||
| + | ! lymphoma | ||
| + | ! melanoma | ||
| + | |- | ||
| + | | 1910 || 80 || 32 || 162 | ||
| + | |- | ||
| + | | 1920 || 104 || 36 || 161 | ||
| + | |- | ||
| + | | 1930 || 214 || 37 || 346 | ||
| + | |- | ||
| + | | 1940 || 314 || 78 || 510 | ||
| + | |- | ||
| + | | 1950 || 1,080 || 284 || 595 | ||
| + | |- | ||
| + | | 1960 || 2,160 || 839 || 1,420 | ||
| + | |- | ||
| + | | 1970 || 4,850 || 2,650 || 2,120 | ||
| + | |- | ||
| + | | 1980 || 12,000 || 7,570 || 4,880 | ||
| + | |- | ||
| + | | 1990 || 23,900 || 15,800 || 9,490 | ||
| + | |- | ||
| + | | 2000 || 66,600 || 40,400 || 25,900 | ||
| + | |- | ||
| + | | 2010 || 144,000 || 95,300 || 69,900 | ||
| + | |- | ||
| + | | 2020 || 67,100 || 62,500 || 55,400 | ||
| + | |- | ||
| + | |} | ||
| + | |||
| + | |||
| + | [[File:Leukemia gsch.png|thumb|center|700px]] | ||
| + | |||
| + | === Google Trends === | ||
| + | |||
| + | The comparative chart below shows {{w|Google Trends}} data for Lymphoma (Disease), Leukemia (Syndrome), Melanoma (Topic) and Hodgkin's lymphoma (Disease), from January 2004 to March 2021, when the screenshot was taken. Interest is also ranked by country and displayed on world map.<ref>{{cite web |title=Lymphoma, Leukemia, Melanoma and Hodgkin's lymphoma |url=https://trends.google.com/trends/explore?date=all&q=%2Fm%2F0jdk0,%2Fm%2F04psf,%2Fm%2F035b2g,%2Fm%2F02qg4h |website=Google Trends |access-date=30 March 2021}}</ref> | ||
| + | |||
| + | [[File:Lymphoma, Leukemia, Melanoma and Hodgkin's lymphoma gt.png|thumb|center|600px]] | ||
| + | |||
| + | |||
| + | === Google Ngram Viewer === | ||
| + | |||
| + | The comparative chart below shows {{w|Google Ngram Viewer}} data for lymphoma, Hodgkin's lymphoma, leukemia and melanoma, from 1700 to 2019. <ref>{{cite web |title=lymphoma, Hodgkin's lymphoma, leukemia and melanoma |url=https://books.google.com/ngrams/graph?content=lymphoma%2CHodgkin%27s+lymphoma%2Cleukemia%2Cmelanoma&year_start=1700&year_end=2019&corpus=26&smoothing=3&direct_url=t1%3B%2Clymphoma%3B%2Cc0%3B.t1%3B%2CHodgkin%20%27s%20lymphoma%3B%2Cc0%3B.t1%3B%2Cleukemia%3B%2Cc0%3B.t1%3B%2Cmelanoma%3B%2Cc0#t1%3B%2Clymphoma%3B%2Cc0%3B.t1%3B%2CHodgkin%20's%20lymphoma%3B%2Cc0%3B.t1%3B%2Cleukemia%3B%2Cc0%3B.t1%3B%2Cmelanoma%3B%2Cc0 |website=books.google.com |access-date=30 March 2021 |language=en}}</ref> | ||
| + | |||
| + | [[File:Lymphoma, Hodgkin's lymphoma, leukemia and melanoma ngram.png|thumb|center|700px]] | ||
| + | |||
| + | === Wikipedia Views === | ||
| + | |||
| + | The chart below shows pageviews of the English Wikipedia article {{w|Lymphoma}}, on desktop from December 2007, and on mobile-web, desktop-spider, mobile-web-spider and mobile app, from July 2015; to February 2021.<ref>{{cite web |title=Lymphoma |url=https://wikipediaviews.org/displayviewsformultiplemonths.php?page=Lymphoma&allmonths=allmonths&language=en&drilldown=all |website=wikipediaviews.org |access-date=9 March 2021}}</ref> | ||
| + | |||
| + | [[File:Lymphoma wv.png|thumb|center|400px]] | ||
| + | |||
==See also== | ==See also== | ||
| − | * [[Timeline of leukemia]] | + | * [[wikipedia:Timeline of leukemia|Timeline of leukemia]] |
| − | * [[Timeline of lung cancer]] | + | * [[wikipedia:Timeline of lung cancer|Timeline of lung cancer]] |
| − | * [[Timeline of melanoma]] | + | * [[wikipedia:Timeline of melanoma|Timeline of melanoma]] |
| − | * [[Timeline of brain cancer]] | + | * [[wikipedia:Timeline of brain cancer|Timeline of brain cancer]] |
==References== | ==References== | ||
{{Reflist|30em}} | {{Reflist|30em}} | ||
{{Cancer timeline}} | {{Cancer timeline}} | ||
