Difference between revisions of "Timeline of fats"

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| 1913 || Scientific development || {{w|Cholesterol}}, {{w|atherosclerosis}} || || Russian pathologist {{w|Nikolay Anichkov}} demonstrates that cholesterol and fat gives rise to atherosclerotic changes in the vessel walls of rabbits, and atherosclerosis occurs by direct deposition of fat in the vascular wall.<ref name="Demeester"/><ref>{{cite journal |last1=Konstantinov |first1=IE |last2=Mejevoi |first2=N |last3=Anichkov |first3=NM |title=Nikolai N. Anichkov and his theory of atherosclerosis. |journal=Texas Heart Institute journal |date=2006 |volume=33 |issue=4 |pages=417-23 |pmid=17215962}}</ref> || {{w|Russia}}
 
| 1913 || Scientific development || {{w|Cholesterol}}, {{w|atherosclerosis}} || || Russian pathologist {{w|Nikolay Anichkov}} demonstrates that cholesterol and fat gives rise to atherosclerotic changes in the vessel walls of rabbits, and atherosclerosis occurs by direct deposition of fat in the vascular wall.<ref name="Demeester"/><ref>{{cite journal |last1=Konstantinov |first1=IE |last2=Mejevoi |first2=N |last3=Anichkov |first3=NM |title=Nikolai N. Anichkov and his theory of atherosclerosis. |journal=Texas Heart Institute journal |date=2006 |volume=33 |issue=4 |pages=417-23 |pmid=17215962}}</ref> || {{w|Russia}}
 
|-
 
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| 1918 || Scientific development || || || German physician Hans Aron in {{w|Breslau}} is arguably the first to suggest that fats have nutritional functions other than provision of food energy.<ref name="CRC Press">{{cite book |last1=Lees |first1=Robert S. |title=Omega-3 Fatty Acids in Health and Disease |date=24 July 2020 |publisher=CRC Press |isbn=978-1-000-14759-9 |url=https://books.google.com.ar/books?id=KC_wDwAAQBAJ&pg=PT93&lpg=PT93&dq=Omega-3+fatty+acid+%22in+1900..1950%22&source=bl&ots=FW5KE67oP2&sig=ACfU3U1nnFDYRh-Fki27f8UinWwQBz4EZQ&hl=en&sa=X&ved=2ahUKEwio_-3N5-rzAhU9pZUCHaU0BAoQ6AF6BAgWEAM#v=onepage&q=Omega-3%20fatty%20acid%20%22in%201900..1950%22&f=false |language=en}}</ref><ref name="Valenzuela">{{cite journal |last1=Uauy |first1=Ricardo |last2=Valenzuela |first2=Alfonso |title=Marine oils: the health benefits of n-3 fatty acids |journal=Nutrition |date=July 2000 |volume=16 |issue=7-8 |pages=680–684 |doi=10.1016/s0899-9007(00)00326-9}}</ref><ref>Aron H. Uber den nahrwert. Biochem Z 1918</ref> This is the first evidence of the existence of fatty acids.<ref name="Essential fatty a">{{cite web |title=Essential fatty acids: definition, functions, and foods |url=https://www.tuscany-diet.net/2012/08/16/essential-fatty-acids/ |website=Tuscany Diet |access-date=29 October 2021 |date=16 August 2012}}</ref><ref name="Spectorv">{{cite journal |last1=Spector |first1=Arthur A. |last2=Kim |first2=Hee-Yong |title=Discovery of essential fatty acids |journal=Journal of Lipid Research |date=January 2015 |volume=56 |issue=1 |pages=11–21 |doi=10.1194/jlr.R055095}}</ref> "The first indication that dietary fat may be essential for healthy growing animals was presented in 1918 by Aron (1918) who proposed that butter has a nutrient value that cannot be provided by other dietary components."<ref name="CRC Pr"/> || {{w|Germany}}
+
| 1918 || Scientific development || Fat as nutrient || || German physician Hans Aron in {{w|Breslau}} is arguably the first to suggest that fats have nutritional functions other than provision of food energy.<ref name="CRC Press">{{cite book |last1=Lees |first1=Robert S. |title=Omega-3 Fatty Acids in Health and Disease |date=24 July 2020 |publisher=CRC Press |isbn=978-1-000-14759-9 |url=https://books.google.com.ar/books?id=KC_wDwAAQBAJ&pg=PT93&lpg=PT93&dq=Omega-3+fatty+acid+%22in+1900..1950%22&source=bl&ots=FW5KE67oP2&sig=ACfU3U1nnFDYRh-Fki27f8UinWwQBz4EZQ&hl=en&sa=X&ved=2ahUKEwio_-3N5-rzAhU9pZUCHaU0BAoQ6AF6BAgWEAM#v=onepage&q=Omega-3%20fatty%20acid%20%22in%201900..1950%22&f=false |language=en}}</ref><ref name="Valenzuela">{{cite journal |last1=Uauy |first1=Ricardo |last2=Valenzuela |first2=Alfonso |title=Marine oils: the health benefits of n-3 fatty acids |journal=Nutrition |date=July 2000 |volume=16 |issue=7-8 |pages=680–684 |doi=10.1016/s0899-9007(00)00326-9}}</ref><ref>Aron H. Uber den nahrwert. Biochem Z 1918</ref> This is the first evidence of the existence of fatty acids.<ref name="Essential fatty a">{{cite web |title=Essential fatty acids: definition, functions, and foods |url=https://www.tuscany-diet.net/2012/08/16/essential-fatty-acids/ |website=Tuscany Diet |access-date=29 October 2021 |date=16 August 2012}}</ref><ref name="Spectorv">{{cite journal |last1=Spector |first1=Arthur A. |last2=Kim |first2=Hee-Yong |title=Discovery of essential fatty acids |journal=Journal of Lipid Research |date=January 2015 |volume=56 |issue=1 |pages=11–21 |doi=10.1194/jlr.R055095}}</ref> "The first indication that dietary fat may be essential for healthy growing animals was presented in 1918 by Aron (1918) who proposed that butter has a nutrient value that cannot be provided by other dietary components."<ref name="CRC Pr"/> || {{w|Germany}}
 
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| 1918 || Scientific development || Continuous centrifuge || || Continuous centrifuge is patented as a method to separate both solids and immiscible liquids.<ref name="Ahmad"/> ||  
 
| 1918 || Scientific development || Continuous centrifuge || || Continuous centrifuge is patented as a method to separate both solids and immiscible liquids.<ref name="Ahmad"/> ||  

Revision as of 15:24, 30 November 2021

This is a timeline of fats, attempting to describe the variety of fats, including saturated, unsaturated, trans fats, and interesterified fats.

Sample questions

The following are some interesting questions that can be answered by reading this timeline:

  • Scientific development
  • What are some of the increasing regulations having been imposed across the world on the use of fats in food products?
    • Sort the full timeline by "Event type" and look for the group of rows with value "Policy".
  • What are some notable or illustrative publications on the topic of fats?
    • Sort the full timeline by "Event type" and look for the group of rows with value "Literature".
  • What are some notable recommendations of fat intake issued by competent entities?
    • Sort the full timeline by "Event type" and look for the group of rows with value "Recommendation".
    • "Program launch"
  • What are some notable events describing the industrialization of fats for mass consumption?
    • Sort the full timeline by "Event type" and look for the group of rows with value "Industrial development".

Big picture

Time period Development summary More details
Ancient times Early history Fatty acids are used already in very early times, specifically in the preparation of soap. The ancient Babylonians use soap as early as 2500 BC. By 800 AD–900 AD, the soap industry is well established in Germany and France.[1]
18th–19th centuries Early scientific development Cholesterol in solid form is identified in the 18th century. In the 19th century Michel Eugène Chevreul stands out for his prolific research on fats. In the 19th century, one of the most important discoveries is the introduction of an industrially relevant method to split fats and oils into fatty acids and glycerin.[1]
20th century (first half) Recognition of fat importance Dietary fat is recognized as a good source of energy and fat-soluble vitamins by the first part of the century.[2] Proteins and carbohydrates are known to be indispensable dietary components by the first decade.[2] In the 1920s, industrial hydrogenation of edible oils develops in Europe and the United States.[3] During the first half of the century, higher-fat milk and dairy products were more costly.[4] Lipases and colipases are isolated and characterized.[4] In the 1930s Burr and Burr demonstrate the concept that some fatty acids may be necessary for the proper growth and development of animals.[5] Concern over the health impacts of trans fats first emerge in the 1940s.[6]
20th century (second half) Recognition of potencial harm Research on trans fatty acids begin in the 1950s.[7] By the late 1950s, scientists demonstrate a clear link between the intake of saturated fat and heart disease,[6][8] while health advocates start proposing a reduction saturated fats, such as in butter and beef, from the diets, which propells the use of margarine instead, a trend that would increase abruptly toward the 1980s.[9] In the 1960s, essential fatty acids start being considered of importance in human nutrition.[5] In the 1980s, an association between high intake of saturated fat and increased risk of heart disease is firmly established.[6] In the 1990s, evidence emerges indicating that trans fats carry a higher risk for heart disease than saturated fats.[6] Several studies conducted in this decade show a connection between trans fat and increased levels of bad cholesterol.[9]
2000s Policy enforcement In the early decade, health agencies in various countries worldwide recognize the need to introduce regulations controlling the amount of trans fats used in manufactured foods.[6]

Numerical and visual data

Google Scholar

The following table summarizes per-year mentions on Google Scholar as of October 6, 2021.

Year "trans fat" "saturated fat" "fatty acid" "triglyceride"
1900 1 2 52 19
1910 0 4 123 9
1920 0 1 171 13
1930 1 6 261 21
1940 1 14 399 41
1950 0 14 811 80
1960 2 72 2,060 376
1970 1 157 5,520 1,980
1980 6 537 9,440 3,440
1990 17 1,240 16,700 5,380
2000 83 2,570 35,300 11,000
2010 1,460 6,330 116,000 30,100
2020 2,360 9,960 68,700 32,200
Fat gsch.png

Google Trends

The chart below shows Google Trends data for Fat (food), from January 2004 to October 2021, when the screenshot was taken. Interest is also ranked by country and displayed on world map.[10]

Fat gt.png

Google Ngram Viewer

The comparative chart below shows Google Ngram Viewer data for trans fat, saturated fat, fatty acid and triglyceride from 1800 to 2019.[11]

Fat ngram.png

Wikipedia Views

The chart below shows pageviews of the English Wikipedia article Fat, from July 2015 to September 2021.[12]


