Difference between revisions of "Timeline of bladder cancer"

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{{Attribute English Wikipedia|original-exists=yes}}
 
{{Attribute English Wikipedia|original-exists=yes}}
  
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This is a '''timeline of [[bladder cancer]]''', describing especially major discoveries and advances in treatment of the disease.
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This is a '''timeline of [[wikipedia:bladder cancer|bladder cancer]]''', describing especially major discoveries and advances in treatment of the disease.
  
 
==Big picture==
 
==Big picture==
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! Year/period !! Key developments
 
! Year/period !! Key developments
 
|-
 
|-
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|19th century||The cytoscope develops. The first [[cystectomy]] for bladder cancer is performed.
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| 16th–17th Centuries || The first operations targeting bladder tumor are performed in these centuries.<ref name="The History of Technologic Advancements in Urology"/>
 
|-
 
|-
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|1940s–1960s||Urine cytology emerges as a tool to detect recurrent bladder and urinary tract cancers.<ref name="Timeline" />
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| 18th Century || It is already theorized that {{w|tobacco}} use might be related to {{w|cancer}}.<ref name="Pathogenesis of Human Urinary Bladder Cancer"/>
 
|-
 
|-
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|1970s||[[Cigarette smoking]] is linked to bladder cancer risk. First chemotherapy drug is released for bladder cancer.<ref name="Timeline" />
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| 19th Century || The cytoscope develops. The first [[wikipedia:cystectomy|cystectomy]] for bladder cancer is performed.
 
|-
 
|-
−
|1980s||[[Mitomycin]] chemotherapy is consolidated. Surgical advances improve bladder cancer survival. First successful combination chemotherapy for advanced bladder cancer is achieved.<ref name="Timeline" />
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| 20th Century || A major discovery is the link between {{w|bladder cancer}} and exposure to {{w|β-Naphthylamine}}. Around mid–century, aromatic amines are found to be the most important carcinogens in occupational bladder cancer. This would prompt worldwide regulatory changes to the manufacture of {{w|rubber}} and {{w|dyestuffs}}.<ref name="THE RISE AND FALL OF OCCUPATIONAL BLADDER CANCER IN THE WESTERN WORLD"/> Among medical advances,  urine {{w|cytology}} emerges as a tool to detect recurrent bladder and urinary tract cancers.<ref name="Timeline" />
 
|-
 
|-
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|1990s||Surgical techniques consolidate. New chemotherapies emerge to treat bladder cancer.<ref name="Timeline" />
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| 1950s || Cigarette smoking is found to be etiologic for human {{w|bladder cancer}}.<ref name="Pathogenesis of Human Urinary Bladder Cancer"/>
 
|-
 
|-
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|2000s||New chemotherapies prove to extend survival against bladder cancer. CT scan improves bladder cancer detection.<ref name="Timeline" />
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| 1970s ||[[wikipedia:Cigarette smoking|Cigarette smoking]] is linked to bladder cancer risk. The first chemotherapy drug is released for bladder cancer.<ref name="Timeline" />
 
|-
 
|-
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|Recent years||As of 2010, bladder cancer resulted in 170,000 deaths up from 114,000 in 1990 worldwide.<ref name=Loz2012>{{cite journal|last=Lozano|first=R|title=Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010|journal=Lancet|date=15 December 2012|volume=380|issue=9859|pages=2095–128|pmid=23245604|doi=10.1016/S0140-6736(12)61728-0|display-authors=etal}}</ref> Current treatment options for people with bladder cancer can include surgery, intravesical therapy, chemotherapy, radiation therapy and immunotherapy.<ref>{{cite web|title=Bladder cancer treatment|url=http://www.cancer.org/cancer/bladdercancer/detailedguide/bladder-cancer-treating-general-info|accessdate=1 October 2016}}</ref>
+
| 1980s ||[[wikipedia:Mitomycin|Mitomycin]] chemotherapy is consolidated. Surgical advances improve bladder cancer survival. First successful combination chemotherapy for advanced bladder cancer is achieved.<ref name="Timeline" />
 +
|-
 +
| 1990s || Surgical techniques consolidate. New chemotherapies emerge to treat bladder cancer.<ref name="Timeline" />
 +
|-
 +
| 2000s || New chemotherapies prove to extend survival against bladder cancer. CT scan improves bladder cancer detection.<ref name="Timeline" />
 +
|-
 +
| Recent years || As of 2010, bladder cancer resulted in 170,000 deaths up from 114,000 in 1990 worldwide.<ref name=Loz2012>{{cite journal|last=Lozano|first=R|title=Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010|journal=Lancet|date=15 December 2012|volume=380|issue=9859|pages=2095–128|pmid=23245604|doi=10.1016/S0140-6736(12)61728-0|display-authors=etal}}</ref> Current treatment options for people with bladder cancer can include surgery, intravesical therapy, chemotherapy, radiation therapy and immunotherapy.<ref>{{cite web|title=Bladder cancer treatment|url=http://www.cancer.org/cancer/bladdercancer/detailedguide/bladder-cancer-treating-general-info|accessdate=1 October 2016}}</ref> Today, the incidence of occupational bladder cancer has decreased in the {{w|Western World}}, but is still widely reported in less developed countries. A lack of adequate data on concurrent smoking history and other risk factors is a possible limitation of actual epidemiological studies.<ref name="THE RISE AND FALL OF OCCUPATIONAL BLADDER CANCER IN THE WESTERN WORLD"/>  
 
|}
 
|}
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 +
  
 
==Full timeline==
 
==Full timeline==
 +
 
{| class="sortable wikitable"
 
{| class="sortable wikitable"
 
