Changes

| 1997 || technological adoption || intermediate storage temperature || {{W|Alcor Life Extension Foundation}} || Alcor brings the crackphone (an acoustic fracturing monitoring device) into clinicaluse.<ref name="IntermediateTemperatureStorage"/>

| 1999 || organisation || closing || CryoCare || BioPreservation doesn't renew its contract with CryoCare, and stops offer offering cryonics services altogether.<ref name="BenBestCryonicsHistory"/> CryoCare doesn't find a new provider.<ref name="BenBestCryonicsHistory"/> They would tansfer their 10 patients from the {{W|American Cryonics Society}} to the Cryonics Institute on 2004-04-06, and their 2 other patients to Alcor on 2001-01-24.<ref name="AlcorCase"/><ref name="BenBestCryonicsHistoryImmortalist"/><ref name="CryoCare/>

| 2000 || science || paper || || The application of {{W|vitrification}} to a relatively large tissue of medical interest is succesful successful for the first time.<ref>{{Cite journal|last=Taylor|first=Michael J.|last2=Brockbank|first2=Kelvin G. M.|last3=Lightfoot|first3=Fred|last4=Khirabadi|first4=Bijan S.|last5=Song|first5=Ying C.|date=2000-03|title=Vitreous cryopreservation maintains the function of vascular grafts|url=https://www.nature.com/articles/nbt0300_296|journal=Nature Biotechnology|language=en|volume=18|issue=3|pages=296–299|doi=10.1038/73737|issn=1546-1696}}</ref>

| 2000 || technological adoption || intermediate storage temperature || {{W|Alcor Life Extension Foundation}} || Alcor acquires a -130ºC −130ºC Harris CryoStar laboratory freezer from GS Laboratory Equipment and begins testing its utility for possible storage of neuropatients.<ref name="IntermediateTemperatureStorage"/><ref>{{Cite journal|last=|first=|date=2000|title=BioTransport Purchases CryoStar Freezer|url=https://alcor.org/cryonics/cryonics2000-3.pdf|journal=Cryonics|volume=|pages=11|via=}}</ref>

| 2002 summer || technological adoption || intermediate storage temperature || {{W|Alcor Life Extension Foundation}} || An Alcor neuropatient receive receives an excellent uniform perfusion, allowing them to reach the lowest temperature without fracturing ever recorded to date, -128°C−128°C. Cryobiologist consultants would evaluate that this may be the best cryopreservation to date. The patient is transferred to the CryoStar freezer for continued slow cooling and annealing for fracture avoidance. However, the patient would be move moved to liquid nitrogen in July 2003 as the maneuver wouldn't be succesful. In December, another patient, A-1034, would be also placed into the CryoStar to accommodate the family's preference for this type of storage, and later transfer transferred in a new validated neuroped in April 2006.<ref name="IntermediateTemperatureStorage"/>

| 2002 || science || paper || || For the first time, a paper shows rigorous demonstration of memory retention after cooling to +10°C (59°F): “Learning "Learning and memory is preserved after induced asanguineous hyperkalemic hypothermic arrest in a swine model of traumatic exsanguination“exsanguination".<ref>{{Cite web|url=https://www.surgjournal.com/action/captchaChallenge?redirectUri=%2Farticle%2FS0039-6060%2802%2900085-5%2Ffulltext|title=Surgery|website=www.surgjournal.com|access-date=2019-01-22}}</ref>

| 2002 || organisation || founding || {{W|Suspended Animation, Inc}} || {{W|Suspended Animation, Inc}}, a for -profit organisation that provides cryonics standby, stabilization, and transport services, is founded.<ref name="Alcor2018-2"/><ref>{{Cite web|url=https://businesssearch.sos.ca.gov/CBS/SearchResults?SearchType=NUMBER&SearchCriteria=C2276225|title=Business Search - Business Entities - Business Programs {{!}} California Secretary of State|website=businesssearch.sos.ca.gov|access-date=2019-01-22}}</ref>

| 2002 || political || || {{W|Alcor Life Extension Foundation}} || Alcor cryopreserves baseball legend {{W|Ted Williams}}.

Following this case, journalists at ''{{W|Sports Illustrated }}'' would write a sensationalistic expose exposé of Alcor based on information that would be supplied to them by Alcor employee Larry Johnson, who had surreptitiously recorded several conversations.