| − | [[Category:Lymphoma]] | + | [[wikipedia:Category:Lymphoma|Category:Lymphoma]] |
| − | [[Category:Health-related timelines]] | + | [[wikipedia:Category:Health-related timelines|Category:Health-related timelines]] |
Latest revision as of 19:54, 20 March 2024
The content on this page is forked from the English Wikipedia page entitled "Timeline of lymphoma". The original page still exists at Timeline of lymphoma. The original content was released under the Creative Commons Attribution/Share-Alike License (CC-BY-SA), so this page inherits this license.
This is a timeline of lymphoma, describing especially major discoveries and advances in treatment against the disease.
Contents
Big picture
| Year/period | Key developments |
|---|---|
| 19th Century | The presence of lymphoma in western medical literature is born after the works of people like Thomas Hodgkin and Samuel Wilks. Hodgkin's lymphoma is the first lymphoma to be described. |
| 1900–1950s | It is found that radiation therapy can cure some patients with Hodgkin lymphoma, one of two major classes of lymphomas. When it is discovered that radiating larger parts of the body improves cure rates, physicians begin increasing the size of the radiation fields. Radiotherapy starts to prove successful as a treatment against Hodgkin's lymphoma in the 1940s.[1] However, long-term effects of radiation to the chest (including cardiovascular disease and second cancers) are later recognized, and efforts start to be taken to reduce radiation exposure to healthy tissue.[2] |
| 1960s–1970s | Very effective treatments for Hodgkin's lymphoma are developed in this period.[3] Chemotherapeutic agents are combined into regimens capable of eradicating and even disseminating the disease.[4] Combination of chemotherapy and high-energy radiation therapy are introduced.[5] |
| 1990s–present | Modern era of treatment for Hodgkin's lymphoma, focusing on reducing both toxicity and duration of chemotherapy.[4] Lymphomas developed in 566,000 people in 2012 and caused 305,000 deaths worldwide.[6] They comprise the seventh-most common form of cancers making up the 3–4% of them.[7] |
Full timeline
| Year/period | Type of event | Event | Location |
|---|---|---|---|
| 1666 | Development | Italian biologist Marcello Malpighi publishes De viscerum structuru exercitatio anatomica, where he describes what later will be known as Hodgkin's lymphoma.[8] | |
| 1832 | Development | British physician Thomas Hodgkin presents a paper describing seven patients with painless enlargement of the lymph nodes, and including autopsy findings and illustrations from one of the patients.[8] | London, United Kingdom |
| 1856 | Book | British physician Samuel Wilks publishes Cases of lardaceous diseases and some allied affections with remarks, describing similar cases to those presented by Thomas Hodgkin. Wilks honors Hodgkin by eponymously referring to this disease as Hodgkin's lymphoma.[8] | |
| 1871 | Development | Billroth reports the first case of non-Hodgkin's lymphoma[9] | |
| 1872–1878 | Development | Microscopic descriptions of Hodgkin's lymphoma are first described.[8] | |
| 1878 | Development | W. S. Greenfield first publishes drawings of the pathognomonic giant cells, later called Reed–Sternberg cells.[10] | |
| 1894 | Development | Osler first mentions use of chemotherapy for lymphoma in his work Textbook of Medicine.[11] | |
| 1898 | Development | Austrian pathologist Carl Sternberg first describes in detail giant cells (Reed–Sternberg cells).[12] | Germany |
| 1902 | Development | American physician Dorothy Reed Mendenhall independently describes Reed-Sternberg cells.[12] | United States |
