Difference between revisions of "Timeline of diphtheria"

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This is a '''timeline of [[wikipedia:diphtheria|diphtheria]]''', describing major events such as epidemics and medical developments.
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== Big picture ==
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{| class="sortable wikitable"
 
{| class="sortable wikitable"
 
! Year/period !! Key developments   
 
! Year/period !! Key developments   
 
|-
 
|-
−
| 19th century || Diphtheria infection grows significantly late in the century to become one of the major causes of death, fuelled by the industrial revolution and increasingly crowded urban centers.<ref name="The strangler"/>
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| Ancient times || Earliy detailed descriptions of dyphtheria date from ancient Syrian, [[wikipedia:Ancient Egypt|Egyptian]], and [[wikipedia:Ancient Greece|Greek]] writings.<ref name="State of the world’s vaccines and immunization"/>
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|-
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| 1600s onward || [[wikipedia:diphtheria|Diphtheria]] infection grows significantly since the 17th century and becomes one of the major causes of death, fuelled by the [[wikipedia:industrial revolution|Industrial Revolution]] and increasingly crowded urban centers.<ref name="The strangler"/>
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|-
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| 1800s || Major scientific breakthroughs consolidate the knowledge on diphtheria, which is given its actual name in this century<ref name="The strangler"/>. Bacterium ''[[wikipedia:corynebacterium diphtheriae|corynebacterium diphtheriae]]'' and the [[wikipedia:diphtheria toxin|diphtheria toxin]] are discovered.<ref name="Diphtheria in Europe"/><ref name="The Comprehensive Sourcebook of Bacterial Protein Toxins"/> Also, the first effective therapeutic serum against diphtheria is developed.<ref name="Emil von Behring: The Founder of Serum Therapy"/>
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|-
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| 1923 onward || After the first [[wikipedia:diphtheria|diphtheria]] toxoid vaccine is developed, its subsequent widespread use would lead to a dramatic decrease of diphtheria rates worldwide.<ref name="Diphtheria Facts"/><ref>{{cite web|title=Clinicians|url=https://www.cdc.gov/diphtheria/clinicians.html|website=cdc.gov|accessdate=10 May 2017}}</ref> A more than 90% decrease in number of cases globally results later, between 1980 and 2000.<ref name="Diphtheria :  Clinical Manifestations ,  Diagnosis ,  and Role  of Immunization In  Prevention"/>
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|-
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| Recent years || Currently most [[wikipedia:diphtheria|diphtheria]] cases occur in [[wikipedia:Sub-Sharan Africa|Sub-Sharan Africa]], [[wikipedia:India|India]], and [[wikipedia:Indonesia|Indonesia]]. Globally 4,530 cases were officially reported in 2015, down from nearly 100,000 in 1980.<ref>{{cite web|title=Diphtheria reported cases|url=http://apps.who.int/immunization_monitoring/globalsummary/timeseries/tsincidencediphtheria.html|website=who.int|accessdate=12 May 2017}}</ref><ref name="Diphtheria :  Clinical Manifestations ,  Diagnosis ,  and Role  of Immunization In  Prevention">{{cite web|title=Diphtheria :  Clinical Manifestations ,  Diagnosis ,  and Role  of Immunization In  Prevention|url=http://www.iosrjournals.org/iosr-jdms/papers/Vol15-Issue%208/Version-3/O1508037176.pdf|website=iosrjournals.org|accessdate=10 May 2017}}</ref>
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|-
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|}
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== Numerical and visual data  ==
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=== Mentions on Google Scholar ===
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The following table summarizes per-year mentions on Google Scholar as of May 22, 2021.
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{| class="sortable wikitable"
 +
! Year
 +
! diphtheria
 +
! diphtheria toxin
 +
! diphtheria vaccine
 +
! diphtheria prevention
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! diphtheria treatment
 +
|-
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| 1980 || 1,230 || 471 || 298 || 264 || 676
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|-
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| 1985 || 1,800 || 769 || 600 || 467 || 975
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|-
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| 1990 || 2,000 || 747 || 784 || 607 || 1,150
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|-
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| 1995 || 2,700 || 1,150 || 1,080 || 842 || 1,560
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|-
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| 2000 || 4,150 || 1,730 || 1,850 || 1,660 || 2,630
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|-
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| 2002 || 5,020 || 2,450 || 2,510 || 2,350 || 3,360
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|-
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| 2004 || 5,980 || 2,210 || 3,170 || 2,890 || 4,080
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|-
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| 2006 || 7,060 || 2,750 || 3,060 || 3,000 || 4,600
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|-
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| 2008 || 11,600 || 3,650 || 4,160 || 4,940 || 8,250
 
|-
 
|-
−
| 1920s || The first diphtheria toxoid vaccine is developed, and its subsequent widespread use leads to a dramatic decrease of diphtheria rates worldwide.<ref name="Diphtheria Facts"/><ref>{{cite web|title=Clinicians|url=https://www.cdc.gov/diphtheria/clinicians.html|website=cdc.gov|accessdate=10 May 2017}}</ref>
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| 2010 || 7,540 || 3,150 || 3,810 || 3,880 || 5,050
 
|-
 
|-
−
| 1990s || The vast majority of diphtheria cases occur during an outbreak in the ex-Soviet Union, in which the World Health Organization reports more than 157,000 cases and 5,000 deaths.<ref name="Diphtheria Facts"/>
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| 2012 || 9,740 || 4,000 || 5,090 || 4,750 || 6,820 
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|-
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| 2014 || 10,100 || 4,160 || 5,260 || 4,790 || 6,970 
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|-
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| 2016 || 10,300 || 4,250 || 5,010 || 4,730 || 7,090 
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|-
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| 2017 || 10,500 || 4,270 || 5,110 || 4,830 || 7,250
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|-
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| 2018 || 10,900 || 4,310 || 5,500 || 5,050 || 7,500 
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|-
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| 2019 || 10,800 || 4,160 || 5,620 || 5,170 || 7,440
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|-
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| 2020 || 11,000 || 4,680 || 5,920 || 5,830 || 8,240
 
|-
 
|-
 
|}
 
|}
  
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==Full timeline==
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[[File:Diphteria tb.png|thumb|center|700px]]
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=== Google Trends ===
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The comparative chart below shows {{w|Google Trends}} data for Diphtheria (Search Term) and Diphtheria (Topic), from January 2004 to February 2021, when the screenshot was taken. Interest in the topic is also ranked by country and displayed on world map.<ref>{{cite web |title=Diphtheria |url=https://trends.google.com/trends/explore?date=all&q=Diphtheria,%2Fm%2F0g2q5 |website=Google Trends |access-date=15 February 2021}}</ref>
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[[File:Diphtheria gt.jpg|thumb|center|800px]]
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=== Google Ngram Viewer ===
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The chart below shows {{w|Google Ngram Viewer}} data for Diphtheria, from 1800 to 2019.<ref>{{cite web |title=Diphtheria |url=https://books.google.com/ngrams/graph?content=Diphtheria&year_start=1800&year_end=2019&corpus=26&smoothing=3&case_insensitive=true |website=books.google.com |access-date=16 February 2021 |language=en}}</ref>
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[[File:Diphtheria ngram.jpg|thumb|center|800px]]
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=== Wikipedia Views ===
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The chart below shows pageviews of the English Wikipedia article {{w|Diphtheria}}, on desktop, mobile-web, desktop-spider, mobile-web-spider and mobile app, from July 2015; to January 2021.<ref>{{cite web |title=Diphtheria |url=https://wikipediaviews.org/displayviewsformultiplemonths.php?page=Diphtheria&allmonths=allmonths-api&language=en&drilldown=all |website=wikipediaviews.org |access-date=21 February 2021}}</ref>
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[[File:Diphtheria wv.jpg|thumb|center|600px]]
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=== Other ===
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[[File:Diphtheria world.png||thumb|center|1100px|Global diphtheria cases reported by the World Health Organization in the period (1980-2015). Local maxima around mid-1990s correlate with large epidemic in the Post-Soviet states.]]
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[[File:Diphtheria cases and deaths per year in the United States. Non-logarithmic scale.png|thumb|center|1100px|Diphtheria cases and deaths per year in the United States. Period (1950-2013).]]
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[[File:Diphtheria cases and deaths per year in the United States. Logarithmic scale..png|thumb|center|1100px|Diphtheria cases and deaths per year in the United States. Period (1950-2013). Logarithmic scale.]]
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== Full timeline ==
  