! Year/period !! Type of event !! Event !!Location
 
! Year/period !! Type of event !! Event !!Location
 
|-
 
|-
−
|1854||Discovery||[[Inverted papilloma]] (a tumor that may occur in the [[bladder]] and other components of the [[urinary tract]]) is first described.<ref>{{cite journal|title=Inverted papillomas and benign nonneoplastic lesions of the nasal cavity|doi=10.2500/ajra.2012.26.3732|pmc=3906506 | pmid=22487294|volume=26|year=2012|journal=Am J Rhinol Allergy|pages=157–63 | last1 = Wood | first1 = JW | last2 = Casiano | first2 = RR}}</ref>||
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| 1551 || Scientific development || Bladder tumors are mentioned first by Lacuna.<ref name="The History of Technologic Advancements in Urology">{{cite book |last1=Patel |first1=Sutchin R. |last2=Moran |first2=Michael E. |last3=Nakada |first3=Stephen Y. |title=The History of Technologic Advancements in Urology |url=https://books.google.com.ar/books?id=has2DwAAQBAJ&pg=PA63&lpg=PA63&dq=urology+%22in+1920..1940%22&source=bl&ots=Z3pyK2a4uV&sig=Qgxy53Ur1IkNRExwXduR1kSR_hQ&hl=en&sa=X&ved=2ahUKEwjDy9z_4JLeAhVHhJAKHSUPB5oQ6AEwAHoECAoQAQ#v=onepage&q=urology%20%22in%201920..1940%22&f=false}}</ref> ||
 +
|-
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| 1761 || Scientific development || Dr. John Hill reports a relationship between {{w|tobacco}} use and cancer.<ref name="Pathogenesis of Human Urinary Bladder Cancer"/> ||
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|-
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| 1854 || Scientific development || [[wikipedia:Inverted papilloma|Inverted papilloma]] (a tumor that may occur in the [[wikipedia:bladder|bladder]] and other components of the [[wikipedia:urinary tract|urinary tract]]) is first described.<ref>{{cite journal|title=Inverted papillomas and benign nonneoplastic lesions of the nasal cavity|doi=10.2500/ajra.2012.26.3732|pmc=3906506 | pmid=22487294|volume=26|year=2012|journal=Am J Rhinol Allergy|pages=157–63 | last1 = Wood | first1 = JW | last2 = Casiano | first2 = RR}}</ref> ||
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|-
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| 1877 || Medical development (device) || German urologist [[wikipedia:Maximilian Nitze|Maximilian Nitze]] develops the [[wikipedia:cystoscope|cystoscope]], a device used to perform endoscopy of the [[wikipedia:urinary bladder|urinary bladder]] via the [[wikipedia:urethra|urethra]].<ref name="Texas Cancer Center" /> ||
 +
|-
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| 1887 || Medical development (treatment) || The first [[wikipedia:cystectomy|cystectomy]] for bladder cancer is performed.<ref name="Texas Cancer Center">{{cite web|title=BLADDER CANCER|url=http://www.texascancercenter.com/bladder.html|accessdate=28 September 2016}}</ref>||[[wikipedia:Cologne|Cologne]], [[wikipedia:Germany|Germany]]
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|-
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| 1895 || Scientific development || Link between bladder cancer and environmental carcinogens is first postulated.<ref>{{cite web|title=Guideline for the Management of Nonmuscle Invasive Bladder Cancer: (Stages Ta, T1 and Tis: Update (2007)|url=https://www.auanet.org/education/guidelines/bladder-cancer.cfm|accessdate=28 September 2016}}</ref>||
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|-
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| 1895 || Scientific development || German surgeon {{w|Ludwig Rehn}}, working at the Hoechst aniline factory near {{w|Frankfurt}}, reports 3 cases of {{w|bladder cancer}} in workers, labeling them ''aniline tumors''. However, it would be hard to prove the association with the chemical at the time as chemical manufacturers begin using several other coal- and oil-based compounds.<ref name="THE RISE AND FALL OF OCCUPATIONAL BLADDER CANCER IN THE WESTERN WORLD">{{cite journal|last1=Wanis|first1=Michael|last2=Hadjipavlou|first2=Marios|title=THE RISE AND FALL OF OCCUPATIONAL BLADDER CANCER IN THE WESTERN WORLD|journal=THE JOURNAL OF UROLOGY|url=http://www.jurology.com/article/S0022-5347(16)00378-5/pdf|accessdate=13 October 2017}}</ref><ref name="Pathogenesis of Human Urinary Bladder Cancer"/> || {{w|Germany}}
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|-
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| 1902 || Organization || The [[wikipedia:American Urological Association|American Urological Association]] is founded.<ref>{{cite web|title=History of the AUA|url=https://www.auanet.org/about/history-of-the-aua.cfm|accessdate=20 November 2016}}</ref>||[[wikipedia:Linthicum|Linthicum]], [[wikipedia:Maryland|Maryland]], [[wikipedia:United States|United States]]
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|-
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| 1903 || Medical development (treatment) || [[wikipedia:Radium|Radium]] is first used to treat bladder tumors.<ref name="Texas Cancer Center" />||[[wikipedia:United States|United States]]
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|-
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| 1911 || Scientific development || Ferguson first first suggests association between [[wikipedia:Schistosomiasis|Schistosomiasis]] and urinary bladder cancer.<ref>{{cite journal|title=Bladder cancer and schistosomiasis|doi=10.1016/j.jnci.2012.08.002|url=http://www.sciencedirect.com/science/article/pii/S1110036212000544 | volume=24|journal=Journal of the Egyptian National Cancer Institute|pages=151–159}}</ref><ref name="Pathogenesis of Human Urinary Bladder Cancer">{{cite journal|last1=Bryan|first1=George T.|title=Pathogenesis of Human Urinary Bladder Cancer|journal=Environmental Health Perspectives|date=1983|pages=201-207|url=http://citeseerx.ist.psu.edu/viewdoc/download;jsessionid=EE13C5A2B104EA5F99ACA5455104B0DD?doi=10.1.1.276.9739&rep=rep1&type=pdf|accessdate=13 October 2017}}</ref> ||
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|-
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| 1929 || Scientific development || Researchers note that patients with {{w|tuberculosis}} have lower rates of cancer when examined at autopsy. This observation is among the first to link the possibility of bladder cancer treatment with [[wikipedia:BCG vaccine|BCG]].<ref>{{cite journal|title=Immunotherapy for bladder cancer|doi=10.2147/RRU.S63447|pmc=4427258 | pmid=26000263|volume=7|year=2015|journal=Res Rep Urol|pages=65–79 | last1 = Fuge | first1 = O | last2 = Vasdev | first2 = N | last3 = Allchorne | first3 = P | last4 = Green | first4 = JS}}</ref>||
 +
|-
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| 1938 || Scientific development || Delaware-based German pathologist {{w|Wilhelm Hueper}} shows an increase in bladder tumors when {{w|β-Naphthylamine}} is administered orally to {{w|dog}}s. With his toxicology research funded by the {{w|chemical industry}}, Hueper would encounter significant resistance in publishing his findings.<ref name="THE RISE AND FALL OF OCCUPATIONAL BLADDER CANCER IN THE WESTERN WORLD"/> ||
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|-
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| 1939 || Scientific development || Researchers communicate a successful attempt to induce papillary vesical lesions of benign and malignant type of {{w|bladder cancer}} in female dogs receiving large doses of commercial {{w|β-Naphthylamine}} by mouth.<ref name="EXPERIMENTAL CANCER OF THE BLADDER">{{cite journal|last1=BONSER|first1=GEORGIANA M.|title=EXPERIMENTAL CANCER OF THE BLADDER|journal=British Medical Bulletin|date=January 1946|pages=379–381|doi=10.1093/oxfordjournals.bmb.a072830|url=https://academic.oup.com/bmb/article-abstract/4/5-6/379/278766/EXPERIMENTAL-CANCER-OF-THE-BLADDER?redirectedFrom=PDF}}</ref> || {{w|United States}}
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|-
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| 1940 || Scientific development || Japanese scientists claim having induced bladder papillomatosis in rabbits and rats by means of subcutaneous injection of an oily solution of o–toluidine.<ref name="EXPERIMENTAL CANCER OF THE BLADDER"/> ||
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|-
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| 1945 || Medical development (diagnosis) ||[[wikipedia:Urine cytology|Urine cytology]] (a test used to diagnose urinary tract cancers) is first described.<ref>{{cite journal|title=Current perspectives in bladder cancer management|doi=10.1111/ijcp.12075|url=http://onlinelibrary.wiley.com/doi/10.1111/ijcp.12075/full | volume=67|journal=International Journal of Clinical Practice|pages=435–448}}</ref>||
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|-
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| 1950 – 1954 || Epidemiology || Incidence rate for bladder cancer per 100,000 population in the {{w|United States}} is reported at 14.1 for males, and 4.4 for females, during the period.<ref name="Pathogenesis of Human Urinary Bladder Cancer"/> || {{w|United States}}
 +
|-
 +
| 1950 – 1959 || Scientific discovery || It is found that cigarette smoking is [[w:etiology|etiologic]] for human bladder cancer.<ref name="Pathogenesis of Human Urinary Bladder Cancer"/> ||
 +
|-