| 1910 | Discovery | Albert Cook, a missionary doctor in Africa, reports a child with a large jaw tumor, in what becomes the first description of Burkitt lymphoma.[13] | Uganda |
| 1925 | Discovery | Follicular lymphoma is first described.[14] | |
| 1932 | Development | Chevalier and Bernard describe the use of radiation therapy to treat Hodgkin's disease.[1] | |
| 1939 | Development | E. Epstein reports better survival prognosis for women against Hodgkin's lymphoma in his book Sex as factor in the prognosis of Hodgkins disease.[12] | |
| 1942 | Development | Gall and Mallory propose the first morphological classification for lymphoma.[9] | |
| 1944 | Discovery | Lymphoplasmacytic lymphoma, also known as Waldenström's macroglobulinemia, is first described by Swedish oncologist Jan G. Waldenström.[15] | Sweden |
| 1949 | Treatment | First chemotherapy drug (nitrogen mustard) is approved by the Food and Drug Administration (FDA) for the treatment of Hodgkin's lymphoma.[2] | United States |
| 1949–1956 | Discovery | After shielding a mouse's spleen, researchers discover that the body recruits stem cells, which are found in the spleen and bone marrow, to protect and heal itself from radiation damage.[2] | |
| 1956 | Development | American chemist Henry Rapoport proposes the first classification of non-Hodgkin's lymphoma based on cellular morphology.[9] | |
| 1963 | Treatment | First program for combination of chemotherapy agents against Hodgkin's lymphoma is designed, combining cyclophosphamide, vincristine, methotrexate, and prednisone (MOMP).[16] | |
| 1965 | Organization | The International Agency for Research on Cancer (IARC) is founded as an intergovernmental agency forming part of the World Health Organization of the United Nations. Its role is to conduct and coordinate research into the causes of cancer.[17] | Lyon, France |
| 1966 | Discovery | It is discovered that Hodgkin's lymphoma spreads through the body in an orderly and somewhat predictable way. This implies that prognosis and appropriate treatment can be determined based on the extent of the spread.[2] | |
| 1967 | Treatment | New chemotherapy regimen called MOPP (mechlorethamine, vincristine, procarbazine and prednisone) is found to cure more than 50 percent of patients with advanced Hodgkin's lymphoma.[2] | |
| 1974 | Treatment | Antibiotic doxorubicin is approved by FDA as part of combination chemotherapy against Hodgkin's lymphoma.[2] | United States |
| 1975 | Discovery | Researchers first identify lymphoblastic lymphoma.[18] | |
| 1975 | Treatment | New chemotherapy combination of doxorubicin, bleomycin, vinblastine, and dacarbazine (known as ABVD) is found to be more effective than the older MOPP combination regimen, and causes fewer side effects.[2] | |
| 1977 | Discovery | Adult T-cell leukemia/lymphoma, a distinct subtype of lymphoma, is reported.[18] | Japan |
| 1983 | Discovery | MALT lymphoma is first described by Isaacson and Wright.[19] | |
| 1985 | Treatment | Bone marrow transplantation is successfully used to cure lymphoma.[2] | |
| 1987 | Discovery | Epstein-Barr virus (EBV) DNA is first reported in Reed–Sternberg cells of a proportion of Hodgkin's lymphoma cases.[8] | |
| 1990 | Organization | The International Lymphoma Study Group is founded.[8] | |
| 1991 | Organization | Lymphoma Research Foundation of America (LRFA) is founded.[12] | Los Angeles, United States |
| 1992 | Discovery | Mantle cell lymphoma subtype is first recognized.[20] | |
