Difference between revisions of "Timeline of lung cancer"

This is a '''timeline of [[lung cancer]]''', describing especially major discoveries, advances in treatment and major organizations.

|1960s onward||Rates of [[adenocarcinoma of the lung]] start to rise relative to other types of lung cancer, partly due to the introduction of [[cigarette filter]]s.<ref name="Charloux">{{Cite journal  |vauthors=Charloux A, Quoix E, Wolkove N, etal | title=The increasing incidence of lung adenocarcinoma: reality or artefact? A review of the epidemiology of lung adenocarcinoma | journal=International Journal of Epidemiology | volume=26 | issue=1 | pages=14–23 |date=February 1997 | pmid=9126499 | url=http://ije.oxfordjournals.org/cgi/reprint/26/1/14 | doi=10.1093/ije/26.1.14 }}</ref>   

|1990s||Several new chemotherapy drugs for non-small cell lung cancer are developed, including [[paclitaxel]], [[docetaxel]], [[vinorelbine]] and [[gemcitabine]].<ref name="Progress & Timeline" />

|2000s onward||Today, lung cancer is a top cause of death among both men and women at a worldwide level, and ranks high in both [[incidence (epidemiology)|incidence]] and mortality. Smoking is still considered to be the principal cause of lung cancer.<ref name="Lung Cancer: Signs, Symptoms, Types & Treatment"/><ref>{{cite book|title=World Cancer Report 2014|date=2014|publisher=World Health Organization|isbn=9283204298|pages=Chapter 1.1}}</ref>

|1870–1879||Crisis||Miners working at mines rich in [[radon]] gas, are found to develop a disproportionate amount of lung disease, eventually recognized as lung cancer.<ref>{{Cite journal | last=Greenberg | first=M |author2=Selikoff IJ  | title=Lung cancer in the Schneeberg mines: a reappraisal of the data reported by Harting and Hesse in 1879 | journal=Annals of Occupational Hygiene | volume=37 | issue=1 | pages=5–14 |date=February 1993 | pmid=8460878 | doi=10.1093/annhyg/37.1.5}}</ref>||[[Germany]]

|1899–1911||Report||Diagnosing lung cancer in living patients are rare. Cases identified in [[autopsy|autopsies]] are very uncommon (i.e., fewer than 1/1000).<ref name="never-smokers" />||

|1929||Discovery||German physician [[Fritz Lickint]] publishes a paper showing that lung cancer patients are particularly likely to be smokers.<ref name="A Short History of Lung Cancer">{{cite journal|title=A Short History of Lung Cancer|doi=10.1093/toxsci/64.1.4|url=http://toxsci.oxfordjournals.org/content/64/1/4.full | volume=64|journal=Toxicological Sciences|pages=4–6|pmid=11606795|date=November 2001 | last1 = Witschi | first1 = H}}</ref>||

|1933||Treatment||The first successful [[pneumonectomy]] for lung cancer is performed.<ref name="AUTOREF32">{{Cite journal | last=Horn | first=L |author2=Johnson DH  | title=Evarts A. Graham and the first pneumonectomy for lung cancer | journal=Journal of Clinical Oncology | volume=26 | issue=19 | pages=3268–3275 |date=July 2008 | pmid=18591561 | url=http://jco.ascopubs.org/cgi/pdf_extract/26/19/3268 | doi=10.1200/JCO.2008.16.8260 }}</ref>||

|1933||Organization||The [[Union for International Cancer Control]] is founded as an [[NGO]]. Its purpose is to help the global health community accelerate the fight against cancer.<ref name="IASLC" />||[[Geneva]], [[Switzerland]] (Serves worldwide)

|1958||Treatment||[[Fluorouracil]] is developed as a chemotherapy drug for treating many cancers, including lung cancer.<ref name="Fifty Years of Milestones in Cancer Research">{{cite web|title=Fifty Years of Milestones in Cancer Research|url=http://www.webmd.com/prostate-cancer/features/fifty-years-of-milestones-in-cancer-research|accessdate=28 August 2016}}</ref>||

|1959–1972||Study||[[Cancer Prevention Study I]] begins. 1 million men and women are recruited. The study will demonstrate that sharp increase in lung cancer death rates is related to cigarette smoking<ref>{{cite web|title=History of the Cancer Prevention Studies|url=http://www.cancer.org/research/researchtopreventcancer/history-cancer-prevention-study|accessdate=28 August 2016}}</ref>||[[United States]]