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| 1952 || Discovery || [[wikipedia:Transitional cell carcinoma|Transitional cell carcinoma in situ of the bladder]] is first described.<ref>{{cite web|title=BCG Immunotherapy for Transitional-Cell Carcinoma in Situ of the Bladder|url=http://www.physicianspractice.com/review-article/bcg-immunotherapy-transitional-cell-carcinoma-situ-bladder|accessdate=26 September 2016}}</ref> ||
 +
|-
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| 1954 || Scientific development || Study by Case and Holster on workers in the British {{w|rubber}} industry demonstrate that {{w|β-Naphthylamine}} accounts for a 200-fold increased risk of bladder cancer with a latency period of 11-25 years. Subsequently, regulatory bodies worldwide would start prohibiting the manufacture and use of the compound.<ref name="THE RISE AND FALL OF OCCUPATIONAL BLADDER CANCER IN THE WESTERN WORLD"/> || {{w|United Kingdom}}
 +
|-
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| 1956 || Medical development (treatment) || Early bladder removal surgery is introduced. This include surgically removing the bladder (cystectomy) and surrounding tissue where cancer is most likely to spread.<ref>{{cite journal|title=A technique for radical total cystectomy|doi=10.1002/1097-0142(195605/06)9:3<585::AID-CNCR2820090325>3.0.CO;2-Z|url=http://onlinelibrary.wiley.com/doi/10.1002/1097-0142%28195605/06%299:3%3C585::AID-CNCR2820090325%3E3.0.CO;2-Z/abstract | volume=9|journal=Cancer|pages=585–595}}</ref> ||
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|-
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| 1970 – 1974 || Epidemiology || Incidence rate for bladder cancer per 100,000 population in the {{w|United States}} is reported at 23.7 for males, and 6.1 for females, during the period.<ref name="Pathogenesis of Human Urinary Bladder Cancer"/> || {{w|United States}}
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|-
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| 1970 – 1975 || Scientific development || Studies in laboratory rats link {{w|saccharin}} with the development of bladder cancer, especially in male {{w|rat}}s.<ref name="Artificial Sweeteners and Cancer">{{cite web|title=Artificial Sweeteners and Cancer|url=https://www.cancer.gov/about-cancer/causes-prevention/risk/diet/artificial-sweeteners-fact-sheet|website=cancer.gov|accessdate=13 October 2017}}</ref>
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|-
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| 1972 || Scientific development || Researchers demonstrate a significantly decreased incidence of {{w|bladder cancer}} since the manufacture of {{w|dyestuff}}s containing {{w|β-Naphthylamine}} was ceased.<ref name="THE RISE AND FALL OF OCCUPATIONAL BLADDER CANCER IN THE WESTERN WORLD"/> ||
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|-
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| 1974 || Discovery || Research ties sharp increase in {{w|bladder cancer}} deaths among British men to the rapid rise in [[wikipedia:cigarette smoking|cigarette smoking]] during prior decades.<ref name="Timeline">{{cite web|title=Timeline|url=http://cancerprogress.net/timeline/bladder-cancer|accessdate=29 September 2016}}</ref>||[[wikipedia:United Kingdom|United Kingdom]]
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|-
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| 1978 || Treatment || United States [[wikipedia:FDA|FDA]] approves the first chemotherapy drug [[wikipedia:cisplatin|cisplatin]] for {{w|bladder cancer}}.<ref>{{cite web|title=The "Accidental" Cure—Platinum-based Treatment for Cancer: The Discovery of Cisplatin|url=https://www.cancer.gov/research/progress/discovery/cisplatin|accessdate=29 September 2016}}</ref> || [[wikipedia:United States|United States]]
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|-
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| 1980–1985 || Treatment || Reconstructive bladder surgery is found to improve quality of life. Surgeons begin to offer a ''neobladder'' to select patients needing surgery ([[wikipedia:cystectomy|cystectomy]]) for bladder cancer. This procedure provides a functional replacement for the bladder using tissue fashioned from the small bowel that allows the passage of urine through the [[wikipedia:urethra|urethra]].<ref name="Timeline" />||
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|-
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| 1982 || Discovery || [[wikipedia:Micropapillary bladder cancer|Micropapillary bladder cancer]] (a rare and aggressive variant of [[wikipedia:urothelial carcinoma|urothelial carcinoma]]) is first described.<ref>{{cite journal|title=Micropapillary bladder cancer: a review of Léon Bérard Cancer Center experience|doi=10.1186/1471-2490-9-5|url=http://bmcurol.biomedcentral.com/articles/10.1186/1471-2490-9-5 | volume=9|journal=BMC Urology}}</ref> ||
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|-
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| 1985 || Treatment || Neoadjuvant chemotherapy combining [[wikipedia:methotrexate|methotrexate]], [[wikipedia:vinblastine|vinblastine]], [[wikipedia:doxorubicin|doxorubicin]], and [[wikipedia:cisplatin|cisplatin]] (MVAC) is first described. MVAC is one of the most active chemotherapy regimens for bladder cancer.<ref>{{cite journal|title=Everything Old Is New Again! Neoadjuvant Chemotherapy in the Treatment of Muscle-Invasive Bladder Cancer|doi=10.1200/JCO.2014.55.4055|url=http://jco.ascopubs.org/content/32/18/1868.full | volume=32|journal=Journal of Clinical Oncology|pages=1868–1870}}</ref> ||
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| 1985–1989 || Medical development || Researchers map out the nerves surrounding the bladder and prostate and develop a new surgical technique that spares key nerves involved in male sexual function, thus preserving it.<ref>{{cite journal|title=Neuroanatomical approach to radical cystoprostatectomy with preservation of sexual function.|pmid=3682067 | volume=138 | journal=J Urol|pages=1402-6 | last1 = Schlegel | first1 = PN | last2 = Walsh | first2 = PC}}</ref> ||
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| 1987 || Treatment || Implant treats bladder cancer without surgery. The procedure involves implanting radioactive sources into cancerous tumors within the bladder.<ref>{{cite news|title=Implant treats bladder cancer without surgery|url=https://news.google.com/newspapers?nid=1320&dat=19870605&id=6T9WAAAAIBAJ&sjid=DuoDAAAAIBAJ&pg=3403,1269372&hl=en|publisher=Gainesville Sun}}</ref> || [[wikipedia:United States|United States]] 
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|-
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| 1988 || Scientific development || Intravesical chemotherapy using [[wikipedia:mitomycin|mitomycin]] is found to reduce risk of bladder cancer's return.<ref>{{cite journal|title=Treatment schedule of intravesical chemotherapy with mitomycin C in superficial bladder cancer: short-term courses or maintenance therapy.|pmid=3126592 | volume=31 | journal=Urology|pages=26-9 | last1 = van der Meijden | first1 = AP | last2 = DeBruyne | first2 = FM}}</ref> ||
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| 1990 || Medical development (treatment) || United States [[wikipedia:FDA|FDA]] approved the use of live bacterium, [[wikipedia:BCG vaccine|bacillus Calmette-Guérin]] (BCG) for superficial bladder cancer. BCG [[wikipedia:immunotherapy|immunotherapy]] helps reduce the risk of bladder cancer recurrence by stimulating an immune response that targets the bacteria as well as any bladder cancer cells.<ref>{{cite web|title=Bladder Cancer|url=http://www.cancerresearch.org/cancer-immunotherapy/impacting-all-cancers/bladder-cancer|accessdate=26 September 2016}}</ref> || [[wikipedia:United States|United States]]
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|-
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| 1997 || Medical development (treatment) || Introduction of combination therapy using both [[wikipedia:radiation|radiation]] and [[wikipedia:cisplatin|cisplatin]] chemotherapy together, is found to be a new treatment alternative for patients with advanced bladder cancer who are older or otherwise unable to undergo bladder surgery.<ref>{{cite journal|title=Radiotherapy with or without Chemotherapy in Muscle-Invasive Bladder Cancer|doi=10.1056/NEJMoa1106106|url=http://www.nejm.org/doi/full/10.1056/NEJMoa1106106 | volume=366|journal=New England Journal of Medicine|pages=1477–1488}}</ref> ||
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| 2000 || Medical development (treatment) || New chemotherapy combination regimen using [[wikipedia:gemcitabine|gemcitabine]] together with [[wikipedia:cisplatin|cisplatin]] is found to be comparably effective but has relatively fewer side effects than standard MVAC therapy.<ref>{{cite web|title=Gemcitabine  and  Cisplatin  Versus  Methotrexate, Vinblastine,  Doxorubicin,  and  Cisplatin  in  Advanced  or Metastatic  Bladder  Cancer:  Results  of  a  Large, Randomized,  Multinational,  Multicenter,  Phase  III  Stud|url=http://jco.ascopubs.org/content/18/17/3068.full.pdf+html?sid=9f02805d-173b-4226-8d12-83912373f41d|accessdate=29 September 2016}}</ref>||
 
