Difference between revisions of "Comparison of methods of malaria control"

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! Method !! Type !! Acts against !! Route of administration !! First use !! First resistance !! Locations where used !! Advantages !! Disadvantages   
 
! Method !! Type !! Acts against !! Route of administration !! First use !! First resistance !! Locations where used !! Advantages !! Disadvantages   
 
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| [[wikipedia:Amodiaquine|Amodiaquine]] || Treatment || "some chloroquine-resistant strains, particularly Plasmodium falciparum"<ref>{{cite web|title=amodiaquine|url=https://pubchem.ncbi.nlm.nih.gov/compound/amodiaquine#section=Top|website=nih.gov|accessdate=24 April 2017}}</ref> || oral<ref>{{cite web|title=ARTESUNATE AMODIAQUINE WINTHROP 25 mg/67.5 mg, tablet|url=http://www.wipo.int/export/sites/www/research/en/data/sanofi/marketed_products/Artesunate_and_Amodiquine.pdf|website=wipo.int|accessdate=24 April 2017}}</ref> || 1951<ref name="Simpli fied R eversed C hloroquines t o Overcome M alaria Resistance to Quinoline-b ased D rugs">{{cite web|title=Simpli fied R eversed C hloroquines t o Overcome M alaria Resistance to Quinoline-b ased D rugs|url=http://pdxscholar.library.pdx.edu/cgi/viewcontent.cgi?article=1399&context=open_access_etds|publisher=Portland State Universit y|accessdate= }}</ref> || 1971<ref name="Simpli fied R eversed C hloroquines t o Overcome M alaria Resistance to Quinoline-b ased D rugs" /> || || Absorption is not influenced by food (compared with partner drug [[wikipedia:lumefantrine|lumefantrine]] which should be taken with fatty food).<ref>{{cite book|last1=Turner|first1=Arthur|title=Logan Turner's Diseases of the Nose, Throat and Ear, 10Ed|url=https://books.google.com.ar/books?id=2-nwinRKtBQC&pg=PA2005&lpg=PA2005&dq=%22amodiaquine%22+%22advantage%22&source=bl&ots=17vhyc7xHa&sig=MnF_LcWpBvjFRkn9B3WkEa7vCpw&hl=en&sa=X&ved=0ahUKEwjZq8jS673TAhXMh5AKHQEeAa8Q6AEITTAI#v=onepage&q=%22amodiaquine%22%20%22advantage%22&f=false|accessdate=24 April 2017}}</ref> ||  
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| [[wikipedia:Amodiaquine|Amodiaquine]] || Treatment || "some chloroquine-resistant strains, particularly Plasmodium falciparum"<ref>{{cite web|title=amodiaquine|url=https://pubchem.ncbi.nlm.nih.gov/compound/amodiaquine#section=Top|website=nih.gov|accessdate=24 April 2017}}</ref> || oral<ref>{{cite web|title=ARTESUNATE AMODIAQUINE WINTHROP 25 mg/67.5 mg, tablet|url=http://www.wipo.int/export/sites/www/research/en/data/sanofi/marketed_products/Artesunate_and_Amodiquine.pdf|website=wipo.int|accessdate=24 April 2017}}</ref> || 1951<ref name="Simpli fied R eversed C hloroquines t o Overcome M alaria Resistance to Quinoline-b ased D rugs">{{cite web|title=Simpli fied R eversed C hloroquines t o Overcome M alaria Resistance to Quinoline-b ased D rugs|url=http://pdxscholar.library.pdx.edu/cgi/viewcontent.cgi?article=1399&context=open_access_etds|publisher=Portland State Universit y|accessdate= }}</ref> || 1971<ref name="Simpli fied R eversed C hloroquines t o Overcome M alaria Resistance to Quinoline-b ased D rugs" /> || || Absorption is not influenced by food (compared with partner drug [[wikipedia:lumefantrine|lumefantrine]] which should be taken with fatty food).<ref>{{cite book|last1=Turner|first1=Arthur|title=Logan Turner's Diseases of the Nose, Throat and Ear, 10Ed|url=https://books.google.com.ar/books?id=2-nwinRKtBQC&pg=PA2005&lpg=PA2005&dq=%22amodiaquine%22+%22advantage%22&source=bl&ots=17vhyc7xHa&sig=MnF_LcWpBvjFRkn9B3WkEa7vCpw&hl=en&sa=X&ved=0ahUKEwjZq8jS673TAhXMh5AKHQEeAa8Q6AEITTAI#v=onepage&q=%22amodiaquine%22%20%22advantage%22&f=false|accessdate=24 April 2017}}</ref> || "Formation of toxic amodiaquine quinone imine (AQQI) metabolites"<ref>{{cite web|title=Medicinal Chemistry of Antimalarial Drugs - PharmaFactz|url=http://pharmafactz.com/medicinal-chemistry-of-antimalarial-drugs/|website=http://pharmafactz.com|accessdate=24 April 2017}}</ref>
 
