Difference between revisions of "Timeline of hematology"

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This is a '''timeline of {{w|hematology}}'''.
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This is a '''timeline of {{w|hematology}}''', listing important events in the development of the field. Events related to {{w|transfusion}} are described in the [[Timeline of transfusion medicine]].
  
 
==Big picture==
 
==Big picture==
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! Time period !! Development summary  
 
! Time period !! Development summary  
 
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| 17th century || "In the 17th century, Dutch microscopist Antonie van Leeuwenhoek, using a primitive, single-lens microscope, observed red blood cells (erythrocytes) and compared their size with that of a grain of sand"<ref name="Hematologyvv">{{cite web |title=Hematology |url=https://www.britannica.com/science/hematology |website=britannica.com |accessdate=7 September 2018}}</ref>
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| Ancient history || “Blood letting” instruments are used in Ancient Egypt.<ref name="Timeline of Major Hematology Landmarks">{{cite web |title=Timeline of Major Hematology Landmarks |url=https://www.scribd.com/document/129934714/Timeline-of-Major-Hematology-Landmarks |website=scribd.com |accessdate=20 September 2018}}</ref>
 
|-
 
|-
| 18th century || "In the 18th century English physiologist William Hewson amplified the description of red cells and demonstrated the role of fibrin in the clotting (coagulation) of blood."<ref name="Hematologyvv"/>
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| 17th century || Dutch microscopist {{w|Antonie van Leeuwenhoek}}, using a primitive, single-lens microscope, already observes red blood cells (erythrocytes) and compared their size with that of a grain of sand.<ref name="Hematologyvv">{{cite web |title=Hematology |url=https://www.britannica.com/science/hematology |website=britannica.com |accessdate=7 September 2018}}</ref>
 
|-
 
|-
| 19th century || " Bone marrow was recognized as the site of blood-cell formation in the 19th century, along with the first clinical descriptions of pernicious anemia, leukemia, and a number of other disorders of the blood."<ref name="Hematologyvv"/>
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| 18th century || English physiologist [[w:William Hewson (surgeon)|William Hewson]] is considered to be the "father of hematology". Hewson manages to amplify the description of red cells and demonstrates the role of fibrin in the clotting (coagulation) of blood.<ref>{{cite journal |last1=Doyle |first1=D |title=William Hewson (1739-74): the father of haematology. |doi=10.1111/j.1365-2141.2006.06037.x |pmid=16643443 |url=https://www.ncbi.nlm.nih.gov/pubmed/16643443}}</ref><ref name="Hematologyvv"/>
 
|-
 
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| 20th century || "The discovery of the ABO blood group system in the first quarter of the 20th century made possible the transfusion of blood from one person to another without the serious ill effects that ensue when incompatible blood is given. The study of the blood disease anemia gained impetus from the introduction of the hematocrit, an apparatus for determining the volume of red blood cells as compared with the volume of plasma, and the introduction in 1932 of a simple method of measuring the volume and hemoglobin" "After World War II the field of hematology broadened."<ref name="Hematologyvv"/> "The [[HIV#Discovery|emergence of HIV]] in the 1980s renewed impetus for development of infection-safe blood substitutes.<ref name="pmid11834811">{{cite journal |author=Squires JE |title=Artificial blood |journal = [[w:Science (journal)|Science]] |volume=295 |issue=5557 |pages=1002–5 |year=2002 |pmid=11834811 |doi=10.1126/science.1068443 |url=http://www.sciencemag.org/cgi/pmidlookup?view=long&pmid=11834811}}</ref>
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| 19th century || Bone marrow is recognized as the site of blood-cell formation in the 19th century, along with the first clinical descriptions of pernicious {{w|anemia}}, {{w|leukemia}}, and a number of other disorders of the blood.<ref name="Hematologyvv"/>
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|-
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| 20th century || The discovery by {{w|Karl Landsteiner}} of the {{w|ABO blood group system}} in the first quarter of the 20th century makes possible the transfusion of blood from one person to another without the serious ill effects that ensue when incompatible blood is given. The study of the blood disease anemia gains impetus from the introduction of the hematocrit, an apparatus for determining the volume of red blood cells as compared with the volume of plasma, and the introduction in 1932 of a simple method of measuring the volume and {{w|hemoglobin}}. After World War II, the field of hematology broadens.<ref name="Hematologyvv"/> In the 1950s, plastic intra venous tubing replaces rubber tubing.<ref name="Textbook of Critical Care E-Book">{{cite book |last1=Vincent |first1=Jean-Louis |last2=Abraham |first2=Edward |last3=Kochanek |first3=Patrick |last4=Moore |first4=Frederick A. |last5=Fink |first5=Mitchell P. |title=Textbook of Critical Care E-Book |url=https://books.google.com.ar/books?id=uAl68tCzm5IC&pg=PA1395&dq=%22in+1818%22+%22James+Blundell%22&hl=en&sa=X&ved=0ahUKEwjMmp32pdbdAhWFf5AKHU32CewQ6AEIQDAE#v=onepage&q=%22in%201818%22%20%22James%20Blundell%22&f=false}}</ref><ref name="Timeline of Major Hematology Landmarks"/> The 1960s is the decade in which most of the modern understanding of platelet funcion is initiated.<ref name="Books on Google Play Platelets in Thrombotic and Non-Thrombotic Disorders: Pathophysiology, Pharmacology and Therapeutics: an Update"/> In the 1970s, the combination of several observational studies identifying a possible role for prophylactic platelet transfusion in hypoproliferative {{w|thrombocytopenia}} and the discovery that platelets are best stored at room temperature with gentle agitation to preserve function allow for the proliferation of platelet transfusions as part of standard management of patients receiving {{w|chemotherapy}}.<ref name="Platelets in Thrombotic and Non-Thrombotic Disorders: Pathophysiology, Pharmacology and Therapeutics: an Update">{{cite book |title=Platelets in Thrombotic and Non-Thrombotic Disorders: Pathophysiology, Pharmacology and Therapeutics: an Update |edition=Paolo Gresele, Neal S. Kleiman, José A. Lopez, Clive P. Page |url=https://books.google.com.ar/books?id=W9FNDgAAQBAJ&pg=PA1391&dq=%22in+1818%22+%22James+Blundell%22&hl=en&sa=X&ved=0ahUKEwjMmp32pdbdAhWFf5AKHU32CewQ6AEIMzAC#v=onepage&q=%22in%201818%22%20%22James%20Blundell%22&f=false}}</ref> In the 1980s, the emergence of {{w|HIV}} renews impetus for development of infection-safe blood substitutes.<ref name="pmid11834811">{{cite journal |author=Squires JE |title=Artificial blood |journal = [[w:Science (journal)|Science]] |volume=295 |issue=5557 |pages=1002–5 |year=2002 |pmid=11834811 |doi=10.1126/science.1068443 |url=http://www.sciencemag.org/cgi/pmidlookup?view=long&pmid=11834811}}</ref>
 
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==Full timeline==
 
==Full timeline==
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! Year !! Event type !! Details !! Location
 