 
{| class="sortable wikitable"
 
{| class="sortable wikitable"
 
! Year/period !! Type of event !! Event !! Present time geographical location
 
! Year/period !! Type of event !! Event !! Present time geographical location
 
|-
 
|-
−
| 5th century BC || Scientific development || Diphtheria is first described by  Greek physician [[wikipedia:Hippocrates|Hippocrates]].<ref>{{cite web|title=Diphtheria|url=http://emedicine.medscape.com/article/782051-overview|website=medscape.com|accessdate=8 May 2017}}</ref><ref name="Corynebacterium diphtheriae"/> || [[wikipedia:Greece|Greece]]
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| 5th century BC || Scientific development || [[wikipedia:diphtheria|Diphtheria]] is first described by  Greek physician [[wikipedia:Hippocrates|Hippocrates]].<ref>{{cite web|title=Diphtheria|url=http://emedicine.medscape.com/article/782051-overview|website=medscape.com|accessdate=8 May 2017}}</ref><ref name="Corynebacterium diphtheriae"/> || [[wikipedia:Greece|Greece]]
 
|-
 
|-
 
| 1600s || Scientific development || Medical reports of a "deadly" strangulation disease first appear early in the century, and emerges as a greater threat with the growth of urbanizations.<ref name="The strangler">{{cite web|title=The strangler|url=http://www.museumofhealthcare.ca/explore/exhibits/vaccinations/diphtheria.html|website=museumofhealthcare.ca|accessdate=9 May 2017}}</ref><ref name="Corynebacterium diphtheriae"/> ||
 
| 1600s || Scientific development || Medical reports of a "deadly" strangulation disease first appear early in the century, and emerges as a greater threat with the growth of urbanizations.<ref name="The strangler">{{cite web|title=The strangler|url=http://www.museumofhealthcare.ca/explore/exhibits/vaccinations/diphtheria.html|website=museumofhealthcare.ca|accessdate=9 May 2017}}</ref><ref name="Corynebacterium diphtheriae"/> ||
 
|-
 
|-
−
| 1826 || Scientific development || French physician [[wikipedia:Pierre Bretonneau|Pierre Bretonneau]] gives diphtheria its official name ''diphtérite'', derived from the Greek word for "leather" or "hide", which describes the pseudomembrane in the throat of the victims.<ref name="The strangler"/><ref name="Pierre Bretonneau">{{cite web|title=Pierre Bretonneau|url=https://www.historyofvaccines.org/content/diphtheria-given-its-name|website=historyofvaccines.org|accessdate=9 May 2017}}</ref> ||  
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| 1613 || Epidemic || [[wikipedia:diphtheria|diphtheria]] epidemic in Spain causes the year to be named ''"El año de los Garotillos"'' ("year of strangulations"), due to the many deaths caused by diphtheria suffocation.<ref name="Current Developments in Biotechnology and Bioengineering">{{cite book|title=Current Developments in Biotechnology and Bioengineering: Human and Animal Health Applications|edition=Vanete Thomaz Soccol, Ashok Pandey, Rodrigo R. Resende|url=https://books.google.com.ar/books?id=8HN_CwAAQBAJ&pg=PA480&lpg=PA480&dq=%221613%22+%22spain%22+%22diphtheria%22&source=bl&ots=t9VgOAXeRX&sig=-JV8FJpe13qyPa-5__xiestFOgI&hl=en&sa=X&ved=0ahUKEwiDgbDuwuXTAhVKjpAKHc0pA88Q6AEIPzAG#v=onepage&q=%221613%22%20%22spain%22%20%22diphtheria%22&f=false|accessdate=10 May 2017}}</ref> || [[wikipedia:Spain|Spain]]
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|-
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| 1771 || Medical development || American physician [[wikipedia:Samuel Bard (physician)|Samuel Bard]] publishes ''An Enquiry into the Nature, Cause and Cure, of the Angina Suffocativa, or, Sore Throat Distemper'', one of the earliest accurate descriptions of diphtheria as well as one of the first original contributions to pediatrics made by an American.<ref>{{cite web|title=Archives & Special Collections Acquires Samuel Bard Work|url=http://library.cumc.columbia.edu/archives-special-collections-acquires-samuel-bard-work|website=columbia.edu|accessdate=11 May 2017}}</ref> || [[wikipedia:United States|United States]]
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|-
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| 1826 || Scientific development || French physician [[wikipedia:Pierre Bretonneau|Pierre Bretonneau]] gives diphtheria its official name ''diphtérite'', derived from the Greek word for "leather" or "hide", which describes the pseudomembrane in the throat of the victims.<ref name="The strangler"/><ref name="Pierre Bretonneau">{{cite web|title=Pierre Bretonneau|url=https://www.historyofvaccines.org/content/diphtheria-given-its-name|website=historyofvaccines.org|accessdate=9 May 2017}}</ref><ref name="Current Developments in Biotechnology and Bioengineering"/><ref name="State of the world’s vaccines and immunization"/> ||  
 
|-
 
|-
−
| 1883 || Scientific development || Swiss pathologist [[wikipedia:Edwin Klebs|Edwin Klebs]] first observes the diphtheria bacterium in diphtheritic membranes.<ref name="Corynebacterium diphtheriae">{{cite web|title=Corynebacterium diphtheriae|url=https://www.cdc.gov/vaccines/pubs/pinkbook/downloads/dip.pdf|website=cdc.gov|accessdate=10 May 2017}}</ref> ||
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| 1856 || Epidemic || [[wikipedia:San Francisco|San Francisco]] doctor [[wikipedia:Victor Fourgeaud|Victor Fourgeaud]] describes an epidemic of diphtheria in California.<ref name="Diphtheria :  Clinical Manifestations ,  Diagnosis ,  and Role  of Immunization In  Prevention"/> || [[wikipedia:United States|United States]]
 
|-
 
|-
−
| 1884 || Scientific development || German bacteriologist [[wikipedia:Friedrich Loeffler|Friedrich Loeffler]] first grows diphtheria bacterium ''[[wikipedia:Corynebacterium diphtheriae|corynebacterium diphtheriae]]'' in pure culture.<ref name="Diphtheria in Europe">{{cite web|last1=KWANTES|first1=W.|title=Diphtheria in Europe|url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2129475/pdf/jhyg00015-0039.pdf|website=nih.gov|accessdate=8 May 2017}}</ref><ref name="Diphtheria Facts">{{cite web|title=Diphtheria Facts|url=http://www.emedicinehealth.com/diphtheria/article_em.htm|website=emedicinehealth.com|accessdate=9 May 2017}}</ref><ref name="Corynebacterium diphtheriae"/> || [[wikipedia:Germany|Germany]]
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| 1883 || Scientific development || Swiss pathologist [[wikipedia:Edwin Klebs|Edwin Klebs]] first observes the bacterium ''[[wikipedia:Corynebacterium diphtheriae|corynebacterium diphtheriae]]'' in diphtheritic membranes.<ref name="Corynebacterium diphtheriae">{{cite web|title=Corynebacterium diphtheriae|url=https://www.cdc.gov/vaccines/pubs/pinkbook/downloads/dip.pdf|website=cdc.gov|accessdate=10 May 2017}}</ref><ref name="Current Developments in Biotechnology and Bioengineering"/> ||
 
