Timeline of hematology

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This is a timeline of hematology, listing important events in the development of the field. Events related to transfusion are described in the Timeline of transfusion medicine.

Big picture

Time period Development summary
Ancient history “Blood letting” instruments are used in Ancient Egypt.[1]
17th century Dutch microscopist Antonie van Leeuwenhoek, using a primitive, single-lens microscope, already observes red blood cells (erythrocytes) and compared their size with that of a grain of sand.[2]
18th century English physiologist William Hewson is considered to be the "father of hematology". Hewson manages to amplify the description of red cells and demonstrates the role of fibrin in the clotting (coagulation) of blood.[3][2]
19th century Bone marrow is recognized as the site of blood-cell formation in the 19th century, along with the first clinical descriptions of pernicious anemia, leukemia, and a number of other disorders of the blood.[2]
20th century The discovery of the ABO blood group system in the first quarter of the 20th century makes possible the transfusion of blood from one person to another without the serious ill effects that ensue when incompatible blood is given. The study of the blood disease anemia gains impetus from the introduction of the hematocrit, an apparatus for determining the volume of red blood cells as compared with the volume of plasma, and the introduction in 1932 of a simple method of measuring the volume and hemoglobin. After World War II, the field of hematology broadens.[2] In the 1950s, plastic intra venous tubing replaces rubber tubing.[4] The 1960s is the decade in which most of the modern understanding of platelet funcion is initiated.[5] In the 1970s, the combination of several observational studies identifying a possible role for prophylactic platelet transfusion in hypoproliferative thrombocytopenia and the discovery that platelets are best stored at room temperature with gentle agitation to preserve function allow for the proliferation of platelet transfusions as part of standard management of patients receiving chemotherapy.[6] In the 1980s, the emergence of HIV renews impetus for development of infection-safe blood substitutes.[7]

Full timeline

Year Event type Details Location
3255 BC The oldest intact red blood cells ever discovered are found in Ötzi, a natural mummy of a man who died around that time.[8]
460 BC – 377 BC Field development Greek physician Hippocrates teaches the humoral theory, a hypothetical system to explain illness in which balance equals health, and excess or deficiency equals illness.[1] Greece
1616 Field development English physician William Harvey discovers blood pathways. Since then many people try to use fluids such as beer, urine, milk, and non-human animal blood as blood substitute.[9] United Kingdom
1628 Field development English physician William Harvey publishes Exercitatio Anatomica de Motu Cordis et Sanguinis in Animalibus (Movement of the Heart and the Blood in Animals), which demonstrates the concept of blood circulation.[5] United Kingdom
1642 Scientific development Dutch scientist Antonie van Leeuwenhoek constructs a microscope and distinguishes blood cells.[1] Netherlands
1656 Field development English anatomist Christopher Wren gives the first intravenous injection in animals.[1] United Kingdom
1658 Field development Dutch biologist Jan Swammerdam first describes red blood cells by means of the use of an early microscope to study the blood of a frog.