! Year !! Event type !! Details !! Location
 
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| 3255 BC || || "The oldest intact red blood cells ever discovered were found in Ötzi the Iceman, a natural mummy of a man who died around 3255 BCE. These cells were discovered in May 2012." ||
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| 3255 BC || || The oldest intact red blood cells ever discovered are found in {{w|Ötzi}}, a natural mummy of a man who died around that time.<ref>{{cite web |title='Iceman' Mummy Holds World's Oldest Blood Cells |url=https://www.livescience.com/20030-ice-mummy-oldest-blood-cells.html |website=livescience.com |accessdate=20 September 2018}}</ref> ||
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|-
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| 460 BC – 377 BC || Field development || Greek physician {{w|Hippocrates}} teaches the humoral theory, a hypothetical system to explain illness in which balance equals health, and excess or deficiency equals illness.<ref name="Timeline of Major Hematology Landmarks"/> || {{w|Greece}}
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|-
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| 1616 || Field development || English physician {{w|William Harvey}} discovers blood pathways. Since then many people try to use fluids such as beer, urine, milk, and non-human animal blood as blood substitute.<ref>{{Cite journal | last1 = Sarkar | first1 = S. | title = Artificial Blood | doi = 10.4103/0972-5229.43685 | journal = Indian Journal of Critical Care Medicine | volume = 12 | issue = 3 | pages = 140–144 | year = 2008 | pmid =  19742251| pmc =2738310 }}</ref> || {{w|United Kingdom}}
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|-
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| 1628 || Field development || English physician {{w|William Harvey}} publishes ''Exercitatio Anatomica de Motu Cordis et Sanguinis in Animalibus'' (Movement of the Heart and the Blood in Animals), which demonstrates the concept of blood circulation.<ref name="Books on Google Play Platelets in Thrombotic and Non-Thrombotic Disorders: Pathophysiology, Pharmacology and Therapeutics: an Update"/> || {{w|United Kingdom}}
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|-
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| 1642 || Scientific development || Dutch scientist {{w|Antonie van Leeuwenhoek}} constructs a microscope and distinguishes {{w|blood cell}}s.<ref name="Timeline of Major Hematology Landmarks"/> || {{w|Netherlands}}
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|-
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| 1656 || Field development || English anatomist {{w|Christopher Wren}} gives the first intravenous injection in animals.<ref name="Timeline of Major Hematology Landmarks"/> || {{w|United Kingdom}}
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|-
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| 1658 || Field development || Dutch biologist Jan Swammerdam first describes red blood cells by means of the use of an early microscope to study the blood of a frog. ||
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|-
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| 1662 || Field development || J. C. Major gives the first intravenous injection in humans.<ref name="Timeline of Major Hematology Landmarks"/> ||
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|-
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| 1665 || Field development || English physician [[w:Richard Lower (physician)|Richard Lower]] performs the first documented blood transfusion using dogs and notes a color difference between veins and arteries.<ref name="Platelets in Thrombotic and Non-Thrombotic Disorders: Pathophysiology, Pharmacology and Therapeutics: an Update"/><ref name="Timeline of Major Hematology Landmarks"/> || {{w|United Kingdom}}
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|-
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| 1666 || Field development || Italian physician {{w|Marcello Malpighi}} notices that fiber filaments remain in a blood clot after it is thoroughly washed.<ref name="=On the origin of microparticles: From “platelet dust” to mediators of intercellular communication"/> || {{w|Italy}}
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|-
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| 1667 || Field development || French physician {{w|Jean-Baptiste Denys}} and [[w:Richard Lower (physician)|Richard Lower]] separately report giving the first human blood transfusion with blood fromlambs. Within 10 years, transfusing the blood of animals to humans becomes prohibited by law, delaying transfusion advances for about 150 years.<ref name="Timeline of Major Hematology Landmarks"/> || {{w|France}}, {{w|United Kingdom}}
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|-
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| 1674 || Field development || Pioneer microscopist {{w|Anton van Leeuwenhoek}} writes his own description of human red blood cells.<ref name="Discovery of Red Blood Cells">{{cite web |title=Discovery of Red Blood Cells |url=https://www.med-ed.virginia.edu/courses/cell/resources/blooddisc.htm |website=med-ed.virginia.edu |accessdate=5 October 2018}}</ref> || {{w|Netherlands}}
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|-
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| 1675 || Field development || {{w|Anton van Leeuwenhoek}} makes the remarkable discovery that "those sanguineous globules in a healthy body must be very flexible and pliant, if they are to pass through the small capillary veins and arteries, and that in their passage they change into an oval figure, reassuming their roundness when they come into a larger room."<ref name="Discovery of Red Blood Cells"/> || {{w|Netherlands}}
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|-
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| 1770 || Field development || British surgeon [[w:William Hewson (surgeon)|William Hewson]] describes leukocytes and some essential clottingfactors. Hewson becomes known as “the father of hematology.”<ref name="Timeline of Major Hematology Landmarks"/> ||
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|-
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| 1771 || Literature || [[w:William Hewson (surgeon)|William Hewson]] publishes ''Experimental Inquiry into the Properties of the Blood''.<ref name="Books on Google Play Platelets in Thrombotic and Non-Thrombotic Disorders: Pathophysiology, Pharmacology and Therapeutics: an Update"/> || {{w|United Kingdom}}
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|-
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| 1795 || Field development || American physician {{w|Philip Syng Physick}} claims to perform the first human-to-human blood transfusion, although he does not publish this information.<ref name="Timeline of Major Hematology Landmarks"/> ||
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|-
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| 1821 – 1902 || Field development || German physician {{w|Rudolf Virchow}} disproves a prominent view that {{w|phlebitis}} (inflammation of a vein) causes most diseases. Virchow demonstrates that masses in the blood vessels result from “{{w|thrombosis}}” (his term) and that portions of a thrombus could become detached to form an “{{w|embolus}}” (also his term).<ref>{{cite web |title=Rudolf Virchow |url=https://www.britannica.com/biography/Rudolf-Virchow |website=britannica.com |accessdate=3 October 2018}}</ref> || {{w|Germany}}
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|-
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| 1827 || Literature || Amateur British opticist {{w|Joseph Jackson Lister}} and fellow Quaker Dr {{w|Thomas Hodgkin}} publish ''Notice of some Microscopic Observations of the Blood and Animal Tissues''.<ref name="Books on Google Play Platelets in Thrombotic and Non-Thrombotic Disorders: Pathophysiology, Pharmacology and Therapeutics: an Update"/> || {{w|United Kingdom}}
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|-
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| 1830 || Instrumental || The gold-plated steel needle for intravenous use is invented.<ref name="Textbook of Critical Care E-Book"/> ||
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|-
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| 1840 || Field development || English surgeon {{w|Samuel Armstrong Lane}} performs the first successful whole blood transfusion to treat {{w|hemophilia}}.<ref name="Inventions & Discoveries">{{cite book |last1=BPI |title=Inventions & Discoveries |url=https://books.google.com.ar/books?id=FP45DAAAQBAJ&pg=PA10&dq=%22in+1840%22+Samuel+Armstrong+Lane&hl=en&sa=X&ved=0ahUKEwjRo_CR2dbdAhWP3VMKHbFJD1cQ6AEIMTAC#v=onepage&q=%22in%201840%22%20Samuel%20Armstrong%20Lane&f=false}}</ref><ref>{{cite book |title=Hemolytic Anemia |url=https://books.google.com.ar/books?id=oz8inTVuxngC&pg=PA166&dq=%22in+1840%22+Samuel+Armstrong+Lane&hl=en&sa=X&ved=0ahUKEwjRo_CR2dbdAhWP3VMKHbFJD1cQ6AEILTAB#v=onepage&q=%22in%201840%22%20Samuel%20Armstrong%20Lane&f=false}}</ref><ref>{{cite book |last1=Madbak |first1=Firas |title=Bridge Across the Abyss: Medical Myths and Misconceptions |url=https://books.google.com.ar/books?id=pLKacxgd05kC&pg=PA22&dq=%22in+1840%22+Samuel+Armstrong+Lane&hl=en&sa=X&ved=0ahUKEwjRo_CR2dbdAhWP3VMKHbFJD1cQ6AEIKDAA#v=onepage&q=%22in%201840%22%20Samuel%20Armstrong%20Lane&f=false}}</ref><ref>{{cite book |last1=Chang |first1=Anne |title=Magill's Medical Guide: Down syndrome-Laser use in surgery |url=https://books.google.com.ar/books?id=kuQ6AQAAIAAJ&q=%22in+1840%22+Samuel+Armstrong+Lane&dq=%22in+1840%22+Samuel+Armstrong+Lane&hl=en&sa=X&ved=0ahUKEwjRo_CR2dbdAhWP3VMKHbFJD1cQ6AEIPDAE}}</ref> || {{w|United Kingdom}}
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|-
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| 1840s || Field development || English anatomist {{w|George Gulliver}} publishes early illustrations of {{w|platelet}}s.<ref name="Books on Google Play Platelets in Thrombotic and Non-Thrombotic Disorders: Pathophysiology, Pharmacology and Therapeutics: an Update"/> || {{w|United Kingdom}}
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|-
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| 1842 || Field development || French microscopist {{w|Alexandre Donné}} identifies {{w|platelet}}s.<ref>{{cite book |title=Sir William Osler: An Annotated Bibliography with Illustrations |edition=Richard L. Golden, Charles G. Roland |url=https://books.google.com.ar/books?id=3Z33qBcbP6MC&pg=PA3&dq=%22in+1842%22+Alexandre+Donne+%22platelets%22&hl=en&sa=X&ved=0ahUKEwi6s_GB2NbdAhVK3FMKHXGsAYAQ6AEIKDAA#v=onepage&q=%22in%201842%22%20Alexandre%20Donne%20%22platelets%22&f=false}}</ref><ref>{{cite book |title=Hematology |url=https://books.google.com.ar/books?id=j-xrAAAAMAAJ&q=%22in+1842%22+Alexandre+Donne+%22platelets%22&dq=%22in+1842%22+Alexandre+Donne+%22platelets%22&hl=en&sa=X&ved=0ahUKEwi6s_GB2NbdAhVK3FMKHXGsAYAQ6AEILTAB}}</ref> ||
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|-
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| 1867 || Field development || British surgeon {{w|Joseph Lister}} uses antiseptics to control infection during transfusions.<ref name="Timeline of Major Hematology Landmarks"/> || {{w|United Kingdom}}
 
|-
 
|-
| 1616 || || "After {{w|William Harvey}} discovered blood pathways in 1616, many people tried to use fluids such as beer, urine, milk, and non-human animal blood as blood substitute."<ref>{{Cite journal | last1 = Sarkar | first1 = S. | title = Artificial Blood | doi = 10.4103/0972-5229.43685 | journal = Indian Journal of Critical Care Medicine | volume = 12 | issue = 3 | pages = 140–144 | year = 2008 | pmid =  19742251| pmc =2738310 }}</ref>
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| 1875 || Field development || Zahn reports that an injured blood vessel is eventually plugged by a fibrin-associated white thrombus. This observation leads to the discovery that platelets are responsible for contributing fibrin in the blood coagulation process.<ref name="=On the origin of microparticles: From “platelet dust” to mediators of intercellular communication"/> ||
 
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| 1658 || || "The first person to describe red blood cells was the young Dutch biologist Jan Swammerdam, who had used an early microscope in 1658 to study the blood of a frog" ||
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| 1877 || Field development || German-Jewish physician {{w|Paul Ehrlich}} develops techniques to stain blood cells to improve microscopic visualization.<ref name="The History of Hematology and Related Sciences">{{cite web |title=The History of Hematology and Related Sciences |url=https://pharmaceuticalintelligence.com/2014/12/05/the-history-of-hematology-and-related-sciences/ |website=pharmaceuticalintelligence.com |accessdate=20 September 2018}}</ref> || {{w|Germany}}
 
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| 1674 || || "Unaware of this work, Anton van Leeuwenhoek provided another microscopic description in 1674, this time providing a more precise description of red blood cells, even approximating their size, "25,000 times smaller than a fine grain of sand"." ||
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| 1882 || Field development || Italian medical researcher {{w|Giulio Bizzozero}} describes blood {{w|platelet}}s.<ref name="Milestones in Antiplatelet Therapy">{{cite web |title=Milestones in Antiplatelet Therapy |url=http://www.hematology.org/About/History/50-Years/1514.aspx |website=hematology.org |accessdate=4 October 2018}}</ref><ref name="Books on Google Play Platelets in Thrombotic and Non-Thrombotic Disorders: Pathophysiology, Pharmacology and Therapeutics: an Update">{{cite book |title=Books on Google Play Platelets in Thrombotic and Non-Thrombotic Disorders: Pathophysiology, Pharmacology and Therapeutics: an Update |edition=Paolo Gresele, Neal S. Kleiman, José A. Lopez, Clive P. Page |url=https://books.google.com.ar/books?id=W9FNDgAAQBAJ&pg=PA5&dq=%22in+1882%22+Giulio+Bizzozero+describes+blood+platelets&hl=en&sa=X&ved=0ahUKEwjOj7jItu7dAhXBPpAKHR8iBp8Q6AEIKDAA#v=onepage&q=%22in%201882%22%20Giulio%20Bizzozero%20describes%20blood%20platelets&f=false}}</ref> || {{w|Italy}}
 