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|1877||Development||German urologist [[Maximilian Nitze]] develops the [[cystoscope]], a device used to perform endoscopy of the [[urinary bladder]] via the [[urethra]].<ref name="Texas Cancer Center" />||
+
| 2002 || Statistics || Approximately 356,000 new bladder cancer cases worldwide are reported during the year.<ref>{{cite journal|title=The present and future burden of urinary bladder cancer in the world|doi=10.1007/s00345-009-0383-3| pmid=19219610|pmc=2694323|volume=27|year=2009|journal=World J Urol|pages=289–93 | last1 = Ploeg | first1 = M | last2 = Aben | first2 = KK | last3 = Kiemeney | first3 = LA}}</ref><ref name="The present and future burden of urinary bladder cancer in the world"/>||
 
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|1887||Treatment||The first [[cystectomy]] for bladder cancer is performed.<ref name="Texas Cancer Center">{{cite web|title=BLADDER CANCER|url=http://www.texascancercenter.com/bladder.html|accessdate=28 September 2016}}</ref>||[[Cologne]], [[Germany]]
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| 2003 || Scientific development || Research demonstrates that giving chemotherapy before bladder surgery improves survival for patients whose cancer has not spread significantly beyond the [[wikipedia:bladder|bladder]], compared with surgery alone.<ref>{{cite journal|title=International Phase III Trial Assessing Neoadjuvant Cisplatin, Methotrexate, and Vinblastine Chemotherapy for Muscle-Invasive Bladder Cancer: Long-Term Results of the BA06 30894 Trial|doi=10.1200/JCO.2010.32.3139|url=http://jco.ascopubs.org/content/29/16/2171.long | volume=29|journal=Journal of Clinical Oncology|pages=2171–2177}}</ref>||
 
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|1895||Discovery||Link between bladder cancer and environmental carcinogens is first postulated.<ref>{{cite web|title=Guideline for the Management of Nonmuscle Invasive Bladder Cancer: (Stages Ta, T1 and Tis: Update (2007)|url=https://www.auanet.org/education/guidelines/bladder-cancer.cfm|accessdate=28 September 2016}}</ref>||
+
| 2004 || Epidemiology || Report estimates that approximately 145,000 patients die from urinary bladder cancer annually worldwide.<ref name="The present and future burden of urinary bladder cancer in the world">{{cite journal|last1=Ploeg|first1=Martine|last2=Aben|first2=Katja K. H.|last3=Kiemeney|first3=Lambertus A.|title=The present and future burden of urinary bladder cancer in the world|journal=World Journal of Urology|doi=10.1007/s00345-009-0383-3|url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2694323/|accessdate=13 October 2017|pmc=2694323}}</ref> ||  
 
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|1902||Organization||The [[American Urological Association]] is founded.<ref>{{cite web|title=History of the AUA|url=https://www.auanet.org/about/history-of-the-aua.cfm|accessdate=20 November 2016}}</ref>||[[Linthicum]], [[Maryland]], [[United States]]
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| 2009 || Organization || Bladder Cancer Canada is formed as a patient advocacy organization dedicated to bladder cancer issues.<ref>{{cite web|title=Bladder Cancer Canada|url=https://bladdercancercanada.org/en/about/|accessdate=1 October 2016}}</ref> || [[wikipedia:Canada|Canada]]
 
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|1903||Treatment||[[Radium]] is first used to treat bladder tumors.<ref name="Texas Cancer Center" />||[[United States]]  
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| 2016 || Scientific development ||Study suggests that alterations in the [[wikipedia:extracellular matrix|extracellular matrix]] (ECM) microenvironment of the bladder, especially type I [[wikipedia:collagen|collagen]], may contribute to bladder cancer progression.<ref>{{cite news|title=Bladder Cancer Progression Linked to Collagen Changes|url=http://www.renalandurologynews.com/bladder-cancer/bladder-cancer-progression-linked-to-collagen-changes/article/524785/|accessdate=29 September 2016}}</ref>||[[wikipedia:Houston|Houston]], [[wikipedia:Texas|Texas]], [[wikipedia:United States|United States]]  
 
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|1911||Discovery||[[Schistosomiasis]] is first linked to urinary bladder cancer.<ref>{{cite journal|title=Bladder cancer and schistosomiasis|doi=10.1016/j.jnci.2012.08.002|url=http://www.sciencedirect.com/science/article/pii/S1110036212000544 | volume=24|journal=Journal of the Egyptian National Cancer Institute|pages=151–159}}</ref>||[[Egypt]]
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| 2016 || Medical development || New technology helps doctors detect cancerous tumors in the bladder that are invisible to the naked eye.<ref>{{cite news|title=New technology detects bladder cancer that even doctors can't see|url=http://www.deseretnews.com/article/865663357/New-technology-detects-bladder-cancer-that-even-doctors-cant-see.html?pg=all|accessdate=29 September 2016}}</ref>||[[wikipedia:Murray, Utah|Murray, Utah]], [[wikipedia:United States|United States]]  
 
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|1929||Discovery||Research notes that patients with tuberculosis have lower rates of cancer when examined at autopsy. This observation is among the first to link the possibility of bladder cancer treatment with [[BCG vaccine|BCG]].<ref>{{cite journal|title=Immunotherapy for bladder cancer|doi=10.2147/RRU.S63447|pmc=4427258 | pmid=26000263|volume=7|year=2015|journal=Res Rep Urol|pages=65–79 | last1 = Fuge | first1 = O | last2 = Vasdev | first2 = N | last3 = Allchorne | first3 = P | last4 = Green | first4 = JS}}</ref>||
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| 2017 (September 7) || Scientific development || Researchers develop new risk-stratification tool able to estimate mortality in patients with [[w:Transitional cell carcinoma|urothelial carcinoma of the bladder]] (UCB) after {{w|cystectomy}}. <ref>{{cite web|title=New Tool Identifies Mortality Risk After Bladder Cancer Surgery|url=http://www.oncologynurseadvisor.com/genitourinary-cancer/tool-identifies-mortality-risk-bladder-surgery/article/699445/|website=oncologynurseadvisor.com|accessdate=13 October 2017}}</ref><ref>{{cite web|title=New tool IDs mortality risk after bladder cancer surgery|url=https://medicalxpress.com/news/2017-10-tool-ids-mortality-bladder-cancer.html|website=medicalxpress.com|accessdate=13 October 2017}}</ref>
 
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|-
−
|1945||Development||[[Urine cytology]] (a test used to diagnose urinary tract cancers) is first described.<ref>{{cite journal|title=Current perspectives in bladder cancer management|doi=10.1111/ijcp.12075|url=http://onlinelibrary.wiley.com/doi/10.1111/ijcp.12075/full | volume=67|journal=International Journal of Clinical Practice|pages=435–448}}</ref>||
+
| 2017 (October 12) || Medical development || Researchers, working with mice and rats, develop a way to successfully deliver nano-sized, platinum-based chemotherapy drugs to treat nonmuscle-invasive bladder cancer, a type of bladder cancer which is found in the lining of the organ and has not invaded deeper into bladder tissue.<ref>{{cite web|title=Experimental 'nano-chemo' particle to treat bladder cancer|url=https://www.sciencedaily.com/releases/2017/10/171012103714.htm|website=sciencedaily.com|publisher=Johns Hopkins Medicine|accessdate=13 October 2017}}</ref><ref>{{cite web|title=Experimental nano-chemo particle to treat bladder cancer|url=https://www.europeanpharmaceuticalreview.com/news/68044/nano-chemo-bladder-cancer/|website=europeanpharmaceuticalreview.com|accessdate=13 October 2017}}</ref><ref>{{cite web|title=Scientists develop experimental 'nano-chemo' particle to treat bladder cancer|url=https://medicalxpress.com/news/2017-10-scientists-experimental-nano-chemo-particle-bladder.html|website=medicalxpress.com|accessdate=13 October 2017}}</ref><ref>{{cite web|title=Johns Hopkins Scientists Develop Experimental “Nano-Chemo” Particle to Treat Bladder Cancer|url=https://www.newswise.com/articles/johns-hopkins-scientists-develop-experimental-nano-chemo-particle-to-treat-bladder-cancer|website=newswise.com|accessdate=13 October 2017}}</ref>
 
|-
 
|-
−
|1952||Discovery||[[Transitional cell carcinoma|Transitional cell carcinoma in situ of the bladder]] is first described.<ref>{{cite web|title=BCG Immunotherapy for Transitional-Cell Carcinoma in Situ of the Bladder|url=http://www.physicianspractice.com/review-article/bcg-immunotherapy-transitional-cell-carcinoma-situ-bladder|accessdate=26 September 2016}}</ref>||
+
|}
 +
 
 +
== Numerical and visual data  ==
 +
 
 +
=== Mentions on Google Scholar ===
 +
 
 +
The following table summarizes per-year mentions on Google Scholar as of May 20, 2021.
 +
 