1662 Field development J. C. Major gives the first intravenous injection in humans.[1]
1665 Field development English physician Richard Lower performs the first documented blood transfusionusing dogs and notes a color difference between veins and arteries.[6][1] United Kingdom
1666 Field development Italian physician Marcello Malpighi notices that fiber filaments remain in a blood clot after it is thoroughly washed.[10] Italy
1667 Field development French physician Jean-Baptiste Denys and Richard Lower separately report giving the first human blood transfusion with blood fromlambs. Within 10 years, transfusing the blood of animals to humans becomes prohibited by law, delaying transfusion advances for about 150 years.[1] France, United Kingdom
1674 Field development Pioneer microscopist Anton van Leeuwenhoek writes his own description of human red blood cells.[11] Netherlands
1675 Field development Anton van Leeuwenhoek makes the remarkable discovery that "those sanguineous globules in a healthy body must be very flexible and pliant, if they are to pass through the small capillary veins and arteries, and that in their passage they change into an oval figure, reassuming their roundness when they come into a larger room."[11] Netherlands
1770 Field development British surgeon William Hewson describes leukocytes and some essential clottingfactors. Hewson becomes known as “the father of hematology.”[1]
1771 Literature William Hewson publishes Experimental Inquiry into the Properties of the Blood.[5] United Kingdom
1795 Field development American physician Philip Syng Physick claims to perform the first human-to-human blood transfusion, although he does not publish this information.[1]
1821 – 1902 Field development German physician Rudolf Virchow disproves a prominent view that phlebitis (inflammation of a vein) causes most diseases. Virchow demonstrates that masses in the blood vessels result from “thrombosis” (his term) and that portions of a thrombus could become detached to form an “embolus” (also his term).[12] Germany
1827 Literature amateur British opticist Joseph Jackson Lister and fellow Quaker Dr Thomas Hodgkin publish Notice of some Microscopic Observations of the Blood and Animal Tissues.[5] United Kingdom
1830 Instrumental The gold-plated steel needle for intravenous use is invented.[4]
1840 Field development English surgeon Samuel Armstrong Lane performs the first successful whole blood transfusion to treat hemophilia.[13][14][15][16] United Kingdom
1840s Field development English anatomist George Gulliver publishes early illustrations of platelets.[5] United Kingdom
1842 Field development French microscopist Alexandre Donné identifies platelets.[17][18]
1867 Field development British surgeon Joseph Lister uses antiseptics to control infectionduring transfusions.[1] United Kingdom
1875 Field development Zahn reports that an injured blood vessel is eventually plugged by a fibrin-associated white thrombus. This observation leads to the discovery that platelets are responsible for contributing fibrin in the blood coagulation process.[10]
1877 Field development German-Jewish physician Paul Ehrlich develops techniques to stain blood cells to improve microscopic visualization.[19] Germany
1882 Field development Italian medical researcher Giulio Bizzozero describes blood platelets.[20][5] Italy
1897 Literature American pediatrician Luther Emmett Holt publishes The Diseases of Infancy and Childhood, which includes a 20-page chapter on diseases of the blood and is the first American pediatric medical textbook to provide significant hematologic information.[19][21] United States
1901 Field development Austrian biologist Karl Landsteiner and his associates define the different blood groups: A, B, AB, and O.[22][23][24][25]
1902 Field development Alfred Decastello and Adriano Sturli add bloodtype AB to the classification system.[26]
1904 Literature Folia Haematologica is established in Germany. It is the first hematology journal in the world.[27] Germany
1906 Field development James Wright describes the bone marrow and megakaryocyte origin of platelets.[5]
1907 Field development American pathologist Ludvig Hektoen from Chicago, explains the significance of isoagglutinins in human blood and how the untoward reactions are related to them.[28][19] United States
1908 Field development American haematologist Reuben Ottenberg develops clinical methods for typing bloods.[28] United States
1910 Field development Sickle cell disease is first described.[29]
1910 Field development Duke notes that transfusions reduce the bleeding time. After this, transfusions become recognized as successful therapeutic hemostatic intervensions.[6]