|1960–1969||Discovery||[[Radon]] is confirmed to be a cause of lung cancer.<ref>{{cite journal|title=Radiation and cancer risk: a continuing challenge for epidemiologists|doi=10.1186/1476-069X-10-S1-S4|pmc=3073196 | pmid=21489214|volume=10 Suppl 1|year=2011|journal=Environ Health|pages=S4 | last1 = Samet | first1 = JM}}</ref>||

|1964|| ||The [[Surgeon General of the United States]] recommends the population not to smoke.<ref>{{cite web|title=Surgeon General of the United States|url=https://profiles.nlm.nih.gov/NN/B/B/M/Q/_/nnbbmq.pdf|accessdate=28 August 2016}}</ref>||[[United States]]

|1965||Organization||The [[International Agency for Research on Cancer]] (IARC) is founded as an intergovernmental agency forming part of the [[World Health Organization]] of the [[United Nations]]. Its role is to conduct and coordinate research into the causes of cancer.<ref>{{cite web|title=IARC|url=https://www.iarc.fr/en/publications/books/iarc50/IARC_50%20years.pdf|accessdate=21 November 2016}}</ref>||[[Lyon]], [[France]]

|1969||Report||New edition of a handbook changes radically from the previous one. The role of cigarette smoking is described in detail. Air pollution is mentioned. Difference in incidence between urban and rural areas is acknowledged.<ref name="A Short History of Lung Cancer" />   

|1986||Discovery||[[Passive smoking]] is formally declared a carcinogen by the International Agency for Research on Cancer. A number of cities around the world start to ban indoor smoking in the years that follow.<ref name="Progress & Timeline">{{cite web|title=Progress & Timeline|url=http://cancerprogress.net/timeline/lung-cancer|accessdate=26 August 2016}}</ref>||

|1987||Discovery||Researchers discover that [[epidermal growth factor receptor]] (EGFR) plays an important role in the growth and spread of [[non-small-cell lung carcinoma]].<ref name="Progress & Timeline" />||  

|1993||Treatment||Researchers demonstrate simultaneous radiation and chemotherapy dramatically improves the effectiveness of treatment for patients with early-stage [[small-cell carcinoma]], compared to starting radiation later in the course of treatment.<ref name="Progress & Timeline" />||  

|1995||Treatment||An analysis of data from more than 50 clinical trials affirms benefits of [[chemotherapy]] for advanced [[non-small-cell lung carcinoma]], concluding that [[cisplatin]] chemotherapy, along with [[surgery]], [[radiation therapy]] or supportive care, substantially extends survival.<ref name="Progress & Timeline" />||

|1995||Organization||[[Lung Cancer Alliance]] is founded as an [[NGO]]. Its stated purpose is to promote lung cancer awareness, reduce lung cancer mortality and end the stigma associated with lung cancer.<ref name="IASLC" />||[[Washington D.C.]], [[United States]]

|1996||Treatment||[[Topotecan]] is approved as second round of treatment for [[small-cell lung carcinoma]].<ref name="Progress & Timeline" />||

|1999||Discovery||Cranial radiation is found to reduce risk of [[small-cell carcinoma]] spreading to the brain.<ref name="Progress & Timeline" />||

|1999||Discovery||Study finds that twice-daily radiation to the chest, together with chemotherapy, prolongs survival against [[small cell lung carcinoma]], compared with once-daily radiation and chemotherapy.<ref name="Progress & Timeline" />||

|2000||Discovery||The Iowa Radon Lung Cancer Study demonstrates that household [[radon]] exposure is associated with increased risk of lung cancer.<ref name="Progress & Timeline" />||[[United States]]

|2001||Organization||The [[Global Lung Cancer Coalition]] (GLCC) is established. GLCC aims to address the following issues: aims to address the following issues: placing lung cancer on the global [[healthcare]] agenda, changing public perceptions and lessen the stigma of lung cancer, empowering lung cancer patients to take an active role in their care, having impact in legislative or regulatory policies to optimize treatment and care.<ref name="IASLC" />||It comprises 28 non-government patient organizations from [[Argentina]], [[Australia]], [[Bulgaria]], [[Canada]], [[Denmark]], [[Egypt]], [[France]], [[Germany]], [[Ireland]], [[Israel]], [[Italy]], [[Japan]], [[Mexico]], [[Netherlands]], [[Norway]], [[Portugal]], [[Russia]], [[Slovenia]], [[Spain]], [[Sweden]], [[Switzerland]], [[Turkey]], [[United Kingdom]] and [[United States]]

