Difference between revisions of "Timeline of gene therapy"

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===What the timeline is still missing===
 
===What the timeline is still missing===
[http://journals.sagepub.com/doi/full/10.1177/0192623307309925], [http://science.jrank.org/pages/2959/Gene-Therapy-history-gene-therapy.html], [https://premier-research.com/perspectives-gene-therapy-101-1960s-today/], [https://www.encyclopedia.com/medicine/divisions-diagnostics-and-procedures/medicine/gene-therapy]
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[http://journals.sagepub.com/doi/full/10.1177/0192623307309925], [http://science.jrank.org/pages/2959/Gene-Therapy-history-gene-therapy.html], [https://premier-research.com/perspectives-gene-therapy-101-1960s-today/], [https://www.encyclopedia.com/medicine/divisions-diagnostics-and-procedures/medicine/gene-therapy], [https://www.researchgate.net/publication/21852975_A_brief_history_of_gene_therapy]
  
 
===Timeline update strategy===
 
===Timeline update strategy===

Revision as of 21:27, 14 October 2018

This is a timeline of FIXME.

Big picture

Time period Development summary More details

Full timeline

Year Event type Details
1953 "(Watson and Crick 1953) Identification of the double-stranded structure of the DNA"[1]
1962 "1962(Lederberg 1968) Possibility of gene therapy is speculated"[1]
1968 "1968 (Rogers and Pfuderer 1968) Early attempts at use of viral vectors"[1]
1970 "1970(Baltimore 1970)Discovery of reverse transcriptase. Copying of RNA into DNA"[1]
1972 "1972(Friedman and Robin 1972)Suggestion that transforming viruses be used for therapeutic gene transfer"[1]
1972 "1972 - Researchers first suggest gene therapy as a treatment for genetic diseases in a paper in the journal Science but they oppose its use in humans “for the foreseeable future”, pending greater understanding of the technology."[2]
1973 "1973 (Graham and van der Erb 1973)Calcium phosphate transfection"[1]
1978 "(Zamecnik and Stephenson 1978) First use of an oligonucleotide to act as inhibitor of translation"[1]
1984 "(Izant and Weintraub 1984)First demonstration that antisense nucleic acid can be used to downregulate gene expression"[1]
1987 "(Hoffman et al 1987)Identification of dystrophin, the protein product of Duchenne muscular dystrophy gene (basis of future gene therapy of this disorder)"[1]
1990 "(Blaese et al 1990)First human gene therapy experiment. Correction of adenosine deaminase deficiency in T-lymphocytes using retroviral-mediated gene transfer"[2]
1990 "1990 - A four-year-old girl with severe immunodeficiency became the first patient to undergo gene therapy in the United States."[2]
1991 (Hazinski et al 1991)Use of cationic liposome for gene transfer in experimental animals"[2]
1992 "(Wells et al 1992)Correction of myopathy in transgenic mice model of Duchenne muscular dystrophy by germline gene transfer of human dystrophin using a retroviral vector"[1]
1993 "(Oldfield and Ram 1993)First clinical trial of herpes simplex virus/thymidine kinase/ganciclovir gene therapy system in glioblastoma multiforme"[1]
1995 "(Aebischer and Kato 1995)Treatment of amyotrophic lateral sclerosis using a gene therapy approach involving implantation of genetically engineered microencapsulated cells releasing neurotrophic factors."[1]
1998 "(Fire et al 1998)RNA interference demonstrated: injection of double stranded RNA shown to inhibit genes."[1]
1999 "1999 - American patient Jesse Gelsinger dies following a gene therapy experiment, setting the field back several years as U.S. regulators put some key experiments on hold."[2]
2000 "(Collins 2000)Completion of sequencing phase of human genome project. Further developments in next-generation sequencing in the following years had considerable impact on personalized medicine. For neurologic disorders, it led to improved diagnostics, identification of gene mutations, and development of therapies targeting these (Yuan et al 2015)."[1]
2002 – 2003 "2002-03 - Cases of leukaemia are diagnosed in French children undergoing gene therapy for genetic immunodeficiency in a further blow to the field."[2]
2003 "2003 - The world’s first gene therapy is approved in China for the treatment of head and neck cancer."[2]
2007 "2007 - British doctors carry out the world’s first operation using gene therapy to treat a serious sight disorder caused by a genetic defect."[2]
2010 "(Garneau et al 2010)Definition of critical components of the CRISPR (clustered regularly interspaced short palindromic repeats)-Cas9 system, which later formed the basis of gene editing."[1]
2012 "2012 - Europe approves the first gene therapy in a Western market to treat an ultra-rare blood disorder."[2]
2014 "2014 - Gene therapy shows promise in clinical trials for inherited blood disorders, certain types of progressive blindness and HIV."[2]

Meta information on the timeline

How the timeline was built

The initial version of the timeline was written by FIXME.

Funding information for this timeline is available.

Feedback and comments

Feedback for the timeline can be provided at the following places:

  • FIXME

What the timeline is still missing

[1], [2], [3], [4], [5]

Timeline update strategy

See also

External links

References

  1. 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 1.12 1.13 1.14 "Gene therapy". medlink.com. Retrieved 15 October 2018. 
  2. 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 2.8 2.9 "TIMELINE-Milestones in gene therapy". reuters.com. Retrieved 15 October 2018.