|-
 
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| [[wikipedia:Artemether|Artemether]] || Treatment<ref name=Artemether>{{cite web|title=Artemether|url=https://pubchem.ncbi.nlm.nih.gov/compound/Artemether#section=Top|publisher=OPEN CHEMISTRY DATABASE|accessdate= }}</ref> || "Acute uncomplicated malaria."<ref name=Artemether /> || Intramuscular injection<ref name="Essential Medicines and Health Products Information Portal">{{cite web|title=Essential Medicines and Health Products Information Portal|url=http://apps.who.int/medicinedocs/en/d/Jh2922e/2.5.10.html|publisher=World Health Organization|accessdate= }}</ref> || || || || ||
 
| [[wikipedia:Artemether|Artemether]] || Treatment<ref name=Artemether>{{cite web|title=Artemether|url=https://pubchem.ncbi.nlm.nih.gov/compound/Artemether#section=Top|publisher=OPEN CHEMISTRY DATABASE|accessdate= }}</ref> || "Acute uncomplicated malaria."<ref name=Artemether /> || Intramuscular injection<ref name="Essential Medicines and Health Products Information Portal">{{cite web|title=Essential Medicines and Health Products Information Portal|url=http://apps.who.int/medicinedocs/en/d/Jh2922e/2.5.10.html|publisher=World Health Organization|accessdate= }}</ref> || || || || ||

Revision as of 12:06, 24 April 2017

Template:INDEX

This page is a comparison of methods of malaria control, covering methods of both prevention and treatment.

TODO

Methods

Use of insecticides has two main variables: method of delivery and the insecticide itself. This table covers the former; the latter are numerous and are covered separately in a second table below.

Type := Prevention | Treatment | Both

ACT (artemisinin combinatorial therapy) -- different from artenisinin?

also "comprehensive surveillance" gets mentioned a lot, in the course of using the other things.

Chemoprophylaxis -- which drugs are included?

consider "patient compliance" as a column

include various Artemisinin-based combination therapies (ACTs)