Fat wv.png

Full timeline

Year Event type Key topic Fat type (when applicable) Details Location
800 AD Industrial development Fatty acid Soap, which is a salt of a fatty acid, is produced in Germany.[1] Germany
1551 Scientific development Adipose tissue Adipose tissue – more specifically brown adipose tissue– is first identified by Swiss naturalist Conrad Gessner.[13]
1769 Scientific development Cholesterol François Poulletier de la Salle first identifies cholesterol in solid form in gallstones. Some consider this to be the start of the story of lipids in humans.[14] France
1770s Medical development Fish liver oil Unsaturated (polyunsaturated (ω−3)) Reports from this time indicate that fish liver oils are used for the treatment of rickets, osteomalacia, general malnutrition, and eye conditions, thus linking, for the first time, fish liver oils and the factor termed “fat-soluble A.”[4] Today, it is known that fish body oil and fish liver oil are rich in omega-3 essential fatty acids, which can help control the immune system and fight joint inflammation.[15]
1779 Scientific development Glycerol Swedish chemist Carl Wilhelm Scheele discovers that glycerol could be obtained from olive oil by heating it with litharge (lead monoxide).[16] Along with fatty acids, glycerol is one of the two main components of a fat molecule.[17] Sweden
1791 Scientific development Essential oil, greasy oil Swiss scientist Jean Senebier reports in the Encyclopédie méthodique, Physiologie végétale a classification of oils. They are separated into essential and greasy oils.[18] Switzerland
1792 Scientific development Oil oxidation Jean Senebier observes that exposure to air causes oils to go white, lose their fluidity, and in time go rancid. Further investigation convinces him that rancidity involves oxidation.[19] Switzerland
1813 Scientific development Fatty acid The concept of fatty acid (acide gras) is introduced by Michel Eugène Chevreul,[20][21] though he initially uses some variant terms: graisse acide and acide huileux ("acid fat" and "oily acid").[22] France
1814 Scientific development Butyric acid Saturated French chemist Michel-Eugène Chevreul first observes butyric acid. By 1818, he purifies it sufficiently to characterize it.[23][1] France
1814 Scientific development Oil body Michel-Eugène Chevreul shows that hog’s lard consists of two distinct oily bodies: one being a solid at room temperature and the other, a liquid.[19] France
1815 Scientific development Cholesterol Michel-Eugène Chevreul demonstrates the chemical nature of fats and oils.[16] He also names the compound "cholesterine".[24][25] France
1815 Scientific development Lipid Henri Braconnot classifies lipids (graisses) in two categories, suifs (solid greases or tallow) and huiles (fluid oils).[26] France
1816 Scientific development Caproic acid Saturated Michel-Eugène Chevreul first isolates caproic acid (from the Latin word caper, meaning goat) from butter.[27] A saturated medium-chain fatty acid with a 6-carbon backbone, caproic acid is found naturally in various plant and animal fats and oils.[28] This fatty acid works as an anti-viral, as well as boots energy, and promotes weight loss.[29] France
1819 Scientific development Elaidic acid Unsaturated (monounsaturated (ω−9)) French chemist Jean-Joseph-Etienne Poutet from Marseille first obtains elaidic acid[30], a monounsaturated trans fatty acid.[31][32] France
1823 Scientific development Lipid classification French chemist Michel Eugène Chevreul develops a more detailed classification of lipids, including oils, greases, tallow, waxes, resins, balsams and volatile oils (or essential oils).[33][34] France
1823 Scientific development Stearic acid Saturated Michel Eugène Chevreul first describes stearic acid, named from the Greek word stéar, meaning tallow (also known as beef fat).[35] France
1823 Scientific development Oleic acid Unsaturated (monounsaturated (ω−9)) Michel Eugène Chevreul first recognizes oleic acid in pork fat.[36] Oleic acid is a fatty acid that occurs naturally in various animal and vegetable fats and oils.[37] France
1823 Literature Michel Eugène Chevreul publishes Chemistry of Fats and Oils.[1] France
1825 Scientific development Fatty acids distillation Distillation of fatty acids is achieved.[1]
1827 Scientific development Fat as nutrient English chemist William Prout recognizes fat ("oily" alimentary matters), along with protein ("albuminous") and carbohydrate ("saccharine"), as an important nutrient for humans and animals.[38][39] United Kingdom
1828 Scientific development Fatty acid separation A method for separation of solid and liquid fatty acids is obtained.[1]
1832 Scientific development Elaidic acid Unsaturated (monounsaturated (ω−9)) F. Boudet, studying accurately J.J.E. Poutet’s work, manages to isolate elaidic acid, and names it acide élaidique.[30]
1840 Scientific development Palmitic acid Saturated French chemist Edmond Frémy discovers palmitic acid in saponified palm oil.[40] France
1841 Scientific development Myristic acid Saturated Lyon Playfair first isolates myristic acid from nutmeg (Myristica fragrans).[41]
1842 Scientific development Lauric acid Saturated T. Marsson discovers lauric acid in the seeds of Laurus nobilis, from which its name.[42]
1844 Scientific development Triglyceride, fat interesterification Interesterified The first synthetic triglyceride is reported by Théophile-Jules Pelouze, who manages to produce tributyrin by treating butyric acid with glycerin in the presence of concentrated sulfuric acid.[43] This is the earliest record of enzymatic Interesterification.[44] France
1844 Scientific development Linoleic acid Unsaturated (polyunsaturated (ω−6)) Linoleic acid (from the Latin linon, meaning flax, plus oleic, meaning oil or olive oil) is isolated by F. Sacc from linseed oil.[45] It is a polyunsaturated essential fatty acid found mostly in plant oils.[46]
1844 Scientific development Propionic acid Saturated Austrian chemist Johann Gottlieb first describes propionic acid, after finding it among the degradation products of sugar.[47]
1847 Scientific development Phospholipid French pharmacist Theodore Nicolas Gobley discovers phospholipids in mammalian brain and hen egg, called by him as "lecithins".[48] France
1848 Scientific development Behenic acid Saturated Behenic acid is first reported by A. Voelcker.[49][1]
1848 Scientific development Ricinoleic acid Unsaturated (monounsaturated (ω−9)) Ricinoleic acid is discovered.[1]
1849 Scientific development Pancreatic juice French physiologist Claude Bernard reports that pancreatic juice is involved in the breakdown of fat to glycerine and fatty acids for subsequent absorption.[4] France
1849 Scientific development Erucic acid Unsaturated (monounsaturated (ω−9))[50] Erucic acid is discovered.[1]
1852 Scientific development Polymorphism Polymorphism is discovered.[1] Today, an important quality parameter in fat research as well as in industrial applications is the polymorphic state of edible fats.[51]
1853 Scientific development Gylceride The term gylceride is first used.[1]
1854 Scientific development Triglyceride (triacetin) Triacetin is first prepared by French chemist Marcellin Berthelot.[52] France
1854 Scientific development Palmitoleic acid Unsaturated (monounsaturated (ω−7)) P.G. Hofstädter first notices palmitoleic acid in sperm whale oil and names physetoleic acid.[53]
1855 Scientific development Glycerol The correct structure of glycerol is determined.[1]
1856 Scientific development Lipid German pathologist Rudolf Virchow first describes lipid accumulation in arterial walls.[54] Germany
1869 Scientific development Margarine Unsaturated French chemist Hippolyte Mège-Mouriès invents the margarine. In the same year, he wins a prize offered by Napoleon III for a satisfactory butter substitute.[16][55] Margarine is made from vegetable oils, so it contains polyunsaturated and monounsaturated fats. These types of fats help reduce low-density lipoprotein (LDL).[56] France
1876 Scientific development Cholesterol German chemist Adolf Windaus reports that plaques in aortas from atherosclerosis patients contain 20 times more cholesterol than normal aortas.[14] Germany
1879 Scientific development Lipid The Soxhlet extractor is invented by German chemist Franz von Soxhlet. It is originally designed for the extraction of a lipid from a solid material.[1]
1881 Scientific development Hydroxy myristic acid Hydroxy myristic acid is discovered.[1]
1886 Scientific development Brassidic acid Unsaturated (monounsaturated) Brassidic acid is first prepared from erucic acid by W. Reimer. It is an unsaturated fatty acid, member of the sub-group called very long chain fatty acids.[57]
1886 Scientific development Linoleic acid Unsaturated (polyunsaturated (ω−6)) The diene structure of linoleic acid is determined.[1]
1887 Scientific development alpha-Linolenic acid Unsaturated (polyunsaturated (ω−3)) alpha-Linolenic acid is isolated by K. Hazura and Monatsh.[58] First found in hempseed oil, it is a type of omega-3 fatty acid found in plants.[59][19]
1887 Scientific development Triene acid Unsaturated (polyunsaturated) Triene acid in hempseed oil is determined.[1]
1888 Scientific development Cholesterol Friedrich Reinitzer describes the molecular structure of cholesterol.[14]
1890 Scientific development It is written that “fat stands between the two great nutrients, proteids (proteins) on the one hand and carbohydrates on the other, and we find that we can indulge in considerable latitude as to its use. When we wish to get our food in a more condensed form, we can use fats freely.”[4]
1892 Scientific development Acetylenic acid The first acetylenic acid is reported.[1]
1894 Scientific development Ricinoleic acid Unsaturated (monounsaturated (ω−9)) The correct structure of ricinoleic acid is determined.[1]
1895 Literature Fat chemistry The first book on the chemistry of fats and oils is published.[1]
1897 Scientific development Hydrogenation French chemist Paul Sabatier describes the hydrogenation of organic compounds in the presence of finely disintegrated metals. Catalytic hydrogenation is considered a major advance in fatty acid chemistry. Sabatier would be later awarded the Nobel Prize in chemistry.[1][19] France
1898 Scientific development Fat-splitting United States chemist Ernst Twitchell patents a catalytic method for fat-splitting. Later known as the Twitchell process, it consists in acid catalyst being prepared by the reaction of oleic acid with sulfuric acid and naphthalene.[60] United States
1898 Scientific development Chromatography Liquid chromatography is reported as a purification method of fatty acids.[1]
1898 Scientific development Oleic acid Unsaturated (monounsaturated (ω−9)) The structure of oleic acid is elucidated by the works of J. Baruch and F.G. Edmed.[36] It is a mono-unsaturated omega-9 fatty acid.[61][1]
1900 Scientific development Benzenestearosulphonic acid Ernst Twitchell reports that treatment of oleic acid and benzene with concentrated sulfuric acid yields benzene stearosulphonic acid useful as a fat-splitting reagent.[1]
1900 Industrial development Oil extraction The first continuous screw press for extracting oil from oil seeds is manufactured V. D. Anderson in Cleveland, Ohio. Called the "expeller", it is much more efficient than earlier hydraulic presses, but it still leaves much of the oil in the meal and much room, therefore, for improvement.[19] United States
1901 Scientific development Hydrogenation German chemist Wilhelm Normann experiments with hydrogenation catalysts and successfully induces the hydrogenation of liquid fat, producing semisolid fat, which came to be known as trans fat.[6] Germany
1902 Scientific development Fat deposition Rosenfeld shows that a high-carbohydrate, low protein diet results in fat deposition.[62]
1903 Scientific development Hydrogenation German chemist Wilhelm Normann patents the hydrogenation of liquid oils,[6] which "converts unsaturated fatty acids into saturated compounds".[19] Germany
1904 Scientific development Cyclopentyl acid The first cyclopentyl acid is discovered.[1]
1905 Scientific development Purified fat Pekelharing observes that mice could not grow optimally while consuming only a mixture of purified fat, carbohydrate, and protein.[4]
1906 Scientific development Palmitoleic acid Unsaturated (monounsaturated (ω−7)) H. Bull discovers the molecular composition of palmitoleic acid, at the time when Lewkowitsch gives the present name.[53]
1906 Scientific development Gadoleic acid Unsaturated (monounsaturated (ω−11)) H. Bull discovers gadoleic acid in cod liver oil.[63]
1906 Industrial development Hydrogenation Joseph Crosfields & Sons in Warrington, England, begin industrial hydrogenation in Europe.[64] United Kingdom
1908 Scientific development Penta-2,3-dienedioic acid Penta-2,3-dienedioic acid is isolated from the leaf resin of European alder Alnus glutinosa (Betulaceae).[60]
1909 Scientific development Cholesterol, atherosclerosis Alexander I. Ignatowski describes the relationship between a diet rich in cholesterol and atherosclerosis.[65][66]
1909 Scientific development alpha-Linolenic acid Unsaturated (polyunsaturated (ω−3)) The exact structure of alpha-Linolenic acid is clarified by E. Erdmann et al.[58] This fatty acid is popular for preventing and treating diseases of the heart and blood vessels.[67]
1909 Scientific development Petroselinic acid Unsaturated (monounsaturated (ω−11))[68] Petroselinic acid is first isolated from parsley seed oil.[69]
1910 Scientific development Cholesterol, atherosclerosis Windaus demonstrates that atherosclerotic lesions contain six times more free cholesterol and 20 times more esterified cholesterol compared with the healthy arterial wall.[65]
1911 Industrial development Shortening Trans fat After acquiring the US rights to Normann’s patent[3], Procter & Gamble introduces Crisco (short for crystallized cotton oil), the first food product that contains trans fat.[6] It is a solid vegetable fat made by hydrogenating cottonseed oil, thus providing a lost-cost, vegetable-derived alternative to butter and lard.[19] This is the first all-vegetable household shortening with cottonseed oil.[70] United States
1911 Industrial development Soybean oil The first commercial quantities of soybeans are imported into the United States from Manchuria and are crushed for oil.[19] United States
1912 Scientific development Lipid Jacob Rosenbloom and William J. Gies propose the substitution of "lipoid" by "lipin".[71]
1912 Scientific development Fat-soluble vitamin A American biochemist Elmer McCollum at the University of Wisconsin begins using rats instead of humans in his experiments rather than cows and sheep. He finds the first fat-soluble vitamin, Vitamin A, and discovers that rats are healthier when they are fed butter rather than lard, as butter contains more Vitamin A.[72] United States
1912 Industrial development Hydrogenated fat Hydrogenated fats appear on the market. Today, they still remain the most important raw material in margarine and shortening.[73]
1913 Scientific development Cholesterol Anitschkow shows that it is possible to establish atherosclerosis in rabbits by feeding cholesterol. Since then virtually all research on atherosclerosis would be centered on both circulating cholesterol and dietary cholesterol.[74]
1913 Scientific development Arachidonic acid Unsaturated (polyunsaturated (ω−6)) Dyerberg and Bang identify very small amounts of an unsaturated fatty acid contained in Eskimos’ blood. They name it arachidonic acid because it is the same length as arachidic acid, a saturated fat found in peanuts, but has multiple double bonds.[19]
1913 Scientific development Fat-soluble vitamin A A “fat-soluble A” factor necessary to support life is identified. This factor is thought to cure xerophthalmia and rickets.[4]
1913 Scientific development Cholesterol, atherosclerosis Russian pathologist Nikolay Anichkov demonstrates that cholesterol and fat gives rise to atherosclerotic changes in the vessel walls of rabbits, and atherosclerosis occurs by direct deposition of fat in the vascular wall.[65][75] Russia
1918 Scientific development Fat as nutrient German physician Hans Aron in Breslau is arguably the first to suggest that fats have nutritional functions other than provision of food energy.[76][5][77] This is the first evidence of the existence of fatty acids.[78][79] "The first indication that dietary fat may be essential for healthy growing animals was presented in 1918 by Aron (1918) who proposed that butter has a nutrient value that cannot be provided by other dietary components."[80] Germany
1918 Scientific development Continuous centrifuge Continuous centrifuge is patented as a method to separate both solids and immiscible liquids.[1]
1919 Scientific development Essential fatty acid Von Groer reports on two infants who were on skim milk diets for 9 months and had retarded growth, poor appetite, and possible respiratory infections. After their diets were supplemented with essential fatty acid for several months, these infants are found to be healthy, with a normal growth rate and weight gain.[76]
1920 Scientific development Unsaturated (polyunsaturated (ω−6)) Meyerhof finds that linoleic acid and sulphur-rich proteins work together to help fatigued muscle recover rapidly from exercise and exertion.[62]
1920 Scientific development Fat interesterification Interesterified Wilhelm Norman, who also patented the catalytic hydrogenation of fatty acids, is granted a patent for the chemical interesterification of edible lipids.[81]
1920 Scientific development Dimer acid Dimer acids are discovered.[1]