|-
 
|-
−
| 1888 || Scientific development || French physicians [[wikipedia:Pierre Paul Émile Roux|Pierre Paul Émile Roux]] and [[wikipedia:Alexandre Yersin|Alexandre Yersin]], working at [[wikipedia:Pasteur Institute|Pasteur Institute]], discover the [[wikipedia:diphtheria toxin|diphtheria toxin]].<ref name="The Comprehensive Sourcebook of Bacterial Protein Toxins">{{cite book|last1=Ladant|first1=Daniel|last2=Alouf|first2=Joseph E.|last3=Popoff|first3=Michel R.|title=The Comprehensive Sourcebook of Bacterial Protein Toxins|url=The Comprehensive Sourcebook of Bacterial Protein Toxins|url=https://books.google.com.ar/books?id=gFol3jKI03EC&pg=PA4&lpg=PA4&dq=%22+Emile+Roux%22+%221888%22+%22diphtheria+toxin%22&source=bl&ots=uCjVueYEPm&sig=ECi9rW7RCyHsUbgPno8Az7emNZg&hl=en&sa=X&ved=0ahUKEwjF04uJ1uPTAhWDW5AKHby-AYQQ6AEIJTAA#v=onepage&q=%22%20Emile%20Roux%22%20%221888%22%20%22diphtheria%20toxin%22&f=false}}</ref> || [[wikipedia:France|France]]
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| 1884 || Scientific development || German bacteriologist [[wikipedia:Friedrich Loeffler|Friedrich Loeffler]] first grows ''[[wikipedia:Corynebacterium diphtheriae|corynebacterium diphtheriae]]'' in pure culture.<ref name="Diphtheria in Europe">{{cite web|last1=KWANTES|first1=W.|title=Diphtheria in Europe|url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2129475/pdf/jhyg00015-0039.pdf|website=nih.gov|accessdate=8 May 2017}}</ref><ref name="Diphtheria Facts">{{cite web|title=Diphtheria Facts|url=http://www.emedicinehealth.com/diphtheria/article_em.htm|website=emedicinehealth.com|accessdate=9 May 2017}}</ref><ref name="Corynebacterium diphtheriae"/><ref name="Current Developments in Biotechnology and Bioengineering"/> || [[wikipedia:Germany|Germany]]
 
|-
 
|-
−
| 1890 || Medical development || German physiologist [[wikipedia:Emil von Behring|Emil von Behring]] develops the first effective therapeutic serum against diphtheria. In 1901 Von Bering would be awarded the first [[wikipedia:Nobel Prize in Physiology or Medicine|Nobel Prize in Physiology or Medicine]] for this work.<ref name="Emil von Behring: The Founder of Serum Therapy">{{cite web|title=Emil von Behring: The Founder of Serum Therapy|url=https://www.nobelprize.org/nobel_prizes/medicine/laureates/1901/behring-article.html|website=nobelprize.org|accessdate=9 May 2017}}</ref><ref name="Vaccine Timeline"/> || [[wikipedia:Germany|Germany]]
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| 1888 || Scientific development || French physicians [[wikipedia:Pierre Paul Émile Roux|Pierre Paul Émile Roux]] and [[wikipedia:Alexandre Yersin|Alexandre Yersin]], working at [[wikipedia:Pasteur Institute|Pasteur Institute]], discover the [[wikipedia:diphtheria toxin|diphtheria toxin]].<ref name="The Comprehensive Sourcebook of Bacterial Protein Toxins">{{cite book|last1=Ladant|first1=Daniel|last2=Alouf|first2=Joseph E.|last3=Popoff|first3=Michel R.|title=The Comprehensive Sourcebook of Bacterial Protein Toxins|url=The Comprehensive Sourcebook of Bacterial Protein Toxins|url=https://books.google.com.ar/books?id=gFol3jKI03EC&pg=PA4&lpg=PA4&dq=%22+Emile+Roux%22+%221888%22+%22diphtheria+toxin%22&source=bl&ots=uCjVueYEPm&sig=ECi9rW7RCyHsUbgPno8Az7emNZg&hl=en&sa=X&ved=0ahUKEwjF04uJ1uPTAhWDW5AKHby-AYQQ6AEIJTAA#v=onepage&q=%22%20Emile%20Roux%22%20%221888%22%20%22diphtheria%20toxin%22&f=false}}</ref><ref name="Current Developments in Biotechnology and Bioengineering"/> || [[wikipedia:France|France]]
 
|-
 
|-
−
| 1891 || Medical development || The first successful therapeutic serum treatment of a child suffering from diphtheria is performed.<ref name="Emil von Behring: The Founder of Serum Therapy"/> ||  
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| 1890 || Medical development || Japanese bacteriologist [[wikipedia:Kitasato Shibasaburo|Kitasato Shibasaburo]], and German physiologist [[wikipedia:Emil von Behring|Emil von Behring]], successfully immunize guinea pigs with a heat-treated diphtheria toxin, thus creating the first effective therapeutic serum against diphtheria. In 1901 Von Bering would be awarded the first [[wikipedia:Nobel Prize in Physiology or Medicine|Nobel Prize in Physiology or Medicine]] for this work.<ref name="Emil von Behring: The Founder of Serum Therapy">{{cite web|title=Emil von Behring: The Founder of Serum Therapy|url=https://www.nobelprize.org/nobel_prizes/medicine/laureates/1901/behring-article.html|website=nobelprize.org|accessdate=9 May 2017}}</ref><ref name="Vaccine Timeline"/><ref name="Diphtheria, Tetanus (Lockjaw), and Pertussis (Whooping Cough) Cases and Deaths, and DTaP Vaccination Rates">{{cite web|title=Diphtheria, Tetanus (Lockjaw), and Pertussis (Whooping Cough) Cases and Deaths, and DTaP Vaccination Rates|url=http://vaccines.procon.org/view.resource.php?resourceID=005971|website=procon.org|accessdate=23 May 2017}}</ref> || [[wikipedia:Germany|Germany]] ([[wikipedia:Berlin|Berlin]])
 +
|-
 +
| 1891 || Medical development || The first successful therapeutic serum treatment of a child suffering from [[wikipedia:diphtheria|diphtheria]] is performed.<ref name="Emil von Behring: The Founder of Serum Therapy"/> ||  
 
|-
 
|-
 
| 1894 || Medical development || The production and marketing of the diphtheria therapeutic serum begins in Germany.<ref name="Emil von Behring: The Founder of Serum Therapy"/> || [[wikipedia:Germany|Germany]]
 
| 1894 || Medical development || The production and marketing of the diphtheria therapeutic serum begins in Germany.<ref name="Emil von Behring: The Founder of Serum Therapy"/> || [[wikipedia:Germany|Germany]]
 
