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| 1960 || Drug || {{w|Methoxyflurane}} is introduced into clinical practice.<ref name="Medical Toxicology of Drug Abuse: Synthesized Chemicals and Psychoactive Plants"/> ||
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| 1963 || Field development || American physician {{w|Edmond I. Eger, II}} describes minimum alveolar concentration (MAC), later characterized as "the concentration [of inhaled anesthetic] producing immobility in 50% of patients subjected to a noxious stimulus."<ref name="History of Anesthesia"/> || {{w|United States}}
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| 1964 || Drug || Team led by Günter Corssen begins human trials of the dissociative intravenous anesthetic ketamine.<ref name="History of Anesthesia"/> || {{w|United States}}