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| 1901 || Field development || Austrian biologist {{w|Karl Landsteiner}} and his associates define the different {{w|blood group}}s: A, B, AB, and O.<ref>{{cite book |last1=DK |title=1000 Inventions and Discoveries |url=https://books.google.com.ar/books?id=IztIBQAAQBAJ&pg=PA173&dq=%22in+1901%22+%22karl+landsteiner%22&hl=en&sa=X&ved=0ahUKEwjM6OWh3andAhVCf5AKHTLVDoQQ6AEIKDAA#v=onepage&q=%22in%201901%22%20%22karl%20landsteiner%22&f=false |ref=}}</ref><ref>{{cite book |last1=Van Luven |first1=Lynne |last2=Page |first2=Kathy |title=In the Flesh: Twenty Writers Explore the Body |url=https://books.google.com.ar/books?id=U-Y-9hvgRRYC&pg=PT194&dq=%22in+1901%22+%22karl+landsteiner%22&hl=en&sa=X&ved=0ahUKEwjM6OWh3andAhVCf5AKHTLVDoQQ6AEIPzAE#v=onepage&q=%22in%201901%22%20%22karl%20landsteiner%22&f=false}}</ref><ref>{{cite book |last1=Hillyer |first1=Christopher D. |title=Blood Banking and Transfusion Medicine: Basic Principles & Practice |url=https://books.google.com.ar/books?id=3QwXx_enKbcC&pg=PT26&dq=%22in+1901%22+%22karl+landsteiner%22&hl=en&sa=X&ved=0ahUKEwjM6OWh3andAhVCf5AKHTLVDoQQ6AEINDAC#v=onepage&q=%22in%201901%22%20%22karl%20landsteiner%22&f=false}}</ref><ref name="What is Hematology?">{{cite web |title=What is Hematology? - Definition & History |url=https://study.com/academy/lesson/what-is-hematology-definition-history.html |website=study.com |accessdate=7 September 2018}}</ref> ||
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| 1897 || Literature || American pediatrician {{w|Luther Emmett Holt}} publishes ''The Diseases of Infancy and Childhood'', which includes a 20-page chapter on diseases of the blood and is the first American pediatric medical textbook to provide significant hematologic information.<ref name="The History of Hematology and Related Sciences"/><ref>{{cite web |title=The diseases of infancy and childhood : for the use of students and practitioners of medicine / by L. Emmett Holt. |url=https://catalog.hathitrust.org/Record/100632876 |website=catalog.hathitrust.org |accessdate=3 October 2018}}</ref> || {{w|United States}}
 
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| 1904 || Journal || {{w|Folia Haematologica}} is established in {{w|Germany}}. It is the first hematology journal in the world.<ref name="Hematology in Japan: past, present and future"/>|| {{w|Germany}}
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| 1901 || Field development || Austrian biologist {{w|Karl Landsteiner}} and his associates discover the {{w|ABO blood group system}}, and define the different {{w|blood group}}s: A, B, AB, and O. Such names refer to the different kinds of {{w|antigen}}s on the surface of the {{w|red blood cell}}.<ref>{{cite book |last1=DK |title=1000 Inventions and Discoveries |url=https://books.google.com.ar/books?id=IztIBQAAQBAJ&pg=PA173&dq=%22in+1901%22+%22karl+landsteiner%22&hl=en&sa=X&ved=0ahUKEwjM6OWh3andAhVCf5AKHTLVDoQQ6AEIKDAA#v=onepage&q=%22in%201901%22%20%22karl%20landsteiner%22&f=false |ref=}}</ref><ref>{{cite book |last1=Van Luven |first1=Lynne |last2=Page |first2=Kathy |title=In the Flesh: Twenty Writers Explore the Body |url=https://books.google.com.ar/books?id=U-Y-9hvgRRYC&pg=PT194&dq=%22in+1901%22+%22karl+landsteiner%22&hl=en&sa=X&ved=0ahUKEwjM6OWh3andAhVCf5AKHTLVDoQQ6AEIPzAE#v=onepage&q=%22in%201901%22%20%22karl%20landsteiner%22&f=false}}</ref><ref>{{cite book |last1=Hillyer |first1=Christopher D. |title=Blood Banking and Transfusion Medicine: Basic Principles & Practice |url=https://books.google.com.ar/books?id=3QwXx_enKbcC&pg=PT26&dq=%22in+1901%22+%22karl+landsteiner%22&hl=en&sa=X&ved=0ahUKEwjM6OWh3andAhVCf5AKHTLVDoQQ6AEINDAC#v=onepage&q=%22in%201901%22%20%22karl%20landsteiner%22&f=false}}</ref><ref name="What is Hematology?">{{cite web |title=What is Hematology? - Definition & History |url=https://study.com/academy/lesson/what-is-hematology-definition-history.html |website=study.com |accessdate=7 September 2018}}</ref> ||
 
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| 1914 || Field development || American scientist, Richard Lewisohn, discovers that sodium citrate can be added to blood to stop it clotting.<ref>{{cite book |last1=Evans |first1=R. Paul |last2=Wilkinson |first2=Alf |title=WJEC Eduqas GCSE History: Changes in Health and Medicine in Britain, c.500 to the present day |url=https://books.google.com.ar/books?id=vFDmDQAAQBAJ&pg=PT256&lpg=PT256&dq=%22in+1914%22+Richard+Lewisohn+discovers+how+sodium+citrate+can+be+used+to+store+blood&source=bl&ots=IUL9WeoY7j&sig=9U2UKjSnFzbHphOwJMs5Yhd_Bxc&hl=en&sa=X&ved=2ahUKEwiRht7M4qndAhXEEZAKHUGvANEQ6AEwDnoECAQQAQ#v=onepage&q=%22in%201914%22%20Richard%20Lewisohn%20discovers%20how%20sodium%20citrate%20can%20be%20used%20to%20store%20blood&f=false}}</ref><ref name="What is Hematology?"/> ||
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| 1902 || Field development || Alfred Decastello and Adriano Sturli add [[w:ABO blood group system|bloodtype]] AB to the classification system.<ref name="Milestones in Transfusion Medicine">{{cite web |title=Milestones in Transfusion Medicine |url=http://www.hematology.org/About/History/50-Years/1520.aspx |website=hematology.org |accessdate=4 October 2018}}</ref> ||
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|-
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| 1904 || Literature || ''{{w|Folia Haematologica}}'' is established in {{w|Germany}}. It is the first hematology journal in the world.<ref name="Hematology in Japan: past, present and future"/>|| {{w|Germany}}
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|-
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| 1906 || Field development || James Wright describes the bone marrow and megakaryocyte origin of {{w|platelets}}.<ref name="Books on Google Play Platelets in Thrombotic and Non-Thrombotic Disorders: Pathophysiology, Pharmacology and Therapeutics: an Update"/> ||
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| 1907 || Field development || American pathologist {{w|Ludvig Hektoen}} from {{w|Chicago}}, explains the significance of isoagglutinins in human blood and how the untoward reactions are related to them.<ref name="Hospital and community: studies in external relationships of the administrator">{{cite book |last1=Jackson |first1=Laura Gertrude |title=Hospital and community: studies in external relationships of the administrator |url=https://books.google.com.ar/books?id=75drAAAAMAAJ&q=%22in+1907%22+%22Ludvig+Hektoen%22&dq=%22in+1907%22+%22Ludvig+Hektoen%22&hl=en&sa=X&ved=0ahUKEwjn6PfWgtfdAhWMIpAKHZLwCuwQ6AEIRTAF}}</ref><ref name="The History of Hematology and Related Sciences"/> || {{w|United States}}
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|-
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| 1908 || Field development || American {{w|haematologist}} {{w|Reuben Ottenberg}} develops clinical methods for typing bloods.<ref name="Hospital and community: studies in external relationships of the administrator"/> || {{w|United States}}
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|-
 +
| 1910 || Field development || {{w|Sickle cell disease}} is first described.<ref>{{cite journal |title=Sickle cell disease: old discoveries, new concepts, and future promise |doi=10.1172/JCI30920 |pmid=17404610 |url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1838946/ |pmc=1838946}}</ref> ||
 +
|-
 +
| 1910 || Field development || Duke notes that transfusions reduce the bleeding time. After this, transfusions become recognized as successful therapeutic hemostatic intervensions.<ref name="Platelets in Thrombotic and Non-Thrombotic Disorders: Pathophysiology, Pharmacology and Therapeutics: an Update"/> ||
 +
|-
 +
| 1914 || Field development || American scientist, Richard Lewisohn, discovers that sodium citrate can be added to blood to stop it clotting.<ref>{{cite book |last1=Evans |first1=R. Paul |last2=Wilkinson |first2=Alf |title=WJEC Eduqas GCSE History: Changes in Health and Medicine in Britain, c.500 to the present day |url=https://books.google.com.ar/books?id=vFDmDQAAQBAJ&pg=PT256&lpg=PT256&dq=%22in+1914%22+Richard+Lewisohn+discovers+how+sodium+citrate+can+be+used+to+store+blood&source=bl&ots=IUL9WeoY7j&sig=9U2UKjSnFzbHphOwJMs5Yhd_Bxc&hl=en&sa=X&ved=2ahUKEwiRht7M4qndAhXEEZAKHUGvANEQ6AEwDnoECAQQAQ#v=onepage&q=%22in%201914%22%20Richard%20Lewisohn%20discovers%20how%20sodium%20citrate%20can%20be%20used%20to%20store%20blood&f=false}}</ref><ref name="What is Hematology?"/><ref name="The History of Hematology and Related Sciences"/> ||
 
|-
 
|-
 
| 1918 || Field development || The use of blood plasma as a substitute for whole blood and for transfusion purposes is proposed by Gordon R. Ward. The use of blood plasma as a substitute for whole blood and for transfusion purposes was proposed in the same year, in the correspondence columns of the British Medical Journal. || {{w|United Kingdom}}
 
| 1918 || Field development || The use of blood plasma as a substitute for whole blood and for transfusion purposes is proposed by Gordon R. Ward. The use of blood plasma as a substitute for whole blood and for transfusion purposes was proposed in the same year, in the correspondence columns of the British Medical Journal. || {{w|United Kingdom}}
Line 39: Line 100:
 
| 1920 || Field development || The investigation of the role of food substances in the production of red blood cells is launched. It would lead to discovery of the beneficial effects of liver extract in treating pernicious anemia and ultimately to the discovery of vitamin B12, the anti-anemic principle of liver.<ref name="Hematologyvv"/> ||
 