1914 Field development American scientist, Richard Lewisohn, discovers that sodium citrate can be added to blood to stop it clotting.[30][25][19]
1918 Field development The use of blood plasma as a substitute for whole blood and for transfusion purposes is proposed by Gordon R. Ward. The use of blood plasma as a substitute for whole blood and for transfusion purposes was proposed in the same year, in the correspondence columns of the British Medical Journal. United Kingdom
1920 Field development The investigation of the role of food substances in the production of red blood cells is launched. It would lead to discovery of the beneficial effects of liver extract in treating pernicious anemia and ultimately to the discovery of vitamin B12, the anti-anemic principle of liver.[2]
1920 Literature Journal Haematologica is first published.[31][32] It is the second in the world to be released.[27] Italy
1924 Literature Pediatrics becomes the first comprehensive American publication on pediatric hematology.[19]
1925 Field development Canadian physician Alfred P. Hart introduces exsanguination ("exchange") transfusion to treat severe neonatal jaundice.[33][34][35][19]
1925 Field development American pediatrician Thomas Benton Cooley describes a Mediterranean hematologic syndrome of anemia, erythroblastosis, skeletal disorders, and splenomegaly that is later called Cooley’s anemia and now thalassemia.[19]
1927 Organization The French Society of Hematology is formed. It is the first hematology organization in the world.[27] France
1927 Literature Journal La Sang is released in France.[27] France
1932 Field development A simple method of measuring the volume and hemoglobin is introduced.[2]
1933 Field development The formation of cryoprecipitate is first observed in relation to a patient with multiple myeloma.[36]
1935 Field development Danish biochemist Carl Peter Henrik Dam finds that bleeding in chicks that developed an excessive bleeding disorder in response to synthetic diets, do not occur if their synthetic chow was replaced with one fortified with a specific vitamin. Dam labels this antihemorrhagic agent “vitamin K” and establishes its essential role in normal blood coagulation.[10] Denmark
1936 Organization The World's first blood bank opens in Chicago.[37][38][25] United States
1936 Field development American hematologist John H. Lawrence of the University of California, Berkeley introduces phosphorus-32 for the treatment of leukemia.[39][40][41] United States
1937 Organization The Japanese Society of Hematology (JSH) is founded in Kyoto. It is the second hematology organization in the world.[42][27] Japan
1937 Field development Karl Landsteiner and Alexander S. Wiener identify the Rh factor in blood.[13]
1938 Literature Journal Acta Haematologica Japonica is established. In 1991, it would be renamed International Journal of Hematology.[27] Japan
1938 Field development American pediatricians {Louis Diamond (known as the “father of American pediatric hematology”) and Kenneth Blackfan describe the anemia still known as Diamond-Blackfan anemia.[19] United States
1941 Literature Blackfan, Diamond, and Leister publish The Atlas of the Blood of Children.[19]
1945 Field development Robin Coombs, Arthur Mourant and Rob Race describe the use of antihuman globulin (later known as the “Coombs Test”) to identify “incomplete” antibodies.[19]
1946 Literature Journal Blood is established by William Dameshek.[43]
1946 Field development Austro-Hungarian biochemist Erwin Chargaff and Randolph West discover that platelet-free plasma exhibits clotting properties.[10]
1947 Field development Lerner and Watson introduce the term "cryoglobulin", demonstrating the reversibility of the phenomenon when the sera are heated to 37°C.[36]
1950s Instrumental The “butterfly” needle and intercath are developed, making intravenous access easier and safer.[19]
1950 Organization The Society for Hematology and Stem Cells is founded by a group of scientists for the presentation and discussion of experimental hematology pre-clinical data.[44]
1954 Field development The blood product cryoprecipitate is developed to treat bleeds in people with hemophilia.[19]
1954 Field development Peterman and Braunsteiner report cryoprecipitates of immunoglobulins with different sedimentation rates, thus introducing the concept of "mixed cryoglobulinaemia".[36]
1955 Literature The British Journal of Haematology is launched.[45][46] United Kingdom
1958 Organization The American Society of Hematology is founded.[47][48] United States
1959 Field development Austrian-born British molecular biologist Max Perutz uses X-ray crystallography to determine the overall structure of hemoglobin.[49][50][51][52]