| 1992 | Treatment | German Hodgkin Study Group (GHSG) develops the BEACOPP regimen for patients with advanced Hodgkin's lymphoma, involving the use of chemotherapy agents bleomycin, etoposide, adriamycin, cyclophosphamide, oncovin, procarbazine and prednisone.[1][21] | Germany |
| 1994 | Development | The Revised European-American Classification of Lymphoid Neoplasms (REAL) is proposed as a new classification for non Hodgkin's lymphoma, taking into account immunologic, genetic and clinical characteristics of the disorders in addition to histopathologic characteristics of the tumor cells.[22] | |
| 1994 | Organization | Cure for Lymphoma Foundation is established.[12] | New York City, United States |
| 1994 | Discovery | Primary effusion lymphoma type is first recognized.[23] | |
| 1995 | Discovery | Researchers discover that lymphocyte transfusion from a biologically matched, healthy donor to a patient with chronic myelogenous leukemia can induce the disease into remission.[2] | |
| 1997 | Treatment | FDA approves rituximab, the first molecularly targeted cancer drug, to treat patients with B-cell non-Hodgkin lymphoma that no longer responds to other treatments[24] | United States |
| 1997 | Discovery | ALK+ large B-cell lymphoma is first reported.[25] | |
| 2001 | Discovery | Scientists discover that diffuse large B-cell lymphoma – the most common form of non-Hodgkin lymphoma – is actually two distinct diseases, each with its own genetic profile.[2] | |
| 2002 | Treatment | FDA approves ibritumomab tiuxetan, which combines radioactive material with a specific protein. The radioactive material kills the cells with which it comes in contact, while sparing the healthy surrounding tissue. It is the first radioimmunotherapy introduced to treat lymphoma.[2] | United States |
| 2008 | Discovery | WHO classification recognizes primary mediastinal (thymic) large B cell lymphoma type.[26][27] | |
| 2013–2014 | Drug | Ibrutinib is approved by the FDA for patients with mantle cell lymphoma or chronic lymphocytic leukemia that progresses despite other standard therapies.[2] | United States |
Numerical and visual data
Google Scholar
The following table summarizes per-year mentions on Google Scholar as of August 10, 2021.
| Year | leukemia | lymphoma | melanoma |
|---|---|---|---|
| 1910 | 80 | 32 | 162 |
| 1920 | 104 | 36 | 161 |
| 1930 | 214 | 37 | 346 |
| 1940 | 314 | 78 | 510 |
| 1950 | 1,080 | 284 | 595 |
| 1960 | 2,160 | 839 | 1,420 |
| 1970 | 4,850 | 2,650 | 2,120 |
| 1980 | 12,000 | 7,570 | 4,880 |
| 1990 | 23,900 | 15,800 | 9,490 |
| 2000 | 66,600 | 40,400 | 25,900 |
| 2010 | 144,000 | 95,300 | 69,900 |
| 2020 | 67,100 | 62,500 | 55,400 |
Google Trends
The comparative chart below shows Google Trends data for Lymphoma (Disease), Leukemia (Syndrome), Melanoma (Topic) and Hodgkin's lymphoma (Disease), from January 2004 to March 2021, when the screenshot was taken. Interest is also ranked by country and displayed on world map.[28]
Google Ngram Viewer
The comparative chart below shows Google Ngram Viewer data for lymphoma, Hodgkin's lymphoma, leukemia and melanoma, from 1700 to 2019. [29]
Wikipedia Views
The chart below shows pageviews of the English Wikipedia article Lymphoma, on desktop from December 2007, and on mobile-web, desktop-spider, mobile-web-spider and mobile app, from July 2015; to February 2021.[30]
See also
References
- ↑ 1.0 1.1 1.2 "Hodgkin's Lymphoma History". Retrieved 22 August 2016.
- ↑ 2.00 2.01 2.02 2.03 2.04 2.05 2.06 2.07 2.08 2.09 2.10 2.11 "Progress & Timeline". Retrieved 23 August 2016.
- ↑ "Lymphoma - Hodgkin - Treatment Options". Retrieved 25 August 2016.