| 1920 || Field development || The investigation of the role of food substances in the production of red blood cells is launched. It would lead to discovery of the beneficial effects of liver extract in treating pernicious anemia and ultimately to the discovery of vitamin B12, the anti-anemic principle of liver.<ref name="Hematologyvv"/> ||
 
|-
 
|-
| 1920 || Journal || Journal ''{{w|Haematologica}}'' is first published.<ref>{{cite journal |last1=Ascari |first1=Edoardo |title=The history of Haematologica |pmid=25552676 |url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4281305/ |pmc=4281305}}</ref><ref>{{cite web |title=About Haematologica |url=http://www.haematologica.org/about-the-journal |website=haematologica.org |accessdate=7 September 2018}}</ref> It is the second in the world to be released.<ref name="Hematology in Japan: past, present and future"/> || {{w|Italy}}
+
| 1920 || Literature || Journal ''{{w|Haematologica}}'' is first published.<ref>{{cite journal |last1=Ascari |first1=Edoardo |title=The history of Haematologica |pmid=25552676 |url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4281305/ |pmc=4281305}}</ref><ref>{{cite web |title=About Haematologica |url=http://www.haematologica.org/about-the-journal |website=haematologica.org |accessdate=7 September 2018}}</ref> It is the second in the world to be released.<ref name="Hematology in Japan: past, present and future"/> || {{w|Italy}}
 +
|-
 +
| 1924 || Literature || ''Pediatrics'' becomes the first comprehensive American publication on pediatric hematology.<ref name="The History of Hematology and Related Sciences"/> ||
 +
|-
 +
| 1925 || Field development || Canadian physician Alfred P. Hart introduces exsanguination ("exchange") transfusion to treat severe neonatal jaundice.<ref>{{cite book |last1=Shorter |first1=Edward |title=Partnership for Excellence: Medicine at the University of Toronto and Academic Hospitals |url=https://books.google.com.ar/books?id=TXa1AAAAQBAJ&pg=PA260&lpg=PA260&dq=Alfred+P.+Hart&source=bl&ots=amiD2h7s8p&sig=BTAl9lm3QvdlDKUeQZ5Vr4FPL8I&hl=en&sa=X&ved=2ahUKEwj5l4aXvtbdAhVBIJAKHU-oBkoQ6AEwCXoECAMQAQ#v=onepage&q=Alfred%20P.%20Hart&f=false}}</ref><ref>{{cite book |last1=Klossner |first1=N. Jayne |title=Introductory Maternity Nursing, Volume 1 |url=https://books.google.com.ar/books?id=B47OVg25g-QC&pg=PA7&dq=%22in+1925%22+Alfred+P.+Hart&hl=en&sa=X&ved=0ahUKEwjcxfuzvtbdAhWFS5AKHS7UD_wQ6AEILjAB#v=onepage&q=%22in%201925%22%20Alfred%20P.%20Hart&f=false}}</ref><ref>{{cite book |last1=Cone |first1=Thomas E. |title=History of American Pediatrics |url=https://books.google.com.ar/books?id=0MVsAAAAMAAJ&q=%22in+1925%22+Alfred+P.+Hart&dq=%22in+1925%22+Alfred+P.+Hart&hl=en&sa=X&ved=0ahUKEwjcxfuzvtbdAhWFS5AKHS7UD_wQ6AEINDAC}}</ref><ref name="The History of Hematology and Related Sciences"/> ||
 +
|-
 +
| 1925 || Field development || American pediatrician {{w|Thomas Benton Cooley}} describes a Mediterranean hematologic syndrome of anemia, {{w|erythroblastosis}}, skeletal disorders, and splenomegaly that is later called Cooley’s anemia and now {{w|thalassemia}}.<ref name="The History of Hematology and Related Sciences"/> ||
 +
|-
 +
| 1927 || Field development || The [[w:P antigen system|P blood group system]] is discovered.<ref>{{cite book |last1=Rudmann |first1=Sally V. |title=Textbook of Blood Banking and Transfusion Medicine |url=https://books.google.com.ar/books?id=dXdISwJQJFIC&pg=PA96&lpg=PA96&dq=Globoside+group+system+%22in+1900..2017%22&source=bl&ots=xjxTr1tPXp&sig=fXKERd_MjRQn1_b3loXnO3KqHeo&hl=en&sa=X&ved=2ahUKEwjRgMi3zPzdAhXDD5AKHRkKAB4Q6AEwAHoECAgQAQ#v=onepage&q=Globoside%20group%20system%20%22in%201900..2017%22&f=false}}</ref> It is considered among the major blood group systems.<ref name="OTHER BLOOD GROUP SYSTEMS"/> ||
 
|-
 
|-
 
| 1927 || Organization || The French Society of Hematology is formed. It is the first hematology organization in the world.<ref name="Hematology in Japan: past, present and future"/> || {{w|France}}
 
| 1927 || Organization || The French Society of Hematology is formed. It is the first hematology organization in the world.<ref name="Hematology in Japan: past, present and future"/> || {{w|France}}
 
|-
 
|-
| 1927 || Journal || Journal La Sang is released in {{w|France}}.<ref name="Hematology in Japan: past, present and future"/> || {{w|France}}
+
| 1927 || Literature || Journal La Sang is released in {{w|France}}.<ref name="Hematology in Japan: past, present and future"/> || {{w|France}}
 +
|-
 +
| 1927 || Field development || {{w|Karl Landsteiner}} and {{w|Philip Levine}} discover the {{w|MNS antigen system}}, after immunizing {{w|rabbit}}s with human {{w|red blood cell}}s.<ref name="APC Essentials of Forensic Medicine and Toxicology"/> It is considered among the major blood group systems.<ref name="OTHER BLOOD GROUP SYSTEMS"/> ||
 +
|-
 +
| 1932 || Field development || A simple method of measuring the volume and {{w|hemoglobin}} is introduced.<ref name="Hematologyvv"/> ||
 +
|-
 +
| 1933 || Field development || The formation of {{w|cryoprecipitate}} is first observed in relation to a patient with {{w|multiple myeloma}}.<ref name="Oxford Textbook of Vasculitis">{{cite book |title=Oxford Textbook of Vasculitis |edition=Gene V. Ball, Barri J. Fessler, S. Louis Bridges |url=https://books.google.com.ar/books?id=b9PQAgAAQBAJ&pg=PA547&lpg=PA547&dq=%22in+1954%22+cryoprecipitate&source=bl&ots=9UvcpSsTnR&sig=gb2G7F7-IxsFfRLK86pXHDglLGg&hl=en&sa=X&ved=2ahUKEwjwyuOSzdbdAhWFxpAKHaBXA18Q6AEwAHoECAEQAQ#v=onepage&q=%22in%201954%22%20cryoprecipitate&f=false}}</ref> ||
 
|-
 
|-
| 1932 || Field development || A simple method of measuring the volume and hemoglobin is introduced.<ref name="Hematologyvv"/> ||
+
| 1935 || Field development || Danish biochemist {{w|Carl Peter Henrik Dam}} finds that bleeding in chicks that developed an excessive bleeding disorder in response to synthetic diets, do not occur if their synthetic chow was replaced with one fortified with a specific vitamin. Dam labels this antihemorrhagic agent “{{w|vitamin K}}” and establishes its essential role in normal blood {{w|coagulation}}.<ref name="=On the origin of microparticles: From “platelet dust” to mediators of intercellular communication"/> || {{w|Denmark}}
 
|-
 
|-
 
| 1936 || Organization || The World's first blood bank opens in {{w|Chicago}}.<ref>{{cite web |title=Blood Banking and Donation |url=http://www.hematology.org/Patients/Basics/Banking.aspx |website=hematology.org |accessdate=8 September 2018}}</ref><ref>{{cite web |title=THE TIMELINE: BLOOD DONATION |url=https://www.independent.co.uk/life-style/health-and-families/features/the-timeline-blood-donation-2297965.html |website=independent.co.uk |accessdate=8 September 2018}}</ref><ref name="What is Hematology?"/> || {{w|United States}}
 
| 1936 || Organization || The World's first blood bank opens in {{w|Chicago}}.<ref>{{cite web |title=Blood Banking and Donation |url=http://www.hematology.org/Patients/Basics/Banking.aspx |website=hematology.org |accessdate=8 September 2018}}</ref><ref>{{cite web |title=THE TIMELINE: BLOOD DONATION |url=https://www.independent.co.uk/life-style/health-and-families/features/the-timeline-blood-donation-2297965.html |website=independent.co.uk |accessdate=8 September 2018}}</ref><ref name="What is Hematology?"/> || {{w|United States}}
 
