Timeline of typhoid fever

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This is a Timeline of typhoid fever, describing major events such as scientific/medical developments and notable epidemics.

Big Picture

Year/period Key developments
1890s Several different researchers work on the idea of protection against typhoid fever at the same time.[1]
20th Century Throughout the century, the incidence of typhoid fever steadily declines, due to the introduction of vaccinations and improvements in public sanitation and hygiene. In particular, the water chlorination would significantly reduce the incidence of typhoid fever among the population.[2]
1970s–1980s Antibiotics like fluoroquinolones such as ciprofloxacin and ofloxacin become widespread especially in countries where multidrug resistance is a problem.[3]
Recent years According to the World Health Organization, there are about 22 million cases of typhoid fever and 200,000 deaths annually.[4][1][3]

Full timeline

Number of confirmed typhoid-paratyphoid fever reported cases in European countries in the period 2008-2012, ilustrating the proportion among countries. Highest rates were given in Northwestern Europe and Scandinavia.[5]
Number of cases and deaths due to typhoid fever, by outbreak. Higher death rates are noticeable in earlier outbreaks.[6]
Year/period Type of event Event Geographical location
460–377 BC Scientific development Greek physician Hippocrates describes clinical features resembling typhoid fever.[7] Greece
430–424 BC Epidemic Typhoid fever epidemic ravages Athens, whiping out about one third of its population.[8] Greece
1643 Scientific development English physician Thomas Willis describes typhoid fever in his Treatise on Fevers.[7][9] United Kingdom
1826 Scientific development French worker Pierre Bretonneau describes the constancy of intestinal lessions and attempts to clarify the pathology of typhoid fever.[7] France
1829 Medical development French physician Pierre Charles Alexander Louis becomes the first to use the word Thyphoide.[7]
1836 Medical development William Wood Gerhard differentiates typhus and typhoid as two distinct clinical entities and establishes the differential clinical and pathological features of both diseases.[7]
1838 Medical development English epidemiologist William Budd, while treating an outbreak of typhoid, notes that the poison (as he then calls it) is present in the excretions of the infected and could be transmitted to healthy people through contaminated water consumption. Upon realizing this association, Budd suggests isolating excrement to help control future outbreaks.[2][10] United Kingdom
1842 Scientific development John Goodsir describes differences in pathological lessons between typhus and typhoid fever.[7] United Kingdom (Edinburgh)
1861–1865 Epidemic About 80,000 soldiers die as a result of typhoid fever or dysentery in the American Civil War.[2] United States
1874 Scientific development Leydon links typhoid to symptoms in the nervous system. For some time typhoid fever would be described as brain fever and nervous fever.[7]
1880 Scientific development Kart Joseph Ebert first demonstrates the presence of bacterium salmonella typhi in the histologic sections of spleen and mesenteric glands of patients who had died of typhoid fever.[7][9]
1885 Scientific development German bacteriologists Richard Pfeiffer first discovers the presence of typhus–causing bacterium salmonella typhi in stools.[7] Germany
1886 Scientific development German bacteriologist Ferdinand Adolph Hueppe demonstrates the presence of typhus–causing bacterium salmonella typhi in urine.[7]
1894 Scientific development Austrian pathologist Hans Chiari successfully cultures typhoid bacillus in gallblader.[7]
1896 Scientific development German bacteriologists Richard Pfeiffer and Wilhelm Kolle demonstrate that inoculation with killed typhoid bacteria results in human immunity against typhoid fever.[1] Germany
1896 Scientific development French physicians Émile Achard and Raoul Bensaude isolate bacterium salmonella paratyphi B and are the first to use the term paratyphoid fever.[7] France
1896 Scientific development George Widal develops a typhoid fever diagnostic using the serum of patients who are recovering from the disease.[9][7]
1897 Medical development British bacteriologist Almroth Wright develops a vaccine prepared from killed typhoid bacilli as a preventive of typhoid.[1] United Kingdom
1897–1898 Epidemic Typhoid fever epidemic breaks out in Maidstone, England, involving 2,000 people and claiming 143 lives.[6] United Kingdom
1899–1902 Epidemic Second Boer War. Typhoid fever is estimated to be the cause of twice as many deaths as from weapons.[7] In an outbreak in 1900 in Bloemfontein, 5,000 cases and 143 deaths are calculated.[6] South Africa
1906 Epidemic Typhoid fever epidemic breaks out in Philadelphia, Pennsylvania, involving 9,712 people and claiming 63 lives.[6] United States
1907–1915 Infection Irish immigrant Mary Mallon (better known as Typhoid Mary) becomes the first person in the United States identified as an asymptomatic carrier of the pathogen associated with typhoid fever. Presumed to have infected 51 people (three of whom die), Mary Mallon would be forcibly isolated for quarantine purposes twice in her life, once in 1907 and again in 1915. The second time she would not be released, dying in isolation at the age of 69.[2][11][9] United States