1920 Scientific development Lipid Bloor introduces a new classification for "lipoids": simple lipoids (greases and waxes), compound lipoids (phospholipoids and glycolipoids), and the derived lipoids (fatty acids, alcohols, sterols).[82][83]
1921 Scientific development The separation of solid and liquid fatty acids is first obtained.[1]
1923 Scientific development Lipid The word lipide, which stems etymologically from Greek λίπος, lipos 'fat', is introduced by French pharmacologist Gabriel Bertrand.[84]
1923 Scientific development Continuous refining Continuous refining of fats is patented.[1]
1924 Scientific development Lipid (chylomicron) Simon Henry Gage and Pierre Augustine Fish show that after a fatty meal human blood contains tiny particles (1 µm) called chylomicrons.[14]
1924 Scientific development Fat interesterification Industrial fat interesterification is patented.[1]
1924 Scientific development Linoleic acid Unsaturated (polyunsaturated (ω−6)) Albert Szent-Györgyi discovers that the system of sulphur-rich protein and linoleic acid takes up oxygen. However, he lacks the biochemical techniques to prove the identity of the components of this system conclusively.[62]
1925 Scientific development Palmitoleic acid Unsaturated (monounsaturated (ω−7)) E.F. Armstrong et al. establish the structure of palmitoleic acid as an unsaturated fatty acid.[53]
1926 Scientific development German physiologist Otto Heinrich Warburg shows that a fatty substance is required to restart oxidation when it is low, as is the case in cancer and other degenerative conditions.[62]
1927 Scientific development Fat deficiency American scientists Herbert McLean Evans and George Oswald Burr demonstrate that, despite the addition of vitamins A, D, and E to the diet, a deficiency of fat severely affects both growth and reproduction of experimental animals.[78] United States
1927 Scientific development Fat classification A method for classifying fats is introduced.[1]
1927 Scientific development Nervonic acid Unsaturated (monounsaturated (ω−9))[85] M. Tsujimoto discovers nervonic acid in fats of Elasmobranchii, a subclass of chondrichthyes including fishes with fusiform (selachii like sharks from with its first name selacholeic acid) or flatten (batoidea like ray) bodies.[86]
1929 Scientific development Dietary fatty acid Unsaturated George and Mildred Burr report that dietary fatty acid is required to prevent a deficiency disease that occurs in rats fed a fat-free diet. They conclude that fatty acids are essential nutrients and show that linoleic acid prevents the disease and is an essential fatty acid. The Burrs surmise that other unsaturated fatty acids are essential and subsequently demonstrate that linolenic acid, the omega-3 fatty acid analog of linoleic acid, is also an essential fatty acid.[2][87][19][80] United States
1929 Scientific development Isomerization Isomerization during hydrogenation is reported.[1]
1930 Industrial development Margarine The votator is patented. It is used for the continuous manufacture of margarine.[1]
1930 Scientific development Prostaglandin Unsaturated (polyunsaturated (ω−6)) Gynecologists working with artificial insemination report that extracts of seminal fluid cause uterine tissue to contract. This observation leads to the discovery of the important cell messengers called prostaglandins,[19] which are first isolated from the prostate gland of sheep, from which they are given the name.[62]
1931 Scientific development X-ray crystallography X-ray diffraction is first used for fatty acids.[1]
1931 Industrial development Fat-splitting Continuous fat-splitting is patented.[1]
1931 Industrial development Edible oil Henry Ford plants 500 acres of soybeans in Dearborn, Michigan. After the Second World War, and after soybean production takes off, the United States would be able to export edible oils.[19] United States
1932 Industrial development Spry vegetable shortening Spry vegetable shortening is introduced by Lever Brothers.[1]
1933 Scientific development Gadoleic acid Unsaturated (monounsaturated (ω−11)) M.Takano clarifies the structure of gadoleic acid.[63]
1933 Industrial development Fatty acid distillation Distillation of fatty acids is patented.[1]
1933 Industrial development Shortening Procter & Gamble implements a significant change for shortenings, adding mono- and diglycerides, which dramatically improves the performance of baking shortenings. This improvement is tempered somewhat for household shortenings because of the required all-purpose performance.[70]
1933 Industrial development Shortening Superglycerinated high-ratio shortenings are introduced. This would bring significant changes for the baker and the shortening industry. These shortenings contain mono- and diglycerides, which contribute to a finer dispersion of fat particles in cake batters, causing a greater number of smaller-sized fat globules that strengthen the batters.[70][1]
1934 Scientific development Oleic acid Unsaturated (polyunsaturated (ω−9)) Oleic acid is synthesized for the first time by C.R. Noller et al.[36] Today, studies suggest that oleic acid reduces inflammation and may even have beneficial effects on genes linked to cancer.[88]
1934 Industrial development The first continuous countercurrent solvent extraction plant in the United States is opened by Archer Daniels Midland Company. The plant uses hexane as the solvent and a 100-tons-per-day Hildebrandt extractor from Germany. By the late 1940s, much of the oil seed–crushing industry would from screw presses to far more efficient solvent extraction.[19] United States
1934 Scientific development Centrifugal refining Centrifugal refining is introduced.[1]
1936 Industrial development Fatty acid distillation Distillation of fatty acids is patented.[1]
1936 Industrial development Shortening Primex shortening is marketed.[1] An all-purpose shortening with a neutral flavor and buttery appearance, it is used for donut frying, pie doughs, cookies, and other bakery applications.[89]
1937 Scientific development Linoleic acid Unsaturated (polyunsaturated (ω−6)) Conjugation of linoleic acid by alkali is obtained.[1]
1938 Scientific development Linoleic acid Unsaturated (polyunsaturated (ω−6)) George and Mildred Burr are unable to prove that linoleic acid is essential for humans. This question would remain unresolved until the 1960s.[19]
1938 Scientific development Monoglyceride, diglyceride The first U.S. patents for mono- and diglycerides is granted.[65] United States
1938 Scientific development Santalbic acid Santalbic acid is first discovered in the seeds of Santalum album.[60][90]
1939 Scientific development Linoleic acid Unsaturated (polyunsaturated (ω−6)) The exact structure of linoleic acid is clarified by English chemist Thomas Percy Hilditch et al.[45] United Kingdom
1940 Industrial development M.F. Bengen first describes the technique of formation of crystalline urea fatty acid complexes, which today is a well-known technique to fractionate fatty acids and is used to separate straight chain compounds found in milk.[60][91] Germany
1940 Industrial development Fatty amines/nitriles Fatty amines/nitriles are patented.[1]
1940 Literature Thomas Percy Hilditch publishes The Chemical Composition of Natural Oils, which would be considered a seminal and influential contribution to chemical analysis of oils.[1]
1945 Literature American chemist Alton E. Bailey publishes Industrial Oil and Fat Products.[1] United States
1945 Scientific development Fatty acid displacement analysis Displacement analysis for fatty acids is reported.[1]
1945 Scientific development Fatty acid oxidation Relative rates of fatty acid oxidation is reported.[1]
1947 Literature Natural fat Thomas Percy Hilditch publishes The chemical constitution of natural fats, which would become famous. Hilditch claims that “unanimity has not yet been reached in the terminology to be adopted in classifying the various types of naturally occurring compounds in which fatty acids are present … even a collective title for the whole group is not completely settled“.[18] United Kingdom
1947 Industrial development Shortening Swiftning shortening is marketed.[1]
1948 Industrial development Fat interesterification Directed interesterification is reported.[1] This process would be put into successful factory use on lard shortenings. Directed interesterification increases the fraction of high melting solids (trisaturated glycerides) and decreases the fraction of intermediate melting glycerides (disaturated glycerides) in lard.[92]
1950 Market trend A broad dietary shift from animal fats begins, favoring liquid oil products. U.S. consumers become increasingly aware of the role of fats and oils in coronary disease, and start replacing solid shortenings with liquid oils.[70] United States
1950 Scientific development Obesity Genetically obese mice are first described.[93]
1950 Scientific development Fat melting/solidification Bailey publishes melting and solidification of fats.[1]
1950 Scientific development Linoleic acid Unsaturated (polyunsaturated (ω−6)) American biochemist Ralph Holman and a graduate student discover that linoleic acid is the precursor of arachidonic acid and that alpha-Linolenic acid is the precursor of docosahexaenoic acid and eicosapentaenoic acid.[19] United States
1950 Scientific development Mycolic acid Asselineau and Lederer describe the first structure of mycolic acids as α-branched, β-hydroxylated long-chain fatty acids, a feature that confers to the molecule the property to be cleaved at high temperature into a "mero"aldehyde main chain, also called "meromycolic" chain, and a "fatty acid", a reaction similar to a reverse Claisen type condensation.[94][95]
1950 Scientific development Linoleic acid Unsaturated (polyunsaturated (ω−6)) Linoleic acid is synthesized by British chemist Ralph Raphael and German-born British chemist Franz Sondheimer.[45] United Kingdom
1950–1970 Market trend Edible vegetable oils In 1950, the food fat marketed in the United States is split approximately equally between animal fats (lard, tallow and butter) and edible vegetable oils. By 1970, edible vegetable oils would account for three-fourths of the total and animal fats only one-fourth.[96] United States
1951 Scientific development Chromatography English scientists Archer Martin and A. J. James perfect the first gas-liquid chromatograph, a powerful analytical and purification tool that enables scientists to separate the many different fatty acids in tissues and foods. For this work, they are later awarded the Nobel Prize in Chemistry in 1952.[19][1] United Kingdom
1951 Scientific development Linolenic acid Unsaturated (polyunsaturated (ω−3)) Herbert Dutton proves that linolenic acid is the cause of the off flavors and odors in soybean oil. This would lead to the expanded use of partial or selective hydrogenation to eliminate this fat.[19]
1952 Scientific development Eicosapentaenoic acid, docosahexaenoic acid Unsaturated (polyunsaturated (ω−3)) An early epidemiological study conducted in Norway finds a lower incidence of multiple sclerosis in coastal communities with a high consumption of fish (high eicosapentaenoic acid and docosahexaenoic acid intakes) compared to communities with a high consumption of animal fat.[65] Norway
1953 Scientific development Sterol The plasma cholesterol-lowering properties of plant sterols are described by Pollak.[97]
1953 Scientific development Fat, heart disease Ancel Keys publishes a chart which directly correlates the incidence of heart disease with the total fat intake of a population.[19]
1955 Scientific development Triglyceride Synthesis of mixed acid triglyceride is introduced.[1]
1955 Scientific development Trans fat Trans fatty acids are found to be naturally present in ruminants but not nonruminants.[19]
1955 Industrial development Shortening Golden Fluffo shortening is marketed.[1]
1956 Scientific development Fat distribution French physician Jean Vague becomes the first to show the importance of fat distribution in relation to various diseases, describing what he terms ‘android’ and ‘gynoid’ types of obesity.[98] France
1956 Scientific development Chromatography Stahl advances thin-layer chromatography.[1]
1956 Scientific development alpha-Linolenic acid Unsaturated (polyunsaturated (ω−3)) alpha-Linolenic acid is synthesized by Nigama and Weedon.[58] This fatty acid has an antithrombotic effect. It has a role as a micronutrient, a nutraceutical and a mouse metabolite.[99]
1957 Scientific development Lipid Kummerow and colleagues[100] find that lipid extracts of tissue specimens from 24 human subjects who died of heart disease contain ≤12.2% trans fatty acids in their adipose tissue, 14.4% in the liver, 9.3% in heart tissue, 8.8% in aortic tissue, and 8.8% in atheroma.[101]
1957 Scientific development Prostaglandin Unsaturated (polyunsaturated (ω−6)) Sune Bergström isolates the first prostaglandins.[19] These are lipid autacoids derived from arachidonic acid.[102]
1957 Industrial development Extrusion Extrusion is developed and patented as a method for microencapsulation of polyunsaturated fatty acid-rich oil emulsions. Extrusion process is found to produce less porous material compared to spray drying; however, it increases production cost as compared to spray drying and use of screw extruders at high pressure are highly detrimental to omega-3 fatty acids.[103]
1958 Scientific development Essential fatty acid deficiency Essential fatty acid deficiency in humans is first described by Arild Hansen et al., in infants fed a milk-based formula lacking them.[78]
1959 Scientific development Mead acid Unsaturated (polyunsaturated (ω−9))[104] James F. Mead at UCLA first identifies what would be named mead acid.[105] United States
1959 Scientific development Microemulsion Microemulsion is first prepared by Hoar and Schulman, by dispersing oil in an aqueous solution of surfactant where alcohol is used as cosurfactant. This forms stable, transparent oil-in-water formulation. The term "microemulsion" is coined by Schulman et al. in this year.[103]
1960 Scientific development Glyceride A theory of glyceride structures is proposed.[1]
1960 Scientific development Trienoic/tetraenoic acid ratio Ralph Holman introduces the concept of the trienoic/tetraenoic acid ratio as an indicator of the severity of essential fatty acid deficiency in rats. He later demonstrates its applicability to other species. A ratio of 0.4 or greater is considered indicaive of EFA deficiency. Later in 1970, Holman would suggest that the upper limit of normality is a ratio of 0.2 for humans.[76][19]
1961 Industrial development Hydrogenation Hydrogenated winterized soybean oil is marketed.[1]
1963 Scientific development Essential fatty acid Unsaturated (polyunsaturated) Arild Hansen and colleagues demonstrate for the first time that humans require the dietary intake of certain polyunsaturated fatty acids (PUFAs) that the body is unable to synthesize. These PUFAs are therefore referred to as essential fatty acids.[106]
1963 Policy Fatty acid The Codex Alimentarius Commission (Codex) is created to develop food standards, guidelines and related texts such as codes of practice under the Joint Food and Agriculture Organization/World Health Organisation Food Standards Programme. Under the Guidelines for Nutrition Labelling of Codex, trans fatty acids must be declared where the amount and/or type of fatty acids or the amount of cholesterol is declared on a label.[3]
1964 Scientific development Fatty acid Konrad Bloch and Feodor Lynen share the Nobel Prize in Physiology or Medicine for their discoveries concerning some of the mechanisms and methods of regulation of cholesterol and fatty acid metabolism.[107]
1964 Literature Klare Markley publishes Fatty acids, an extensive five volume set on the chemistry of fatty acids.[1]
1964 Scientific development Prostaglandin Unsaturated (polyunsaturated (ω−6)) Swedish biochemist Sune Bergström and Dutch chemist David Adriaan van Dorp demonstrate that prostaglandins are made from twenty-carbon fatty acids, such as arachidonic and eicosapentaenoic acid.[19] Thanks to these scientists, fatty acids are found to be the precursors for the synthesis of prostaglandins.[78]
1964 Scientific development Ralph Holman proposes a new system for naming the different families of unsaturated fatty acids, the omega system, and hypothesizes that the different families compete for the same elongation and desaturation enzymes.[19]
1965 Scientific development Cholesterol Keys et al. and Hegsted et al. independently develop formulae for predicting changes in cholesterol levels based on changes in the diet. Their formulae are based upon changes in quantity of saturated and unsaturated fat and in dietary cholesterol.[74]
1965 Recommendation The American Heart Association deletes the recommendation to decrease the intake of hydrogenated fats and removes a negative reference to the trans fatty acids. The revised statement encourages the consumption of partially hydrogenated fats.[108] United States
1966 Scientific development Larsson first describes the crystal structure of pure, racemic 1-monoglycerides, which would be later reviewed by Small in 1986 and Larsson in 1994.[109]
1967 Scientific development Unsaturated (polyunsaturated (ω−3)) Trout are the first animal to be recognized as requiring omega-3 fatty acids, as those raised with corn oil as the only fat in their diet develop a shock syndrome and suffer a high mortality.[19]
1967 Scientific development Gunstone claims that over 300 fatty acids are known in nature at this time.[64]
1968 Scientific development Michael Crawford shows that the fats of domestic animals are much more saturated than the fats of wild animals.[19]