Following more media turmoil, Arizona state representative Bob Stump would attempt to put Alcor under the control of the Funeral Board. The Arizona Funeral Board Director would tell the ''{{W|New York Times }}'' "These companies need to be regulated or deregulated out of business". After a hard fight by Alcor, the legislation would finally be withdrawn in 2004. Alcor would hire a full-time lobbyist to watch after their interests in the Arizona legislature.<ref name="BenBestCryonicsHistory"/>

| 2002 || social || || Frozen Dead Guy Days festival || After media turmoil from Trygve Bauge having brought his cryopreserved grandfather to the the town of Nederland, Colorado, some people take take this opportunity to create an annual Frozen Dead Guy Days festival which would feature coffin races, snow sculptures, and many other activities.

| 2002-12-13 || writing || newsletter || {{W|Alcor Life Extension Foundation}} || The first issue of ''Alcor News'', an online newsletter, is distributed.<ref>{{Cite web|url=https://alcor.org/Library/html/alcornewsarchive.html|title=Alcor News Archive|website=alcor.org|access-date=2019-01-22}}</ref>

| 2003-08 || R&D || intermediate storage temperature || Camegie Carnegie Mellon University || Carnegie Mellon University receives a $1.3 million grant from the U.S. government to study fracturing during {{W|vitrification}} of tissue for medical applications, which would considerably advance the field.<ref name="IntermediateTemperatureStorage"/>

| 2004 || science || paper || || The first report of the consistent survival of transplanted kidneys after cooling to and rewarming from -45°C −45°C is published.<ref>{{Cite journal|last=Fahy|first=Gregory M|last2=Wowk|first2=Brian|last3=Wu|first3=Jun|last4=Phan|first4=John|last5=Rasch|first5=Chris|last6=Chang|first6=Alice|last7=Zendejas|first7=Eric|date=2004-04-01|title=Cryopreservation of organs by vitrification: perspectives and recent advances|url=http://www.sciencedirect.com/science/article/pii/S0011224004000264|journal=Cryobiology|series=Special issue: Keynote papers from CRYOBIOMOL- 2003|volume=48|issue=2|pages=157–178|doi=10.1016/j.cryobiol.2004.02.002|issn=0011-2240}}</ref>

| 2004 || legal || || Cryonics Institute || As a result from of media coverage of {{W|Ted Williams }}'s cryopreservation, even though the Cryonics Institute was not involved in that case, the State of Michigan places the organization under a "Cease and Desist" order for six months, ultimately classifying and regulating the Cryonics Institute as a cemetery in 2004. In the spirit of de-regulation, the new Republican Michigan government would remove the cemetary designation for CI in 2012.<ref name="BenBestCryonicsHistory"/>

| 2004-08 || technological adoptoin adoption || vitrification || Cryonics Institute || CI uses a cryoprotectant, CI-VM-1, for the first time. The dog of a CI members member is the patient of the experimental perfusion. The mixture was developed by CI Staff Cryobiologist Yuri Pichugin, PhD.

| 2004-10-23 || technological adoption || field cryoprotection || {{W|Suspended Animation, Inc}} || {{W|Suspended Animation, Inc}} performes performs a field cryoprotection with glycerol for the {{W|American Cryonics Society}} before transporting the patient on dry ice to the Cryonics Institute for long-term care.<ref name="fieldcryoprotection">{{Cite web|url=https://alcor.org/Library/html/fieldcryoprotection.html|title=Field Cryoprotection|website=alcor.org|access-date=2019-01-22}}</ref>

| 2005 (mid) || organisation || founding || Neural Archives Foundation || The Neural Archives Foundation is conceived, an . The organisation that offers brain preservation services. In 2008 it would get be incorporated.<ref>{{Cite web|url=http://neuralarchivesfoundation.org/|title=NAF|website=neuralarchivesfoundation.org|access-date=2019-01-22}}</ref>

| 2005-02 || technological adoptoin || vitrification || Cryonics Institute || The used use of {{W|vitrification}} mixture is published for the first time; the subject being the dog Thor.

| 2006-01 || technological adoption || intermediate storage temperature || {{W|Alcor Life Extension Foundation}} || An Alcor neuropatient cryopreserved with M22 {{W|vitrification}} solution sets a new record for lowest temperature reached without fracturing of -134 °C−134°C.<ref name="IntermediateTemperatureStorage"/>

| 2010 || organisation || standby || Cryonics Institute || The Cryonics Institute started starts offering, through {{W|Suspended Animation, Inc}}, standby and transport options.<ref>{{Cite web|url=https://www.cryonics.org/resources/suspended-animation-inc-standby-stabilization-and-transport-for-ci-members|title=Resources {{!}} Cryonics Institute|website=www.cryonics.org|access-date=2019-01-22}}</ref>

| 2012 || organisation || || {{W|Brain Preservation Foundation}} || Shawn Mikula at the Winfred Denk lab in Germany uses uses plastic embedding to preserve mouse brains, and submit submits his results for the Small Mammal Brain Preservation Prize. But the preservation quality is not complete.<ref name="SmallMammalBrainPrize"/>

| 2012 || organisation || || {{W|Brain Preservation Foundation}} || {{W|Greg Fahy}} at {{W|21st Century Medicine}} (21CM) uses cryobiological techniques to preserve mouse brains, and submit submits his results for the Small Mammal Brain Preservation Prize. But the preservation quality is not complete.<ref name="SmallMammalBrainPrize"/>

