Difference between revisions of "Timeline of diphtheria"

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| 19th century || Diphtheria infection grows significantly late in the century to become one of the major causes of death, fuelled by the industrial revolution and increasingly crowded urban centers.<ref name="The strangler"/>
 
| 19th century || Diphtheria infection grows significantly late in the century to become one of the major causes of death, fuelled by the industrial revolution and increasingly crowded urban centers.<ref name="The strangler"/>
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| 1920s || The first diphtheria toxoid vaccine is developed, and its subsequent widespread use leads to a dramatic decrease of diphtheria worldwide.<ref name="Diphtheria Facts"/>
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| 1990s || The vast majority of diphtheria cases occur during an outbreak in the ex-Soviet Union, in which the World Health Organization reports more than 157,000 cases and 5,000 deaths.<ref name="Diphtheria Facts"/>
 
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| 1826 || Scientific development || French physician [[wikipedia:Pierre Bretonneau|Pierre Bretonneau]] gives diphtheria its official name ''diphtérite'', derived from the Greek word for "leather" or "hide", which describes the pseudomembrane in the throat of the victims.<ref name="The strangler"/><ref name="Pierre Bretonneau">{{cite web|title=Pierre Bretonneau|url=https://www.historyofvaccines.org/content/diphtheria-given-its-name|website=historyofvaccines.org|accessdate=9 May 2017}}</ref> ||  
 
| 1826 || Scientific development || French physician [[wikipedia:Pierre Bretonneau|Pierre Bretonneau]] gives diphtheria its official name ''diphtérite'', derived from the Greek word for "leather" or "hide", which describes the pseudomembrane in the throat of the victims.<ref name="The strangler"/><ref name="Pierre Bretonneau">{{cite web|title=Pierre Bretonneau|url=https://www.historyofvaccines.org/content/diphtheria-given-its-name|website=historyofvaccines.org|accessdate=9 May 2017}}</ref> ||  
 
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| 1884 || Scientific development || German bacteriologist [[wikipedia:Friedrich Loeffler|Friedrich Loeffler]] first grows diphtheria bacterium ''[[wikipedia:Corynebacterium diphtheriae|corynebacterium diphtheriae]]'' in pure culture.<ref name="Diphtheria in Europe">{{cite web|last1=KWANTES|first1=W.|title=Diphtheria in Europe|url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2129475/pdf/jhyg00015-0039.pdf|website=nih.gov|accessdate=8 May 2017}}</ref> || [[wikipedia:Germany|Germany]]
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| 1884 || Scientific development || German bacteriologist [[wikipedia:Friedrich Loeffler|Friedrich Loeffler]] first grows diphtheria bacterium ''[[wikipedia:Corynebacterium diphtheriae|corynebacterium diphtheriae]]'' in pure culture.<ref name="Diphtheria in Europe">{{cite web|last1=KWANTES|first1=W.|title=Diphtheria in Europe|url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2129475/pdf/jhyg00015-0039.pdf|website=nih.gov|accessdate=8 May 2017}}</ref><ref name="Diphtheria Facts">{{cite web|title=Diphtheria Facts|url=http://www.emedicinehealth.com/diphtheria/article_em.htm|website=emedicinehealth.com|accessdate=9 May 2017}}</ref> || [[wikipedia:Germany|Germany]]
 
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| 1888 || Scientific development || French physicians [[wikipedia:Pierre Paul Émile Roux|Pierre Paul Émile Roux]] and [[wikipedia:Alexandre Yersin|Alexandre Yersin]], working at [[wikipedia:Pasteur Institute|Pasteur Institute]], discover the [[wikipedia:diphtheria toxin|diphtheria toxin]].<ref name="The Comprehensive Sourcebook of Bacterial Protein Toxins">{{cite book|last1=Ladant|first1=Daniel|last2=Alouf|first2=Joseph E.|last3=Popoff|first3=Michel R.|title=The Comprehensive Sourcebook of Bacterial Protein Toxins|url=The Comprehensive Sourcebook of Bacterial Protein Toxins|url=https://books.google.com.ar/books?id=gFol3jKI03EC&pg=PA4&lpg=PA4&dq=%22+Emile+Roux%22+%221888%22+%22diphtheria+toxin%22&source=bl&ots=uCjVueYEPm&sig=ECi9rW7RCyHsUbgPno8Az7emNZg&hl=en&sa=X&ved=0ahUKEwjF04uJ1uPTAhWDW5AKHby-AYQQ6AEIJTAA#v=onepage&q=%22%20Emile%20Roux%22%20%221888%22%20%22diphtheria%20toxin%22&f=false}}</ref> || [[wikipedia:France|France]]
 