 +
{| class="sortable wikitable"
 +
! Year
 +
! Bladder cancer
 +
! Invasive bladder cancer
 +
! Urinary bladder cancer
 +
! Chemotherapy bladder cancer
 +
! Superficial bladder cancer
 +
! Bladder cancer intravesical
 +
! Bladder cancer recurrence
 
|-
 
|-
−
|1956||Treatment||Early bladder removal surgery is introduced. This include surgically removing the bladder (cystectomy) and surrounding tissue where cancer is most likely to spread.<ref>{{cite journal|title=A technique for radical total cystectomy|doi=10.1002/1097-0142(195605/06)9:3<585::AID-CNCR2820090325>3.0.CO;2-Z|url=http://onlinelibrary.wiley.com/doi/10.1002/1097-0142%28195605/06%299:3%3C585::AID-CNCR2820090325%3E3.0.CO;2-Z/abstract | volume=9|journal=Cancer|pages=585–595}}</ref>||
+
| 1980 || 3,990 || 835 || 5,820 || 2,100 || 616 || 143 || 1,820 
 
|-
 
|-
−
|1974||Discovery||Research ties sharp increase in bladder cancer deaths among British men to the rapid rise in [[cigarette smoking]] during prior decades.<ref name="Timeline">{{cite web|title=Timeline|url=http://cancerprogress.net/timeline/bladder-cancer|accessdate=29 September 2016}}</ref>||[[United Kingdom]]
+
| 1985 || 5,650 || 1,280 || 7,530 || 3,010 || 978 || 274 || 2,500
 
|-
 
|-
−
|1978||Treatment||United States [[FDA]] approves the first chemotherapy drug [[cisplatin]] for bladder cancer.<ref>{{cite web|title=The "Accidental" Cure—Platinum-based Treatment for Cancer: The Discovery of Cisplatin|url=https://www.cancer.gov/research/progress/discovery/cisplatin|accessdate=29 September 2016}}</ref>||[[United States]]
+
| 1990 || 7,740 || 2,000 || 9,250 || 3,710 || 1,340 || 404 || 3,110
 
|-
 
|-
−
|1980–1985||Treatment||Reconstructive bladder surgery is found to improve quality of life. Surgeons begin to offer a ''neobladder'' to select patients needing surgery ([[cystectomy]]) for bladder cancer. This procedure provides a functional replacement for the bladder using tissue fashioned from the small bowel that allows the passage of urine through the [[urethra]].<ref name="Timeline" />||
+
| 1995 || 10,400 || 3,340 || 12,300 || 4,580 || 1,780 || 534 || 4,310
 
|-
 
|-
−
|1982||Discovery||[[Micropapillary bladder cancer]] (a rare and aggressive variant of [[urothelial carcinoma]]) is first described.<ref>{{cite journal|title=Micropapillary bladder cancer: a review of Léon Bérard Cancer Center experience|doi=10.1186/1471-2490-9-5|url=http://bmcurol.biomedcentral.com/articles/10.1186/1471-2490-9-5 | volume=9|journal=BMC Urology}}</ref>||
+
| 2000 || 16,300 || 6,460 || 17,500 || 7,590 || 2,950 || 838 || 7,850
 
|-
 
|-
−
|1985||Treatment||Neoadjuvant chemotherapy combining [[methotrexate]], [[vinblastine]], [[doxorubicin]], and [[cisplatin]] (MVAC) is first described. MVAC is one of the most active chemotherapy regimens for bladder cancer.<ref>{{cite journal|title=Everything Old Is New Again! Neoadjuvant Chemotherapy in the Treatment of Muscle-Invasive Bladder Cancer|doi=10.1200/JCO.2014.55.4055|url=http://jco.ascopubs.org/content/32/18/1868.full | volume=32|journal=Journal of Clinical Oncology|pages=1868–1870}}</ref>||
+
| 2002 || 18,800 || 8,090 || 19,100 || 8,750 || 3,240 || 959 || 8,650
 
|-
 
|-
−
|1985–1989||Treatment||Researchers map out the nerves surrounding the bladder and prostate and develop a new surgical technique that spares key nerves involved in male sexual function, thus preserving it.<ref>{{cite journal|title=Neuroanatomical approach to radical cystoprostatectomy with preservation of sexual function.|pmid=3682067 | volume=138 | journal=J Urol|pages=1402-6 | last1 = Schlegel | first1 = PN | last2 = Walsh | first2 = PC}}</ref>||  
+
| 2004 || 25,200 || 10,000 || 21,800 || 11,500 || 4,170 || 1,180 || 11,600
 
|-
 
|-
−
|1987||Treatment||Implant treats bladder cancer without surgery. The procedure involves implanting radioactive sources into cancerous tumors within the bladder.<ref>{{cite news|title=Implant treats bladder cancer without surgery|url=https://news.google.com/newspapers?nid=1320&dat=19870605&id=6T9WAAAAIBAJ&sjid=DuoDAAAAIBAJ&pg=3403,1269372&hl=en|publisher=Gainesville Sun}}</ref>||[[United States]] 
+
| 2006 || 31,000 || 12,200 || 24,000 || 14,600 || 5,090 || 1,630 || 14,300
 
|-
 
|-
−
|1988||Discovery||Intravesical chemotherapy using [[mitomycin]] is found to reduce risk of bladder cancer's return.<ref>{{cite journal|title=Treatment schedule of intravesical chemotherapy with mitomycin C in superficial bladder cancer: short-term courses or maintenance therapy.|pmid=3126592 | volume=31 | journal=Urology|pages=26-9 | last1 = van der Meijden | first1 = AP | last2 = DeBruyne | first2 = FM}}</ref>||  
+
| 2008 || 36,400 || 16,300 || 26,700 || 17,500 || 5,980 || 1,830 || 17,000
 
|-
 
|-
−
|1990||Treatment||United States [[FDA]] approved the use of live bacterium, [[BCG vaccine|bacillus Calmette-Guérin]] (BCG) for superficial bladder cancer. BCG [[immunotherapy]] helps reduce the risk of bladder cancer recurrence by stimulating an immune response that targets the bacteria as well as any bladder cancer cells.<ref>{{cite web|title=Bladder Cancer|url=http://www.cancerresearch.org/cancer-immunotherapy/impacting-all-cancers/bladder-cancer|accessdate=26 September 2016}}</ref>||[[United States]]
+
| 2010 || 42,300 || 17,900 || 26,700 || 19,100 || 5,790 || 1,820 || 18,000
 
|-
 
|-
−
|1997||Treatment||Introduction of combination therapy using both [[radiation]] and [[cisplatin]] chemotherapy together, is found to be a new treatment alternative for patients with advanced bladder cancer who are older or otherwise unable to undergo bladder surgery.<ref>{{cite journal|title=Radiotherapy with or without Chemotherapy in Muscle-Invasive Bladder Cancer|doi=10.1056/NEJMoa1106106|url=http://www.nejm.org/doi/full/10.1056/NEJMoa1106106 | volume=366|journal=New England Journal of Medicine|pages=1477–1488}}</ref>||
+
| 2012 || 56,300 || 21,100 || 31,100 || 22,100 || 7,460 || 2,370 || 20,700 
 
|-
 
|-
−
|2000||Treatment||New chemotherapy combination regimen using [[gemcitabine]] together with [[cisplatin]] is found to be comparably effective but has relatively fewer side effects than standard MVAC therapy.<ref>{{cite web|title=Gemcitabine  and  Cisplatin  Versus  Methotrexate, Vinblastine, Doxorubicin, and  Cisplatin  in  Advanced  or Metastatic  Bladder  Cancer:  Results  of  a  Large, Randomized,  Multinational,  Multicenter,  Phase  III  Stud|url=http://jco.ascopubs.org/content/18/17/3068.full.pdf+html?sid=9f02805d-173b-4226-8d12-83912373f41d|accessdate=29 September 2016}}</ref>||
+
| 2014 || 60,200 || 23,300 || 33,300 || 24,800 || 7,190 || 2,320 || 22,100 
 