|-
 
|-
−
| 1901 || Medical development || [[wikipedia:Emil von Behring|Emil von Behring]], for the first time, uses a diphtheria innoculation of bacteria with reduced virulence, hoping with this active immunization to help the body also produce antitoxins.<ref name="Emil von Behring: The Founder of Serum Therapy"/> || [[wikipedia:Germany|Germany]]
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| 1894 || || In Britain, the Burroughs-Wellcome pharmaceutical company begins producing diphtheria anti-toxin.<ref name="Manchester">{{cite book |title=The politics of vaccination : a global history |date=2017 |location=Manchester |isbn=978-1-5261-1088-6}}</ref> || {{w|United Kingdom}}
 +
|-
 +
| 1894 || Medical development || American pharmaceutical [[wikipedia:H. K. Mulford Company|H. K. Mulford Company]] of [[wikipedia:Philadelphia|Philadelphia]] starts production and testing of diphtheria antitoxin in the United States.<ref>{{cite book|title=A Brief History of Pharmacy: Humanity's Search for Wellness|edition=Virgil Schijns, Derek O'Hagan|url=https://books.google.com.ar/books?id=ab1mCgAAQBAJ&pg=PT237&lpg=PT237&dq=%22H.+K.+Mulford+Company%22+%22diphtheria+antitoxin%22+%22in+1895%22&source=bl&ots=xpOETd2nVe&sig=-l21t0pY67ItI0pUZkxJZM72544&hl=en&sa=X&ved=0ahUKEwjY1tXFw-bTAhWBUZAKHZoZBw0Q6AEIMjAE#v=onepage&q=%22H.%20K.%20Mulford%20Company%22%20%22diphtheria%20antitoxin%22%20%22in%201895%22&f=false|accessdate=11 May 2017}}</ref> || [[wikipedia:United States|United States]]
 +
|-
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| 1895 || Publication || Hermann M. Biggs publishes ''The New Treatment of Diphtheria''.<ref name="Bacteriology, c.1810-c.1917: Chronology of a Victorian Medical Advance">{{cite web|last1=Dyer, PhD|title=Bacteriology, c.1810-c.1917: Chronology of a Victorian Medical Advance|url=http://www.victorianweb.org/science/biology/bacteriology/chronology.html|website=victorianweb.org|accessdate=11 April 2018}}</ref> ||
 +
|-
 +
| 1901 || Medical development || {{w|Emil von Behring}}, for the first time, uses a diphtheria {{w|inoculation}} of bacteria with reduced virulence, hoping with this active immunization to help the body also produce antitoxins.<ref name="Emil von Behring: The Founder of Serum Therapy"/> || {{w|Germany}}
 +
|-
 +
| 1902 || || The Danish Statens Serum Institut (State Serum Institute or SSI) is established to produce diphtheria antitoxin.<ref name="Manchester"/>  || {{w|Denmark}}
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|-
 +
| 1904 || || || {{w|Emil von Behring}} establishes Behringwerke to produce diphtheria antitoxin.<ref name="Manchester"/> || {{w|Germany}}
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|-
 +
| 1905 || Medical development || Franklin Royer publishes a paper urging timely treatment for diphtheria and adequate doses of antitoxin.<ref name="Diphtheria :  Clinical Manifestations ,  Diagnosis ,  and Role  of Immunization In  Prevention"/> ||
 +
|-
 +
| 1907 || Medical development || Experiments start using a toxin–antitoxin (TAT) solution to induce protective immunity against diphtheria, under the assumption that the toxin would stimulate [[wikipedia:immunity|immunity]] and the antitoxin ([[wikipedia:antibody|antibodies]]) would counteract the toxicity of the toxin and prevent it from causing disease in the recipient.<ref name="State of the world’s vaccines and immunization">{{cite web|title=State of the world’s vaccines and immunization|url=http://apps.who.int/iris/bitstream/10665/44169/1/9789241563864_eng.pdf|website=who.int|accessdate=30 May 2017}}</ref> ||
 +
|-
 +
| 1907 || Campaign || Several cities in Europe and the United States begin immunization programs to administer the toxin–antitoxin (TAT) complex.<ref name="State of the world’s vaccines and immunization"/> || [[wikipedia:Europe|Europe]], [[wikipedia:United States|United States]]
 
|-
 
|-
 
| 1913 || Medical development || [[wikipedia:Emil von Behring|Emil von Behring]] publishes his diphtheria protective agent, T.A. (Toxin-Antitoxin), which contains a mixture of diphtheria toxin and therapeutic serum antitoxin. Designed to provide long-term protection, the new drug would further be tested at various clinics and proven to be non-harmful and effective.<ref name="Emil von Behring: The Founder of Serum Therapy"/> || [[wikipedia:Germany|Germany]]
 
| 1913 || Medical development || [[wikipedia:Emil von Behring|Emil von Behring]] publishes his diphtheria protective agent, T.A. (Toxin-Antitoxin), which contains a mixture of diphtheria toxin and therapeutic serum antitoxin. Designed to provide long-term protection, the new drug would further be tested at various clinics and proven to be non-harmful and effective.<ref name="Emil von Behring: The Founder of Serum Therapy"/> || [[wikipedia:Germany|Germany]]
 
|-
 
|-
−
| 1921 || Report || A high of 206,000 cases of diphtheria and 15,520 deaths (case-fatality ratio of 7.5%) are recorded in the United States.<ref name="Diphtheria: The Plague Among Children">{{cite web|title=Diphtheria: The Plague Among Children|url=https://www.historyofvaccines.org/timeline?timeline_categories[]=50|website=historyofvaccines.org|accessdate=8 May 2017}}</ref><ref name="Diphtheria. Symptoms and Causative Agent">{{cite web|title=Diphtheria. Symptoms and Causative Agent|url=https://www.historyofvaccines.org/content/articles/diphtheria|website=historyofvaccines.org|accessdate=10 May 2017}}</ref> || [[wikipedia:United States|United States]]
+
| 1921 || Report || A high of 206,000 cases of [[wikipedia:diphtheria|diphtheria]] and 15,520 deaths (case-fatality ratio of 7.5%) are recorded in the United States.<ref name="Diphtheria: The Plague Among Children">{{cite web|title=Diphtheria: The Plague Among Children|url=https://www.historyofvaccines.org/timeline?timeline_categories[]=50|website=historyofvaccines.org|accessdate=8 May 2017}}</ref><ref name="Diphtheria. Symptoms and Causative Agent">{{cite web|title=Diphtheria. Symptoms and Causative Agent|url=https://www.historyofvaccines.org/content/articles/diphtheria|website=historyofvaccines.org|accessdate=10 May 2017}}</ref> || [[wikipedia:United States|United States]]
 +
|-
 +
| 1923 || Scientific development || French biologist [[wikipedia:Gaston Ramon|Gaston Ramon]], working at [[wikipedia:Pasteur Institute|Pasteur Institute]], develops diphtheria toxoid that could later be used for a toxoid vaccination. The product is licensed; prepared from inactivated bacterial toxin that has lost its toxicity but retaining its antitoxin producing properties. This would be considered the first diphtheria vaccine.<ref name="Diphtheria, Tetanus (Lockjaw), and Pertussis (Whooping Cough) Cases and Deaths, and DTaP Vaccination Rates"/><ref name="Diphtheria :  Clinical Manifestations ,  Diagnosis ,  and Role  of Immunization In  Prevention"/><ref name="Vaccine Timeline"/>  || [[wikipedia:France|France]]
 +
|-
 +
| 1924 || Scientific development || [[wikipedia:Gaston Ramon|Gaston Ramon]] discovers diphtheria and tetanus toxoid, then referred to as ''anatoxins''.<ref>{{cite book|title=Medical Sciences - Volume I|edition=B.P. Mansourian, S.M. Mahfouz, A. Wojtezak|url=https://books.google.com.ar/books?id=Fb3VCwAAQBAJ&pg=PA124&dq=%221924%22+%22gaston+ramon%22+%22diphtheria%22&hl=en&sa=X&ved=0ahUKEwjfi-GgruPTAhVLgpAKHbY-BIIQ6AEIITAA#v=onepage&q=%221924%22%20%22gaston%20ramon%22%20%22diphtheria%22&f=false|accessdate=9 May 2017}}</ref> || [[wikipedia:France|France]]
 
|-
 
|-
−
| 1923 || Medical development || Diphtheria toxoid is licensed; prepared from inactivated bacterial toxin that has lost its toxicity but retains its antitoxin producing properties.<ref name="Vaccine Timeline"/> ||
+
| 1926 || Medical development || British immunologist [[wikipedia:Alexander Glenny|Alexander Glenny]], working at [[wikipedia:Wellcome Research Laboratories|Wellcome Research Laboratories]], develops the [[wikipedia:adjuvant|adjuvant]] (the substance that enhances the body's immune response to an antigen) for the toxoid vaccine by increasing the effectiveness of diphtheria toxoid when treating it with aluminum salts.<ref name="Diphtheria :  Clinical Manifestations ,  Diagnosis ,  and Role  of Immunization In  Prevention"/><ref name="Diphtheria, Tetanus (Lockjaw), and Pertussis (Whooping Cough) Cases and Deaths, and DTaP Vaccination Rates"/> || [[wikipedia:United Kingdom|United Kingdom]] ([[wikipedia:London|London]])
 