1968 Scientific development Saturated monoglyceride Krog and Larsson first publish binary phase diagrams of distilled saturated monoglycerides based on hydrogenated lard.[109]
1969 Industrial development Margarine Trans-free margarine is patented, mentioning Fondu and Willems as its inventors. It describes a hardstock that is obtained by interesterifying palm stearin with a lauric oil. However, neither of these components is hydrogenated, and consequently, the interesterification product contains quite a large proportion of triglycerides that do not contribute to blend consistency but nevertheless introduce saturated fatty acids.[64]
1972 Scientific development Docosahexaenoic acid Unsaturated (polyunsaturated (ω−3)) Michael Crawford shows that docosahexaenoic acid is important to brain function.[19]
1972 Scientific development Methyl oleate Self-metathesis of methyl oleate is first reported. It gives dimethyl octadec-9-ene-1,18-dioate and octadec-9-ene as products.[110][60]
1972 Scientific development Fish oil Unsaturated (polyunsaturated (ω−3)) Hans Olaf Bang and Jørn Dyerberg report that compared to Danes, Greenland Eskimos have lower levels of heart disease —and of serum cholesterol and triglycerides, despite a diet rich in fat and blubber. This is associated with polyunsaturated fatty acid in fish oil.[19]
1973 Scientific development Prostaglandin Unsaturated (polyunsaturated (ω−6)) American nutritional biochemist William E.M. Lands reports that prostaglandins made from omega-3 fatty acids are much less inflammatory than those made from omega-6 fatty acids, a finding that would lead to the use of fish oil in treating patients with arthritis, ulcerative colitis, Crohn’s disease, dysmenorrhea, and other inflammatory disorders.[19] United States
1973 Industrial development Commercial whaling is banned in the United States. As a result, jojoba oil (a long-chain wax ester) is brought to commercialization as a result of research done at the National Center for Agricultural Utilization Research.[60] United States
1974 Scientific development Metathesis for synthesis of mono- and dicarboxylic acids.[1]
1975 Policy Saturated fat, polyunsaturated fatty acid, cholesterol Saturated, Unsaturated Guidelines for voluntary nutrition labeling start taking effect in the United States. Foods are labeled on the basis of total, saturated (lauric, myristic, palmitic, and stearic acids), and polyunsaturated fatty acids and cholesterol content. These standards are established based on the observed association between saturated fat intake and risk of cardiovascular disease.[4] United States
1975 Market The world market for edible fats and oils is over 41 million tons in this year, with products sold for almost 29 billion dollars.[62] Worldwide
1975 Scientific development Docosahexaenoic acid Unsaturated (polyunsaturated (ω−3)) Robert Anderson identifies docosahexaenoic acid as a key part of the eye’s photoreceptor.[19]
1976 Scientific development Coronary artery disease Saturated, trans fat The Nurses' Health Study is incepted as a cohort study following 120,000 female nurses. The researchers would analyze data from 900 coronary events from the study's population during 14 years of followup, and would determine that a nurse's coronary artery disease (CAD) risk roughly doubled (relative risk of 1.93, confidence interval: 1.43 to 2.61) for each 2% increase in trans fat calories consumed (instead of carbohydrate calories). By contrast, for each 5% increase in saturated fat calories (instead of carbohydrate calories) there was a 17% increase in risk (relative risk of 1.17, CI: 0.97 to 1.41). The replacement of saturated fat or trans unsaturated fat by cis (unhydrogenated) unsaturated fats is associated with larger reductions in risk than an isocaloric replacement by carbohydrates.[111] The researchers would also report on the benefits of reducing trans fat consumption. Replacing 2% of food energy from trans fat with non-trans unsaturated fats more than halves the risk of CAD (53%). By comparison, replacing a larger 5% of food energy from saturated fat with non-trans unsaturated fats reduces the risk of CAD by 43%. This study provides the major evidence for the effect of trans fat on coronary artery disease.[111] United States
1976 Scientific development Lipid A summary of the lipid hypothesis describes it as: "measures used to lower the plasma lipids in patients with hyperlipidemia will lead to reductions in new events of coronary heart disease".[112]
1977 Scientific development The World Health Organization issues a repport concluding that infant formulas should match the milk from well-nourished mothers with respect both to parent and long-chain fatty acids and to the balance of the omega-6 and omega-3 families.[19]
1977 Industrial development Linoleic acid Unsaturated (polyunsaturated (ω−6)) United States FDA approves of Intralipid, a linoleic acid-rich lipid emulsion made with soybean oil, phospholipids, and glycerol. This marks the beginning of parenteral use of fats in the United States.[80] United States
1977 Industrial development Enzymatic interesterification Enzymatic interesterification is patented. However, its early use is very limited until later when immobilized enzymes become affordable for large-scale industrial use. Today, enzymatic interesterification is widely used for the production of low-TFA plastic fats for numerous applications.[3]
1978 Scientific development Eicosapentaenoic acid Unsaturated (polyunsaturated (ω−3)) J.Dyerberg et al. suggest that eicosapentaenoic acid, an omega-3 fat, plays a role in the prevention of thrombosis and atherosclerosis.[19][113]
1979 Literature Fatty Acid Everett Pryde publishes Fatty Acids, which covers the fatty acid literature up to date.[1]
1980 Recommendation Saturated The United States Department of Agriculture and the United States Department of Health and Human Services jointly release the first Dietary Guidelines for Americans. These reports emphasize a leading harmful role of saturated fats.[114] United States
1983 Scientific development Ischemic heart disease Researchers show that the concentration of trans 18:1 and 16:1 fatty acids is 6.8% higher in the adipose tissue of individuals who died of ischemic heart disease compared with individuals who died of other causes.[115][116][101]
1984 Recommendation Fat The United Kingdom issues dietary guidelines similar to the Dietary Guidelines for Americans issued in 1980. Both guidelines recommend reducing overall fat consumption to 30% of total calories, and saturated fat to no more than 10% of calories. These values would remain essentially unchanged in subsequent iterations.[114] United Kingdom
1984 Industrial development Oleic acid Unsaturated (monounsaturated (ω−9)) High-oleic seed is grown commercially in the United States for the first time in North Dakota, California, and Texas.[80] United States
1984–1986 Intake Trans fat Hunter and Applewhite report an estimate of trans fatty acids available for consumption in the U.S. diet for 1984 of 7.6 g/person/day. A similar value, 8.3 g/person/day, is obtained independently by a Federation of American Societies for Experimental Biology (FASEB) Review Panel on Trans Fatty Acids.[80]
1985 Recommendation Cholesterol Health organizations begin recommending diet modifications to lower serum cholesterol levels.[70]
1985 Program launch Cholesterol The National Institutes of Health establishes the National Cholesterol Education Program.[117] United States
1985 Scientific development Cholesterol American researchers Michael Stuart Brown and Joseph L. Goldstein receive the Nobel Prize in Physiology or Medicine for their work on genetic causes for high levels of cholesterol in the blood that can lead to heart disease at a young age.[93] United States
1985 Intake In this year, Americans consume approximately 36%–37% of their calories as fat, which is comprised of 13.2% saturated, 13.8% monounsaturated, and 7.0% polyunsaturated fatty acids.[80] United States
1985 Scientific development Unsaturated (polyunsaturated (ω-3, ω-6)) Scientists begin linking an imbalance of omega-6 and omega-3 fatty acids to numerous diseases, raising questions about the food supply of Western countries.[19]
1985 Industrial development Canola oil Canola oil is granted the status of Generally Recognized as Safe (GRAS) by the United States FDA, and starts being commercialized.[80] United States
1985 Industrial development Microbial oil Microbial oils are introduced into the marketplace. Since then, these would gradually become of increasing importance and value in the niche market of high-value nutraceuticals.[1]
1985 Industrial development Canola oil Unsaturated (polyunsaturated (ω−3)) Canola oil is introduced into the United States. Being high in alpha linolenic acid, the parent omega-3, canola oil is associated with good health as is responsible for a small increase in the omega-3 content in modern western diet in the following decades.[19] United States
1985 Industrial development Linolenic acid Unsaturated (polyunsaturated (ω−3)) The first single cell oil is launched. This microbial oil is rich in gamma-linolenic acid and is produced using the fungus Mucor circinelloides. This would prompt the appreciation that, with being a novel product, it would have to undergo stringent trials before it could be sold to the general public.[60]
1986 Industrial development Partially hydrogenated oil Saturated McDonald's replaces the saturated fats in some of its products with partially hydrogenated oils, the major source of trans fats.[118]
1986 Scientific development Docosahexaenoic acid Docosahexaenoic acid is discovered in bacteria.[119]
1986 Scientific development Unsaturated (polyunsaturated (ω−3)) American endocrinologist Artemis Simopoulos reports that there are more omega-3 fatty acids in leaves than in seeds—and in the leaves of wild plants like purslane than in cultivated plants.[19] United States
1987 Recommendation Cholesterol The report of National Cholesterol Education Program, Adult Treatment Panels suggests the total blood cholesterol level should be: < 200 mg/dL normal blood cholesterol, 200–239 mg/dL borderline-high, > 240 mg/dL high cholesterol.[120]
1987 Scientific development Fish oil Unsaturated (polyunsaturated (ω−3)) Leonard Storlien from University of Sydney finds that fish oil prevents insulin resistance and obesity in rats.[19]
1987 Medical development Cholesterol Lovastatin (sold under the brand name Mevacor among others) is approved for medical use.[121] It is used for treating high blood cholesterol and reduceing the risk of cardiovascular disease.[122]
1987 Policy Fish oil (menhaden) Unsaturated (polyunsaturated (ω−3)) Federal approval for the use of partially hydrogenated menhaden oil in food products is granted in the United States.[80] United States
1988 Publication Lipid The National Cholesterol Education Program, Adult Treatment Panel I (NCEP–ATP I) develops its first set of guidelines, establishing clear goals for patients with lipid abnormalities.[117] United States
1988 Scientific development Trans fatty acid The first hypotheses are formulated concerning the effect of eating trans fatty acids on risk of coronary diseases.[3]
1989 Scientific development Fish Unsaturated (polyunsaturated (ω−3)) A number of trials reveal the benefits of omega-3 fatty acids in preventing death from myocardial infarction. Similar findings report that fish consumption as low as 35 grams per day, or about one serving a week, significantly reduces the risk of myocardial infarction.[19]
1989 Scientific development Unsaturated (polyunsaturated (ω−3)) Dennis Hoffman first finds significant differences in the visual and mental acuity of infants raised on formulas with and without omega-3 fatty acids.[19]
1989 Medical development Lipid Pravastatin (sold under the brand name Pravachol) is approved for medical use.[123] It is used for treatment of blood lipids.[124]
1990 Policy Fat The Nutrition Labeling and Education Act of 1990 becomes effective in the United States. It focuses on saturated fat (redefined as all saturated fatty acids) and calls for it to be labeled based on grams per serving and percentage of total energy. The labeling of monounsaturated and polyunsaturated fatty acids is deemed optional. These standards are based on the association between saturated fat intake and risk of cardiovascular disease, but also on observed associations with certain forms of cancer, diabetes, and other diseases.[4] United States
1990 Scientific development Cholesterol Mensink and Katan demonstrate the plasma cholesterol-raising effect of industrially produced trans-octadecenoic acids in human volunteers.[125]
1990 Scientific development Trans fat, cholesterol A large, well-controlled study published in the New England Journal of Medicine shows Conclusively that trans-fatty acids increase total cholesterol and "bad" low-density lipoprotein (LDL), both of which are correlated with increased cardiovascular disease, disproving manufacturers’ advertising which claims that suggest that margarines can be good for the health of the heart.[62]
1990 Scientific development Trans fat A Dutch study reports that the trans fatty acids do have an adverse effect on serum cholesterol.[108] Netherlands
1990 Scientific development Trans fat An Institute of Medicine report determines that trans fats have "no deleterious effects" on human health.[118] United States
1991 Intake Trans fat Hunter and Applewhite update their estimate of trans fatty acid availability in the U.S. diet for 1989 to be 8.1 g/person/day.[80] United States
1991 Recommendation Trans fat The British Committee on Medical Aspects of Health (COMA) recommends that trans fatty acids be limited to 2% of the caloric (energy) intake.[108] United Kingdom
1991 Organization The International Society for the Study of Fatty Acids and Lipids (ISSFAL) is founded. With more than 500 members from more than 40 countries, it is the foremost International Scientific Society dealing exclusively with the health impact of dietary lipids.[126]
1992 Medical development Lipid Simvastatin (sold under the brand name Zocor) is approved for medical use.[127] It is a lipid-lowering medication.[128]
1993 Recommendation Partially hydrogenated oil Health advocacy groups start calling for fast food chains to stop frying with partially hydrogenated oil.[9]
1993 Scientific development Lipoprotein Additional evidence for age, gender, and high-density lipoprotein importance emerges, reinforcing the need to address these factors.[117]
1993 Policy Saturated fat, cholesterol Saturated The United States FDA requires that saturated fat and cholesterol be listed on food labels.[9] United States
1994 Statistics Trans fat A study estimates that over 30,000 cardiac deaths per year in the United States are attributable to the consumption of trans fats.[129]
1994 Medical development Cholesterol Fluvastatin is introduced for medical use.[130] This drug lowers the total and low density lipoprotein cholesterol levels in hypercholesterolemia.[131]
Mid–1990s Industrial development Hydrogenation By this time, approximately 25 million tons of fats, oils and fatty acids are hydrogenated every year for the food, cosmetics and lubricant industries.[3]
1995 Scientific development Unsaturated (polyunsaturated (ω−3)) American physician Alexander Leaf reports that omega-3 fatty acids also prevent arrhythmia and sudden cardiac death.[19]
1995 Intake Americans report an average of 25% of daily calories from fats added in food or meal preparation and at the table. As total calories from fat averaged 33% of daily calories, most fats consumed are added at the discretion of food processors, consumers, or preparers rather than naturally occurring.[80] United States
1995–1996 Intake The European multicentre TRANSFAIR Study is conducted. In it, samples of foods contributing to 95% total fat intake in 14 countries are analyzed centrally for trans-fatty acid content. Among the hydrogenated products, oils and fats are the main contributors (35%) followed by biscuits and cakes (16.5%). As for the biohydrogenated products, dairy products provide 18.8% of the total trans-fatty acids, while meat and meat products contribute 10.3% and butter another 5.9%. Overall, approximately, two-thirds of TFA in European diets are from foods with PHVO, while the remaining one-third is from natural food sources. Thus, in general, Europeans consume a lower proportion of TFA from partially hydrogenated vegetable oils compared with North Americans (∼80%).[64]
1996 Literature Lipid, fatty acid F. D Gunstone publishes Fatty acid and lipid chemistry.[132]
1996 Scientific development Fatty acid Gunstone estimates the existence of over 1000 fatty acids at this time, compared to 300 in 1967.[64]
1996 Medical development Triglyceride, cholesterol Atorvastatin (sold under the brand name Lipitor) is approved for medical use in the United States. This drug reduces levels of triglycerides and harmful low-density lipoprotein cholesterol in the blood and increases levels of beneficial high-density lipoprotein cholesterol.[133] United States
1996 Scientific development Sterol Mellanen et al. suggest that plant sterols may be oestrogenic.[97][134] Finland (University of Turku)
1997 Industrial development Omega-3 eggs Unsaturated (polyunsaturated (ω−3)) Commercial omega-3 eggs are first introduced to the public.[103]
1997 Statistics Fat The United States Department of Agriculture (USDA) reports that fat consumption by humans in the United States can exceed 100 g/day.[135] United States
1998 Literature Fat Caroline M. Pond publishes The Fats of Life.[136]