|-
 
|-
−
|2002||Report||Approximately 356,000 new bladder cancer cases worldwide are reported.<ref>{{cite journal|title=The present and future burden of urinary bladder cancer in the world|doi=10.1007/s00345-009-0383-3| pmid=19219610|pmc=2694323|volume=27|year=2009|journal=World J Urol|pages=289–93 | last1 = Ploeg | first1 = M | last2 = Aben | first2 = KK | last3 = Kiemeney | first3 = LA}}</ref>||
+
| 2016 || 61,000 || 26,200 || 34,400 || 27,100 || 7,620 || 2,470 || 23,800 
 
|-
 
|-
−
|2003||Treatment||Research demonstrates that giving chemotherapy before bladder surgery improves survival for patients whose cancer has not spread significantly beyond the [[bladder]], compared with surgery alone.<ref>{{cite journal|title=International Phase III Trial Assessing Neoadjuvant Cisplatin, Methotrexate, and Vinblastine Chemotherapy for Muscle-Invasive Bladder Cancer: Long-Term Results of the BA06 30894 Trial|doi=10.1200/JCO.2010.32.3139|url=http://jco.ascopubs.org/content/29/16/2171.long | volume=29|journal=Journal of Clinical Oncology|pages=2171–2177}}</ref>||
+
| 2017 || 58,500 || 27,100 || 35,200 || 29,100 || 7,650 || 2,660 || 24,600 
 
|-
 
|-
−
|2009||Organization||Bladder Cancer Canada is formed as a patient advocacy organization dedicated to bladder cancer issues.<ref>{{cite web|title=Bladder Cancer Canada|url=https://bladdercancercanada.org/en/about/|accessdate=1 October 2016}}</ref>||[[Canada]]
+
| 2018 || 55,400 || 29,600 || 36,200 || 31,200 || 7,920 || 2,820 || 25,600 
 
|-
 
|-
−
|2016||Discovery||Study suggests that alterations in the [[extracellular matrix]] (ECM) microenvironment of the bladder, especially type I [[collagen]], may contribute to bladder cancer progression.<ref>{{cite news|title=Bladder Cancer Progression Linked to Collagen Changes|url=http://www.renalandurologynews.com/bladder-cancer/bladder-cancer-progression-linked-to-collagen-changes/article/524785/|accessdate=29 September 2016}}</ref>||[[Houston]], [[Texas]], [[United States]]
+
| 2019 || 51,000 || 30,900 || 36,900 || 30,200 || 7,730 || 2,810 || 26,700
 
|-
 
|-
−
|2016||Development||New technology helps doctors detect cancerous tumors in the bladder that are invisible to the naked eye.<ref>{{cite news|title=New technology detects bladder cancer that even doctors can't see|url=http://www.deseretnews.com/article/865663357/New-technology-detects-bladder-cancer-that-even-doctors-cant-see.html?pg=all|accessdate=29 September 2016}}</ref>||[[Murray, Utah]], [[United States]]
+
| 2020 || 42,800 || 33,500 || 39,700 || 31,800 || 7,960 || 3,370 || 31,200   
 
|-
 
|-
 
|}
 
|}
 +
 +
[[File:Bladder cancer tb.png|thumb|center|700px]]
 +
 +
=== Google Trends ===
 +
 +
The comparative chart below shows {{w|Google Trends}} data for Bladder cancer (search term and topic) from January 2004 to January 2021, when the screenshot was taken.<ref>{{cite web |title=Bladder cancer |url=https://trends.google.com/trends/explore?date=all&q=%2Fm%2F01bcp7,Bladder%20cancer |website=trends.google.com |access-date=13 January 2021}}</ref>
 +
 +
[[File:Bladder gt.jpeg|thumb|center|800px]]
 +
 +
=== Google Ngram Viewer ===
 +
 +
The chart below shows {{w|Google Ngram Viewer}} data for Bladder cancer from 1700 to 2019.<ref>{{cite web |title=Bladder cancer |url=https://books.google.com/ngrams/graph?content=Bladder+cancer&year_start=1700&year_end=2019&corpus=26&smoothing=3&case_insensitive=true |website=books.google.com |access-date=15 January 2021}}</ref>
 +
 +
[[File:Bladder cancer ngram.jpeg|thumb|center|800px]]
 +
 +
=== Wikipedia views ===
 +
 +
The chart below shows Wikipedia views of the article {{w|bladder cancer}} on desktop from December 2007, and on mobile-web, desktop-spider, mobile-web-spider and mobile app, from June 2015; to January 2021.
 +
 +
[[File:Bladder c wv.jpeg|thumb|center|600px]]
 +
 +
==Meta information on the timeline==
 +
 +
===How the timeline was built===
 +
 +
The initial version of the timeline was written by [[User:Sebastian]].
 +
 +
{{funding info}} is available.
 +
 +
===What the timeline is still missing===
 +
 +
===Timeline update strategy===
  
 
==See also==
 
==See also==
−
* [[Timeline of lung cancer]]
+
 
−
* [[Timeline of brain cancer]]
+
* [[wikipedia:Timeline of lung cancer|Timeline of lung cancer]]
−
* [[Timeline of colorectal cancer]]
+
* [[wikipedia:Timeline of brain cancer|Timeline of brain cancer]]
−
* [[Timeline of pancreatic cancer]]
+
* [[wikipedia:Timeline of colorectal cancer|Timeline of colorectal cancer]]
−
* [[Timeline of cervical cancer]]
+
* [[wikipedia:Timeline of pancreatic cancer|Timeline of pancreatic cancer]]
−
* [[Timeline of kidney cancer]]
+
* [[wikipedia:Timeline of cervical cancer|Timeline of cervical cancer]]
 +
* [[wikipedia:Timeline of kidney cancer|Timeline of kidney cancer]]
  
 
==References==
 
==References==
−
{{Reflist}}
+
{{Reflist|30em}}
 
{{Cancer timeline}}
 
{{Cancer timeline}}
−
[[Category:Health-related timelines|Cancer, bladder]]
+
[[wikipedia:Category:Health-related timelines|Cancer, bladder]]
−
[[Category:Bladder cancer]]
+
[[wikipedia:Category:Bladder cancer|Category:Bladder cancer]]

Latest revision as of 18:57, 22 June 2023

The content on this page is forked from the English Wikipedia page entitled "Timeline of bladder cancer". The original page still exists at Timeline of bladder cancer. The original content was released under the Creative Commons Attribution/Share-Alike License (CC-BY-SA), so this page inherits this license.

This is a timeline of bladder cancer, describing especially major discoveries and advances in treatment of the disease.

Big picture

Year/period Key developments
16th–17th Centuries The first operations targeting bladder tumor are performed in these centuries.[1]
18th Century It is already theorized that tobacco use might be related to cancer.[2]
19th Century The cytoscope develops. The first cystectomy for bladder cancer is performed.
20th Century A major discovery is the link between bladder cancer and exposure to β-Naphthylamine. Around mid–century, aromatic amines are found to be the most important carcinogens in occupational bladder cancer. This would prompt worldwide regulatory changes to the manufacture of rubber and dyestuffs.[3] Among medical advances, urine cytology emerges as a tool to detect recurrent bladder and urinary tract cancers.[4]
1950s Cigarette smoking is found to be etiologic for human bladder cancer.[2]
1970s Cigarette smoking is linked to bladder cancer risk. The first chemotherapy drug is released for bladder cancer.[4]
1980s Mitomycin chemotherapy is consolidated. Surgical advances improve bladder cancer survival. First successful combination chemotherapy for advanced bladder cancer is achieved.[4]
1990s Surgical techniques consolidate. New chemotherapies emerge to treat bladder cancer.[4]
2000s New chemotherapies prove to extend survival against bladder cancer. CT scan improves bladder cancer detection.[4]
Recent years As of 2010, bladder cancer resulted in 170,000 deaths up from 114,000 in 1990 worldwide.[5] Current treatment options for people with bladder cancer can include surgery, intravesical therapy, chemotherapy, radiation therapy and immunotherapy.[6] Today, the incidence of occupational bladder cancer has decreased in the Western World, but is still widely reported in less developed countries. A lack of adequate data on concurrent smoking history and other risk factors is a possible limitation of actual epidemiological studies.[3]