Method Type Acts against Route of administration First use First resistance Locations where used Advantages Disadvantages
Amodiaquine Treatment "some chloroquine-resistant strains, particularly Plasmodium falciparum"[1] oral[2] 1951[3] 1971[3] Absorption is not influenced by food (compared with partner drug lumefantrine which should be taken with fatty food).[4] "Formation of toxic amodiaquine quinone imine (AQQI) metabolites"[5]
Artemether Treatment[6] "Acute uncomplicated malaria."[6] Intramuscular injection[7]
Artemisinin Treatment Plasmodium falciparum oral, intramuscular, rectal[8][9] 1970s[3] 1998[3], 2009[10] Safe antimalarial in pregnancy.[11] More expensive than SP or chloroquine.[12]:165
Artemotil Treatment "Rapidly against Plasmodium during the early blood stage of its development. It also shows gametocytocidal activity against Plasmodium falciparium."[13] "Intramuscular injection only."[14]
Artesunate/amodiaquine Treatment[15] "Uncomplicated Plasmodium falciparum malaria, especially in paediatric patients"[15]
Atovaquone/proguanil (Malarone) Both 1996[3] 2002[3]
Chloroquine Both "Intraerythrocytic Plasmodium falciparum stages"[16] ~1940s (during WWII) 1957[17] Safer than quinine. Safe antimalarial in pregnancy.[11] "Low toxicity and cost" "high effectiveness".[18]
Chlorproguanil-Dapsone Treatment "uncomplicated falciparum malaria"[19] "cheap, rapidly eliminated, more potent than pyrimethamine-sulfadoxine, and could be introduced in the near future to delay the onset of antifolate resistance and as "salvage therapy" for pyrimethamine-sulfadoxine failure."[19]
Clindamycin Treatment[20] Plasmodium falciparum[20] 1960s[20]
Dihydroartemisinin-Piperaquine (Artekin) Oral (pills)[21]
Doxycycline
Exchange transfusion (ET) Treatment[22] Severe malaria[22]
Halofantrine Treatment "Introduced in the 1980s"[23] "Due to its short half life of 1 to 2 days, is not suitable for use as a prophylactic."[23] "Resistant forms are increasingly being reported and there is some concern about its side effects. Halofantrin has been associated with neuropsychiatric disturbances. It is contraindicated during pregnancy and is not advised to women who are breastfeeding. Abdominal pain, diarrhea, puritus and skin rash have also been reported."[23]
Indoor residual spraying Prevention Mosquito "Large-scale IRS with DDT for malaria control started in 1946."[24] "A single spraying can protect a home for up to 9 months."[25] "Spraying requires no behavourial change – after spraying teams have treated a dwelling, the occupiers can continue as before."[25] "homes must be regularly resprayed for the treatment to remain effective over longer periods."[25]
Lumefantrine (benflumetol) Treatment[14] "Multidrug resistant Plasmodium falciparum".[14] "Oral preparation coformulated with artemether."[14]
Proguanil Both Plasmodium falciparum
Atovaquone-proguanil (Malarone) Treatment, prevention[26] "released in the late 1990s"[23] found to be 95% effective in otherwise drug resistant falciparum malaria.[23]
Mefloquine Both Plasmodium falciparum, Plasmodium vivax 1977[3] 1982[3]
Mosquito net Prevention
Piperaquine
Pyrethroid nets Prevention It has promoted resistance among malaria vectors in specific geographic areas.[27]
Quinine Treatment "asexual erythrocytic forms of malaria, including Plasmodium vivax, Plasmodium malariae and Plasmodium falciparum and is gametosidal to Plasmodium vivax and Plasmodium malariae."[28] <1700[29] 1910[3]
Quinidine
Tafenoquine
Trimethoprim-sulfamethoxazole Treatment[30]
Intermittent preventive therapy
Artemether/lumefantrine Treatment Plasmodium falciparum
Artesunate suppositories
Sulfadoxine/pyrimethamine (Fansidar) Treatment 1967[3] 1967 (same year it was introduced)[3] "cheap, practicable (only one dose is needed because it eliminates from the body slowly)"[3]
Primaquine Treatment "Plasmodium vivax and plasmodium ovale."[14] "Gametocytocidal against plasmodium falciparum".[14] "The only antimalatial drug that is effective against exo-erythrocytic schizogony and is used for radical cure of Plasmodium vivax malaria."[11] "Hemolysis in patients with Glucose-6-phosphate dehydrogenase deficiency."[11]
Artesunate Treatment Advantages over quinine: Acts rapidly. Causes faster clearance of parasite. It is better tolerated, more effective and more safe.[11]
Sulfonamide compounds
Swamp draining Prevention Mosquito
Fogging
Larviciding (application of insecticides to mosquito breeding sites)
Genetic blood disorders
Selective eradication of certain mosquito species
Use of decoys[31]
RTS,S Plasmodium falciparum
Personal protection (like long-sleeved clothing?)
Other forms of larval control?
Mosquito coil Prevention Mosquito
Mosquito mat Prevention Mosquito
Immunity from repeated infection Prevention Malaria (just P. falciparum?)

Insecticides

All insecticides act against mosquitoes and are used for prevention. (?)

Surface := Bednet | Wall | Swamp

Also consider the length the insecticide lasts (in different contexts)? For IRS, DCP2 p423 gives 6+ months for DDT, 3–6 months for lambda-cyhalothrin, and 2–3 months for malathion and deltamethrin.

Name Surface First use First resistance Locations where used Advantages Disadvantages Usage status
Dichlorodiphenyltrichloroethane (DDT) 1943[32]:7 1946[32]:9 Cheap, chemically stable, lipophilic (so not easily washed off)[32]:7 Persists in environment, accumulates along food chain[32]:7
Dihydrolipoamide dehydrogenase (DLD)
BHC (Lindane?)
Dieldrin
HCH
Deltamethrin
Paris green

Carbamate insecticides http://files.givewell.org/files/conversations/Abraham%20Mnzava10-%2018-13%20(public).pdf