|-
 
|-
−
| 1924 || Scientific development || French biologist [[wikipedia:Gaston Ramon|Gaston Ramon]], working at Pasteur Institute, discoveres diphtheria and tetanus toxoid, then referred to as anatoxins.<ref>{{cite book|title=Medical Sciences - Volume I|edition=B.P. Mansourian, S.M. Mahfouz, A. Wojtezak|url=https://books.google.com.ar/books?id=Fb3VCwAAQBAJ&pg=PA124&dq=%221924%22+%22gaston+ramon%22+%22diphtheria%22&hl=en&sa=X&ved=0ahUKEwjfi-GgruPTAhVLgpAKHbY-BIIQ6AEIITAA#v=onepage&q=%221924%22%20%22gaston%20ramon%22%20%22diphtheria%22&f=false|accessdate=9 May 2017}}</ref> || [[wikipedia:France|France]]
+
| 1926 || Medical development || Fluid form of diphtheria toxoid is licensed in the United States.<ref name="Vaccines: A Biography">{{cite book|last1=Artenstein|first1=Andrew W.|title=Vaccines: A Biography|url=https://books.google.com.ar/books?id=ewdL8ilILZAC&pg=PA113&lpg=PA113&dq=%22zoeller%22+%22tetanus%22&source=bl&ots=bozaXpAwFE&sig=g682bYGBYp2gJTOfntduv7rlZ1w&hl=en&sa=X&ved=0ahUKEwi0kMf3gI7UAhVEDJAKHSPzAIwQ6AEIOzAF#v=onepage&q=%22zoeller%22%20%22tetanus%22&f=false|accessdate=26 May 2017}}</ref> || [[wikipedia:United States|United States]]
 +
|-
 +
| 1943 || Epidemic || Aproximately one million diphtheria cases and 50,000 deaths occur in Europe. A similar number of cases and deaths are believed to occur every year in developing countries at the time.<ref name="State of the world’s vaccines and immunization"/> ||
 
|-
 
|-
 
| 1947 || Medical development || Combination diphtheria and tetanus toxoids for pediatric use is first licensed in the United States.<ref name="Vaccine Timeline"/>  || [[wikipedia:United States|United States]]
 
| 1947 || Medical development || Combination diphtheria and tetanus toxoids for pediatric use is first licensed in the United States.<ref name="Vaccine Timeline"/>  || [[wikipedia:United States|United States]]
 +
|-
 +
| 1948 || Medical development || The [[wikipedia:pertussis|pertussis]] vaccine becomes available in combination with diphtheria and tetanus antigens (DTP).<ref name="State of the world’s vaccines and immunization"/> ||
 +
|-
 +
| 1949 || Medical development || American Microbiologist, Stephen Dyonis Elek develops the immuno diffusion technique, also called [[wikipedia:Elek's test|Elek's test]].  It is used to test for toxigenicity of ''[[wikipedia:corynebacterium diphtheriae|corynebacterium diphtheriae]]''.<ref name="The Plate Virulence Test for Diphtheria">{{cite web|last1=|title=The Plate Virulence Test for Diphtheria|url=http://jcp.bmj.com/content/2/4/250.long|website=bmj.com|accessdate=11 May 2017}}</ref> || [[wikipedia:United States|United States]]
 
|-
 
|-
 
| 1953 || Medical development || Tetanus and diphtheria toxoids (adult formulation) are first licensed in the United States, after the concentration of diphtheria toxoid is reduced.<ref name="Vaccine Timeline"/>  || [[wikipedia:United States|United States]]
 
| 1953 || Medical development || Tetanus and diphtheria toxoids (adult formulation) are first licensed in the United States, after the concentration of diphtheria toxoid is reduced.<ref name="Vaccine Timeline"/>  || [[wikipedia:United States|United States]]
Line 49: Line 164:
 
| 1964 || Policy || [[wikipedia:World Health Organization|World Health Organization]] recommendations for the production and quality control of diphtheria vaccines are first formulated.<ref name="Biologicals"/> ||
 
| 1964 || Policy || [[wikipedia:World Health Organization|World Health Organization]] recommendations for the production and quality control of diphtheria vaccines are first formulated.<ref name="Biologicals"/> ||
 
|-
 
|-
−
| 1971 || Epidemic || [[wikipedia:Seattle|Seattle]] experiences the last major diphtheria outbreak in the United States.<ref name="History in Focus: Diphtheria Epidemic">{{cite web|title=History in Focus: Diphtheria Epidemic|url=http://www.hampton.lib.nh.us/hampton/history/diphtheriaepidemicHU20080627.htm|website=hampton.lib.nh.us|accessdate=10 May 2017}}</ref> || [[wikipedia:United States|United States]]  
+
| 1971 || Epidemic || [[wikipedia:Seattle|Seattle]] experiences the last major [[wikipedia:diphtheria|diphtheria]] outbreak in the United States.<ref name="History in Focus: Diphtheria Epidemic">{{cite web|title=History in Focus: Diphtheria Epidemic|url=http://www.hampton.lib.nh.us/hampton/history/diphtheriaepidemicHU20080627.htm|website=hampton.lib.nh.us|accessdate=10 May 2017}}</ref> || [[wikipedia:United States|United States]]  
 
|-
 
|-
−
| 1974 || Program launch || Diphtheria toxoid combined with tetanus and pertussis vaccines (DTP) is included in the newly incepted WHO [[wikipedia:Expanded Program on Immunization|Expanded Programme on Immunization]].<ref name="Biologicals">{{cite web|title=Diphtheria|url=http://www.who.int/biologicals/vaccines/diphtheria/en/|website=who.int|accessdate=10 May 2017}}</ref> ||
+
| 1974 || Policy || Diphtheria toxoid combined with tetanus and pertussis vaccines (DTP) is included in the newly incepted [[wikipedia:World Health Organization|World Health Organization]] [[wikipedia:Expanded Program on Immunization|Expanded Programme on Immunization]].<ref name="Biologicals">{{cite web|title=Diphtheria|url=http://www.who.int/biologicals/vaccines/diphtheria/en/|website=who.int|accessdate=10 May 2017}}</ref><ref name="State of the world’s vaccines and immunization"/> ||
 
|-
 
|-
 
| 1974 || Epidemic || Diphtheria epidemic breaks out in [[wikipedia:Lisbon|Lisbon]]. 500 persons are involved, and about 40 deaths are recorded.<ref name="Diphtheria in Europe"/> || [[wikipedia:Portugal|Portugal]]
 
| 1974 || Epidemic || Diphtheria epidemic breaks out in [[wikipedia:Lisbon|Lisbon]]. 500 persons are involved, and about 40 deaths are recorded.<ref name="Diphtheria in Europe"/> || [[wikipedia:Portugal|Portugal]]
Line 57: Line 172:
 
| 1982 || Epidemic || 5 deaths are recorded in Germany during a diphtheria outbreak.<ref name="Diphtheria in Europe"/> || [[wikipedia:Germany|Germany]]
 
| 1982 || Epidemic || 5 deaths are recorded in Germany during a diphtheria outbreak.<ref name="Diphtheria in Europe"/> || [[wikipedia:Germany|Germany]]
 