1999 Scientific development Unsaturated (polyunsaturated (ω−3)) Joe Hibbeln and Andrew Stoll independently report an inverse correlation between omega-3 fatty acid consumption and the incidence of depression and that fish oil reduces episodes of mania and depression in patients with bipolar disorder.[19] United States
1999 Scientific development Unsaturated (polyunsaturated (ω-3, ω-6)) Tony Hulbert and Paul Else publish data indicating that the degree of unsaturation of an animal’s membranes, a function, in part, of the dietary intake of omega-3s and omega-6s, is the pacemaker of that animal’s metabolism. This discovery creates a new way of looking at the role that greens and seeds play in human health and a framework on which to hang all the other findings about omega-3s.[19]
1999 Recommendation An expert panel including the International Society for the Study of Fatty Acids and Lipids (ISSFAL), the U.S. National Institute on Alcohol Abuse and Alcoholism, the U.S. Office of Dietary Supplements at the National Institutes of Health, and the Center for Genetics, Nutrition, and Health, is convened to formulate recommendations for dietary intakes of omega-3 and omega-6 fatty acids. The recommendation for docosahexaenoic acid during pregnancy put forward by the expert panel is 200 mg/day[137]. In addition, the panel recommends 2.22 g/day of linolenic acid for all adults, and an upper limit was established for linoleic acid of 6.67 g/day.[138]
2000 Statistics Oils, fats The global consumption of oils and fats ia 116.4 million tons. The largest volumes are for soybean oil (26.4 mt), palm oil (22.8 mt), rape seed oil (14.5 mt) and sunflower oil (9.4 mt).[139] Worldwide
2001 Scientific development Diabetes Trans fat One study finds that risk of diabetes is higher for those in the highest quartile of trans fat consumption.[140]
2001 Scientific development Unsaturated (polyunsaturated (ω−3)) Jeffrey et al.[141] (later Hoffman et al. in 2009[142]) report on docosahexaenoic acid as exerting several roles in the visual system from photoreceptor differentiation to synaptic plasticity in a series of events leading to a direct influence on visual acuity.[138]
2002 Scientific development Unsaturated (polyunsaturated (ω−3)) Ki Shuk Shim and G. Lubec postulate several mechanisms for the possible protective role of omega-3 fatty acids in dementia.[143] The brain is particularly rich in fatty acids.[138]
2002 Scientific development "Burdge et al. upset the essentiality of α-linolenic acid by showing that 33% of a labeled dose given to a human was exhaled as CO2 in the first 24 h."[80]
2002 Recommendation Monounsaturated fat, Polyunsaturated fat The Institute of Medicine of the National Academies releases the 'Dietary Reference Intakes for Energy, Carbohydrate, Fiber, Fat, Fatty Acids, Cholesterol, Protein and Amino Acids'. The report brief indicates that "monounsaturated and polyunsaturated fatty acids reduce blood cholesterol concentration and help lower the risk of heart disease when they replace saturated fatty acids in the diet".[144] It also recommends that the consumption of trans fatty acids be as low as possible.[7] United States
2003 Recommendation Saturated A report by the World Health Organization and the Food and Agriculture Organization (FAO) recommends limiting the saturated fatty acids to less than 10% of daily energy intake and less than 7% for high-risk groups.[145]
2003 Scientific development Saturated A meta-analysis finds a significant positive relationship between saturated fat and breast cancer.[146]
2003 Scientific development Cholesteryl ester Trans fat A randomized crossover study comparing the effect of eating a meal on blood lipids of (relatively) cis and trans-fat-rich meals shows that cholesteryl ester transfer (CET) is 28% higher after the trans meal than after the cis meal and that lipoprotein concentrations are enriched in apolipoprotein(a) after the trans meals.[147]
2003 Scientific development Alzheimer disease Saturated, trans fat A study published in Archives of Neurology suggests that the intake of both trans fats and saturated fats promotes the development of Alzheimer disease.[148]
2003 Intake In the United States, 81.3% of total edible fats and oils consumed comprise vegetable oils, an increase from 56.7% in 1965.[64] United States
2003 Policy Trans fat Denmark pioneers the banning of industrially-produced trans fats in food.[149] The food regulatory agency of that country bans the use of all hydrogenated fats from food products, but at the same time made an explicit exception allowing the use of animal fats containing natural trans fatty acids as these were viewed as chemically different.[3] Denmark
2003 Medical development Cholesterol, triglyceride Pitavastatin is approved for medical use.[150] It is used for lowing blood total cholesterol, low-density lipoprotein cholesterol and triglycerides.[151]
2003 Medical development Triglyceride, cholesterol Lipitor becomes the best-selling pharmaceutical in history.[152]
2003 Policy Trans-fat United States FDA rules that the amount of trans-fat in a food item must be stated on the label after January 1, 2006. Food items could be labeled 0% trans if they contain less than 0.5 g per serving.[60] United States
2004 Scientific development Saturated A review concludes that "no lower safe limit of specific saturated fatty acid intakes has been identified" and recommends that the influence of varying saturated fatty acid intakes against a background of different individual lifestyles and genetic backgrounds should be the focus in future studies.[153]
2004 Recommendation Coronary heart disease Trans fat The European Food Safety Authority produces a scientific opinion on trans fatty acids, surmising that "higher intakes of TFA may increase risk for coronary heart disease.[154]
2004 Literature Oil, fat F. D. Gunstone publishes The Chemistry of Oils and Fats: Sources, Composition, Properties, and Uses.[155]
2004 Policy Phytosterol, phytostanol The European Union Commission publishes Regulation 608/2004/EC concerning the labelling of foods and food ingredients with added phytosterols, phytosterol esters, phytostanols and/or phytostanol esters, requiring such products to be labelled with additional information including the words “with added plant sterols/plant stanols”.[97]
2004–2005 Industrial development World production of fats and oil is about 137 million metric tons in this period. At the same time, the consumption of oil is forecast to be 138 MMTs. Palm oil overtakes soybean oil for the first time in worldwide production.[80] Worldwide
2004–2005 Scientific development Trans fat An analysis of samples of McDonald's French fries collected finds that fries served in New York City contain twice as much trans fat as in Hungary, and 28 times as much as in Denmark, where trans fats are restricted. For Kentucky Fried Chicken products, the pattern is reversed: the Hungarian product containing twice the trans fat of the New York product. Even within the United States, there is variation, with fries in New York containing 30% more trans fat than those from Atlanta.[156]
2005 Scientific development Unsaturated (polyunsaturated (ω-3, ω-6)) The influence of the ω-6/ω-3 ratio upon bone mineral density in elderly adults is assessed by Weiss et al. An increase in the ratio is seen to be significantly and independently correlated with increased bone mineral density of the hip in all participating women, and of the spine in women receiving hormone therapy. Similar results would be obtained in other studies.[106][157][158]
2005 Scientific development Yves Chauvin, Robert H. Grubbs, and Richard R. Schrock are awarded the Nobel Prize in Chemistry for their pioneering work in metathesis catalyst development (Grubbs and Schrock) and elucidation of the reaction mechanism (Chauvin).[60]
2006 (January 1) Policy Trans fat The first direct regulation of trans fat by the United States FDA is a requirement that it be labeled in amounts above 0.5g per serving, which takes effect on January 1.[159] United States
2006 Research Saturated A study indicates that the intake of saturated fat has a negative effect on the mineral density of bones. The study suggests that men may be particularly vulnerable.[160]
2006 Policy Trans fat New York City passes a law banning artificial trans fats in all restaurant foods.[8] United States
2006 Policy Trans fat Argentina starts requiring trans fat content labeling.[161] Argentina
2006 Scientific development Trans fat An analysis of some industrialized foods finds up to 30% "trans fats" in artificial shortening, 10% in breads and cake products, 8% in cookies and crackers, 4% in salty snacks, 7% in cake frostings and sweets, and 26% in margarine and other processed spreads.[162]
2007 Scientific development Palm oil Interesterified A study funded by the Malaysian Palm Oil Board[163] claims that replacing natural palm oil by other interesterified or partial hydrogenated fats cause adverse health effects, such as higher LDL/HDL ratio and plasma glucose levels. However, these effects could be attributed to the higher percentage of saturated acids in the IE and partially hydrogenated fats, rather than to the IE process itself.[164][165]
2007 Scientific development Phytosterol P.G. Bradford and A.B. Awad claim a cancer-protective effect for phytosterols in humans.[97][166] United States
2007 Scientific development Trans fat A study finds that each 2% increase in the intake of energy from trans unsaturated fats, as opposed to that from carbohydrates, is associated with a 73% greater risk of ovulatory infertility.[167]
2007 Program launch Trans fat The American Heart Association launches its "Face the Fats" campaign to help educate the public about the negative effects of trans fats.[168] United States
2008 Scientific development Plant sterol The European Food Safety Authority judges that the available scientific evidence justifying the claim that plant sterols lower/reduce blood cholesterol, and that blood cholesterol lowering may reduce the risk of coronary heart disease.[97]
2008 Recommendation Type 2 diabetes The American Diabetes Association recommends low-carbohydrate or low-fat diets for weight management in patients with established type 2 diabetes, while the amount of monounsaturated fatty acids is not specified.[169] United States
2008 Policy Trans fat Switzerland bans trans fats.[170] Switzerland
2008 Policy Trans fat Calgary becomes the first city in Canada to ban trans fats from restaurants and fast-food chains.[171] Canada
2008 Scientific development Unsaturated (monounsaturated (ω−7)) Researchers at Harvard University discover that the palmitoleic acid in omega-7 fatty acid acts like a hormone in the human body, rather than a protein, and is what the weight loss factor is attributed to; it's this part of the amino acid that fights against obesity and its related diseases and conditions.[172][173] United States
2009 Literature Oil, fat Frank Gunstone publishes Oils and Fats in the Food Industry.[174]
2009 Scientific development Unsaturated (polyunsaturated (ω-3, ω-6)) Artemis P. Simopoulos suggests that a ω-6/ω-3 ratio of 5:1 exerts beneficial effects upon asthma, while a ratio of 10:1 has adverse effects.[175][106]
2010 Recommendation Saturated, Unsaturated A conference of the American Dietetic Association takes place, at which concerns are expressed that a blanket recommendation to avoid saturated fats could drive people to also reduce the amount of polyunsaturated fats, which may have health benefits, and/or replace fats by refined carbohydrates — which carry a high risk of obesity and heart disease.[176] United States
2010 Statistics Trans fat According to the FDA, the average American consumes 5.8 grams of trans fat per day (2.6% of energy intake).[177] United States
2011 Scientific development Triglyceride The American Heart Association's scientific statement says triglyceride is not a direct cause of atherosclerosis but it is a marker of cardiovascular disease risk.[178][179] United States
2012 Recommendation Industrially produced trans fatty acid Trans fat The Conseil Supérieur de la Santé in Belgium publishes a science-policy advisory report on industrially produced trans fatty acids that focuses on the general population. Its recommendation to the legislature is to prohibit more than 2 g of trans fatty acids per 100 g of fat in food products.[180] Belgium
2012 Scientific development Trans fat An observational analysis of subjects of an earlier study finds a strong relation between dietary trans fat acids and self-reported behavioral aggression and irritability, suggesting but not establishing causality.[181]
2013 Scientific development Industrial trans fatty acid Trans fat A team of Dutch scientists confidently write that "the detrimental effects of industrial trans fatty acids on heart health are beyond dispute".[118] Netherlands
2013 (late year) Policy The United States FDA announces plans to remove partially hydrogenated oils from the list of generally regarded as safe (GRAS).[60] United States
2014 Policy Fat It becomes obligatory in Israel to mark food products with more than 2% of fat by weight.[182] Israel
2014 Policy Vegetable oil From December, all food products produced in the European Union are legally required to indicate the specific vegetable oil used in their manufacture, following the introduction of the Food Information to Consumers Regulation.[183] European Union
2015 Recommendation Cholesterol, saturated fat The United States Department of Agriculture Dietary Guidelines Advisory Committee (DGAC) recommends that Americans eat as little dietary cholesterol as possible, because most foods that are rich in cholesterol are also high in saturated fat and thereby may increase the risk of cardiovascular disease.[184][185] United States
2015 Recommendation Partially hydrogenated oil The Food and Drug Administration Trusted Source states that partially hydrogenated oil is not safe, and removing it from food could prevent thousands of heart attacks each year.[186] United States
2015 Policy Artificial trans-fat Trans fat The Food and Drug Administration decides that artificial trans-fat must be removed from the food supply in United States over the next 3 years because of health concern. However, all trans-fat would not be eliminated because those which occur naturally in meat and dairy products would still be permitted. FDA also agrees that small amount of TFAs produced during commercial refining can remain.[60] United States
2015 Recommendation Trans fat The Food and Drug Administration Trusted Source declares that trans fat is not “generally recognized as safe” and has to be phased out by 2018.[186] United States
2015 Scientific development Unsaturated (polyunsaturated (ω−3)) According to a study, trans fats are one of several components of Western pattern diets which promote acne, along with carbohydrates with high glycemic load such as refined sugars or refined starches, milk and dairy products, and saturated fats, while omega-3 fatty acids, which reduce acne, are deficient in Western pattern diets.[187]
2015 Scientific development Trans fat A study argues that "greater dietary trans fatty acid consumption is linked to worse word memory in adults during years of high productivity, adults age <45".[188]
2017 Scientific development Cardiovascular disease Unsaturated (polyunsaturated) A review by the American Heart Association estimates that replacement of saturated fat with polyunsaturated fat in the American diet could reduce the risk of cardiovascular diseases by 30%.[189] United States
2017 Policy Trans fat Health Canada announces complete ban of trans fats in the country.[190] Canada
2018 Program launch Trans fat The World Health Organization launches a plan to eliminate trans fat from the global food supply. They estimate that trans fat leads to more than 500,000 deaths from cardiovascular disease yearly.[191]
2018 Statistics Trans fat The 2018 Dutch Nutrition Survey reports that in this year, trans fatty acids only provided ∼0.3% of the daily energy requirement, as opposed to 5–10% several decades ago.[101]
2018 Literature Fat Vinood B. Patel publishes The Molecular Nutrition of Fats, which presents the nutritional and molecular aspects of fats by assessing their dietary components, their structural and metabolic effects on the cell, and their role in health and disease.[192]
2019 Policy Partially-hydrogenated oil The Ministry of Health of Singapore announces that partially-hydrogenated oils (PHOs) will be banned.[193] Singapore
2010 (April 15) Recommendation Trans fat A British Medical Journal editorial calls for trans fats to be "virtually eliminated in the United Kingdom by next year".[194] United Kingdom
2016 Literature Fat Michelle Phillipov publishes Fats: A Global History.[195]
2020 Policy Trans fat The Saudi Minister of Health announces the ban of trans fat in all food products in the country due to their health risks.[196] Saudi Arabia
2020 (August 19) Policy Trans fat The President of Romania promulgates a law that limits trans fats to 2 grams per every 100 grams of fat, max. The food producers not conforming would be fined with a sum ranging between 10,000 and 30,000 lei.[197][198] Romania
2021 Scientific development Saturated A review finds that diets high in saturated fat are associated with higher mortality from all-causes and cardiovascular disease.[199]
2021 Policy Trans fat Foods in the EU intended for consumers are required to contain less than 2g of industrial trans fat per 100g of fat.[200]
2025 Market trend The polyunsaturated fatty acids Market is forecast to reach US$10.59 billion by this year, due to growing popularity.[201]