Full timeline

Year/period Type of event Event Location
1551 Scientific development Bladder tumors are mentioned first by Lacuna.[1]
1761 Scientific development Dr. John Hill reports a relationship between tobacco use and cancer.[2]
1854 Scientific development Inverted papilloma (a tumor that may occur in the bladder and other components of the urinary tract) is first described.[7]
1877 Medical development (device) German urologist Maximilian Nitze develops the cystoscope, a device used to perform endoscopy of the urinary bladder via the urethra.[8]
1887 Medical development (treatment) The first cystectomy for bladder cancer is performed.[8] Cologne, Germany
1895 Scientific development Link between bladder cancer and environmental carcinogens is first postulated.[9]
1895 Scientific development German surgeon Ludwig Rehn, working at the Hoechst aniline factory near Frankfurt, reports 3 cases of bladder cancer in workers, labeling them aniline tumors. However, it would be hard to prove the association with the chemical at the time as chemical manufacturers begin using several other coal- and oil-based compounds.[3][2] Germany
1902 Organization The American Urological Association is founded.[10] Linthicum, Maryland, United States
1903 Medical development (treatment) Radium is first used to treat bladder tumors.[8] United States
1911 Scientific development Ferguson first first suggests association between Schistosomiasis and urinary bladder cancer.[11][2]
1929 Scientific development Researchers note that patients with tuberculosis have lower rates of cancer when examined at autopsy. This observation is among the first to link the possibility of bladder cancer treatment with BCG.[12]
1938 Scientific development Delaware-based German pathologist Wilhelm Hueper shows an increase in bladder tumors when β-Naphthylamine is administered orally to dogs. With his toxicology research funded by the chemical industry, Hueper would encounter significant resistance in publishing his findings.[3]
1939 Scientific development Researchers communicate a successful attempt to induce papillary vesical lesions of benign and malignant type of bladder cancer in female dogs receiving large doses of commercial β-Naphthylamine by mouth.[13] United States
1940 Scientific development Japanese scientists claim having induced bladder papillomatosis in rabbits and rats by means of subcutaneous injection of an oily solution of o–toluidine.[13]
1945 Medical development (diagnosis) Urine cytology (a test used to diagnose urinary tract cancers) is first described.[14]
1950 – 1954 Epidemiology Incidence rate for bladder cancer per 100,000 population in the United States is reported at 14.1 for males, and 4.4 for females, during the period.[2] United States
1950 – 1959 Scientific discovery It is found that cigarette smoking is etiologic for human bladder cancer.[2]
1952 Discovery Transitional cell carcinoma in situ of the bladder is first described.[15]
1954 Scientific development Study by Case and Holster on workers in the British rubber industry demonstrate that β-Naphthylamine accounts for a 200-fold increased risk of bladder cancer with a latency period of 11-25 years. Subsequently, regulatory bodies worldwide would start prohibiting the manufacture and use of the compound.[3] United Kingdom
1956 Medical development (treatment) Early bladder removal surgery is introduced. This include surgically removing the bladder (cystectomy) and surrounding tissue where cancer is most likely to spread.[16]
1970 – 1974 Epidemiology Incidence rate for bladder cancer per 100,000 population in the United States is reported at 23.7 for males, and 6.1 for females, during the period.[2] United States
1970 – 1975 Scientific development Studies in laboratory rats link saccharin with the development of bladder cancer, especially in male rats.[17]
1972 Scientific development Researchers demonstrate a significantly decreased incidence of bladder cancer since the manufacture of dyestuffs containing β-Naphthylamine was ceased.[3]
1974 Discovery Research ties sharp increase in bladder cancer deaths among British men to the rapid rise in cigarette smoking during prior decades.[4] United Kingdom
1978 Treatment United States FDA approves the first chemotherapy drug cisplatin for bladder cancer.[18] United States
1980–1985 Treatment Reconstructive bladder surgery is found to improve quality of life. Surgeons begin to offer a neobladder to select patients needing surgery (cystectomy) for bladder cancer. This procedure provides a functional replacement for the bladder using tissue fashioned from the small bowel that allows the passage of urine through the urethra.[4]
1982 Discovery Micropapillary bladder cancer (a rare and aggressive variant of urothelial carcinoma) is first described.[19]
1985 Treatment Neoadjuvant chemotherapy combining methotrexate, vinblastine, doxorubicin, and cisplatin (MVAC) is first described. MVAC is one of the most active chemotherapy regimens for bladder cancer.[20]
1985–1989 Medical development Researchers map out the nerves surrounding the bladder and prostate and develop a new surgical technique that spares key nerves involved in male sexual function, thus preserving it.[21]
1987 Treatment Implant treats bladder cancer without surgery. The procedure involves implanting radioactive sources into cancerous tumors within the bladder.[22] United States
1988 Scientific development Intravesical chemotherapy using mitomycin is found to reduce risk of bladder cancer's return.[23]
1990 Medical development (treatment) United States FDA approved the use of live bacterium, bacillus Calmette-Guérin (BCG) for superficial bladder cancer. BCG immunotherapy helps reduce the risk of bladder cancer recurrence by stimulating an immune response that targets the bacteria as well as any bladder cancer cells.[24] United States
1997 Medical development (treatment) Introduction of combination therapy using both radiation and cisplatin chemotherapy together, is found to be a new treatment alternative for patients with advanced bladder cancer who are older or otherwise unable to undergo bladder surgery.[25]
2000 Medical development (treatment) New chemotherapy combination regimen using gemcitabine together with cisplatin is found to be comparably effective but has relatively fewer side effects than standard MVAC therapy.[26]
2002 Statistics Approximately 356,000 new bladder cancer cases worldwide are reported during the year.[27][28]
2003 Scientific development Research demonstrates that giving chemotherapy before bladder surgery improves survival for patients whose cancer has not spread significantly beyond the bladder, compared with surgery alone.[29]
2004 Epidemiology Report estimates that approximately 145,000 patients die from urinary bladder cancer annually worldwide.[28]
2009 Organization Bladder Cancer Canada is formed as a patient advocacy organization dedicated to bladder cancer issues.[30] Canada
2016 Scientific development Study suggests that alterations in the extracellular matrix (ECM) microenvironment of the bladder, especially type I collagen, may contribute to bladder cancer progression.[31] Houston, Texas, United States
2016 Medical development New technology helps doctors detect cancerous tumors in the bladder that are invisible to the naked eye.[32] Murray, Utah, United States
2017 (September 7) Scientific development Researchers develop new risk-stratification tool able to estimate mortality in patients with urothelial carcinoma of the bladder (UCB) after cystectomy. [33][34]
2017 (October 12) Medical development Researchers, working with mice and rats, develop a way to successfully deliver nano-sized, platinum-based chemotherapy drugs to treat nonmuscle-invasive bladder cancer, a type of bladder cancer which is found in the lining of the organ and has not invaded deeper into bladder tissue.[35][36][37][38]

Numerical and visual data

Mentions on Google Scholar

The following table summarizes per-year mentions on Google Scholar as of May 20, 2021.

Year Bladder cancer Invasive bladder cancer Urinary bladder cancer Chemotherapy bladder cancer Superficial bladder cancer Bladder cancer intravesical Bladder cancer recurrence
1980 3,990 835 5,820 2,100 616 143 1,820
1985 5,650 1,280 7,530 3,010 978 274 2,500
1990 7,740 2,000 9,250 3,710 1,340 404 3,110
1995 10,400 3,340 12,300 4,580 1,780 534 4,310
2000 16,300 6,460 17,500 7,590 2,950 838 7,850
2002 18,800 8,090 19,100 8,750 3,240 959 8,650
2004 25,200 10,000 21,800 11,500 4,170 1,180 11,600
2006 31,000 12,200 24,000 14,600 5,090 1,630 14,300
2008 36,400 16,300 26,700 17,500 5,980 1,830 17,000
2010 42,300 17,900 26,700 19,100 5,790 1,820 18,000
2012 56,300 21,100 31,100 22,100 7,460 2,370 20,700
2014 60,200 23,300 33,300 24,800 7,190 2,320 22,100
2016 61,000 26,200 34,400 27,100 7,620 2,470 23,800
2017 58,500 27,100 35,200 29,100 7,650 2,660 24,600
2018 55,400 29,600 36,200 31,200 7,920 2,820 25,600
2019 51,000 30,900 36,900 30,200 7,730 2,810 26,700
2020 42,800 33,500 39,700 31,800 7,960 3,370 31,200
Bladder cancer tb.png

Google Trends

The comparative chart below shows Google Trends data for Bladder cancer (search term and topic) from January 2004 to January 2021, when the screenshot was taken.[39]

Bladder gt.jpeg

Google Ngram Viewer

The chart below shows Google Ngram Viewer data for Bladder cancer from 1700 to 2019.[40]

Bladder cancer ngram.jpeg

Wikipedia views

The chart below shows Wikipedia views of the article bladder cancer on desktop from December 2007, and on mobile-web, desktop-spider, mobile-web-spider and mobile app, from June 2015; to January 2021.