1959 Organization The Japanese Society of Clinical Hematology is established in Tokyo.[27] Japan
1960 Organization The British Society for Haematology is founded.[53] United Kingdom
1961 Field development Researchers identify role of platelets in treating cancer patients.[54][25]
1962 Field development At an International Committee on Blood Clotting Factors conference in Stockholm, English hematologist Robert Gwyn Macfarlane of Oxford and American researcher Oscar Ratnoff propose that the coagulation process involves an enzyme acting on its substrate to make it an active enzyme, which subsequently acts on its own distinct substrate. This type of enzymatic activation continues down a line of substrates before coagulation is achieved.[10] Sweden
1962 Field development The first antihemophilic factor concentrate to treat coagulation disorders in hemophilia patients is developed through fractionation.[19]
1962 Field development Researchers at CSL Behring develop a new plasma fractionation method that provides significantly better yields of the valuable proteins isolated from human plasma.[55]
1962 Field development Platelet transfusion begins to be used more routinely, especially in cancer patients when the relationship between thrombocytopenia and hemorrage is noted.[6]
1967 Field development Peter Wolf first identifies microparticles as a product of platelets.[10]
1970 Field development Webber and Johnson find that platelet alpha granule contents are encompassed into vesicles, which come together to form a membrane complex at the surface of the platelet.[10]
1972 Literature Journal Experimental Hematology is launched by the International Society for Experimental Hematology, incorporated the same year as the continuation of the Society for Hematology and Stem Cells.[56]
1974 Literature Davis Nathan and Stuart Oski publish Hematology of Infancy and Childhood.[19]
1975 Literature Journal Blood Cells, Molecules and Diseases is established.[57]
1976 Literature The American Journal of Hematology is established.[58] United States
1977 Field development Kitamura first observes that mast cells are derived from hematopoietic stem cells shown by transplantation of bone marrow cells from mutant mice.[27] Japan
1977 Field development Miyake et al first purify erythropoietin.[27] Japan
1970s Field development Alan T. Nurden, Jacques P. Caen, David R. Phillips, and others describe the molecular basis of platelet aggregation.[20]
1981 Organization The American Society of Pediatric Hematology/Oncology is founded.[59][60] United States
1983 Field development Doctors in France and the United States discover the human immunodeficiency virus (HIV).[25] United States, France
1986 Field development Granulocyte colony-stimulating factor is cloned independently in Japan.[27] Japan
1987 Literature Journal Blood Reviews is established.[61]
1990s Field development Recombinant factor replacement products are used to treat hemophilia.[25]
1990 Literature Peer-reviewed medical journal Platelets is first issued.[62]
1992 Organization The International Society for Laboratory Hematology is founded by an international group of laboratory professionals in order to chart new directions for laboratory hematology.[63]
1992 Organization The European Hematology Association is founded in Brussels.[64] Belgium
1994 Field development Researchers investigating the effects of lipopolysaccharide (LPS) stimulation on monocyte procoagulant activity, reveal that the microparticles released by stimulated human monocytes possess more tissue factor activity than their parent monocytes.[10]
2008 Literature Journal Expert Review of Hematology is released.[65]
2008 Literature The Open Hematology Journal is released.[66]

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References

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 "Timeline of Major Hematology Landmarks". scribd.com. Retrieved 20 September 2018. 
  2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 "Hematology". britannica.com. Retrieved 7 September 2018. 
  3. ↑ Doyle, D. "William Hewson (1739-74): the father of haematology.". PMID 16643443. doi:10.1111/j.1365-2141.2006.06037.x. 
  4. ↑ 4.0 4.1 Cite error: Invalid <ref> tag; no text was provided for refs named Textbook_of_Critical_Care_E-Book
  5. ↑ 5.0 5.1 5.2 5.3 5.4 5.5 5.6 Books on Google Play Platelets in Thrombotic and Non-Thrombotic Disorders: Pathophysiology, Pharmacology and Therapeutics: an Update (Paolo Gresele, Neal S. Kleiman, José A. Lopez, Clive P. Page ed.). 
  6. ↑ 6.0 6.1 6.2 6.3 Platelets in Thrombotic and Non-Thrombotic Disorders: Pathophysiology, Pharmacology and Therapeutics: an Update (Paolo Gresele, Neal S. Kleiman, José A. Lopez, Clive P. Page ed.). 