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  • Vipul: "One thing that would be valuable to capture (but hard!) is how the affect / sentiment around different kinds of fats has changed over time. e.g. saturated fats started going out oof favor in the late 20th century, and polyunsaturated rose. But now, even many polyunsaturated (particularly omega-6) are out of favor, ad at least in some circles saturated fats have redeemed themselves -- many of the evils originally thought to be due to saturated fats are now considered a result of trans fats created during th hydrogenation process. Best would be if there are surveys of nutritionist sentiment on different kinds of fats that we can plot over time? Or any other ideas for sentiment capture?"
  • Vipul: "since all the know essential fatty acids are polyunsaturated, any row about essential fatty acids can be classified as Unsaturated (polyunsaturated)"

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See also

External links

References

  1. 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 1.12 1.13 1.14 1.15 1.16 1.17 1.18 1.19 1.20 1.21 1.22 1.23 1.24 1.25 1.26 1.27 1.28 1.29 1.30 1.31 1.32 1.33 1.34 1.35 1.36 1.37 1.38 1.39 1.40 1.41 1.42 1.43 1.44 1.45 1.46 1.47 1.48 1.49 1.50 1.51 1.52 1.53 1.54 1.55 1.56 1.57 1.58 1.59 Ahmad, Moghis U. (21 July 2017). Fatty Acids: Chemistry, Synthesis, and Applications. Elsevier. ISBN 978-0-12-809544-7. 
  2. 2.0 2.1 2.2 Spector, Arthur A.; Kim, Hee-Yong (January 2015). "Discovery of essential fatty acids". Journal of Lipid Research. 56 (1): 11–21. doi:10.1194/jlr.R055095. 
  3. 3.0 3.1 3.2 3.3 3.4 3.5 3.6 Trans fatty acids in human nutrition (2nd ed.). Bridgwater, England: Oily Press. 2009. ISBN 0955251230. 
  4. 4.0 4.1 4.2 4.3 4.4 4.5 4.6 4.7 4.8 Lichtenstein, Alice H. (27 April 2009). "Dietary Fat: A History". Nutrition Reviews. 57 (1): 11–14. doi:10.1111/j.1753-4887.1999.tb01770.x. 
  5. 5.0 5.1 5.2 Uauy, Ricardo; Valenzuela, Alfonso (July 2000). "Marine oils: the health benefits of n-3 fatty acids". Nutrition. 16 (7-8): 680–684. doi:10.1016/s0899-9007(00)00326-9. 
  6. 6.0 6.1 6.2 6.3 6.4 6.5 6.6 6.7 "Trans fat | food product". Encyclopedia Britannica. Retrieved 5 October 2021. 
  7. 7.0 7.1 Storey, Maureen L; Anderson, Patricia A (1 May 2015). "Changes in Mean Intake of Fatty Acids and Intake of Saturated and trans Fats from Potatoes: NHANES 2005–2006, 2007–2008, and 2009–2010". Advances in Nutrition. 6 (3): 376S–382S. doi:10.3945/an.114.007039. 
  8. 9.0 9.1 9.2 9.3 "Rise and fall of trans fat: A history of partially hydrogenated oil". latimes.com. Retrieved 7 October 2021. 
  9. "Fat". Google Trends. Retrieved 6 October 2021. 
  10. "trans fat, saturated fat, fatty acid, triglyceride". books.google.com. Retrieved 6 October 2021. 
  11. "Fat". wikipediaviews.org. Retrieved 6 October 2021. 
  12. Cannon, Barbara; Nedergaard, Jan (August 2008). "Neither fat nor flesh". Nature. 454 (7207): 947–948. doi:10.1038/454947a. 
  13. 14.0 14.1 14.2 14.3 Kuijpers', 'Petra M. J. C. "History in medicine: the story of cholesterol, lipids and cardiology". www.escardio.org. Retrieved 30 October 2021. 
  14. "Fish oils". Versus Arthritis. Retrieved 30 October 2021. 
  15. 16.0 16.1 16.2 "Fat | substance". Encyclopedia Britannica. Retrieved 16 September 2021. 
  16. "Lipids | Boundless Chemistry". courses.lumenlearning.com. Retrieved 6 October 2021. 
  17. 18.0 18.1 "Description of various lipids | Cyberlipid". cyberlipid.gerli.com. Retrieved 16 October 2021. 
  18. 19.00 19.01 19.02 19.03 19.04 19.05 19.06 19.07 19.08 19.09 19.10 19.11 19.12 19.13 19.14 19.15 19.16 19.17 19.18 19.19 19.20 19.21 19.22 19.23 19.24 19.25 19.26 19.27 19.28 19.29 19.30 19.31 19.32 19.33 19.34 19.35 19.36 19.37 19.38 19.39 Allport, Susan (2006). The queen of fats : why omega-3s were removed from the Western diet and what we can do to replace them. Berkeley: University of California Press. ISBN 9780520242821. 
  19. Chevreul, M. E. (1813). Sur plusieurs corps gras, et particulièrement sur leurs combinaisons avec les alcalis. Annales de Chimie, t. 88, p. 225-261. link (Gallica), link (Google).
  20. Chevreul, M. E. Recherches sur les corps gras d'origine animale. Levrault, Paris, 1823. link.
  21. Menten, P. Dictionnaire de chimie: Une approche étymologique et historique. De Boeck, Bruxelles. link.
  22. Chevreul (1815) "Lettre de M. Chevreul à MM. les rédacteurs des Annales de chimie" (Letter from Mr. Chevreul to the editors of the Annals of Chemistry), Annales de chimie, 94 : 73–79; in a footnote spanning pages 75–76, he mentions that he had found a substance that is responsible for the smell of butter.
  23. Chevreul (1816) "Recherches chimiques sur les corps gras, et particulièrement sur leurs combinaisons avec les alcalis. Sixième mémoire. Examen des graisses d'homme, de mouton, de boeuf, de jaguar et d'oie" (Chemical researches on fatty substances, and particularly on their combinations o filippos ine kapios with alkalis. Sixth memoir. Study of human, sheep, beef, jaguar and goose fat), Annales de Chimie et de Physique, 2 : 339–372. From page 346 : "Je nommerai cholesterine, de χολη, bile, et στερεος, solide, la substance cristallisée des calculs biliares humains, ... " (I will name cholesterine – from χολη (bile) and στερεος (solid) – the crystalized substance from human gallstones ... )
  24. Olson RE (February 1998). "Discovery of the lipoproteins, their role in fat transport and their significance as risk factors". The Journal of Nutrition. 128 (2 Suppl): 439S–443S. PMID 9478044. doi:10.1093/jn/128.2.439SFreely accessible. 
  25. Braconnot H (31 March 1815). "Sur la nature des corps gras.". Annales de chimie. 2 (XCIII): 225–277. 
  26. "Caproic acid: structural and chemical formula, sources". Tuscany Diet. Retrieved 29 October 2021. 
  27. "Hexanoic acid". pubchem.ncbi.nlm.nih.gov. Retrieved 29 October 2021. 
  28. "Caproic Acid Natural (Decanoic Acid)". Vigon. 30 October 2019. Retrieved 29 October 2021. 
  29. 30.0 30.1 "Elaidic acid: chemical structure, properties and food sources". Tuscany Diet. Retrieved 29 October 2021. 
  30. "Elaidic Acid (CAS 112-79-8)". www.caymanchem.com. Retrieved 29 October 2021. 
  31. "§ POUTET (Jean-Joseph-Etienne). Instruction... - Lot 495". Millon (in français). Retrieved 30 October 2021. 
  32. Chevreul ME (1823). Recherches sur les corps gras d'origine animale. Paris: Levrault. 
  33. Leray C (2012). Introduction to Lipidomics. Boca Raton: CRC Press. ISBN 9781466551466. 
  34. "Stearic acid: chemical structure, properties, food sources". Tuscany Diet. Retrieved 28 October 2021. 
  35. 36.0 36.1 36.2 "Oleic acid: structure, health benefits, and food sources". Tuscany Diet. Retrieved 29 October 2021. 
  36. "oleic acid (CHEBI:16196)". www.ebi.ac.uk. Retrieved 29 October 2021. 
  37. "Wayback Machine". web.archive.org. 13 October 2017. 
  38. Prout W (1827). "On the ultimate composition of simple alimentary substances, with some preliminary remarks on the analysis of organised bodies in general.". Phil. Trans.: 355–388. 
  39. Frémy, E. (1842). "Memoire sur les produits de la saponification de l'huile de palme". Journal de Pharmacie et de Chimie. XII: 757. 
  40. Playfair, Lyon (2009). "XX. On a new fat acid in the butter of nutmegs". Philosophical Magazine. Series 3. 18 (115): 102–113. ISSN 1941-5966. doi:10.1080/14786444108650255. 
  41. "Lauric acid: chemical structure, properties, food sources". Tuscany Diet. Retrieved 27 October 2021. 
  42. Pelouze TJ, Gélis A (1844). "Mémoire sur l'acide butyrique". Annales de Chimie et de Physique. 10: 434. 
  43. Chim Phys 10 (1844). Pelouze, J. Ann. Page 434.
  44. 45.0 45.1 45.2 "Linoleic acid: definition, structure, function, and foods". Tuscany Diet. Retrieved 29 October 2021. 
  45. "Linoleic acid". pubchem.ncbi.nlm.nih.gov. Retrieved 29 October 2021. 
  46. Johann Gottlieb (1844) "Ueber die Einwirkung von schmelzendem Kalihydrat auf Rohrzucker, Gummi, Stärkmehl und Mannit" (On the effect of molten potassium hydroxide on raw sugar, rubber, starch powder, and mannitol), Annalen der Chemie und Pharmacie, 52 : 121–130. After combining raw sugar with an excess of potassium hydroxide and distilling the result, Gottlieb obtained a product that he called "Metacetonsäure" (meta-acetone acid) on p. 122: "Das Destillat ist stark sauer und enthält Ameisensäure, Essigsäure und eine neue Säure, welche ich, aus unten anzuführenden Gründen, Metacetonsäure nenne." (The distillate is strongly acidic and contains formic acid, acetic acid, and a new acid, which for reasons to be presented below I call "meta-acetone acid".)
  47. Zeisel, Steven H. (2012). "A Brief History of Choline". Annals of Nutrition and Metabolism. 61 (3): 254–258. doi:10.1159/000343120. 
  48. "Behenic acid: chemical structure, properties, food sources". Tuscany Diet. Retrieved 9 November 2021. 
  49. "Erucic acid a possible health risk for highly exposed children | EFSA". www.efsa.europa.eu. Retrieved 9 November 2021. 
  50. "Characterisation of Fat Crystal Polymorphism in Cocoa Butter". 
  51. Berthelot, Marcellin (1854). "Sur les combinaisons de le glycérine avec les acides et sur la synthèse des principes immédiats des graisses des animaux" [On the compounds of glycerin with acids and on the synthesis of immediate principles of animal fats]. Annales de Chimie et de Physique. 3rd series (in French). 41: 216–319.  ; see "Triacétine", pp. 282–283.
  52. 53.0 53.1 53.2 "Palmitoleic acid: structure, synthesis, sources, lipokines". Tuscany Diet. Retrieved 29 October 2021. 
  53. Virchow, Rudolf (1856). "Gesammelte Abhandlungen zur wissenschaftlichen Medizin". Vierteljahrschrift für die praktische Heilkunde. Germany: Staatsdruckerei Frankfurt. Phlogose und Thrombose im Gefäßsystem. 
  54. Preedy, Victor R.; Srirajaskanthan, Rajaventhan; Patel, Vinood B. (4 July 2013). Handbook of Food Fortification and Health: From Concepts to Public Health Applications Volume 1. Springer Science & Business Media. ISBN 978-1-4614-7076-2. 
  55. "Butter vs. margarine: Which is better for my heart?". Mayo Clinic. Retrieved 28 October 2021. 
  56. "Brassidic acid: chemical structure, properties". Tuscany Diet. Retrieved 29 October 2021. 
  57. 58.0 58.1 58.2 "alpha-Linolenic acid: structure, metabolism, food sources". Tuscany Diet. Retrieved 29 October 2021. 
  58. "Alpha-linolenic acid Information | Mount Sinai - New York". Mount Sinai Health System. Retrieved 29 October 2021. 
  59. 60.00 60.01 60.02 60.03 60.04 60.05 60.06 60.07 60.08 60.09 60.10 Ahmad, Moghis U. (21 July 2017). Fatty Acids: Chemistry, Synthesis, and Applications. Elsevier. ISBN 978-0-12-809544-7. 
  60. "Omega-9 Fatty Acid - an overview | ScienceDirect Topics". www.sciencedirect.com. Retrieved 29 October 2021. 
  61. 62.0 62.1 62.2 62.3 62.4 62.5 62.6 Taubes, Gary (2008). Good Calories, Bad Calories: Fats, Carbs, and the Controversial Science of Diet and Health. Anchor Books. ISBN 978-1-4000-3346-1. 
  62. 63.0 63.1 "Gadoleic acid: chemical structure, properties, and food sources". Tuscany Diet. Retrieved 6 November 2021. 
  63. 64.0 64.1 64.2 64.3 64.4 64.5 Trans fatty acids. Oxford: Blackwell Pub. 2008. ISBN 1405156910. 
  64. 65.0 65.1 65.2 65.3 65.4 Watson, Ronald Ross; Demeester, Fabien (9 December 2015). Handbook of Lipids in Human Function: Fatty Acids. Elsevier. ISBN 978-1-63067-035-1. 
  65. Konstantinov, IE; Jankovic, GM (2013). "Alexander I. Ignatowski: a pioneer in the study of atherosclerosis.". Texas Heart Institute journal. 40 (3): 246–9. PMID 23914012. 
  66. "Alpha-linolenic Acid: Health Benefits, Side Effects, Uses, Dose & Precautions". RxList. Retrieved 29 October 2021. 
  67. Team, EBI Web. "petroselinic acid (CHEBI:28194)". www.ebi.ac.uk. Retrieved 6 November 2021. 
  68. Vongerichten, E.; Köhler, A. (April 1909). "Über Petroselinsäure, eine neue Ölsäure". Berichte der deutschen chemischen Gesellschaft. 42 (2): 1638–1639. doi:10.1002/cber.19090420232. 
  69. 70.0 70.1 70.2 70.3 70.4 O'Brien, Richard D. (5 December 2008). Fats and Oils: Formulating and Processing for Applications, Third Edition. CRC Press. ISBN 978-1-4200-6167-3. 