| 2014 || science || || {{W|21st Century Medicine}} || Robert McIntyre from {{W|21st Century Medicine}} wins the Small Mammal Prize from the {{W|Brain Preservation Foundation}} with a technique called vitrifixation, an Aldehyde Stabilized Cryopreservation (ASC). He combines research done by {{W|Greg Fahy}} and Shawn Mikula.<ref name="SmallMammalBrainPrize"/>

| 2014-05-06 || organisation || || OregonCryo || OregonCryo preserves their its first patient, a dog named Cupcake.<ref>{{Cite web|url=http://www.oregoncryo.com/caseReportsPets.html|title=Oregon Cryonics - Pet Case Reports|website=www.oregoncryo.com|access-date=2019-01-22}}</ref>

| 2015-03-13 || technological adoption || fixation || OregonCryo || For the first time, someone is preserved using fixation technology, by having her brain immerse immersed in a fixative solution. The patient was Deborah Cheek, and she was preserved by OregonCryo.<ref name="OregonCryoCaseReports">{{Cite web|url=http://www.oregoncryo.com/caseReports.html|title=Oregon Cryonics - Cases|website=www.oregoncryo.com|access-date=2019-01-22}}</ref>

| 2016 || science || || {{W|21st Century Medicine}} || Robert McIntyre, {{W|Greg Fahy}}, and {{W|21st Century Medicine}} wins win the Large Mammal Prize from the {{W|Brain Preservation Foundation}} with a vitrifixation technique.<ref>{{Cite web|url=https://www.brainpreservation.org/large-mammal-announcement/|title=Large Mammal BPF Prize Winning Announcement – The Brain Preservation Foundation|language=en-US|access-date=2019-01-22}}</ref>

| 2016 || organisation || founding || Nectome || Nectome is started by Robert McIntyre after having won the {{W|Brain Preservation Foundation}}al 's Large Mammal Prize. Nectome is a research organization developing biological preservation techniques to better preserve the physical traces of memory.<ref name="Nectome">{{Cite web|url=https://nectome.com/|title=Nectome|website=nectome.com|access-date=2019-01-22}}</ref>

| 2016-06-06 || risk management || economic stability || {{W|Alcor Life Extension Foundation}} || The Alcor Care Trust Supporting Organization (“ACT”ACT) is created. The Patient Care Trust (PCT) continues in existence to receive inital initial funding from new cryopreservations, and to pay for ongoing costs for maintain maintaining patients' cryopreservation. The ACT will make long term investments, continue maintaining the PCT, and possibly eventual eventually fund resuscitation research. Both trusts have different board of directors that can check on each other.<ref>{{Cite web|url=https://alcor.org/Library/html/alcorcaretrust.htm|title=Alcor Care Trust Supporting Organization|website=alcor.org|access-date=2019-01-22}}</ref>

| 2018 winter || organisation || || Nectome || Nectome participates to in {{W|Y Combinator}}.<ref name="Nectome"/><ref>{{Cite web|url=https://blog.ycombinator.com/10-companies-from-yc-winter-2018/|title=10 Companies From YC Winter 2018|last=Combinator|first=Y.|website=Y Combinator|language=en-US|access-date=2019-01-22}}</ref>

| 2018-04-06 || organisation || founding || International Cryomedicine Experts || Alcor signs an agreement with the newly funded International Cryomedicine Experts, a for -profit organisation providing international cryonics standby, stabilization, and transport services.

| 2018-05-16 || risk management || economic stability || {{W|Alcor Life Extension Foundation}} || Alcor announces the creation of a sibling organisation called the Alcor Endowment Trust Supporting Organization. Its goal is to maintain funds that is are invested, and which support Alcor's general operation and research through giving a fraction of the interests made.<ref>{{Cite web|url=https://www.alcor.org/blog/the-alcor-endowment-trust-supporting-organization/|title=The Alcor Endowment Trust Supporting Organization|last=admin|date=2018-05-16|website=Alcor News|language=en-US|access-date=2019-01-22}}</ref>

| 2018-11 || social || || Society for Cryobiology || The Society for Cryobiology release releases a position statement clarifying their stance in regards to cryonics.: "The Society recognizes and respects the freedom of individuals to hold and express their own opinions and to act, within lawful limits, according to their beliefs. Preferences regarding disposition of postmortem human bodies or brains are clearly a matter of personal choice and, therefore, inappropriate subjects of Society policy. The Society does, however, take the position that the knowledge necessary for the revival of live or dead whole mammals following cryopreservation does not currently exist and can come only from conscientious and patient research in cryobiology and medicine. In short, the act of preserving a body, head or brain after clinical death and storing it indefinitely on the chance that some future generation may restore it to life is an act of speculation or hope, not science, and as such is outside the purview of the Society for Cryobiology."<ref>{{Cite web|url=https://www.societyforcryobiology.org/assets/documents/Position_Statement_Cryonics_Nov_18.pdf|title=Society for Cryobiology Position Statement - Cryonics|last=|first=|date=November 2018|website=Society for Cryobiology|archive-url=|archive-date=|dead-url=|access-date=2019-01-23}}</ref>