|-
 
|-
−
| 1990-1998 || Epidemic || Massive diphtheria epidemic breaks out in the ex-Spviet Union. Starting in Russia, the outbreak reaches the Newly Independent States in 1991.<ref name="Diphtheria Outbreak -- Russian Federation, 1990-1993">{{cite web|title=Diphtheria Outbreak -- Russian Federation, 1990-1993|url=https://www.cdc.gov/mmwr/preview/mmwrhtml/00022128.htm|website=cdc.gov|accessdate=10 May 2017}}</ref><ref name="History in Focus: Diphtheria Epidemic"> ||  
+
| 1990-1998 || Epidemic || Massive diphtheria epidemic breaks out in the ex-Soviet Union. Starting in [[wikipedia:Russia|Russia]], the outbreak reaches the [[wikipedia:Post-Soviet states|Newly Independent States]] in 1991. By 1998, the [[wikipedia:Red Cross|Red Cross]] estimates as many as 200,000 cases, with 5,000 deaths in the region.<ref>{{cite web|title=Diphtheria|url=http://the-medical-dictionary.com/diphtheria.htm|website=the-medical-dictionary.com|accessdate=11 May 2017}}</ref><ref name="Diphtheria Outbreak -- Russian Federation, 1990-1993">{{cite web|title=Diphtheria Outbreak -- Russian Federation, 1990-1993|url=https://www.cdc.gov/mmwr/preview/mmwrhtml/00022128.htm|website=cdc.gov|accessdate=10 May 2017}}</ref><ref name="History in Focus: Diphtheria Epidemic"/> || [[wikipedia:Post-Soviet states|Post-Soviet states]]
 +
|-
 +
| 1993 || Organization || The European Laboratory Working Group on Diphtheria (ELWGD) is formed as a result of the epidemic situation in [[wikipedia:Eastern Europe|Eastern Europe]].<ref>{{cite book|last1=Wheeler|first1=Ben S.|title=Trends in Diphtheria Research|url=https://books.google.com.ar/books?id=sucL_unjKVwC&pg=PA7&lpg=PA7&dq=Diphtheria&source=bl&ots=GrSGrV50fd&sig=ne3p8FCGbAXTdLIyO7K8wG52ZRw&hl=en&sa=X&ved=0ahUKEwiwv9WGzujTAhUFDZAKHdtFDygQ6AEIgAEwBQ#v=onepage&q=Diphtheria&f=false|accessdate=12 May 2017}}</ref> ||
 
|-
 
|-
−
| 1996 || Medical development || Lederle Laboratories licenses diphtheria and tetanus toxoids and acellular pertussis vaccine Acel-Imune, for use as the first through fifth doses in the series.<ref name="Vaccine Timeline"/> ||
+
| 1996 || Medical development || Lederle Laboratories licenses diphtheria and tetanus toxoids, and acellular pertussis vaccine Acel-Imune, for use as the first through fifth doses in the series.<ref name="Vaccine Timeline"/> ||
 
|-
 
|-
 
| 1997 || Medical development || British pharmaceutical company [[wikipedia:GlaxoSmithKline|SmithKline Beecham]] licenses Infanrix (diphtheria and tetanus toxoids and acellular pertussis vaccine adsorbed), for the first four doses of the series.<ref name="Vaccine Timeline"/> ||
 
| 1997 || Medical development || British pharmaceutical company [[wikipedia:GlaxoSmithKline|SmithKline Beecham]] licenses Infanrix (diphtheria and tetanus toxoids and acellular pertussis vaccine adsorbed), for the first four doses of the series.<ref name="Vaccine Timeline"/> ||
Line 75: Line 192:
 
| 2005 || Medical development || [[wikipedia:Sanofi Pasteur|Sanofi Pasteur]] licenses [[wikipedia:Menactra|Menactra]], the first meningococcal polysaccharide (Serogroups A, C, Y and W-135) diphtheria toxoid conjugate vaccine. This would be the first immunogenic meningococcal vaccine indicated for children younger than 2 years of age.<ref name="Vaccine Timeline"/> ||
 
| 2005 || Medical development || [[wikipedia:Sanofi Pasteur|Sanofi Pasteur]] licenses [[wikipedia:Menactra|Menactra]], the first meningococcal polysaccharide (Serogroups A, C, Y and W-135) diphtheria toxoid conjugate vaccine. This would be the first immunogenic meningococcal vaccine indicated for children younger than 2 years of age.<ref name="Vaccine Timeline"/> ||
 
|-
 
|-
−
| 2007 || Report || 4,190 cases of diphtheria are reported globally.<ref name="Diphtheria: The Plague Among Children"/> ||
+
| 2007 || Report || 4,190 cases of [[wikipedia:diphtheria|diphtheria]] are reported globally.<ref name="Diphtheria: The Plague Among Children"/> ||
 
|-
 
|-
−
| 2011 || Medical development || United States [[wikipedia:Food and Drug Administration|Food and Drug Administration]] approves Boostrix (developed by [[wikipedia:GlaxoSmithKline|GlaxoSmithKline]]) to prevent [[wikipedia:tetanus|tetanus]], diphtheria, and [[wikipedia:pertussis|pertussis]] in older people.<ref name="Vaccine Timeline">{{cite web|title=Vaccine Timeline|url=http://www.immunize.org/timeline/|website=immunize.org|accessdate=8 May 2017}}</ref> || [[wikipedia:United States|United States]]
+
| 2011 || Medical development || United States [[wikipedia:Food and Drug Administration|Food and Drug Administration]] approves Boostrix (developed by [[wikipedia:GlaxoSmithKline|GlaxoSmithKline]]) to prevent tetanus, [[wikipedia:diphtheria|diphtheria]], and pertussis in older people.<ref name="Vaccine Timeline">{{cite web|title=Vaccine Timeline|url=http://www.immunize.org/timeline/|website=immunize.org|accessdate=8 May 2017}}</ref> || [[wikipedia:United States|United States]]
 +
|-
 +
| 2016 || Epidemic || Diphtheria reemerges in Venezuela. A cumulative total of 324 diphtheria cases are reported in the country.<ref>{{cite web|title=Venezuela releases 1st Epi bulletin in a long time: Malaria and diphtheria summary|url=http://outbreaknewstoday.com/venezuela-releases-1st-epi-bulletin-long-time-malaria-diphtheria-summary-94649/|website=outbreaknewstoday.com|accessdate=12 May 2017}}</ref> || [[wikipedia:Venezuela|Venezuela]]
 +
|-
 +
| 2017 || Report || [[wikipedia:World Health Organization|World Health Organization]] vaccine advisors report diphtheria as a "newly neglected disease that still resides among the cracks of the most privileged health systems."<ref>{{cite web|title=WHO vaccine advisors weigh in on polio, cholera, Ebola, diphtheria|url=http://www.cidrap.umn.edu/news-perspective/2017/04/who-vaccine-advisors-weigh-polio-cholera-ebola-diphtheria|website=umn.edu|accessdate=12 May 2017}}</ref> ||
 
|-
 
|-
 
|}
 
|}
  
 
==See also==
 
==See also==
 +
 +
* [[Timeline of tetanus]]
 +
 +
== References ==

Latest revision as of 11:27, 12 November 2021

This is a timeline of diphtheria, describing major events such as epidemics and medical developments.

Big picture

Year/period Key developments
Ancient times Earliy detailed descriptions of dyphtheria date from ancient Syrian, Egyptian, and Greek writings.[1]
1600s onward Diphtheria infection grows significantly since the 17th century and becomes one of the major causes of death, fuelled by the Industrial Revolution and increasingly crowded urban centers.[2]
1800s Major scientific breakthroughs consolidate the knowledge on diphtheria, which is given its actual name in this century[2]. Bacterium corynebacterium diphtheriae and the diphtheria toxin are discovered.[3][4] Also, the first effective therapeutic serum against diphtheria is developed.[5]
1923 onward After the first diphtheria toxoid vaccine is developed, its subsequent widespread use would lead to a dramatic decrease of diphtheria rates worldwide.[6][7] A more than 90% decrease in number of cases globally results later, between 1980 and 2000.[8]
Recent years Currently most diphtheria cases occur in Sub-Sharan Africa, India, and Indonesia. Globally 4,530 cases were officially reported in 2015, down from nearly 100,000 in 1980.[9][8]

Numerical and visual data

Mentions on Google Scholar

The following table summarizes per-year mentions on Google Scholar as of May 22, 2021.