  7. ↑ Squires JE (2002). "Artificial blood". Science. 295 (5557): 1002–5. PMID 11834811. doi:10.1126/science.1068443. 
  8. ↑ "'Iceman' Mummy Holds World's Oldest Blood Cells". livescience.com. Retrieved 20 September 2018. 
  9. ↑ Sarkar, S. (2008). "Artificial Blood". Indian Journal of Critical Care Medicine. 12 (3): 140–144. PMC 2738310Freely accessible. PMID 19742251. doi:10.4103/0972-5229.43685. 
  10. ↑ 10.0 10.1 10.2 10.3 10.4 10.5 10.6 10.7 Hargett, Leslie A.; Bauer, Natalie N. "On the origin of microparticles: From "platelet dust" to mediators of intercellular communication". PMC 3757826Freely accessible. PMID 24015332. doi:10.4103/2045-8932.114760. 
  11. ↑ 11.0 11.1 "Discovery of Red Blood Cells". med-ed.virginia.edu. Retrieved 5 October 2018. 
  12. ↑ "Rudolf Virchow". britannica.com. Retrieved 3 October 2018. 
  13. ↑ 13.0 13.1 BPI. Inventions & Discoveries. 
  14. ↑ Hemolytic Anemia. 
  15. ↑ Madbak, Firas. Bridge Across the Abyss: Medical Myths and Misconceptions. 
  16. ↑ Chang, Anne. Magill's Medical Guide: Down syndrome-Laser use in surgery. 
  17. ↑ Sir William Osler: An Annotated Bibliography with Illustrations (Richard L. Golden, Charles G. Roland ed.). 
  18. ↑ Hematology. 
  19. ↑ 20.0 20.1 "Milestones in Antiplatelet Therapy". hematology.org. Retrieved 4 October 2018. 
  20. ↑ "The diseases of infancy and childhood : for the use of students and practitioners of medicine / by L. Emmett Holt.". catalog.hathitrust.org. Retrieved 3 October 2018. 
  21. ↑ DK. 1000 Inventions and Discoveries. 
  22. ↑ Van Luven, Lynne; Page, Kathy. In the Flesh: Twenty Writers Explore the Body. 
  23. ↑ Hillyer, Christopher D. Blood Banking and Transfusion Medicine: Basic Principles & Practice. 
  24. ↑ 25.0 25.1 25.2 25.3 25.4 25.5 "What is Hematology? - Definition & History". study.com. Retrieved 7 September 2018. 
  25. ↑ "Milestones in Transfusion Medicine". hematology.org. Retrieved 4 October 2018. 
  26. ↑ 27.0 27.1 27.2 27.3 27.4 27.5 27.6 27.7 27.8 27.9 "Hematology in Japan: past, present and future". healio.com. Retrieved 7 September 2018. 
  27. ↑ 28.0 28.1 Jackson, Laura Gertrude. Hospital and community: studies in external relationships of the administrator. 
  28. ↑ "Sickle cell disease: old discoveries, new concepts, and future promise". PMC 1838946Freely accessible. PMID 17404610. doi:10.1172/JCI30920. 
  29. ↑ Evans, R. Paul; Wilkinson, Alf. WJEC Eduqas GCSE History: Changes in Health and Medicine in Britain, c.500 to the present day. 
  30. ↑ Ascari, Edoardo. "The history of Haematologica". PMC 4281305Freely accessible. PMID 25552676. 
  31. ↑ "About Haematologica". haematologica.org. Retrieved 7 September 2018. 
  32. ↑ Shorter, Edward. Partnership for Excellence: Medicine at the University of Toronto and Academic Hospitals. 
  33. ↑ Klossner, N. Jayne. Introductory Maternity Nursing, Volume 1. 
  34. ↑ Cone, Thomas E. History of American Pediatrics. 
  35. ↑ 36.0 36.1 36.2 Oxford Textbook of Vasculitis (Gene V. Ball, Barri J. Fessler, S. Louis Bridges ed.). 