1909 Medical development United States Army physcian Frederick F. Russell develops a perfected typhoid fever vaccine, and the first in the United States. Russell would begin immunizing volunteers in the army, and after demonstrating its effectiveness, the army would make would make typhoid immunization compulsory, reducing the rate from 243 to 4.41 in three years.[12][1][13] United States
1914 Campaign Typhoid vaccination moves beyond military forces and are released for the general public.[1] United States
1927 Epidemic Typhoid fever epidemic breaks out in Montreal. 5,353 cases and 538 deaths are recorded. Milk is found to be the source of the outbreak.[6] Canada
1948 Medical development American medical researcher Theodore Woodward and colleagues publish the first report on the use of Chloramphenicol for the treatment of typhoid fever. Chloroamphenicol would revolutionize the field by reducing both morbidity and mortality.[3][14][9][7]
1953 Scientific development Antibacterial agent furazolidone is reported effective in vitro for treating common species of salmonella. The drug would later be used for the treatment against typhoid fever.[15][7]
1961 Medical development Ampicillin is introduced for the treatment against typhoid fever.[16][7]
1963 Epidemic Typhoid fever outbreak is reported at a ski resort in Zermatt, Switzerland, affecting tourists from across Europe and the United States. 437 cases and 3 deaths are reported.[6] Switzerland
1969 Medical development Antibiotic agent Trimethoprim/sulfamethoxazole (also known as co-trimoxazole) is introduced. The drug would prove to be effective in the treatment against typhoid fever.[17][7]
1972 Medical development Researchers from Beecham Group develop antibiotic amoxicillin. It would prove to be very effective against typhoid fever, reducing the risk of the carrier state. Amoxicilin is on the World Health Organization's List of Essential Medicines.[7][18]
1972–1973 Epidemic Typhoid fever epidemic breaks out in Mexico City. 2,343 cases and 39 deaths are reported.[6] Mexico
1975–1976 Epidemic Typhoid fever epidemic breaks out in Maharashtra, involving 9,000 cases. Contamination of a municipal water suply is found to be the source of the outbreak.[6] India
1983 Outbreak 58 cases of typhoid fever are reported among tourists at a hotel in Greece.[6] Greece
1986 Medical development Researchers at the United States National Institutes of Health develop an injectable subunit vaccine Vi-polysaccharide vaccine (sold as Typhim Vi by Sanofi Pasteur and Typherix by GlaxoSmithKline), for immunization against typhoid fever.[3] United States
1990-1993 Epidemic Typhoid fever epidemic breaks out in South Vietnam. A total per year of 3,853 to 9,179 cases is registered, and from 8 to 31 deceases.[19] Vietnam
1993 Epidemic Typhoid fever epidemic breaks out in Mpumalanga, South Africa. Contamination of water supplies is associated. 2,129 cases are reported.[20][6] South Africa
1996-1997 Epidemic Multidrug-resistant typhoid fever epidemic breaks out in Tajikistan. Between 8,000 and 17,000 cases and 150 deaths are estimated. Municipal water is identified as the source.[6][21] Tajikistan
2001 Epidemic Typhoid fever epidemic breaks out in vaccinated members of the French Armed Forces in Ivory Coast.[22] Ivory Coast
2002 Epidemic Typhoid fever epidemic breaks out in Bharatpur, Nepal. 65% of the town population is involved. 5,963 and 4 deaths are reported.[6] Nepal
2003 Epidemic Typhoid fever epidemic breaks out in Dushanbe, Tajikistan. 1,000 cases and 80 deaths are reported.[6] Tajikistan
2004-2005 Epidemic Typhoid fever epidemic breaks out in Kinshasa. 11 cases of typhoidal peritonitis are treated in a single hospital. A total of 42,564 infections (including 696 intestinal perforations) and 214 deaths are reported.[6] Democratic Republic of the Congo
2006 Epidemic Typhoid fever epidemic breaks out in Southern Highlands Province, Papua New Guinea. 1,200 cases and 6 death are reported.[6] Papua New Guinea
2007 Medical development Live attenuated vaccine (DV-STM-07) is developed for immunization against typhoid fever.[3]
2008 Epidemic Typhoid fever epidemic breaks out in Calamba City, Philippines. 1,477 cases are reported.[6] Philippines
2010 Outbreak 12 cases of typhoid are reported in the United States. The outbreak is ascribed to ingestion of contaminated mamey fruit pulp imported from Guatemala.[6] United States
2011-2012 Epidemic Typhoid fever epidemic breaks out in Zambia. 4,396 cases and 9 deaths are reported.[6] Zambia
2011-2013 Epidemic Typhoid fever epidemic breaks out in Zimbabwe. 4,185 cases are confirmed in Harare and 2,094 in Mupambe Township. Contaminated water sources are associated. As of 2017, the epidemic is still ongoing.[20][6] Zimbabwe
2013 Epidemic Typhoid fever epidemic breaks out in Kasai-Occidental, D.R. Congo. 1,092 cases are reported.[6] Democratic Republic of the Congo
2014-2015 Outbreak 18 cases of salmonella paratyphi A infection are reported among Japanese travellers returning from Cambodia.[6] Cambodia, Japan
2015 Epidemic Large typhoid fever epidemic breaks out in Kampala, Wakiso and Mukono districts in Uganda. 12,000 cases are reported.[6] Uganda

