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| 1863 || {{w|Undernutrition}} || {{w|Micronutrient}} ({{w|vitamin deficiency}}) || Scientific development || {{w|Vitamin A deficiency}}. French physician {{w|Pierre Bitot}} first describes the later called {{w|Bitot's spots}}.<ref>{{cite journal|last1=Shukla|first1=M|last2=Behari|first2=K|title=Congenital Bitot spots.|journal={{w|Indian Journal of Ophthalmology}}|date=Jul 1979|volume=27|issue=2|pages=63–4|pmid=541036|url=http://www.ijo.in/article.asp?issn=0301-4738;year=1979;volume=27;issue=2;spage=63;epage=64;aulast=Shukla}}</ref> ||
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| 1865 || {{w|Overnutrition}} || {{w|Micronutrient}} ({{w|Mineral}} ) || Medical development || {{w|HFE hereditary haemochromatosis}} is first described by {{w|Armand Trousseau}} in a report on diabetes in patients presenting with a bronze pigmentation of their skin. It is related to excess of {{w|iron}}.<ref name=Trousseau_1865>{{cite journal | author = Trousseau A| title = Glycosurie, diabète sucré | journal = Clinique Médicale de l'Hôtel-Dieu de Paris | year = 1865 | volume = 2| pages = 663–98 | url= }}</ref> ||
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| 1869 || {{w|Undernutrition}} || {{w|Mineral deficiency}} || Scientific development || {{w|Zinc deficiency}}. Significant historical events related to zinc deficiency begin when zinc is first discovered to be essential to the growth of an organism ''{{w|Aspergillus niger}}''.<ref>{{cite journal | vauthors = Raulin J | year = 1869 | title = Chemical studies on vegetation | journal = Annales des Sciences Naturelles | volume = 11 | pages = 293–299 }}</ref> ||