Bladder c wv.jpeg

Meta information on the timeline

How the timeline was built

The initial version of the timeline was written by User:Sebastian.

Funding information for this timeline is available.

What the timeline is still missing

Timeline update strategy

See also

References

  1. ↑ 1.0 1.1 Patel, Sutchin R.; Moran, Michael E.; Nakada, Stephen Y. The History of Technologic Advancements in Urology. 
  2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 Bryan, George T. (1983). "Pathogenesis of Human Urinary Bladder Cancer". Environmental Health Perspectives: 201–207. Retrieved 13 October 2017. 
  3. ↑ 3.0 3.1 3.2 3.3 3.4 3.5 Wanis, Michael; Hadjipavlou, Marios. "THE RISE AND FALL OF OCCUPATIONAL BLADDER CANCER IN THE WESTERN WORLD". THE JOURNAL OF UROLOGY. Retrieved 13 October 2017. 
  4. ↑ 4.0 4.1 4.2 4.3 4.4 4.5 4.6 "Timeline". Retrieved 29 September 2016. 
  5. ↑ Lozano, R; et al. (15 December 2012). "Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010". Lancet. 380 (9859): 2095–128. PMID 23245604. doi:10.1016/S0140-6736(12)61728-0. 
  6. ↑ "Bladder cancer treatment". Retrieved 1 October 2016. 
  7. ↑ Wood, JW; Casiano, RR (2012). "Inverted papillomas and benign nonneoplastic lesions of the nasal cavity". Am J Rhinol Allergy. 26: 157–63. PMC 3906506Freely accessible. PMID 22487294. doi:10.2500/ajra.2012.26.3732. 
  8. ↑ 8.0 8.1 8.2 "BLADDER CANCER". Retrieved 28 September 2016. 
  9. ↑ "Guideline for the Management of Nonmuscle Invasive Bladder Cancer: (Stages Ta, T1 and Tis: Update (2007)". Retrieved 28 September 2016. 
  10. ↑ "History of the AUA". Retrieved 20 November 2016. 
  11. ↑ "Bladder cancer and schistosomiasis". Journal of the Egyptian National Cancer Institute. 24: 151–159. doi:10.1016/j.jnci.2012.08.002. 
  12. ↑ Fuge, O; Vasdev, N; Allchorne, P; Green, JS (2015). "Immunotherapy for bladder cancer". Res Rep Urol. 7: 65–79. PMC 4427258Freely accessible. PMID 26000263. doi:10.2147/RRU.S63447. 
  13. ↑ 13.0 13.1 BONSER, GEORGIANA M. (January 1946). "EXPERIMENTAL CANCER OF THE BLADDER". British Medical Bulletin: 379–381. doi:10.1093/oxfordjournals.bmb.a072830. 
  14. ↑ "Current perspectives in bladder cancer management". International Journal of Clinical Practice. 67: 435–448. doi:10.1111/ijcp.12075. 
  15. ↑ "BCG Immunotherapy for Transitional-Cell Carcinoma in Situ of the Bladder". Retrieved 26 September 2016. 
  16. ↑ "A technique for radical total cystectomy". Cancer. 9: 585–595. doi:10.1002/1097-0142(195605/06)9:3<585::AID-CNCR2820090325>3.0.CO;2-Z. 
  17. ↑ "Artificial Sweeteners and Cancer". cancer.gov. Retrieved 13 October 2017. 
  18. ↑ "The "Accidental" Cure—Platinum-based Treatment for Cancer: The Discovery of Cisplatin". Retrieved 29 September 2016. 
  19. ↑ "Micropapillary bladder cancer: a review of Léon Bérard Cancer Center experience". BMC Urology. 9. doi:10.1186/1471-2490-9-5. 
  20. ↑ "Everything Old Is New Again! Neoadjuvant Chemotherapy in the Treatment of Muscle-Invasive Bladder Cancer". Journal of Clinical Oncology. 32: 1868–1870. doi:10.1200/JCO.2014.55.4055. 
  21. ↑ Schlegel, PN; Walsh, PC. "Neuroanatomical approach to radical cystoprostatectomy with preservation of sexual function.". J Urol. 138: 1402–6. PMID 3682067. 
  22. ↑ "Implant treats bladder cancer without surgery". Gainesville Sun. 
  23. ↑ van der Meijden, AP; DeBruyne, FM. "Treatment schedule of intravesical chemotherapy with mitomycin C in superficial bladder cancer: short-term courses or maintenance therapy.". Urology. 31: 26–9. PMID 3126592. 
  24. ↑ "Bladder Cancer". Retrieved 26 September 2016. 
  25. ↑ "Radiotherapy with or without Chemotherapy in Muscle-Invasive Bladder Cancer". New England Journal of Medicine. 366: 1477–1488. doi:10.1056/NEJMoa1106106. 
  26. ↑ "Gemcitabine and Cisplatin Versus Methotrexate, Vinblastine, Doxorubicin, and Cisplatin in Advanced or Metastatic Bladder Cancer: Results of a Large, Randomized, Multinational, Multicenter, Phase III Stud" (PDF). Retrieved 29 September 2016. 
  27. ↑ Ploeg, M; Aben, KK; Kiemeney, LA (2009). "The present and future burden of urinary bladder cancer in the world". World J Urol. 27: 289–93. PMC 2694323Freely accessible. PMID 19219610. doi:10.1007/s00345-009-0383-3. 
  28. ↑ 28.0 28.1 Ploeg, Martine; Aben, Katja K. H.; Kiemeney, Lambertus A. "The present and future burden of urinary bladder cancer in the world". World Journal of Urology. PMC 2694323Freely accessible. doi:10.1007/s00345-009-0383-3. Retrieved 13 October 2017. 
  29. ↑ "International Phase III Trial Assessing Neoadjuvant Cisplatin, Methotrexate, and Vinblastine Chemotherapy for Muscle-Invasive Bladder Cancer: Long-Term Results of the BA06 30894 Trial". Journal of Clinical Oncology. 29: 2171–2177. doi:10.1200/JCO.2010.32.3139. 
  30. ↑ "Bladder Cancer Canada". Retrieved 1 October 2016. 
  31. ↑ "Bladder Cancer Progression Linked to Collagen Changes". Retrieved 29 September 2016. 
  32. ↑ "New technology detects bladder cancer that even doctors can't see". Retrieved 29 September 2016. 
  33. ↑ "New Tool Identifies Mortality Risk After Bladder Cancer Surgery". oncologynurseadvisor.com. Retrieved 13 October 2017. 
  34. ↑ "New tool IDs mortality risk after bladder cancer surgery". medicalxpress.com. Retrieved 13 October 2017. 
  35. ↑ "Experimental 'nano-chemo' particle to treat bladder cancer". sciencedaily.com. Johns Hopkins Medicine. Retrieved 13 October 2017. 
  36. ↑ "Experimental nano-chemo particle to treat bladder cancer". europeanpharmaceuticalreview.com. Retrieved 13 October 2017. 
  37. ↑ "Scientists develop experimental 'nano-chemo' particle to treat bladder cancer". medicalxpress.com. Retrieved 13 October 2017. 
  38. ↑ "Johns Hopkins Scientists Develop Experimental "Nano-Chemo" Particle to Treat Bladder Cancer". newswise.com. Retrieved 13 October 2017. 
  39. ↑ "Bladder cancer". trends.google.com. Retrieved 13 January 2021. 
  40. ↑ "Bladder cancer". books.google.com. Retrieved 15 January 2021. 

Cancer, bladder Category:Bladder cancer

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