|-
 
|-
| 1936 || Field development || American hematologist John H. Lawrence of the {{w|University of California, Berkeley}} introduces phosphorus-32 for the treatment of {{w|leukemia}}.<ref>{{cite book |last1=Marks |first1=Geoffrey |last2=Beatty |first2=William K. |title=The Precious Metals of Medicine |url=https://books.google.com.ar/books?id=QO5sAAAAMAAJ&q=%22in+1936%22+John+Lawrence+uses+phosphorus-32+to+treat+leukaemia&dq=%22in+1936%22+John+Lawrence+uses+phosphorus-32+to+treat+leukaemia&hl=en&sa=X&ved=0ahUKEwiP-JPz47jdAhWMHpAKHQNECI4Q6AEIMjAC}}</ref><ref>{{cite book |last1=Oreskes |first1=Naomi |last2=Krige |first2=John |title=Science and Technology in the Global Cold War |url=https://books.google.com.ar/books?id=FjMqBQAAQBAJ&pg=PA37&dq=%22in+1936%22+John+Lawrence+uses+phosphorus-32+to+treat+leukaemia&hl=en&sa=X&ved=0ahUKEwiP-JPz47jdAhWMHpAKHQNECI4Q6AEIKDAA#v=onepage&q=%22in%201936%22%20John%20Lawrence%20uses%20phosphorus-32%20to%20treat%20leukaemia&f=false}}</ref><ref>{{cite book |title=Positron Emission Tomography: Basic Sciences |edition=Dale L. Bailey, David W. Townsend, Peter E. Valk, Michael N. Maisey |url=https://books.google.com.ar/books?id=svliBnNd2LcC&pg=PR6&dq=%22in+1936%22+John+Lawrence+uses+phosphorus-32+to+treat+leukaemia&hl=en&sa=X&ved=0ahUKEwiP-JPz47jdAhWMHpAKHQNECI4Q6AEILTAB#v=onepage&q=%22in%201936%22%20John%20Lawrence%20uses%20phosphorus-32%20to%20treat%20leukaemia&f=false}}</ref> || {{w|United States}}
+
| 1936 || Field development || American hematologist {{w|John H. Lawrence}} of the {{w|University of California, Berkeley}} introduces phosphorus-32 for the treatment of {{w|leukemia}}.<ref>{{cite book |last1=Marks |first1=Geoffrey |last2=Beatty |first2=William K. |title=The Precious Metals of Medicine |url=https://books.google.com.ar/books?id=QO5sAAAAMAAJ&q=%22in+1936%22+John+Lawrence+uses+phosphorus-32+to+treat+leukaemia&dq=%22in+1936%22+John+Lawrence+uses+phosphorus-32+to+treat+leukaemia&hl=en&sa=X&ved=0ahUKEwiP-JPz47jdAhWMHpAKHQNECI4Q6AEIMjAC}}</ref><ref>{{cite book |last1=Oreskes |first1=Naomi |last2=Krige |first2=John |title=Science and Technology in the Global Cold War |url=https://books.google.com.ar/books?id=FjMqBQAAQBAJ&pg=PA37&dq=%22in+1936%22+John+Lawrence+uses+phosphorus-32+to+treat+leukaemia&hl=en&sa=X&ved=0ahUKEwiP-JPz47jdAhWMHpAKHQNECI4Q6AEIKDAA#v=onepage&q=%22in%201936%22%20John%20Lawrence%20uses%20phosphorus-32%20to%20treat%20leukaemia&f=false}}</ref><ref>{{cite book |title=Positron Emission Tomography: Basic Sciences |edition=Dale L. Bailey, David W. Townsend, Peter E. Valk, Michael N. Maisey |url=https://books.google.com.ar/books?id=svliBnNd2LcC&pg=PR6&dq=%22in+1936%22+John+Lawrence+uses+phosphorus-32+to+treat+leukaemia&hl=en&sa=X&ved=0ahUKEwiP-JPz47jdAhWMHpAKHQNECI4Q6AEILTAB#v=onepage&q=%22in%201936%22%20John%20Lawrence%20uses%20phosphorus-32%20to%20treat%20leukaemia&f=false}}</ref> || {{w|United States}}
 
|-
 
|-
 
| 1937 || Organization || The Japanese Society of Hematology (JSH) is founded in {{w|Kyoto}}. It is the second hematology organization in the world.<ref>{{cite web |title=Japanese Society of Hematology (JSH) |url=https://www.ishworld.org/menu/49/japanese-society-of-hematology-jsh |website=ishworld.org |accessdate=7 September 2018}}</ref><ref name="Hematology in Japan: past, present and future">{{cite web |title=Hematology in Japan: past, present and future |url=https://www.healio.com/hematology-oncology/news/print/hemonc-today/%7B8ba22607-e605-4c5e-9929-ca6ced0c0b29%7D/hematology-in-japan-past-present-and-future |website=healio.com |accessdate=7 September 2018}}</ref> || {{w|Japan}}  
 
| 1937 || Organization || The Japanese Society of Hematology (JSH) is founded in {{w|Kyoto}}. It is the second hematology organization in the world.<ref>{{cite web |title=Japanese Society of Hematology (JSH) |url=https://www.ishworld.org/menu/49/japanese-society-of-hematology-jsh |website=ishworld.org |accessdate=7 September 2018}}</ref><ref name="Hematology in Japan: past, present and future">{{cite web |title=Hematology in Japan: past, present and future |url=https://www.healio.com/hematology-oncology/news/print/hemonc-today/%7B8ba22607-e605-4c5e-9929-ca6ced0c0b29%7D/hematology-in-japan-past-present-and-future |website=healio.com |accessdate=7 September 2018}}</ref> || {{w|Japan}}  
 
|-
 
|-
| 1938 || Journal || Journal [[w:International Journal of Hematology|Acta Haematologica Japonica]] is established. In 1991, it would be renamed International Journal of Hematology.<ref name="Hematology in Japan: past, present and future"/> || {{w|Japan}}
+
| 1937 || Field development || {{w|Karl Landsteiner}} and {{w|Alexander S. Wiener}} identify the [[w:Rh blood group system|Rh factor]] (an abbreviation of "Rhesus factor") in blood.<ref name="Inventions & Discoveries"/> The Rhesus-system is the second most important blood group system after [[w:ABO blood group system|ABO]].<ref name="Blood groups systems">{{cite journal |last1=Mitra |first1=Ranadhir |last2=Mishra |first2=Nitasha |last3=Rath |first3=Girija Prasad |title=Blood groups systems |pmid=25535412 |url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4260296/ |pmc=4260296}}</ref> ||
 
|-
 
|-
| 1946 || Journal || Journal ''[[w:Blood (journal)|Blood]]'' is established by {{w|William Dameshek}}. ||
+
| 1938 || Literature || Journal [[w:International Journal of Hematology|Acta Haematologica Japonica]] is established. In 1991, it would be renamed International Journal of Hematology.<ref name="Hematology in Japan: past, present and future"/> || {{w|Japan}}
 +
|-
 +
| 1938 || Field development || American pediatricians {{{w|Louis Diamond}} (known as the “father of American pediatric hematology”) and {{w|Kenneth Blackfan}} describe the anemia still known as {{w|Diamond-Blackfan anemia}}.<ref name="The History of Hematology and Related Sciences"/> || {{w|United States}}
 +
|-
 +
| 1941 || Literature || Blackfan, Diamond, and Leister publish ''The Atlas of the Blood of Children''.<ref name="The History of Hematology and Related Sciences"/> ||
 +
|-
 +
| 1945 || Field development || Robin Coombs, Arthur Mourant and Rob Race describe the use of antihuman globulin (later known as the “Coombs Test”) to identify “incomplete” antibodies.<ref name="The History of Hematology and Related Sciences"/> ||
 +
|-
 +
| 1945 || Field development || Antigen Lu{{sup|a}}, the first in the {{w|Lutheran antigen system}}, is found in the serum of a patient with {{w|lupus erythematosus}}.<ref>{{cite book |last1=Harmening |first1=Denise M |title=Modern Blood Banking and Transfusion Practices |url=https://books.google.com.ar/books?id=QdE-AAAAQBAJ&pg=PA199&lpg=PA199&dq=Lutheran+antigen+system+%22in+1900..2000%22&source=bl&ots=suahZEiF91&sig=KN9tEF8wu80t88_XY9qegVcAPnc&hl=en&sa=X&ved=2ahUKEwiTrpnBwpbeAhXM1VkKHQbuA-UQ6AEwAnoECAIQAQ#v=onepage&q=Lutheran%20antigen%20system%20%22in%201900..2000%22&f=false}}</ref> Antibodies against this blood group are rare and generally not considered clinically significant.<ref name="Blood groups systems"/> ||
 +
|-
 +
| 1946 || Literature || Journal ''[[w:Blood (journal)|Blood]]'' is established by {{w|William Dameshek}}.<ref>{{cite web |title=About Blood |url=http://www.bloodjournal.org/page/about-blood?sso-checked=true |website=bloodjournal.org |accessdate=20 September 2018}}</ref> ||
 +
|-
 +
| 1946–1948 || Field development || The {{w|Lewis blood group system}} is identified. It is considered among the major blood group systems.<ref name="OTHER BLOOD GROUP SYSTEMS">{{cite web |title=OTHER BLOOD GROUP SYSTEMS |url=https://www.slideshare.net/ferdiefatiga/other-blood-group-systems |website=slideshare.net |accessdate=21 October 2018}}</ref> Consisting in antigens Le{{sup|a}} and Le{{sup|b}}, the second reaches a frequency of 70 percent in Europeans.<ref>{{cite web |title=Lewis blood group system |url=https://www.britannica.com/science/Lewis-blood-group-system |website=britannica.com |accessdate=21 October 2018}}</ref> ||
 +
|-
 +
| 1946 || Field development || Austro-Hungarian biochemist {{w|Erwin Chargaff}} and Randolph West discover that platelet-free plasma exhibits clotting properties.<ref name="=On the origin of microparticles: From “platelet dust” to mediators of intercellular communication"/> ||
 +
|-
 +
| 1946 || Field development || The [[w:Kell antigen system|Kell blood group system]] is discovered.<ref>{{cite web |title=Kell blood group system |url=https://www.britannica.com/science/Kell-blood-group-system |website=britannica.com |accessdate=10 October 2018}}</ref> It is considered among the major blood group systems.<ref name="OTHER BLOOD GROUP SYSTEMS"/> These erythrocyte antigens are the third most potent immunogenic antigen after [[w:ABO blood group system|ABO]] and [[w:Rh blood group system|Rh]] system.<ref name="Blood groups systems"/> ||
 +
|-
 +
| 1947 || Field development || Lerner and Watson introduce the term "{{w|cryoglobulin}}", demonstrating the reversibility of the phenomenon when the sera are heated to 37°C.<ref name="Oxford Textbook of Vasculitis"/> ||
 +
|-
 +
| 1947 || Field development || Australian serologist Ruth Ann Sanger and Robert Russell Race identify the S and s genes.<ref name="Milestones in Transfusion Medicine"/> ||
 +
|-
 +
| 1950s || Instrumental || The [[w:Winged infusion set|“butterfly” needle]] and intercath are developed, making intravenous access easier and safer.<ref name="The History of Hematology and Related Sciences"/> ||
 
|-
 
|-
 
| 1950 || Organization || The {{w|Society for Hematology and Stem Cells}} is founded by a group of scientists for the presentation and discussion of experimental hematology pre-clinical data.<ref>{{cite web |title=Society for Hematology and Stem Cells |url=https://www.omicsonline.org/societies/society-for-hematology-and-stem-cells/ |website=omicsonline.org |accessdate=10 September 2018}}</ref> ||
 