See also

External links

References

  1. ↑ "amodiaquine". nih.gov. Retrieved 24 April 2017. 
  2. ↑ "ARTESUNATE AMODIAQUINE WINTHROP 25 mg/67.5 mg, tablet" (PDF). wipo.int. Retrieved 24 April 2017. 
  3. ↑ 3.00 3.01 3.02 3.03 3.04 3.05 3.06 3.07 3.08 3.09 3.10 3.11 "Simpli fied R eversed C hloroquines t o Overcome M alaria Resistance to Quinoline-b ased D rugs". Portland State Universit y. 
  4. ↑ Turner, Arthur. Logan Turner's Diseases of the Nose, Throat and Ear, 10Ed. Retrieved 24 April 2017. 
  5. ↑ "Medicinal Chemistry of Antimalarial Drugs - PharmaFactz". http://pharmafactz.com. Retrieved 24 April 2017.  External link in |website= (help)
  6. ↑ 6.0 6.1 "Artemether". OPEN CHEMISTRY DATABASE. 
  7. ↑ "Essential Medicines and Health Products Information Portal". World Health Organization. 
  8. ↑ "The pharmacokinetics of artemisinin after oral, intramuscular and rectal administration to volunteers.". PMID 1982311. Retrieved 24 April 2017. 
  9. ↑ "Rectal administration of artemisinin derivatives for the treatment of malaria". Retrieved 24 April 2017. 
  10. ↑ "San Antonio scientist awarded $4.6 million for malaria research". 
  11. ↑ 11.0 11.1 11.2 11.3 11.4 Mondal, Sudeb. "Basic Undergraduate Pharmacology". 
  12. ↑ Dowling, John Malcolm; Yap, Chin-Fang (2014). Communicable Diseases in Developing Countries: Stopping the global epidemics of HIV/AIDS, Tuberculosis, Malaria and Diarrhoea. Palgrave and Macmillan. 
  13. ↑ "Artemotil". sciencedirect.com. Retrieved 24 April 2017. 
  14. ↑ 14.0 14.1 14.2 14.3 14.4 14.5 Guidelines for the Treatment of Malaria. World Health Organization. 
  15. ↑ 15.0 15.1 "APPLICATION FOR INCLUSION OF ARTESUNATE/AMODIAQUINE FIXED DOSE COMBINATION TABLETS IN THE WHO MODEL LISTS OF ESSENTIAL MEDICINES" (PDF). WHO. 
  16. ↑ "dentification of a Chloroquine Importer in Plasmodium falciparum" (PDF). THE JOURNAL OF BIOLOGICAL C HEMISTRY. 
  17. ↑ "Chloroquine resistance". 
  18. ↑ Semba, Richard David; Bloem, Martin W. Nutrition and Health in Developing Countries. 
  19. ↑ 19.0 19.1 "Chlorproguanil-dapsone: effective treatment for uncomplicated falciparum malaria.". PMC 164103Freely accessible. 
  20. ↑ 20.0 20.1 20.2 "Clindamycin as an Antimalarial Drug: Review of Clinical Trials". Members of the AAC Editorial Board >> ASM Journal Press Releases Antimicrobial Agents and Chemotherapy. doi:10.1128/AAC.46.8.2315-2320.2002. 
  21. ↑ "Dihydroartemisinin + piperaquine (Inclusion) -- Adults and Children". WHO. 
  22. ↑ 22.0 22.1 "Exchange Transfusion for Severe Malaria: Evidence Base and Literature Review". Oxford Academic. 
  23. ↑ 23.0 23.1 23.2 23.3 23.4 "Malaria: Past and Present History of Treatment and Prophylaxis". 
  24. ↑ "Indoor Residual Spraying". 
  25. ↑ 25.0 25.1 25.2 "Malaria and Vector Control Question and Answers - IVCC". UNITAID. 
  26. ↑ "Malarone". 
  27. ↑ "ITNs: Challenges - Insecticide Resistance". 
  28. ↑ "QUININE". 
  29. ↑ "Quinine, an old anti-malarial drug in a modern world: role in the treatment of malaria". doi:10.1186/1475-2875-10-144. 
  30. ↑ "Trimethoprim-sulfamethoxazole in the treatment of malaria, toxoplasmosis, and pediculosis.". PMID 7051240. 
  31. ↑ "Malaria Site: History of Malaria Control". Retrieved December 20, 2016. 
  32. ↑ 32.0 32.1 32.2 32.3 Palmer, Michael (March 26, 2016). "The ban of DDT did not cause millions to die from malaria" (PDF). Retrieved December 22, 2016. 
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