Year diphtheria diphtheria toxin diphtheria vaccine diphtheria prevention diphtheria treatment
1980 1,230 471 298 264 676
1985 1,800 769 600 467 975
1990 2,000 747 784 607 1,150
1995 2,700 1,150 1,080 842 1,560
2000 4,150 1,730 1,850 1,660 2,630
2002 5,020 2,450 2,510 2,350 3,360
2004 5,980 2,210 3,170 2,890 4,080
2006 7,060 2,750 3,060 3,000 4,600
2008 11,600 3,650 4,160 4,940 8,250
2010 7,540 3,150 3,810 3,880 5,050
2012 9,740 4,000 5,090 4,750 6,820
2014 10,100 4,160 5,260 4,790 6,970
2016 10,300 4,250 5,010 4,730 7,090
2017 10,500 4,270 5,110 4,830 7,250
2018 10,900 4,310 5,500 5,050 7,500
2019 10,800 4,160 5,620 5,170 7,440
2020 11,000 4,680 5,920 5,830 8,240
Diphteria tb.png

Google Trends

The comparative chart below shows Google Trends data for Diphtheria (Search Term) and Diphtheria (Topic), from January 2004 to February 2021, when the screenshot was taken. Interest in the topic is also ranked by country and displayed on world map.[10]

Diphtheria gt.jpg


Google Ngram Viewer

The chart below shows Google Ngram Viewer data for Diphtheria, from 1800 to 2019.[11]

Diphtheria ngram.jpg

Wikipedia Views

The chart below shows pageviews of the English Wikipedia article Diphtheria, on desktop, mobile-web, desktop-spider, mobile-web-spider and mobile app, from July 2015; to January 2021.[12]

Diphtheria wv.jpg

Other

Global diphtheria cases reported by the World Health Organization in the period (1980-2015). Local maxima around mid-1990s correlate with large epidemic in the Post-Soviet states.
Diphtheria cases and deaths per year in the United States. Period (1950-2013).
Diphtheria cases and deaths per year in the United States. Period (1950-2013). Logarithmic scale.

Full timeline

Year/period Type of event Event Present time geographical location
5th century BC Scientific development Diphtheria is first described by Greek physician Hippocrates.[13][14] Greece
1600s Scientific development Medical reports of a "deadly" strangulation disease first appear early in the century, and emerges as a greater threat with the growth of urbanizations.[2][14]
1613 Epidemic diphtheria epidemic in Spain causes the year to be named "El año de los Garotillos" ("year of strangulations"), due to the many deaths caused by diphtheria suffocation.[15] Spain
1771 Medical development American physician Samuel Bard publishes An Enquiry into the Nature, Cause and Cure, of the Angina Suffocativa, or, Sore Throat Distemper, one of the earliest accurate descriptions of diphtheria as well as one of the first original contributions to pediatrics made by an American.[16] United States
1826 Scientific development French physician Pierre Bretonneau gives diphtheria its official name diphtérite, derived from the Greek word for "leather" or "hide", which describes the pseudomembrane in the throat of the victims.[2][17][15][1]
1856 Epidemic San Francisco doctor Victor Fourgeaud describes an epidemic of diphtheria in California.[8] United States
1883 Scientific development Swiss pathologist Edwin Klebs first observes the bacterium corynebacterium diphtheriae in diphtheritic membranes.[14][15]
1884 Scientific development German bacteriologist Friedrich Loeffler first grows corynebacterium diphtheriae in pure culture.[3][6][14][15] Germany
1888 Scientific development French physicians Pierre Paul Émile Roux and Alexandre Yersin, working at Pasteur Institute, discover the diphtheria toxin.[4][15] France
1890 Medical development Japanese bacteriologist Kitasato Shibasaburo, and German physiologist Emil von Behring, successfully immunize guinea pigs with a heat-treated diphtheria toxin, thus creating the first effective therapeutic serum against diphtheria. In 1901 Von Bering would be awarded the first Nobel Prize in Physiology or Medicine for this work.[5][18][19] Germany (Berlin)
1891 Medical development The first successful therapeutic serum treatment of a child suffering from diphtheria is performed.[5]
1894 Medical development The production and marketing of the diphtheria therapeutic serum begins in Germany.[5] Germany
1894 In Britain, the Burroughs-Wellcome pharmaceutical company begins producing diphtheria anti-toxin.[20] United Kingdom
1894 Medical development American pharmaceutical H. K. Mulford Company of Philadelphia starts production and testing of diphtheria antitoxin in the United States.[21] United States
1895 Publication Hermann M. Biggs publishes The New Treatment of Diphtheria.[22]
1901 Medical development Emil von Behring, for the first time, uses a diphtheria inoculation of bacteria with reduced virulence, hoping with this active immunization to help the body also produce antitoxins.[5] Germany
1902 The Danish Statens Serum Institut (State Serum Institute or SSI) is established to produce diphtheria antitoxin.[20] Denmark
1904 Emil von Behring establishes Behringwerke to produce diphtheria antitoxin.[20] Germany
1905 Medical development Franklin Royer publishes a paper urging timely treatment for diphtheria and adequate doses of antitoxin.[8]
1907 Medical development Experiments start using a toxin–antitoxin (TAT) solution to induce protective immunity against diphtheria, under the assumption that the toxin would stimulate immunity and the antitoxin (antibodies) would counteract the toxicity of the toxin and prevent it from causing disease in the recipient.[1]
1907 Campaign Several cities in Europe and the United States begin immunization programs to administer the toxin–antitoxin (TAT) complex.[1] Europe, United States
1913 Medical development Emil von Behring publishes his diphtheria protective agent, T.A. (Toxin-Antitoxin), which contains a mixture of diphtheria toxin and therapeutic serum antitoxin. Designed to provide long-term protection, the new drug would further be tested at various clinics and proven to be non-harmful and effective.[5] Germany
1921 Report A high of 206,000 cases of diphtheria and 15,520 deaths (case-fatality ratio of 7.5%) are recorded in the United States.[23][24] United States
1923 Scientific development French biologist Gaston Ramon, working at Pasteur Institute, develops diphtheria toxoid that could later be used for a toxoid vaccination. The product is licensed; prepared from inactivated bacterial toxin that has lost its toxicity but retaining its antitoxin producing properties. This would be considered the first diphtheria vaccine.[19][8][18] France
1924 Scientific development Gaston Ramon discovers diphtheria and tetanus toxoid, then referred to as anatoxins.[25] France
1926 Medical development British immunologist Alexander Glenny, working at Wellcome Research Laboratories, develops the adjuvant (the substance that enhances the body's immune response to an antigen) for the toxoid vaccine by increasing the effectiveness of diphtheria toxoid when treating it with aluminum salts.[8][19] United Kingdom (London)
1926 Medical development Fluid form of diphtheria toxoid is licensed in the United States.[26] United States
1943 Epidemic Aproximately one million diphtheria cases and 50,000 deaths occur in Europe. A similar number of cases and deaths are believed to occur every year in developing countries at the time.[1]
1947 Medical development Combination diphtheria and tetanus toxoids for pediatric use is first licensed in the United States.[18] United States
1948 Medical development The pertussis vaccine becomes available in combination with diphtheria and tetanus antigens (DTP).[1]
1949 Medical development American Microbiologist, Stephen Dyonis Elek develops the immuno diffusion technique, also called Elek's test. It is used to test for toxigenicity of corynebacterium diphtheriae.[27] United States
1953 Medical development Tetanus and diphtheria toxoids (adult formulation) are first licensed in the United States, after the concentration of diphtheria toxoid is reduced.[18] United States
1964 Policy World Health Organization recommendations for the production and quality control of diphtheria vaccines are first formulated.[28]
1971 Epidemic Seattle experiences the last major diphtheria outbreak in the United States.[29] United States
1974 Policy Diphtheria toxoid combined with tetanus and pertussis vaccines (DTP) is included in the newly incepted World Health Organization Expanded Programme on Immunization.[28][1]
1974 Epidemic Diphtheria epidemic breaks out in Lisbon. 500 persons are involved, and about 40 deaths are recorded.[3] Portugal
1982 Epidemic 5 deaths are recorded in Germany during a diphtheria outbreak.[3] Germany
1990-1998 Epidemic Massive diphtheria epidemic breaks out in the ex-Soviet Union. Starting in Russia, the outbreak reaches the Newly Independent States in 1991. By 1998, the Red Cross estimates as many as 200,000 cases, with 5,000 deaths in the region.[30][31][29] Post-Soviet states
1993 Organization The European Laboratory Working Group on Diphtheria (ELWGD) is formed as a result of the epidemic situation in Eastern Europe.[32]
1996 Medical development Lederle Laboratories licenses diphtheria and tetanus toxoids, and acellular pertussis vaccine Acel-Imune, for use as the first through fifth doses in the series.[18]
1997 Medical development British pharmaceutical company SmithKline Beecham licenses Infanrix (diphtheria and tetanus toxoids and acellular pertussis vaccine adsorbed), for the first four doses of the series.[18]
1998 Medical development North American Vaccine Inc licenses Certiva (diphtheria and tetanus toxoids and acellular pertussis vaccine adsorbed), for boosting immunization of infants and children.[18]
1999 Medical development Connaught Laboratories licenses diphtheria and tetanus toxoids and acellular pertussis vaccine Tripedia.[18]
2002 Medical development British pharmaceutical GlaxoSmithKline licenses Pediarix, a vaccine combining diphtheria, tetanus, acellular pertussis, inactivated polio, and hepatitis B antigens.[18]
2002 Medical development Aventis Pasteur licenses diphtheria and tetanus toxoids and acellular pertussis vaccine Daptacel.[18]
2004 Medical development Aventis Pasteur licenses vaccine Decavac, indicated for active immunization against tetanus and diphtheria.[18][33]
2005 Medical development Sanofi Pasteur licenses Menactra, the first meningococcal polysaccharide (Serogroups A, C, Y and W-135) diphtheria toxoid conjugate vaccine. This would be the first immunogenic meningococcal vaccine indicated for children younger than 2 years of age.[18]
2007 Report 4,190 cases of diphtheria are reported globally.[23]
2011 Medical development United States Food and Drug Administration approves Boostrix (developed by GlaxoSmithKline) to prevent tetanus, diphtheria, and pertussis in older people.[18] United States
2016 Epidemic Diphtheria reemerges in Venezuela. A cumulative total of 324 diphtheria cases are reported in the country.[34] Venezuela
2017 Report World Health Organization vaccine advisors report diphtheria as a "newly neglected disease that still resides among the cracks of the most privileged health systems."[35]