| 1950 || Organization || The {{w|Society for Hematology and Stem Cells}} is founded by a group of scientists for the presentation and discussion of experimental hematology pre-clinical data.<ref>{{cite web |title=Society for Hematology and Stem Cells |url=https://www.omicsonline.org/societies/society-for-hematology-and-stem-cells/ |website=omicsonline.org |accessdate=10 September 2018}}</ref> ||
 
|-
 
|-
| 1955 || Journal || The ''{{w|British Journal of Haematology}}'' is launched.<ref>{{cite book |last1=Goldman |first1=Lawrence |title=Oxford Dictionary of National Biography 2005-2008 |url=https://books.google.com.ar/books?id=nbGcAQAAQBAJ&pg=PA281&dq=%22in+1955%22+%22British+Journal+of+Haematology%22&hl=en&sa=X&ved=0ahUKEwjMjNiV4KndAhVFDJAKHc2lA7cQ6AEIKDAA#v=onepage&q=%22in%201955%22%20%22British%20Journal%20of%20Haematology%22&f=false}}</ref><ref>{{cite book |last1=Harrison |first1=Brian |last2=Aston |first2=Trevor Henry |title=The History of the University of Oxford: Volume VIII: The Twentieth Century |url=https://books.google.com.ar/books?id=OP5ePl7i5EIC&pg=PA463&dq=%22in+1955%22+%22British+Journal+of+Haematology%22&hl=en&sa=X&ved=0ahUKEwjMjNiV4KndAhVFDJAKHc2lA7cQ6AEILTAB#v=onepage&q=%22in%201955%22%20%22British%20Journal%20of%20Haematology%22&f=false}}</ref> || {{w|United Kingdom}}
+
| 1950 || Field development || The {{w|Duffy antigen system}} is discovered.<ref name="APC Essentials of Forensic Medicine and Toxicology"/> It is considered among the major blood group systems.<ref name="OTHER BLOOD GROUP SYSTEMS"/> ||
 +
|-
 +
| 1951 || Field development || The [[W:Kidd antigen system|Kidd blood group system]] is discovered.<ref>{{cite book |title=Blood: Physiology and Circulation |edition=Kara Rogers Senior Editor, Biomedical Sciences |url=https://books.google.com.ar/books?id=iObZwlOu1mMC&pg=PA106&lpg=PA106&dq=Diego+antigen+system+in+1940..1980&source=bl&ots=aHUPunj1aG&sig=9qoLdXfpfZx6z4bFwC7h5_LCIh4&hl=en&sa=X&ved=2ahUKEwj1vNa0pfzdAhXCE5AKHVnGDi0Q6AEwAHoECAQQAQ#v=onepage&q=Diego%20antigen%20system%20in%201940..1980&f=false}}</ref> It is considered among the major blood group systems.<ref name="OTHER BLOOD GROUP SYSTEMS"/> Kidd antibodies are rare but can cause severe transfusion reactions.<ref name="Blood groups systems"/> ||
 +
|-
 +
| 1952 || Field development || {{w|Hh blood group}} (also known as Oh or the Bombay blood group) is first discovered in {{w|Bombay}} (Mumbai), India.<ref>{{cite journal |title=Chapter 6The Hh blood group |url=https://www.ncbi.nlm.nih.gov/books/NBK2268/}}</ref> It is a very rare histo-blood group phenotype.<ref>{{cite web |title=Hh blood group |url=https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/hh-blood-group |website=sciencedirect.com |accessdate=21 October 2018}}</ref> || {{w|India}}
 +
|-
 +
| 1954 || Field development || The {{w|blood product}} {{w|cryoprecipitate}} is developed to treat bleeds in people with {{w|hemophilia}}.<ref name="The History of Hematology and Related Sciences"/> ||
 +
|-
 +
| 1954 || Field development || Peterman and Braunsteiner report cryoprecipitates of {{w|immunoglobulin}}s with different sedimentation rates, thus introducing the concept of "mixed cryoglobulinaemia".<ref name="Oxford Textbook of Vasculitis"/> ||
 +
|-
 +
| 1955 || Literature || The ''{{w|British Journal of Haematology}}'' is launched.<ref>{{cite book |last1=Goldman |first1=Lawrence |title=Oxford Dictionary of National Biography 2005-2008 |url=https://books.google.com.ar/books?id=nbGcAQAAQBAJ&pg=PA281&dq=%22in+1955%22+%22British+Journal+of+Haematology%22&hl=en&sa=X&ved=0ahUKEwjMjNiV4KndAhVFDJAKHc2lA7cQ6AEIKDAA#v=onepage&q=%22in%201955%22%20%22British%20Journal%20of%20Haematology%22&f=false}}</ref><ref>{{cite book |last1=Harrison |first1=Brian |last2=Aston |first2=Trevor Henry |title=The History of the University of Oxford: Volume VIII: The Twentieth Century |url=https://books.google.com.ar/books?id=OP5ePl7i5EIC&pg=PA463&dq=%22in+1955%22+%22British+Journal+of+Haematology%22&hl=en&sa=X&ved=0ahUKEwjMjNiV4KndAhVFDJAKHc2lA7cQ6AEILTAB#v=onepage&q=%22in%201955%22%20%22British%20Journal%20of%20Haematology%22&f=false}}</ref> || {{w|United Kingdom}}
 +
|-
 +
| 1955 || Field development || The {{w|Diego antigen system}} is discovered.<ref name="APC Essentials of Forensic Medicine and Toxicology">{{cite book |last1=Aggrawal |first1=Anil |title=APC Essentials of Forensic Medicine and Toxicology |url=https://books.google.com.ar/books?id=iSH8CgAAQBAJ&pg=PA413&lpg=PA413&dq=Diego+antigen+system+in+1940..1980&source=bl&ots=qKrQZJjNCW&sig=2EG4y1f9SSPbGKlcmvPqGR6egpE&hl=en&sa=X&ved=2ahUKEwj1vNa0pfzdAhXCE5AKHVnGDi0Q6AEwAnoECAIQAQ#v=onepage&q=Diego%20antigen%20system%20in%201940..1980&f=false}}</ref> It is very rare among [[w:caucasian race|Caucasians}} and [[w:Black people|Blacks]], but relatively common among the South American Indians and Asians of Mongolian origin.<ref>{{cite journal |last1=Tar Wei |first1=Cheong |last2=Al-Hassan |first2=Faisal Muti |last3=Naim |first3=Norris |last4=Knight |first4=Aishah |last5=Joshi |first5=Sanmukh R. |title=Prevalence of Diego blood group antigen and the antibody in three ethnic population groups in Klang valley of Malaysia |doi=10.4103/0973-6247.106725 |pmid=23559760 |url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3613656/ |pmc=3613656}}</ref> || {{w|Venezuela}}
 
|-
 
|-
 
| 1958 || Organization || The {{w|American Society of Hematology}} is founded.<ref>{{cite web |title=American Society of Hematology sponsors high school symposium at San Diego annual meeting |url=https://www.eurekalert.org/pub_releases/2003-12/uou-aso120503.php |website=eurekalert.org |accessdate=8 September 2018}}</ref><ref>{{cite journal |last1=Silver |first1=Samuel M. |title=The American Society of Hematology: Advancing Knowledge and Treatment of Blood Disorders |pmid=29447514 |pmc=2793577}}</ref> || {{w|United States}}
 
| 1958 || Organization || The {{w|American Society of Hematology}} is founded.<ref>{{cite web |title=American Society of Hematology sponsors high school symposium at San Diego annual meeting |url=https://www.eurekalert.org/pub_releases/2003-12/uou-aso120503.php |website=eurekalert.org |accessdate=8 September 2018}}</ref><ref>{{cite journal |last1=Silver |first1=Samuel M. |title=The American Society of Hematology: Advancing Knowledge and Treatment of Blood Disorders |pmid=29447514 |pmc=2793577}}</ref> || {{w|United States}}
 
|-
 
|-
| 1959 || || "In 1959, by use of {{w|X-ray crystallography}}, Dr. {{w|Max Perutz}} was able to unravel the structure of hemoglobin, the red blood cell protein that carries oxygen" ||
+
| 1959 || Field development || Austrian-born British molecular biologist {{w|Max Perutz}} uses {{w|X-ray crystallography}} to determine the overall structure of {{w|hemoglobin}}.<ref>{{cite book |last1=Rezende |first1=Lisa |title=Chronology of Science |url=https://books.google.com.ar/books?id=079t8r9RIcIC&pg=PA367&dq=%22in+1959%22+Max+Perutz+hemoglobin&hl=en&sa=X&ved=0ahUKEwiR2LSnhsrdAhVBDpAKHQJZBO8Q6AEILjAB#v=onepage&q=%22in%201959%22%20Max%20Perutz%20hemoglobin&f=false}}</ref><ref>{{cite book |last1=Lee |first1=W. David |last2=Drazen |first2=Jeffrey |last3=Sharp |first3=Phillip A. |last4=Langer |first4=Robert S. |title=From X-rays to DNA: How Engineering Drives Biology |url=https://books.google.com.ar/books?id=WTgTAgAAQBAJ&pg=PA58&dq=%22in+1959%22+Max+Perutz+hemoglobin&hl=en&sa=X&ved=0ahUKEwiR2LSnhsrdAhVBDpAKHQJZBO8Q6AEINDAC#v=onepage&q=%22in%201959%22%20Max%20Perutz%20hemoglobin&f=false}}</ref><ref>{{cite book |last1=Lee |first1=W. David |last2=Drazen |first2=Jeffrey |last3=Sharp |first3=Phillip A. |last4=Langer |first4=Robert S. |title=From X-rays to DNA: How Engineering Drives Biology |url=https://books.google.com.ar/books?id=WTgTAgAAQBAJ&pg=PA58&dq=%22in+1959%22+Max+Perutz+hemoglobin&hl=en&sa=X&ved=0ahUKEwiR2LSnhsrdAhVBDpAKHQJZBO8Q6AEINDAC#v=onepage&q=%22in%201959%22%20Max%20Perutz%20hemoglobin&f=false}}</ref><ref>{{cite book |last1=Zecchina |first1=Adriano |last2=Califano |first2=Salvatore |title=The Development of Catalysis: A History of Key Processes and Personas in Catalytic Science and Technology |url=https://books.google.com.ar/books?id=inEwDgAAQBAJ&pg=PA278&dq=%22in+1959%22+Max+Perutz+hemoglobin&hl=en&sa=X&ved=0ahUKEwiR2LSnhsrdAhVBDpAKHQJZBO8Q6AEIPDAD#v=onepage&q=%22in%201959%22%20Max%20Perutz%20hemoglobin&f=false}}</ref> ||
 