See also


  1. 1.0 1.1 1.2 1.3 1.4 1.5 "Typhoid Fever Symptoms and Causative Agent". historyofvaccines.org. Retrieved 10 February 2017. 
  2. 2.0 2.1 2.2 2.3 "Typhoid Fever History". news-medical.net. Retrieved 11 February 2017. 
  3. 3.0 3.1 3.2 3.3 3.4 Marathe, Sandhya A.; Lahiri, Amit; Devi Negi, Vidya; Chakravortty, Dipshikha. "Typhoid fever & vaccine development: a partially answered question". PMC 3336846Freely accessible. 
  4. "Typhoid Fever Quick Overview". emedicinehealth.com. Retrieved 10 February 2017. 
  5. "Annual epidemiological report 2014" (PDF). europa.eu. Retrieved 4 March 2017. 
  6. 6.00 6.01 6.02 6.03 6.04 6.05 6.06 6.07 6.08 6.09 6.10 6.11 6.12 6.13 6.14 6.15 6.16 6.17 6.18 6.19 6.20 6.21 Berger, Stephen. Typhoid and Enteric Fever: Global Status: 2017 edition. Retrieved 4 March 2017. 
  7. 7.00 7.01 7.02 7.03 7.04 7.05 7.06 7.07 7.08 7.09 7.10 7.11 7.12 7.13 7.14 7.15 7.16 7.17 7.18 Khosla, S.N. Typhoid FeverIts Cause, Transmission And Prevention. Retrieved 3 March 2017. 
  8. "Top 10 epidemic diseases that were common in ancient world". ancienthistorylists.com. Retrieved 3 March 2017. 
  9. 9.0 9.1 9.2 9.3 9.4 Emmeluth, Donald; Alcamo, Edward. Typhoid Fever. Retrieved 3 March 2017. 
  10. Moorhead, Robert. "William Budd and typhoid fever". PMC 1279260Freely accessible. 
  11. "'TYPHOID MARY' DIES OF A STROKE AT 68; Carrier of Disease, Blamed for 51 Cases and 3 Deaths, but She Was Held Immune Services This Morning Epidemic Is Traced". archive.org. Retrieved 11 February 2017. 
  12. Byerly, Carol R. Fever of War: The Influenza Epidemic in the U.S. Army during World War I. Retrieved 4 March 2017. 
  13. Cirillo, Vincent J. Bullets and Bacilli: The Spanish-American War and Military Medicine. Retrieved 4 March 2017. 
  14. Bitar, R; Tarpley, J. "Intestinal perforation in typhoid fever: a historical and state-of-the-art review.". PMID 3890098. 
  15. Bierer, Bert W.; Vickers, C. L. "Nitrofuran Medication for Experimental Salmonella typhimurium Infection in Poults". Avian Diseases. JSTOR 1587464. doi:10.2307/1587464. 
  16. Simon, Harold J.; Miller, Raymond C. "Ampicillin in the Treatment of Chronic Typhoid Carriers — Report on Fifteen Treated Cases and a Review of the Literature". doi:10.1056/NEJM196604142741501. Retrieved 3 March 2017. 
  18. "Amoxicillin". emedexpert.com. Retrieved 3 March 2017. 
  19. Nguyen, TA; Ha, Ba K; Nguyen, TD. "[Typhoid fever in South Vietnam, 1990-1993].". PMID 7819805. Retrieved 5 April 2017. 
  20. 20.0 20.1 "Typhoid -caused by Salmonella Typhi-Frequently Asked Questions". South African National Institute for Communicable Diseases. Retrieved 4 March 2017. 
  21. "Salmonella typhi (Typhoid Fever) and S. paratyphi (Paratyphoid Fever)". antimicrobe.org. Retrieved 4 March 2017. 
  22. Michel, Rémy; Garnotel, Eric; Spiegel, André; Morillon, Marc; Saliou, Pierre; Boutin, Jean-Paul. "Outbreak of Typhoid Fever in Vaccinated Members of the French Armed Forces in the Ivory Coast". European Journal of Epidemiology. 

Category:Typhoid fever Category:Medicine timelines