See also

References

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 "State of the world's vaccines and immunization" (PDF). who.int. Retrieved 30 May 2017. 
  2. ↑ 2.0 2.1 2.2 2.3 "The strangler". museumofhealthcare.ca. Retrieved 9 May 2017. 
  3. ↑ 3.0 3.1 3.2 3.3 KWANTES, W. "Diphtheria in Europe" (PDF). nih.gov. Retrieved 8 May 2017. 
  4. ↑ 4.0 4.1 Ladant, Daniel; Alouf, Joseph E.; Popoff, Michel R. The Comprehensive Sourcebook of Bacterial Protein Toxins. 
  5. ↑ 5.0 5.1 5.2 5.3 5.4 5.5 "Emil von Behring: The Founder of Serum Therapy". nobelprize.org. Retrieved 9 May 2017. 
  6. ↑ 6.0 6.1 "Diphtheria Facts". emedicinehealth.com. Retrieved 9 May 2017. 
  7. ↑ "Clinicians". cdc.gov. Retrieved 10 May 2017. 
  8. ↑ 8.0 8.1 8.2 8.3 8.4 8.5 "Diphtheria : Clinical Manifestations , Diagnosis , and Role of Immunization In Prevention" (PDF). iosrjournals.org. Retrieved 10 May 2017. 
  9. ↑ "Diphtheria reported cases". who.int. Retrieved 12 May 2017. 
  10. ↑ "Diphtheria". Google Trends. Retrieved 15 February 2021. 
  11. ↑ "Diphtheria". books.google.com. Retrieved 16 February 2021. 
  12. ↑ "Diphtheria". wikipediaviews.org. Retrieved 21 February 2021. 
  13. ↑ "Diphtheria". medscape.com. Retrieved 8 May 2017. 
  14. ↑ 14.0 14.1 14.2 14.3 "Corynebacterium diphtheriae" (PDF). cdc.gov. Retrieved 10 May 2017. 
  15. ↑ 15.0 15.1 15.2 15.3 15.4 Current Developments in Biotechnology and Bioengineering: Human and Animal Health Applications (Vanete Thomaz Soccol, Ashok Pandey, Rodrigo R. Resende ed.). Retrieved 10 May 2017. 
  16. ↑ "Archives & Special Collections Acquires Samuel Bard Work". columbia.edu. Retrieved 11 May 2017. 
  17. ↑ "Pierre Bretonneau". historyofvaccines.org. Retrieved 9 May 2017. 
  18. ↑ 18.00 18.01 18.02 18.03 18.04 18.05 18.06 18.07 18.08 18.09 18.10 18.11 18.12 "Vaccine Timeline". immunize.org. Retrieved 8 May 2017. 
  19. ↑ 19.0 19.1 19.2 "Diphtheria, Tetanus (Lockjaw), and Pertussis (Whooping Cough) Cases and Deaths, and DTaP Vaccination Rates". procon.org. Retrieved 23 May 2017. 
  20. ↑ 20.0 20.1 20.2 The politics of vaccination : a global history. Manchester. 2017. ISBN 978-1-5261-1088-6. 
  21. ↑ A Brief History of Pharmacy: Humanity's Search for Wellness (Virgil Schijns, Derek O'Hagan ed.). Retrieved 11 May 2017. 
  22. ↑ Dyer, PhD. "Bacteriology, c.1810-c.1917: Chronology of a Victorian Medical Advance". victorianweb.org. Retrieved 11 April 2018. 
  23. ↑ 23.0 23.1 "Diphtheria: The Plague Among Children". historyofvaccines.org. Retrieved 8 May 2017. 
  24. ↑ "Diphtheria. Symptoms and Causative Agent". historyofvaccines.org. Retrieved 10 May 2017. 
  25. ↑ Medical Sciences - Volume I (B.P. Mansourian, S.M. Mahfouz, A. Wojtezak ed.). Retrieved 9 May 2017. 
  26. ↑ Artenstein, Andrew W. Vaccines: A Biography. Retrieved 26 May 2017. 
  27. ↑ "The Plate Virulence Test for Diphtheria". bmj.com. Retrieved 11 May 2017. 
  28. ↑ 28.0 28.1 "Diphtheria". who.int. Retrieved 10 May 2017. 
  29. ↑ 29.0 29.1 "History in Focus: Diphtheria Epidemic". hampton.lib.nh.us. Retrieved 10 May 2017. 
  30. ↑ "Diphtheria". the-medical-dictionary.com. Retrieved 11 May 2017. 
  31. ↑ "Diphtheria Outbreak -- Russian Federation, 1990-1993". cdc.gov. Retrieved 10 May 2017. 
  32. ↑ Wheeler, Ben S. Trends in Diphtheria Research. Retrieved 12 May 2017. 
  33. ↑ "HIGHLIGHTS OF PRESCRIBING INFORMATION" (PDF). vaccineshoppe.com. Retrieved 8 May 2017. 
  34. ↑ "Venezuela releases 1st Epi bulletin in a long time: Malaria and diphtheria summary". outbreaknewstoday.com. Retrieved 12 May 2017. 
  35. ↑ "WHO vaccine advisors weigh in on polio, cholera, Ebola, diphtheria". umn.edu. Retrieved 12 May 2017. 
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