|-
 
|-
 
| 1959 || Organization || The Japanese Society of Clinical Hematology is established in {{w|Tokyo}}.<ref name="Hematology in Japan: past, present and future"/> || {{w|Japan}}
 
| 1959 || Organization || The Japanese Society of Clinical Hematology is established in {{w|Tokyo}}.<ref name="Hematology in Japan: past, present and future"/> || {{w|Japan}}
Line 69: Line 178:
 
| 1960 || Organization || The {{w|British Society for Haematology}} is founded.<ref>{{cite web |title=British Society for Haematology (BSH) |url=https://www.emedevents.com/organizer-profile/british-society-for-haematology-bsh-28662 |website=emedevents.com |accessdate=7 September 2018}}</ref> || {{w|United Kingdom}}
 
| 1960 || Organization || The {{w|British Society for Haematology}} is founded.<ref>{{cite web |title=British Society for Haematology (BSH) |url=https://www.emedevents.com/organizer-profile/british-society-for-haematology-bsh-28662 |website=emedevents.com |accessdate=7 September 2018}}</ref> || {{w|United Kingdom}}
 
|-
 
|-
| 1961 || || Researchers identify role of platelets in treating cancer patients.<ref name="A Historical Perspective on Evidence-Based Immunology">{{cite book |last1=Moticka |first1=Edward J. |title=A Historical Perspective on Evidence-Based Immunology |url=https://books.google.com.ar/books?id=2TMwAAAAQBAJ&pg=PA302&dq=%22in+1961%22+platelets+in+treating+cancer+patients&hl=en&sa=X&ved=0ahUKEwjGgern78ndAhWTPpAKHb47AjwQ6AEIPzAF#v=onepage&q=%22in%201961%22%20platelets%20in%20treating%20cancer%20patients&f=false}}</ref>
+
| 1960 || Field development || The {{w|Gerbich blood group system}} is discovered.<ref name="Wintrobe's Clinical Hematology, Volume 1"/> ||
<ref name="What is Hematology?"/> ||
+
|-
 +
| 1961 || Field development || Researchers identify role of platelets in treating cancer patients.<ref name="A Historical Perspective on Evidence-Based Immunology">{{cite book |last1=Moticka |first1=Edward J. |title=A Historical Perspective on Evidence-Based Immunology |url=https://books.google.com.ar/books?id=2TMwAAAAQBAJ&pg=PA302&dq=%22in+1961%22+platelets+in+treating+cancer+patients&hl=en&sa=X&ved=0ahUKEwjGgern78ndAhWTPpAKHb47AjwQ6AEIPzAF#v=onepage&q=%22in%201961%22%20platelets%20in%20treating%20cancer%20patients&f=false}}</ref><ref name="What is Hematology?"/> ||
 +
|-
 +
| 1962 || Field development || At an {{w|International Committee on Blood Clotting Factors}} conference in {{w|Stockholm}}, English hematologist {{w|Robert Gwyn Macfarlane}} of Oxford and American researcher {{w|Oscar Ratnoff}} propose that the coagulation process involves an {{w|enzyme}} acting on its substrate to make it an active enzyme, which subsequently acts on its own distinct substrate. This type of enzymatic activation continues down a line of substrates before coagulation is achieved.<ref name="=On the origin of microparticles: From “platelet dust” to mediators of intercellular communication"/> || {{w|Sweden}}
 +
|-
 +
| 1962 || Field development || The {{w|Xg antigen system}} is discovered by Mann in the serum of a multiply transfused male.<ref name="Wintrobe's Clinical Hematology, Volume 1">{{cite book |title=Wintrobe's Clinical Hematology, Volume 1 |edition=John P. Greer |url=https://books.google.com.ar/books?id=68enzUD7BVgC&pg=PA644&lpg=PA644&dq=Dombrock+system+%22in+1960..1998%22&source=bl&ots=fGFWhJSb_r&sig=a1u8d0NhOxoD5FZm75np7wEmL_8&hl=en&sa=X&ved=2ahUKEwiBgd-bqvzdAhWHTJAKHfjwA7MQ6AEwBXoECAIQAQ#v=onepage&q=Dombrock%20system%20%22in%201960..1998%22&f=false}}</ref> ||
 +
|-
 +
| 1962 || Field development || The first antihemophilic factor concentrate to treat coagulation disorders in hemophilia patients is developed through fractionation.<ref name="The History of Hematology and Related Sciences"/> ||
 +
|-
 +
| 1962 || Field development || Researchers at {{w|CSL Behring}} develop a new plasma fractionation method that provides significantly better yields of the valuable proteins isolated from human plasma.<ref>{{cite web |title=CSL Behring |url=http://www.bstquarterly.com/Assets/downloads/BSTQ/Articles/BSTQ_2013-07_Supplement_AR_CSL-Behring.pdf |website=bstquarterly.com |accessdate=25 September 2018}}</ref> ||
 +
|-
 +
| 1962 || Field development || Platelet transfusion begins to be used more routinely, especially in cancer patients when the relationship between {{w|thrombocytopenia}} and {{w|hemorrage}} is noted.<ref name="Platelets in Thrombotic and Non-Thrombotic Disorders: Pathophysiology, Pharmacology and Therapeutics: an Update"/> ||
 +
|-
 +
| 1965 || Field development || The {{w|Cromer blood group system}} is discovered.<ref name="Wintrobe's Clinical Hematology, Volume 1"/> ||
 +
|-
 +
| 1965 || Field development || The first {{w|antibody}} of the {{w|Dombrock system}} is identified.<ref>{{cite book |last1=Hillyer |first1=Christopher D. |title=Blood Banking and Transfusion Medicine: Basic Principles & Practice |url=https://books.google.com.ar/books?id=3QwXx_enKbcC&pg=PT123&lpg=PT123&dq=Dombrock+system+%22in+1960..1998%22&source=bl&ots=-8uKh9-y_E&sig=BE7PnHz1Bg6INXqHocmhp-E8keo&hl=en&sa=X&ved=2ahUKEwiBgd-bqvzdAhWHTJAKHfjwA7MQ6AEwAHoECAUQAQ#v=onepage&q=Dombrock%20system%20%22in%201960..1998%22&f=false}}</ref> ||
 +
|-
 +
| 1967 || Organization || The Turkish Society of Hematology is founded.<ref>{{cite book |last1=Svendsen |first1=Clive |last2=Ebert |first2=Allison D. |title=Encyclopedia of Stem Cell Research, Volume 2 |url=https://books.google.com.ar/books?id=UhvtbMmxXeAC&pg=PA557&lpg=PA557&dq=Turkish+Society+of+Gene+%26+Cell+Therapy+%22in+1950..2017%22&source=bl&ots=kvmzsRtVc5&sig=jIncYO7H9vlEQlbcS9m4fRMzB1U&hl=en&sa=X&ved=2ahUKEwiQr8mT8qLeAhXJEZAKHa1UBqIQ6AEwAHoECAkQAQ#v=onepage&q=Turkish%20Society%20of%20Gene%20%26%20Cell%20Therapy%20%22in%201950..2017%22&f=false}}</ref> || {{w|Turkey}}
 +
|-
 +
| 1967 || Field development || Peter Wolf first identifies microparticles as a product of platelets.<ref name="=On the origin of microparticles: From “platelet dust” to mediators of intercellular communication">{{cite journal |last1=Hargett |first1=Leslie A. |last2=Bauer |first2=Natalie N. |title=On the origin of microparticles: From “platelet dust” to mediators of intercellular communication |doi=10.4103/2045-8932.114760 |pmid=24015332 |url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757826/ |pmc=3757826}}</ref> ||
 +
|-
 +
| 1967 || Field development || The [[w:Colton antigen system|Colton blood group system]] is identified.<ref>{{cite book |last1=McPherson |first1=Richard A. |last2=Pincus |first2=Matthew R. |title=Henry's Clinical Diagnosis and Management by Laboratory Methods E-Book |url=https://books.google.com.ar/books?id=xAzhCwAAQBAJ&pg=PA706&lpg=PA706&dq=Colton+antigen+system+%22in+1800..2016%22&source=bl&ots=mFSpAi70uN&sig=iLm9GdNutNeesUyP6q6L6IRgDwQ&hl=en&sa=X&ved=2ahUKEwiS6pnTo_zdAhWInJAKHY4DCiMQ6AEwAHoECAcQAQ#v=onepage&q=Colton%20antigen%20system%20%22in%201800..2016%22&f=false}}</ref> ||
 +
|-
 +
| 1968 || Field development || Rh immune globulin (RhIg) is first licensed as a human plasma-derived product consisting of [[w:Immunoglobulin G|IgG antibodies]] to the {{w|D antigen}}. It is used to prevent immunization to the D antigen in D-negative individuals and for the treatment of {{w|immune thrombocytopenia}} (ITP).<ref>{{cite web |title=Rho(D) immune globulin |url=https://www.sciencedirect.com/topics/neuroscience/rho-d-immune-globulin |website=sciencedirect.com |accessdate=12 October 2018}}</ref> ||  
 
|-
 
|-
| 1971 || || "Healthcare professionals in the United States start testing blood for Hepatitis B."<ref name="What is Hematology?"/> || {{w|United States}}
+
| 1970 || Field development || Webber and Johnson find that platelet alpha granule contents are encompassed into vesicles, which come together to form a membrane complex at the surface of the platelet.<ref name="=On the origin of microparticles: From “platelet dust” to mediators of intercellular communication"/> ||
 