|2003||Treatment||[[FDA]] approves [[gefitinib]] for first-line treatment of patients with metastatic [[non-small-cell lung carcinoma]].<ref>{{cite web|title=FDA approves targeted therapy for first-line treatment of patients with a type of metastatic lung cancer|url=http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm454678.htm|accessdate=26 August 2016}}</ref>||[[United States]]

|2005||Policy||[[Bhutan]] becomes the first country to impose nationwide ban on the sale of tobacco products.<ref>{{cite web|title=Bhutan's smokers face public ban|url=http://news.bbc.co.uk/2/hi/south_asia/4305715.stm|accessdate=26 August 2016}}</ref>||[[Bhutan]]

|2006||Organization||[[Women Against Lung Cancer in Europe]] is founded as [[nonprofit organization]], with aims at supporting and helping lung cancer patients and their families and  circulating accurate, correct and updated information about the disease in terms of prevention, diagnosis and therapy.<ref name="IASLC" />||[[Italy]] (active at national and international level)  

|2007||Organization||[[Lung Cancer Foundation of America]] (LCFA) is established with aims at  improving survival against lung cancer through the funding on research.<ref name="IASLC">{{cite web|title=IASLC|url=https://www.iaslc.org/patient-resources/advocacy-partners|accessdate=26 August 2016}}</ref><ref>{{cite web|title=Lung Cancer Foundation of America|url=http://lcfamerica.org/about/board/director/lori-monroe/|accessdate=21 November 2016}}</ref>||[[Marina Del Rey]], [[California]], [[United States]]

|2008||Policy||[[Indian government]] bans smoking in public.<ref>{{cite web|title=Indian ban on smoking in public|url=http://news.bbc.co.uk/2/hi/south_asia/7645868.stm|accessdate=26 August 2016}}</ref>||[[India]]

|2010||Organization||[[Lungevity Foundation]] is established as a [[nonprofit organization]]. It funds research into early detection and treatment of lung cancer.<ref name="IASLC" /><ref>{{cite web|title=Lungevity|url=https://www.lungevity.org/about-us/our-history|accessdate=28 August 2016}}</ref>||[[United States]]

|2010||Organization||[[Global Resource For Advancing Cancer Education]] (GRACE) is founded. Its purpose is to provide expert-mediated information on current and emerging cancer management options in order to empower patients, caregivers, and health professionals to become direct partners in cancer care.<ref>{{cite web|title=GRACE|url=http://www.unitedstatesbusinessonline.com/global-resource-for-advancing-cancer-education-seattle-wa-98103.usb|accessdate=21 November 2016}}</ref>||[[Seattle]], [[Washington (state)|Washington]], [[United States]]

|2012||Report||According to the US [[National Lung Association]], deaths due to lung cancer increase by about 3.5% in the period 1999–2012.<ref name="Lung Cancer: Signs, Symptoms, Types & Treatment">{{cite web|title=Lung Cancer: Signs, Symptoms, Types & Treatment|url=http://www.livescience.com/34767-lung-cancer-carcinoma-prognosis-treatment.html|accessdate=28 August 2016}}</ref>||

|2013|| ||The [[International Agency for Research on Cancer]] classifies air pollutants as leading causes of lung cancer.<ref name="Air pollution causes lung cancer, warns World Health Organisation">{{cite web|title=Air pollution causes lung cancer, warns World Health Organisation|url=http://www.independent.co.uk/life-style/health-and-families/health-news/air-pollution-causes-lung-cancer-warns-world-health-organisation-8886943.html|accessdate=28 August 2016}}</ref>||[[Lyon]], [[France]]

|2015||Report||Lung cancer surpasses [[breast cancer]] as the leading cause of cancer deaths for women in rich countries.<ref>{{cite web|title=Lung cancer now top cancer killer for women in rich nations|url=http://www.cbc.ca/news/health/lung-cancer-now-top-cancer-killer-for-women-in-rich-nations-1.2944804|accessdate=28 August 2016}}</ref>||

|2016||Discovery||Scientists discover drug combination that slows cell growth in a type of non small cell lung cancer, using [[trametinib]] and [[AZD2014]].||[[The Institute of Cancer Research]], [[London]], [[UK]]  

* [[Timeline of lymphoma]]

[[Category:Lung cancer]]

[[Category:Health-related timelines]]

[[Category:Medicine timelines]]