| 1888 || Scientific development || French physicians [[wikipedia:Pierre Paul Émile Roux|Pierre Paul Émile Roux]] and [[wikipedia:Alexandre Yersin|Alexandre Yersin]], working at [[wikipedia:Pasteur Institute|Pasteur Institute]], discover the [[wikipedia:diphtheria toxin|diphtheria toxin]].<ref name="The Comprehensive Sourcebook of Bacterial Protein Toxins">{{cite book|last1=Ladant|first1=Daniel|last2=Alouf|first2=Joseph E.|last3=Popoff|first3=Michel R.|title=The Comprehensive Sourcebook of Bacterial Protein Toxins|url=The Comprehensive Sourcebook of Bacterial Protein Toxins|url=https://books.google.com.ar/books?id=gFol3jKI03EC&pg=PA4&lpg=PA4&dq=%22+Emile+Roux%22+%221888%22+%22diphtheria+toxin%22&source=bl&ots=uCjVueYEPm&sig=ECi9rW7RCyHsUbgPno8Az7emNZg&hl=en&sa=X&ved=0ahUKEwjF04uJ1uPTAhWDW5AKHby-AYQQ6AEIJTAA#v=onepage&q=%22%20Emile%20Roux%22%20%221888%22%20%22diphtheria%20toxin%22&f=false}}</ref> || [[wikipedia:France|France]]
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| 1982 || Epidemic || 5 deaths are recorded in Germany during a diphtheria outbreak.<ref name="Diphtheria in Europe"/> || [[wikipedia:Germany|Germany]]
 
| 1982 || Epidemic || 5 deaths are recorded in Germany during a diphtheria outbreak.<ref name="Diphtheria in Europe"/> || [[wikipedia:Germany|Germany]]
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| 1990 || ||DIphtheria epidemic breaks out in parts of Russia
 
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| 1996 || Medical development || Lederle Laboratories licenses diphtheria and tetanus toxoids and acellular pertussis vaccine Acel-Imune, for use as the first through fifth doses in the series.<ref name="Vaccine Timeline"/> ||
 
| 1996 || Medical development || Lederle Laboratories licenses diphtheria and tetanus toxoids and acellular pertussis vaccine Acel-Imune, for use as the first through fifth doses in the series.<ref name="Vaccine Timeline"/> ||

Revision as of 13:28, 9 May 2017

Year/period Key developments
19th century Diphtheria infection grows significantly late in the century to become one of the major causes of death, fuelled by the industrial revolution and increasingly crowded urban centers.[1]
1920s The first diphtheria toxoid vaccine is developed, and its subsequent widespread use leads to a dramatic decrease of diphtheria worldwide.[2]
1990s The vast majority of diphtheria cases occur during an outbreak in the ex-Soviet Union, in which the World Health Organization reports more than 157,000 cases and 5,000 deaths.[2]