- ↑ 4.0 4.1 "Hodgkin's Lymphoma: The Hazards of Success". Retrieved 25 August 2016.
- ↑ "Second Cancer Risk Up to 40 Years after Treatment for Hodgkin's Lymphoma". New England Journal of Medicine. 373: 2499–2511. doi:10.1056/NEJMoa1505949.
- ↑ World Cancer Report 2014. World Health Organization. 2014. pp. Chapter 5.13. ISBN 9283204298.
- ↑ Marcus, Robert (2013). Lymphoma : pathology, diagnosis and treatment (Second ed.). p. 1. ISBN 9781107010598.
- ↑ 8.0 8.1 8.2 8.3 8.4 8.5 Lakhtakia, R; Burney, I (2015). "A Historical Tale of Two Lymphomas". Sultan Qaboos Univ Med J. 15: e202–6. PMC 4450782
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- ↑ Hoffman, Ronald. Hematology: Basic Principles and Practice, Expert Consult Premium Edition. p. 1138.
- ↑ Specht, Lena. Radiotherapy for Hodgkin Lymphoma. p. 45.
- ↑ 12.0 12.1 12.2 12.3 12.4 "Hodgkin's Disease - Historical Timeline". Retrieved 22 August 2016.
- ↑ Robertson, Erle S. Burkitt’s Lymphoma. p. 1.
- ↑ van Besien, K; Schouten, H. "Follicular lymphoma: a historical overview.". Leuk Lymphoma. 48: 232–43. PMID 17325883. doi:10.1080/10428190601059746.
- ↑ "Waldenström's Macroglobulinemia — Clinical and Pathological Report of a Case Resembling Multiple Myeloma". New England Journal of Medicine. 258: 1293–1296. doi:10.1056/NEJM195806262582604.
- ↑ Heinz, Beverley. Trends in Hodgkin's Disease Research.
- ↑ "International Agency for Research on Cancer". Retrieved 28 August 2016.
- ↑ 18.0 18.1 "Historical review of lymphomas". Retrieved 23 August 2016.
- ↑ Troppan, K; Wenzl, K; Neumeister, P; Deutsch, A (2015). "Molecular Pathogenesis of MALT Lymphoma". Gastroenterol Res Pract. 2015: 102656. PMC 4397421. PMID 25922601. doi:10.1155/2015/102656.
- ↑ "Aggressive Non-Hodgkin's Lymphoma (Mantle Cell Lymphoma) On The Rise". Retrieved 25 August 2016.
- ↑ Diehl, V. "Could BEACOPP be the new standard for the treatment of advanced Hodgkin's lymphoma (HL)?". Cancer Invest. 24: 713–7. PMID 17118782. doi:10.1080/07357900600981380.
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- ↑ "Primary Effusion Lymphoma". Retrieved 25 August 2016.
- ↑ Grillo-López, AJ; White, CA; Dallaire, BK; Varns, CL; Shen, CD; Wei, A; Leonard, JE; McClure, A; Weaver, R; Cairelli, S; Rosenberg, J. "Rituximab". Curr Pharm Biotechnol. 1: 1–9. PMID 11467356.
- ↑ Morgan EA, Nascimento AF (2012). "Anaplastic lymphoma kinase-positive large B-cell lymphoma: an underrecognized aggressive lymphoma". Adv Hematol. 2012: 529572. PMC 3299366. PMID 22474449. doi:10.1155/2012/529572.
- ↑ Swerdlow, Steven H.; International Agency for Research on Cancer; World Health Organization (2008). WHO classification of tumours of haematopoietic and lymphoid tissues. World Health Organization classification of tumours. 2 (4th ed.). International Agency for Research on Cancer. ISBN 9789283224310.
- ↑ Jaffe, ES; Harris NL; Vardiman JW; Campo E; Arber DA (2011). Hematopathology (1st ed.). Elsevier Saunders. ISBN 9780721600406.
- ↑ "Lymphoma, Leukemia, Melanoma and Hodgkin's lymphoma". Google Trends. Retrieved 30 March 2021.
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