  70. Rosenbloom J, Gies WJ (1911). "Suggestion to teachers of biochemistry. I. A proposed chemical classification of lipins, with a note on the intimate relation between cholesterols and bile salts.". Biochem. Bull. 1: 51–6. 
  71. "Read How Nutrition Careers Have Evolved Over Time". Natural Healers. 7 October 2016. Retrieved 14 September 2021. 
  72. Hamilton, R. J. (6 December 2012). Recent Advances in Chemistry and Technology of Fats and Oils. Springer Science & Business Media. ISBN 978-94-011-7471-8. 
  73. 74.0 74.1 Guide to Nutritional Supplements. Academic Press. 2 September 2009. ISBN 978-0-12-375661-9. 
  74. Konstantinov, IE; Mejevoi, N; Anichkov, NM (2006). "Nikolai N. Anichkov and his theory of atherosclerosis.". Texas Heart Institute journal. 33 (4): 417–23. PMID 17215962. 
  75. 76.0 76.1 76.2 Lees, Robert S. (24 July 2020). Omega-3 Fatty Acids in Health and Disease. CRC Press. ISBN 978-1-000-14759-9. 
  76. Aron H. Uber den nahrwert. Biochem Z 1918
  77. 78.0 78.1 78.2 78.3 "Essential fatty acids: definition, functions, and foods". Tuscany Diet. 16 August 2012. Retrieved 29 October 2021. 
  78. Spector, Arthur A.; Kim, Hee-Yong (January 2015). "Discovery of essential fatty acids". Journal of Lipid Research. 56 (1): 11–21. doi:10.1194/jlr.R055095. 
  79. 80.00 80.01 80.02 80.03 80.04 80.05 80.06 80.07 80.08 80.09 80.10 80.11 Fatty acids in foods and their health implications. CRC Press. 2008. ISBN 0849372615. 
  80. Template:Patent
  81. Bloor, W. R. (1 March 1920). "Outline of a classification of the lipoids". Experimental Biology and Medicine. 17 (6): 138–140. doi:10.3181/00379727-17-75. 
  82. Christie WW, Han X (2010). Lipid Analysis: Isolation, Separation, Identification and Lipidomic Analysis. Bridgwater, England: The Oily Press. ISBN 9780857097866. 
  83. Bertrand G (1923). "Projet de reforme de la nomenclature de Chimie biologique". Bulletin de la Société de Chimie Biologique. 5: 96–109. 
  84. "Nervonic acid". pubchem.ncbi.nlm.nih.gov. Retrieved 7 November 2021. 
  85. "Nervonic acid: structure, function, synthesis, sources". Tuscany Diet. Retrieved 7 November 2021. 
  86. "Essential Fatty Acids and Skin Health". Linus Pauling Institute. 7 November 2016. 
  87. "11 Proven Benefits of Olive Oil". Healthline. 14 September 2018. Retrieved 29 October 2021. 
  88. "Primex All Purpose Vegetable Shortening - For Frying". bakersauthority.com. Retrieved 30 November 2021. 
  89. Aitzetmüller, Kurt (November 2012). "Santalbic acid in the plant kingdom". Plant Systematics and Evolution. 298 (9): 1609–1617. doi:10.1007/s00606-012-0678-5. 
  90. Bengen, M. F. (7 May 1951). "Mein Weg zu den neuen Harnstoff-Einschluß-Verbindungen". Angewandte Chemie. 63 (9): 207–208. doi:10.1002/ange.19510630903. 
  91. Hawley, H. K.; Holman, G. W. (1 January 1956). "Directed interesterification as a new processing tool for lard". Journal of the American Oil Chemists Society. 33 (1): 29–35. ISSN 1558-9331. doi:10.1007/BF02638347. 
  92. 93.0 93.1 Pond, Caroline M. (13 August 1998). The Fats of Life. Cambridge University Press. ISBN 978-0-521-63577-6. 
  93. Biogenesis of fatty acids, lipids and membranes. Cham. 2018. ISBN 9783319436760. 
  94. Asselineau, J.; Lederer, E. (November 1950). "Structure of the Mycolic Acids of Mycobacteria". Nature. 166 (4227): 782–783. ISSN 1476-4687. doi:10.1038/166782a0. 
  95. "What are fatty acids and their derivatives?" (PDF). tdx.cat. 
  96. 97.0 97.1 97.2 97.3 97.4 "Phytosterol esters (Plant Sterol and Stanol Esters)". IFST. 1 November 2011. Retrieved 26 October 2021. 
  97. Ross, Robert; Neeland, Ian J.; Yamashita, Shizuya; Shai, Iris; Seidell, Jaap; Magni, Paolo; Santos, Raul D.; Arsenault, Benoit; Cuevas, Ada; Hu, Frank B.; Griffin, Bruce A.; Zambon, Alberto; Barter, Philip; Fruchart, Jean-Charles; Eckel, Robert H.; Matsuzawa, Yuji; Després, Jean-Pierre (March 2020). "Waist circumference as a vital sign in clinical practice: a Consensus Statement from the IAS and ICCR Working Group on Visceral Obesity". Nature Reviews Endocrinology. 16 (3): 177–189. ISSN 1759-5037. doi:10.1038/s41574-019-0310-7. 
  98. "Linolenic acid". pubchem.ncbi.nlm.nih.gov. Retrieved 29 October 2021. 
  99. Conner, Robert L. (11 October 1957). "Interaction of Stigmasterol and 2,4-Dinitrophenol in the Growth of Tetrahymena piriformis". Science. 126 (3276): 698–698. doi:10.1126/science.126.3276.698-a. 
  100. 101.0 101.1 101.2 Oteng, Antwi-Boasiako; Kersten, Sander (1 May 2020). "Mechanisms of Action of trans Fatty Acids". Advances in Nutrition. 11 (3): 697–708. doi:10.1093/advances/nmz125. 
  101. Ricciotti, Emanuela; FitzGerald, Garret A. (May 2011). "Prostaglandins and Inflammation". Arteriosclerosis, Thrombosis, and Vascular Biology. 31 (5): 986–1000. doi:10.1161/ATVBAHA.110.207449. 
  102. 103.0 103.1 103.2 Hegde, Mahabaleshwar V.; Zanwar, Anand Arvind; Adekar, Sharad P. (15 September 2016). Omega-3 Fatty Acids: Keys to Nutritional Health. [Cham]: Humana Press. ISBN 978-3-319-40458-5. 
  103. "Mead acid". pubchem.ncbi.nlm.nih.gov. Retrieved 7 November 2021. 
  104. "Mead acid: chemical structure, synthesis, and metabolism". Tuscany Diet. Retrieved 29 October 2021. 
  105. 106.0 106.1 106.2 Gómez Candela, C.; Bermejo López, L. M. ª; Loria Kohen, V. (April 2011). "Importancia del equilibrio del índice omega-6/omega-3 en el mantenimiento de un buen estado de salud: Recomendaciones nutricionales". Nutrición Hospitalaria. 26 (2): 323–329. ISSN 0212-1611. 
  106. "The Nobel Prize in Physiology or Medicine, 1964". =Nobel Prize, Nobel Media. 
  107. 108.0 108.1 108.2 Enig, Mary G. (1 January 2000). Know Your Fats: The Complete Primer for Understanding the Nutrition of Fats, Oils and Cholesterol. Bethesda Press. ISBN 978-0-9678126-0-1. 
  108. 109.0 109.1 Garti, Nissim; Sato, Kiyotaka (20 July 2001). Crystallization Processes in Fats and Lipid Systems. CRC Press. ISBN 978-1-4822-7088-4. 
  109. Dam, P. B. van; Mittelmeijer, M. C.; Boelhouwer, C. (1 January 1972). "Metathesis of unsaturated fatty acid esters by a homogeneous tungsten hexachloride–tetramethyltin catalyst". Journal of the Chemical Society, Chemical Communications (22): 1221–1222. ISSN 0022-4936. doi:10.1039/C39720001221. 
  110. 111.0 111.1 Hu FB, Stampfer MJ, Manson JE, Rimm E, Colditz GA, Rosner BA, et al. (November 1997). "Dietary fat intake and the risk of coronary heart disease in women". The New England Journal of Medicine. 337 (21): 1491–9. PMID 9366580. doi:10.1056/NEJM199711203372102. 
  111. Ahrens EH Jr (Jul 1976). "The management of hyperlipidemia: whether, rather than how". Ann Intern Med. 85 (1): 87–93. PMID 779574. doi:10.7326/0003-4819-85-1-87. 
  112. Dyerberg, J (July 1978). "EICOSAPENTAENOIC ACID AND PREVENTION OF THROMBOSIS AND ATHEROSCLEROSIS?". The Lancet. 312 (8081): 117–119. doi:10.1016/s0140-6736(78)91505-2. 
  113. 114.0 114.1 "Big fat controversy: changing opinions about saturated fats". www.aocs.org. Retrieved 22 October 2021. 
  114. Thomas, L H; Winter, J A; Scott, R G (1 March 1983). "Concentration of 18:1 and 16:1 transunsaturated fatty acids in the adipose body tissue of decedents dying of ischaemic heart disease compared with controls: analysis by gas liquid chromatography.". Journal of Epidemiology & Community Health. 37 (1): 16–21. doi:10.1136/jech.37.1.16. 
  115. Thomas, L H; Winter, J A; Scott, R G (1 March 1983). "Concentration of transunsaturated fatty acids in the adipose body tissue of decedents dying of ischaemic heart disease compared with controls.". Journal of Epidemiology & Community Health. 37 (1): 22–24. doi:10.1136/jech.37.1.22. 
  116. 117.0 117.1 117.2 Safeer, Richard S.; Ugalat, Prabha S. (1 March 2002). "Cholesterol Treatment Guidelines Update". American Family Physician. 65 (5): 871. ISSN 0002-838X. 
  117. 118.0 118.1 118.2 Penders, Bart; Vermeulen, Niki; Parker, John (3 March 2016). Collaboration across Health Research and Medical Care: Healthy Collaboration. Routledge. ISBN 978-1-317-16450-0. 
  118. Valentine, Raymond C.; Valentine, David L. (3 December 2009). Omega-3 Fatty Acids and the DHA Principle. CRC Press. ISBN 978-1-4398-1300-3. 
  119. "Report of the National Cholesterol Education Program Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. The Expert Panel". Archives of Internal Medicine. 148 (1): 36–69. January 1988. PMID 3422148. doi:10.1001/archinte.148.1.36. 
  120. Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 472. ISBN 9783527607495. 
  121. "Lovastatin / Cholesterol Topical Cream Compounded". www.cfspharmacy.pharmacy. Retrieved 30 October 2021. 
  122. Analogue-based drug discovery. Weinheim: Wiley-VCH. 2006. ISBN 9783527607495. 
  123. Keech, A.; Colquhoun, D.; Best, J.; Kirby, A.; Simes, R. J.; Hunt, D.; Hague, W.; Beller, E.; Arulchelvam, M.; Baker, J.; Tonkin, A. (1 October 2003). "Secondary Prevention of Cardiovascular Events With Long-Term Pravastatin in Patients With Diabetes or Impaired Fasting Glucose: Results from the LIPID trial". Diabetes Care. 26 (10): 2713–2721. doi:10.2337/diacare.26.10.2713. 
  124. Mensink, Ronald P.; Katan, Martijn B. (16 August 1990). "Effect of Dietary trans Fatty Acids on High-Density and Low-Density Lipoprotein Cholesterol Levels in Healthy Subjects". New England Journal of Medicine. 323 (7): 439–445. doi:10.1056/NEJM199008163230703. 
  125. Research, F. A. B. "FAB: International Society for the Study of Fatty Acids and Lipids". www.fabresearch.org. Retrieved 20 November 2021. 
  126. Plant Bioactives and Drug Discovery : Principles, Practice, and Perspectives. Hoboken, N.J.: John Wiley & Sons. 2012. ISBN 9780470582268. 
  127. "Simvastatin Monograph for Professionals - Drugs.com". web.archive.org. 10 January 2015. Retrieved 30 October 2021. 
  128. Willett, W C; Ascherio, A (May 1994). "Trans fatty acids: are the effects only marginal?". American Journal of Public Health. 84 (5): 722–724. doi:10.2105/AJPH.84.5.722. 
  129. Analogue-based drug discovery. Weinheim: Wiley-VCH. 2006. ISBN 9783527607495. 
  130. Haramaki, Nobuya; Ikeda, Hisao; Takenaka, Katsuhiko; Katoh, Atsushi; Sugano, Ryo; Yamagishi, Sho-ichi; Matsuoka, Hidehiro; Imaizumi, Tsutomu (June 2007). "Fluvastatin Alters Platelet Aggregability in Patients With Hypercholesterolemia: Possible Improvement of Intraplatelet Redox Imbalance via HMG-CoA Reductase". Arteriosclerosis, Thrombosis, and Vascular Biology. 27 (6): 1471–1477. doi:10.1161/atvbaha.106.128793. 
  131. Gunstone, F. D. (30 June 1996). Fatty Acid and Lipid Chemistry. Springer. ISBN 978-0-8342-1342-5. 
  132. "Lipitor: How does this statin affect cholesterol levels?". www.medicalnewstoday.com. 25 February 2019. Retrieved 30 October 2021. 
  133. Mellanen, Pirkko; Petänen, Tiina; Lehtimäki, Jyrki; Mäkelä, Sari; Bylund, Göran; Holmbom, Bjarne; Mannila, Erkki; Oikari, Aimo; Santti, Risto (February 1996). "Wood-Derived Estrogens: Studiesin Vitrowith Breast Cancer Cell Lines andin Vivoin Trout". Toxicology and Applied Pharmacology. 136 (2): 381–388. doi:10.1006/taap.1996.0046. 
  134. Driskell, Judy A. (19 April 2007). Sports Nutrition: Fats and Proteins. CRC Press. ISBN 978-1-4200-0850-0. 
  135. Pond, Caroline M. (13 August 1998). The Fats of Life. Cambridge University Press. ISBN 978-0-521-63577-6. 
  136. Koletzko, Berthold; Lien, Eric; Agostoni, Carlo; Böhles, Hansjosef; Campoy, Cristina; Cetin, Irene; Decsi, Tamas; Dudenhausen, Joachim W.; Dupont, Cristophe; Forsyth, Stewart; Hoesli, Irene; Holzgreve, Wolfgang; Lapillonne, Alexandre; Putet, Guy; Secher, Niels J.; Symonds, Mike; Szajewska, Hania; Willatts, Peter; Uauy, Ricardo (1 January 2008). "The roles of long-chain polyunsaturated fatty acids in pregnancy, lactation and infancy: review of current knowledge and consensus recommendations". Journal of Perinatal Medicine. 36 (1). doi:10.1515/JPM.2008.001. 
  137. 138.0 138.1 138.2 Watson, Ronald Ross (25 June 2014). Omega-3 Fatty Acids in Brain and Neurological Health. Elsevier. ISBN 978-0-12-410547-8. 
  138. Industry as a Partner for Sustainable Development: Food and Drink. UNEP/Earthprint. 2002. ISBN 978-92-807-2185-0. 
  139. Hu FB, van Dam RM, Liu S (July 2001). "Diet and risk of Type II diabetes: the role of types of fat and carbohydrate". Diabetologia. 44 (7): 805–17. PMID 11508264. doi:10.1007/s001250100547. 