Full timeline

Year/period Type of event Event Present time geographical location
5th century BC Scientific development Diphtheria is first described by Greek physician Hippocrates.[3] Greece
1600s Scientific development Medical reports of a "deadly" strangulation disease first appear early in the century, and emerges as a greater threat with the growth.[1]
1826 Scientific development French physician Pierre Bretonneau gives diphtheria its official name diphtérite, derived from the Greek word for "leather" or "hide", which describes the pseudomembrane in the throat of the victims.[1][4]
1884 Scientific development German bacteriologist Friedrich Loeffler first grows diphtheria bacterium corynebacterium diphtheriae in pure culture.[5][2] Germany
1888 Scientific development French physicians Pierre Paul Émile Roux and Alexandre Yersin, working at Pasteur Institute, discover the diphtheria toxin.[6] France
1890 Medical development German physiologist Emil von Behring develops the first effective therapeutic serum against diphtheria. In 1901 Von Bering would be awarded the first Nobel Prize in Physiology or Medicine for this work.[7][8] Germany
1891 Medical development The first successful therapeutic serum treatment of a child suffering from diphtheria is performed.[7]
1894 Medical development The production and marketing of the diphtheria therapeutic serum begins in Germany.[7] Germany
1901 Medical development Emil von Behring, for the first time, uses a diphtheria innoculation of bacteria with reduced virulence, hoping with this active immunization to help the body also produce antitoxins.[7] Germany
1913 Medical development Emil von Behring publishes his diphtheria protective agent, T.A. (Toxin-Antitoxin), which contains a mixture of diphtheria toxin and therapeutic serum antitoxin. Designed to provide long-term protection, the new drug would further be tested at various clinics and proven to be non-harmful and effective.[7] Germany
1921 Report 206,000 cases of diphtheria and 15,520 deaths are recorded in the United States.[9] United States
1923 Medical development Diphtheria toxoid is licensed; prepared from inactivated bacterial toxin that has lost its toxicity but retains its antitoxin producing properties.[8]
1924 Scientific development French biologist Gaston Ramon, working at Pasteur Institute, discoveres diphtheria and tetanus toxoid, then referred to as anatoxins.[10] France
1947 Medical development Combination diphtheria and tetanus toxoids for pediatric use is first licensed in the United States.[8] United States
1953 Medical development Tetanus and diphtheria toxoids (adult formulation) are first licensed in the United States, after the concentration of diphtheria toxoid is reduced.[8] United States
1974 Epidemic Diphtheria epidemic breaks out in Lisbon. 500 persons are involved, and about 40 deaths are recorded.[5] Portugal
1982 Epidemic 5 deaths are recorded in Germany during a diphtheria outbreak.[5] Germany
1990 DIphtheria epidemic breaks out in parts of Russia
1996 Medical development Lederle Laboratories licenses diphtheria and tetanus toxoids and acellular pertussis vaccine Acel-Imune, for use as the first through fifth doses in the series.[8]
1997 Medical development British pharmaceutical company SmithKline Beecham licenses Infanrix (diphtheria and tetanus toxoids and acellular pertussis vaccine adsorbed), for the first four doses of the series.[8]
1998 Medical development North American Vaccine Inc licenses Certiva (diphtheria and tetanus toxoids and acellular pertussis vaccine adsorbed), for boosting immunization of infants and children.[8]
1999 Medical development Connaught Laboratories licenses diphtheria and tetanus toxoids and acellular pertussis vaccine Tripedia.[8]
2002 Medical development British pharmaceutical GlaxoSmithKline licenses Pediarix, a vaccine combining diphtheria, tetanus, acellular pertussis, inactivated polio, and hepatitis B antigens.[8]
2002 Medical development Aventis Pasteur licenses diphtheria and tetanus toxoids and acellular pertussis vaccine Daptacel.[8]
2004 Medical development Aventis Pasteur licenses vaccine Decavac, indicated for active immunization against tetanus and diphtheria.[8][11]
2005 Medical development Sanofi Pasteur licenses Menactra, the first meningococcal polysaccharide (Serogroups A, C, Y and W-135) diphtheria toxoid conjugate vaccine. This would be the first immunogenic meningococcal vaccine indicated for children younger than 2 years of age.[8]
2007 Report 4,190 cases of diphtheria are reported globally.[9]
2011 Medical development United States Food and Drug Administration approves Boostrix (developed by GlaxoSmithKline) to prevent tetanus, diphtheria, and pertussis in older people.[8] United States

See also

  1. ↑ 1.0 1.1 1.2 "The strangler". museumofhealthcare.ca. Retrieved 9 May 2017. 
  2. ↑ 2.0 2.1 2.2 "Diphtheria Facts". emedicinehealth.com. Retrieved 9 May 2017. 
  3. ↑ "Diphtheria". medscape.com. Retrieved 8 May 2017. 
  4. ↑ "Pierre Bretonneau". historyofvaccines.org. Retrieved 9 May 2017. 
  5. ↑ 5.0 5.1 5.2 KWANTES, W. "Diphtheria in Europe" (PDF). nih.gov. Retrieved 8 May 2017. 
  6. ↑ Ladant, Daniel; Alouf, Joseph E.; Popoff, Michel R. The Comprehensive Sourcebook of Bacterial Protein Toxins. 
  7. ↑ 7.0 7.1 7.2 7.3 7.4 "Emil von Behring: The Founder of Serum Therapy". nobelprize.org. Retrieved 9 May 2017. 
  8. ↑ 8.00 8.01 8.02 8.03 8.04 8.05 8.06 8.07 8.08 8.09 8.10 8.11 8.12 "Vaccine Timeline". immunize.org. Retrieved 8 May 2017. 
  9. ↑ 9.0 9.1 "Diphtheria: The Plague Among Children". historyofvaccines.org. Retrieved 8 May 2017. 
  10. ↑ Medical Sciences - Volume I (B.P. Mansourian, S.M. Mahfouz, A. Wojtezak ed.). Retrieved 9 May 2017. 
  11. ↑ "HIGHLIGHTS OF PRESCRIBING INFORMATION" (PDF). vaccineshoppe.com. Retrieved 8 May 2017. 
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