  36. ↑ "Blood Banking and Donation". hematology.org. Retrieved 8 September 2018. 
  37. ↑ "THE TIMELINE: BLOOD DONATION". independent.co.uk. Retrieved 8 September 2018. 
  38. ↑ Marks, Geoffrey; Beatty, William K. The Precious Metals of Medicine. 
  39. ↑ Oreskes, Naomi; Krige, John. Science and Technology in the Global Cold War. 
  40. ↑ Positron Emission Tomography: Basic Sciences (Dale L. Bailey, David W. Townsend, Peter E. Valk, Michael N. Maisey ed.). 
  41. ↑ "Japanese Society of Hematology (JSH)". ishworld.org. Retrieved 7 September 2018. 
  42. ↑ "About Blood". bloodjournal.org. Retrieved 20 September 2018. 
  43. ↑ "Society for Hematology and Stem Cells". omicsonline.org. Retrieved 10 September 2018. 
  44. ↑ Goldman, Lawrence. Oxford Dictionary of National Biography 2005-2008. 
  45. ↑ Harrison, Brian; Aston, Trevor Henry. The History of the University of Oxford: Volume VIII: The Twentieth Century. 
  46. ↑ "American Society of Hematology sponsors high school symposium at San Diego annual meeting". eurekalert.org. Retrieved 8 September 2018. 
  47. ↑ Silver, Samuel M. "The American Society of Hematology: Advancing Knowledge and Treatment of Blood Disorders". PMC 2793577Freely accessible. PMID 29447514. 
  48. ↑ Rezende, Lisa. Chronology of Science. 
  49. ↑ Lee, W. David; Drazen, Jeffrey; Sharp, Phillip A.; Langer, Robert S. From X-rays to DNA: How Engineering Drives Biology. 
  50. ↑ Lee, W. David; Drazen, Jeffrey; Sharp, Phillip A.; Langer, Robert S. From X-rays to DNA: How Engineering Drives Biology. 
  51. ↑ Zecchina, Adriano; Califano, Salvatore. The Development of Catalysis: A History of Key Processes and Personas in Catalytic Science and Technology. 
  52. ↑ "British Society for Haematology (BSH)". emedevents.com. Retrieved 7 September 2018. 
  53. ↑ Moticka, Edward J. A Historical Perspective on Evidence-Based Immunology. 
  54. ↑ "CSL Behring" (PDF). bstquarterly.com. Retrieved 25 September 2018. 
  55. ↑ Fagan, Melinda. Philosophy of Stem Cell Biology: Knowledge in Flesh and Blood. 
  56. ↑ "BLOOD CELLS, MOLECULES, AND DISEASES: PAST, PRESENT, AND FUTURE". kundoc.com. Retrieved 10 September 2018. 
  57. ↑ "The American Journal of Hematology turns 40". onlinelibrary.wiley.com. Retrieved 10 September 2018. 
  58. ↑ Maurer, Harold M.; Ruymann, Frederick B.; Pochedly, Carl E. Rhabdomyosarcoma and Related Tumors in Children and Adolescents. 
  59. ↑ Pochedly, Carl E. Neuroblastoma. 
  60. ↑ "Blood Reviews". bloodreviews.com. Retrieved 7 September 2018. 
  61. ↑ "Platelets: The end of an era, start of a new beginning". tandfonline.com. Retrieved 20 September 2018. 
  62. ↑ "International Society for Laboratory Hematology". islh.org. Retrieved 10 September 2018. 
  63. ↑ "European Hematology Association (EHA)". linkedin.com. Retrieved 4 October 2018. 
  64. ↑ "Expert Review of Hematology". tandfonline.com. Retrieved 8 September 2018. 
  65. ↑ "Effects Of Benzene on Human Hematopoiesis". citeseerx.ist.psu.edu. Retrieved 30 September 2018. 
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