  140. Jeffrey, Brett G.; Weisinger, Harrison S.; Neuringer, Martha; Mitchell, Drake C. (2001). "The role of docosahexaenoic acid in retinal function". Lipids. 36 (9): 859–871. doi:10.1007/s11745-001-0796-3. 
  141. Hoffman, Dennis R.; Boettcher, Julia A.; Diersen-Schade, Deborah A. (1 August 2009). "Toward optimizing vision and cognition in term infants by dietary docosahexaenoic and arachidonic acid supplementation: A review of randomized controlled trials". Prostaglandins, Leukotrienes and Essential Fatty Acids. 81 (2): 151–158. doi:10.1016/j.plefa.2009.05.003. 
  142. Shim, Ki Shuk; Lubec, Gert (May 2002). "Drebrin, a dendritic spine protein, is manifold decreased in brains of patients with Alzheimer's disease and Down syndrome". Neuroscience Letters. 324 (3): 209–212. doi:10.1016/s0304-3940(02)00210-0. 
  143. Canada, Health (26 March 2012). "Summary of Health Canada's Assessment of a Health Claim about the Replacement of Saturated Fat with Mono- and Polyunsaturated Fat and Blood Cholesterol Lowering". www.canada.ca. Retrieved 27 October 2021. 
  144. Joint WHO/FAO Expert Consultation (2003). Diet, Nutrition and the Prevention of Chronic Diseases (WHO technical report series 916) (PDF). World Health Organization. pp. 81–94. ISBN 978-92-4-120916-8. 
  145. Boyd NF, Stone J, Vogt KN, Connelly BS, Martin LJ, Minkin S (November 2003). "Dietary fat and breast cancer risk revisited: a meta-analysis of the published literature". British Journal of Cancer. 89 (9): 1672–1685. PMC 2394401Freely accessible. PMID 14583769. doi:10.1038/sj.bjc.6601314. 
  146. Gatto LM, Sullivan DR, Samman S (May 2003). "Postprandial effects of dietary trans fatty acids on apolipoprotein(a) and cholesteryl ester transfer". The American Journal of Clinical Nutrition. 77 (5): 1119–24. PMID 12716661. doi:10.1093/ajcn/77.5.1119. 
  147. Morris MC, Evans DA, Bienias JL, Tangney CC, Bennett DA, Aggarwal N, et al. (February 2003). "Dietary fats and the risk of incident Alzheimer disease". Archives of Neurology. 60 (2): 194–200. PMID 12580703. doi:10.1001/archneur.60.2.194. 
  148. "Denmark, trans fat ban pioneer: lessons for other countries". www.who.int. Retrieved 5 October 2021. 
  149. Analogue-based drug discovery. Weinheim: Wiley-VCH. 2006. ISBN 9783527607495. 
  150. Adams, Stephen P; Alaeiilkhchi, Nima; Wright, James M (19 June 2020). "Pitavastatin for lowering lipids". Cochrane Database of Systematic Reviews. 2020 (7). doi:10.1002/14651858.CD012735.pub2. 
  151. Simons, J (20 January 2003). "The $10 billion pill.". Fortune. 147 (1): 58–62, 66, 68. PMID 12602122. 
  152. German JB, Dillard CJ (September 2004). "Saturated fats: what dietary intake?". American Journal of Clinical Nutrition. 80 (3): 550–559. PMID 15321792. doi:10.1093/ajcn/80.3.550Freely accessible. 
  153. "Opinion of the Scientific Panel on Dietetic products, nutrition and allergies [NDA] related to the presence of trans fatty acids in foods and the effect on human health of the consumption of trans fatty acids | EFSA". www.efsa.europa.eu. Retrieved 12 October 2021. 
  154. Gunstone, F. D. (2004). The Chemistry of Oils and Fats: Sources, Composition, Properties, and Uses. Blackwell Pub. ISBN 978-0-8493-2373-7. 
  155. "What's in that french fry? Fat varies by city". NBC News. 12 April 2006. Retrieved 7 January 2007.  AP story concerning Stender, S; Dyerberg, J; Astrup, A (April 2006). "High levels of industrially produced trans fat in popular fast foods". N. Engl. J. Med. 354 (15): 1650–2. PMID 16611965. doi:10.1056/NEJMc052959. 
  156. Högström, Magnus; Nordström, Peter; Nordström, Anna (1 March 2007). "n−3 Fatty acids are positively associated with peak bone mineral density and bone accrual in healthy men: the NO2 Study". The American Journal of Clinical Nutrition. 85 (3): 803–807. doi:10.1093/ajcn/85.3.803. 
  157. Weiss, Lauren A; Barrett-Connor, Elizabeth; von Mühlen, Denise (1 April 2005). "Ratio of n–6 to n–3 fatty acids and bone mineral density in older adults: the Rancho Bernardo Study". The American Journal of Clinical Nutrition. 81 (4): 934–938. doi:10.1093/ajcn/81.4.934. 
  158. "301. Mono- and diglycerides (WHO Food Additives Series 5)". inchem.org. Retrieved 13 October 2021. 
  159. Corwin, Rebecca L.; Hartman, Terryl J.; Maczuga, Steven A.; Graubard, Barry I. (1 January 2006). "Dietary Saturated Fat Intake Is Inversely Associated with Bone Density in Humans: Analysis of NHANES III1". The Journal of Nutrition. 136 (1): 159–165. doi:10.1093/jn/136.1.159. 
  160. "A.N.M.A.T." (PDF). www.anmat.gov.ar. Retrieved 12 October 2021. 
  161. Tarrago-Trani MT, Phillips KM, Lemar LE, Holden JM (June 2006). "New and existing oils and fats used in products with reduced trans-fatty acid content". Journal of the American Dietetic Association. 106 (6): 867–80. PMID 16720128. doi:10.1016/j.jada.2006.03.010. 
  162. Sundram K, Karupaiah T, Hayes K (2007). "Stearic acid-rich interesterified fat and trans-rich fat raise the LDL/HDL ratio and plasma glucose relative to palm olein in humans" (PDF). Nutr Metab. 4: 3. PMC 1783656Freely accessible. PMID 17224066. doi:10.1186/1743-7075-4-3. 
  163. Destaillats, Frédéric; Moulin, Julie; Bezelgues, Jean-Baptiste (2007). "Letter to the editor: healthy alternatives to trans fats". Nutrition & Metabolism. 4 (1): 10. doi:10.1186/1743-7075-4-10. 
  164. Mensink, Ronald P; Zock, Peter L; Kester, Arnold DM; Katan, Martijn B (1 May 2003). "Effects of dietary fatty acids and carbohydrates on the ratio of serum total to HDL cholesterol and on serum lipids and apolipoproteins: a meta-analysis of 60 controlled trials". The American Journal of Clinical Nutrition. 77 (5): 1146–1155. doi:10.1093/ajcn/77.5.1146. 
  165. Bradford, Peter G.; Awad, Atif B. (February 2007). "Phytosterols as anticancer compounds". Molecular Nutrition & Food Research. 51 (2): 161–170. doi:10.1002/mnfr.200600164. 
  166. Chavarro JE, Rich-Edwards JW, Rosner BA, Willett WC (January 2007). "Dietary fatty acid intakes and the risk of ovulatory infertility". The American Journal of Clinical Nutrition. 85 (1): 231–7. PMID 17209201. doi:10.1093/ajcn/85.1.231Freely accessible. 
  167. Eckel RH, Kris-Etherton P, Lichtenstein AH, Wylie-Rosett J, Groom A, Stitzel KF, Yin-Piazza S (February 2009). "Americans' awareness, knowledge, and behaviors regarding fats: 2006-2007". Journal of the American Dietetic Association. 109 (2): 288–96. PMID 19167956. doi:10.1016/j.jada.2008.10.048. 
  168. Schwingshackl, L.; Strasser, B.; Hoffmann, G. (2011). "Effects of Monounsaturated Fatty Acids on Glycaemic Control in Patients with Abnormal Glucose Metabolism: A Systematic Review and Meta-Analysis". Annals of Nutrition and Metabolism. 58 (4): 290–296. doi:10.1159/000331214. 
  169. Scherer, Lauri S. (28 December 2012). Artificial Ingredients. Greenhaven Publishing LLC. ISBN 978-0-7377-6284-6. 
  170. Sardesai, Vishwanath (11 October 2011). Introduction to Clinical Nutrition, Third Edition. CRC Press. ISBN 978-1-4398-1818-3. 
  171. "The Truth About Purified Omega 7, Sea Buckthorn, & Palmitic Acid". Sibu Seaberry. Retrieved 28 October 2021. 
  172. "Omega-7: The New 'Healthy Fat'? - Heart Health Center - Everyday Health". EverydayHealth.com. Retrieved 28 October 2021. 
  173. Gunstone, F. D. (2008). Oils and fats in the food industry. Oxford: Wiley-Blackwell Pub. ISBN 9781405171212. 
  174. Simopoulos, Artemis P. (2008). "Omega–6/Omega–3 Essential Fatty Acids: Biological Effects". World Review of Nutrition and Dietetics. 99: 1–16. doi:10.1159/000192755. 
  175. Zelman, Kathleen (May 2011). "The Great Fat Debate: A Closer Look at the Controversy—Questioning the Validity of Age-Old Dietary Guidance". Journal of the American Dietetic Association. 111 (5): 655–658. doi:10.1016/j.jada.2011.03.026. 
  176. "Revealing Trans Fats". web.archive.org. 11 March 2010. Retrieved 13 October 2021. 
  177. Miller, Michael; Stone, Neil J.; Ballantyne, Christie; Bittner, Vera; Criqui, Michael H.; Ginsberg, Henry N.; Goldberg, Anne Carol; Howard, William James; Jacobson, Marc S.; Kris-Etherton, Penny M.; Lennie, Terry A.; Levi, Moshe; Mazzone, Theodore; Pennathur, Subramanian (24 May 2011). "Triglycerides and Cardiovascular Disease: A Scientific Statement From the American Heart Association". Circulation. 123 (20): 2292–2333. doi:10.1161/CIR.0b013e3182160726. 
  178. "Can High Triglycerides Increase Your Risk of Stroke?". Verywell Health. Retrieved 26 October 2021. 
  179. Conseil Supérieur de la Santé, ed. (July 2012). "acides gras trans d'origine industrielle" (PDF). Avis du Conseil Supérieur de la Santé N° 8666. Retrieved 12 October 2021. 
  180. Golomb BA, Evans MA, White HL, Dimsdale JE (2012). "Trans fat consumption and aggression". PLOS ONE. 7 (3): e32175. PMC 3293881Freely accessible. PMID 22403632. doi:10.1371/journal.pone.0032175. 
  181. "נכנסה לתוקף בישראל חובת סימון שומן טראנס על גבי אריזות מזון ארוז". health.gov.il. 
  182. "Regulation (EU) No 1169/2011 of the European Parliament and of the Council", Official Journal of the European Union, 2011-11-21 
  183. Goldman, T. R. (31 March 2016). "Health Policy Brief: Final 2015-20 Dietary Guidelines for Americans". Health Affairs. doi:10.1377/hpb20160331.683121. Retrieved 7 June 2021. 
  184. Soliman, Ghada (16 June 2018). "Dietary Cholesterol and the Lack of Evidence in Cardiovascular Disease". Nutrients. 10 (6): 780. doi:10.3390/nu10060780. 
  185. 186.0 186.1 "Hydrogenated oil: What is it? Is it bad? Learn more here". www.medicalnewstoday.com. 26 February 2021. Retrieved 27 October 2021. 
  186. Melnik, Bodo (July 2015). "Linking diet to acne metabolomics, inflammation, and comedogenesis: an update". Clinical, Cosmetic and Investigational Dermatology: 371. doi:10.2147/CCID.S69135. 
  187. Golomb, Beatrice Alexandra; Bui, Alexis K. (17 June 2015). "A Fat to Forget: Trans Fat Consumption and Memory". PLOS ONE. 10 (6): e0128129. doi:10.1371/journal.pone.0128129. 
  188. Sacks, Frank M.; Lichtenstein, Alice H.; Wu, Jason H.Y.; Appel, Lawrence J.; Creager, Mark A.; Kris-Etherton, Penny M.; Miller, Michael; Rimm, Eric B.; Rudel, Lawrence L.; Robinson, Jennifer G.; Stone, Neil J.; Van Horn, Linda V. (18 July 2017). "Dietary Fats and Cardiovascular Disease: A Presidential Advisory From the American Heart Association". Circulation. 136 (3). doi:10.1161/CIR.0000000000000510. 
  189. "Health Canada trans fat ban takes effect next year". cbc.ca. Retrieved 12 October 2021. 
  190. "WHO plan to eliminate industrially-produced trans-fatty acids from global food supply". www.who.int. Retrieved 6 October 2021. 
  191. Patel, Vinood B. (29 October 2018). The Molecular Nutrition of Fats. Academic Press. ISBN 978-0-12-811298-4. 
  192. Choo, Felicia (6 March 2019). "MOH to ban artificial trans fat in cookies and noodles". The Straits Times. Retrieved 12 October 2021. 
  193. Mozaffarian, D.; Stampfer, M. J. (15 April 2010). "Removing industrial trans fat from foods". BMJ. 340 (apr15 1): c1826–c1826. doi:10.1136/bmj.c1826. 
  194. Phillipov, Michelle (15 May 2016). Fats: A Global History. Reaktion Books. ISBN 978-1-78023-575-2. 
  195. الربيعة, توفيق. "عد ١٣ شهراً (في ١-١-٢٠٢٠) سوف يتم منع الزيوت المهدرجة من جميع الأغذية نظراً لأضرارها الصحية". Twitter. Retrieved 12 October 2021. 
  196. Lascu, Dana. "Legea care face mâncarea românilor mai SĂNĂTOASĂ. Adrian Wiener: Nu interzice alimente! Oprește un ABUZ criminal URIAȘ!". www.dcmedical.ro (in română). Retrieved 15 October 2021. 
  197. "Lege cu impact major în industria alimentară și fast-food, promulgată de președinte. Producătorii, obligați să limiteze acizii grași". www.digi24.ro (in română). Retrieved 15 October 2021. 
  198. Kim, Youngyo; Je, Youjin; Giovannucci, Edward L. (March 2021). "Association between dietary fat intake and mortality from all-causes, cardiovascular disease, and cancer: A systematic review and meta-analysis of prospective cohort studies". Clinical Nutrition. 40 (3): 1060–1070. doi:10.1016/j.clnu.2020.07.007. 
  199. "Trans fat in food". ec.europa.eu. Retrieved 13 October 2021. 
  200. "Polyunsaturated Fatty Acids Market Share, Size and Industry Growth Analysis 2020 - 2025". www.industryarc.com. Retrieved 11 November 2021.