|-
 
|-
| 1972 || Journal || Journal ''{{w|Experimental Hematology}}'' is launched by the International Society for Experimental Hematology, incorporated the same year as the continuation of the Society for Hematology and Stem Cells.<ref>{{cite book |last1=Fagan |first1=Melinda |title=Philosophy of Stem Cell Biology: Knowledge in Flesh and Blood |url=https://books.google.com.ar/books?id=KD1y63M-5R4C&pg=PA248&dq=%22in+1972%22+journal+%22Experimental+Hematology%22&hl=en&sa=X&ved=0ahUKEwi-1ueooardAhUMg5AKHcT_DFMQ6AEIKDAA#v=onepage&q=%22in%201972%22%20journal%20%22Experimental%20Hematology%22&f=false}}</ref> ||
+
| 1972 || Literature || Journal ''{{w|Experimental Hematology}}'' is launched by the International Society for Experimental Hematology, incorporated the same year as the continuation of the Society for Hematology and Stem Cells.<ref>{{cite book |last1=Fagan |first1=Melinda |title=Philosophy of Stem Cell Biology: Knowledge in Flesh and Blood |url=https://books.google.com.ar/books?id=KD1y63M-5R4C&pg=PA248&dq=%22in+1972%22+journal+%22Experimental+Hematology%22&hl=en&sa=X&ved=0ahUKEwi-1ueooardAhUMg5AKHcT_DFMQ6AEIKDAA#v=onepage&q=%22in%201972%22%20journal%20%22Experimental%20Hematology%22&f=false}}</ref> ||
 
|-
 
|-
| 1975 || Journal || Journal {{w|Blood Cells, Molecules and Diseases}} is established.<ref>{{cite web |title=BLOOD CELLS, MOLECULES, AND DISEASES: PAST, PRESENT, AND FUTURE |url=https://kundoc.com/pdf-blood-cells-molecules-and-diseases-past-present-and-future-.html |website=kundoc.com |accessdate=10 September 2018}}</ref> ||
+
| 1974 || Literature || Davis Nathan and Stuart Oski publish ''Hematology of Infancy and Childhood''.<ref name="The History of Hematology and Related Sciences"/> ||
 
|-
 
|-
| 1976 || Journal || The ''{{w|American Journal of Hematology}}'' is established.<ref>{{cite web |title=The American Journal of Hematology turns 40 |url=https://onlinelibrary.wiley.com/doi/pdf/10.1002/ajh.24237 |website=onlinelibrary.wiley.com |accessdate=10 September 2018}}</ref> || {{w|United States}}
+
| 1974 || Field development || The [[w:ERMAP|Scianna]] blood group system is established.<ref>{{cite book |last1=Harmening |first1=Denise M |title=Modern Blood Banking and Transfusion Practices |url=https://books.google.com.ar/books?id=QdE-AAAAQBAJ&pg=PA203&lpg=PA203&dq=blood+system+is+established+in+1900..2017&source=bl&ots=su9q_ErG90&sig=3m9AHLiiBI5BXVLRSHqlRgooxcI&hl=en&sa=X&ved=2ahUKEwiAq6zSy_zdAhUJl5AKHdh7CZUQ6AEwCnoECAYQAQ#v=onepage&q=blood%20system%20is%20established%20in%201900..2017&f=false}}</ref> Composed of three antigens, the first, Sc1, a high frequency antigen, is found in greater than 99 % of most populations. The frequency of Sc2 is about 1% of Northern Europeans but the frequency is much lower in other populations. The incidence of Sc:1,2 is more common in {{w|Mennonites}}.<ref>{{cite web |title=Scianna |url=http://scarfex.jove.prohosting.com/blood/13.html |website=scarfex.jove.prohosting.com |accessdate=21 October 2018}}</ref> ||
 +
|-
 +
| 1975 || Literature || Journal {{w|Blood Cells, Molecules and Diseases}} is established.<ref>{{cite web |title=BLOOD CELLS, MOLECULES, AND DISEASES: PAST, PRESENT, AND FUTURE |url=https://kundoc.com/pdf-blood-cells-molecules-and-diseases-past-present-and-future-.html |website=kundoc.com |accessdate=10 September 2018}}</ref> ||
 +
|-
 +
| 1976 || Literature || The ''{{w|American Journal of Hematology}}'' is established.<ref>{{cite web |title=The American Journal of Hematology turns 40 |url=https://onlinelibrary.wiley.com/doi/pdf/10.1002/ajh.24237 |website=onlinelibrary.wiley.com |accessdate=10 September 2018}}</ref> || {{w|United States}}
 
|-
 
|-
 
| 1977 || Field development || Kitamura first observes that mast cells are derived from hematopoietic stem cells shown by transplantation of bone marrow cells from mutant mice.<ref name="Hematology in Japan: past, present and future"/> || {{w|Japan}}
 
| 1977 || Field development || Kitamura first observes that mast cells are derived from hematopoietic stem cells shown by transplantation of bone marrow cells from mutant mice.<ref name="Hematology in Japan: past, present and future"/> || {{w|Japan}}
 
|-
 
|-
 
| 1977 || Field development || Miyake et al first purify {{w|erythropoietin}}.<ref name="Hematology in Japan: past, present and future"/> || {{w|Japan}}
 
| 1977 || Field development || Miyake et al first purify {{w|erythropoietin}}.<ref name="Hematology in Japan: past, present and future"/> || {{w|Japan}}
 +
|-
 +
| 1978 || Field development || The {{w|Duclos antigen}} is identified.<ref name="The Blood Group Antigen FactsBook"/> ||
 +
|-
 +
| 1970s || Field development || Alan T. Nurden, Jacques P. Caen, David R. Phillips, and others describe the molecular basis of platelet aggregation.<ref name="Milestones in Antiplatelet Therapy"/> ||
 +
|-
 +
| 1980 || Field development || The [[w:International Society of Blood Transfusion|ISBT]] Working Party on Terminology for Red Cell Surface Antigens is established with the goal of creating a uniform nomenclature.<ref name="Wintrobe's Clinical Hematology, Volume 1"/> ||
 +
|-
 +
| 1980 || Field development || {{w|Molecular biology}} is applied to the study of blood groups.<ref name="Transfusion Medicine and Patient Safety">{{cite book |last1=De Silvestro |first1=Giustina |last2=Veronesi |first2=Arianna |last3=Vicarioto |first3=Maria |title=Transfusion Medicine and Patient Safety |url=https://books.google.com.ar/books?id=pM5c_mQr9FUC&pg=PA1&lpg=PA1&dq=1945+%7C%7C+%7C%7C+Robin+Coombs,+Arthur+Mourant+and+Robert+Race&source=bl&ots=cl3l1jVL-F&sig=8isSV4CTy60ee31fvxWBWlOpPXs&hl=en&sa=X&ved=2ahUKEwiY07m6_P7dAhWMg5AKHTPeBHsQ6AEwC3oECAMQAQ#v=onepage&q=1945%20%7C%7C%20%7C%7C%20Robin%20Coombs%2C%20Arthur%20Mourant%20and%20Robert%20Race&f=false}}</ref> ||
 
|-
 
|-
 
| 1981 || Organization || The {{w|American Society of Pediatric Hematology/Oncology}} is founded.<ref>{{cite book |last1=Maurer |first1=Harold M. |last2=Ruymann |first2=Frederick B. |last3=Pochedly |first3=Carl E. |title=Rhabdomyosarcoma and Related Tumors in Children and Adolescents |url=https://books.google.com.ar/books?id=W9TfFbMvQJgC&pg=PP9&dq=%22in+1981%22+American+Society+of+Pediatric+Hematology/Oncology&hl=en&sa=X&ved=0ahUKEwjYx5CCnq_dAhVCgpAKHQjtCGgQ6AEIKDAA#v=onepage&q=%22in%201981%22%20American%20Society%20of%20Pediatric%20Hematology%2FOncology&f=false}}</ref><ref>{{cite book |last1=Pochedly |first1=Carl E. |title=Neuroblastoma |url=https://books.google.com.ar/books?id=gxNNDtrHYYEC&pg=PP7&dq=%22in+1981%22+American+Society+of+Pediatric+Hematology/Oncology&hl=en&sa=X&ved=0ahUKEwjYx5CCnq_dAhVCgpAKHQjtCGgQ6AEILzAB#v=onepage&q=%22in%201981%22%20American%20Society%20of%20Pediatric%20Hematology%2FOncology&f=false}}</ref> || {{w|United States}}  
 
| 1981 || Organization || The {{w|American Society of Pediatric Hematology/Oncology}} is founded.<ref>{{cite book |last1=Maurer |first1=Harold M. |last2=Ruymann |first2=Frederick B. |last3=Pochedly |first3=Carl E. |title=Rhabdomyosarcoma and Related Tumors in Children and Adolescents |url=https://books.google.com.ar/books?id=W9TfFbMvQJgC&pg=PP9&dq=%22in+1981%22+American+Society+of+Pediatric+Hematology/Oncology&hl=en&sa=X&ved=0ahUKEwjYx5CCnq_dAhVCgpAKHQjtCGgQ6AEIKDAA#v=onepage&q=%22in%201981%22%20American%20Society%20of%20Pediatric%20Hematology%2FOncology&f=false}}</ref><ref>{{cite book |last1=Pochedly |first1=Carl E. |title=Neuroblastoma |url=https://books.google.com.ar/books?id=gxNNDtrHYYEC&pg=PP7&dq=%22in+1981%22+American+Society+of+Pediatric+Hematology/Oncology&hl=en&sa=X&ved=0ahUKEwjYx5CCnq_dAhVCgpAKHQjtCGgQ6AEILzAB#v=onepage&q=%22in%201981%22%20American%20Society%20of%20Pediatric%20Hematology%2FOncology&f=false}}</ref> || {{w|United States}}  
Line 90: Line 234:
 
| 1986 || Field development || Granulocyte colony-stimulating factor is cloned independently in Japan.<ref name="Hematology in Japan: past, present and future"/> || {{w|Japan}}
 
| 1986 || Field development || Granulocyte colony-stimulating factor is cloned independently in Japan.<ref name="Hematology in Japan: past, present and future"/> || {{w|Japan}}
 
|-
 
|-
| 1987 || || "The Food and Drug Administration approves the use of azidothymidine (AZT) to treat HIV."<ref name="What is Hematology?"/> ||
+
| 1986 || Field development || The Ol{{sup|a}} antigen is identified.<ref name="The Blood Group Antigen FactsBook"/> A rare blood group antigen, Only one Ol{{sup|a+}} person was found among the 7, 151 blood donors tested.<ref>{{cite web |last1=Kornstad |first1=Leif |title=A Rare Blood Group Antigen, Ola (Oldeide), Associated with Weak Rh Antigens1 |url=https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1423-0410.1986.tb04888.x |website=onlinelibrary.wiley.com |accessdate=21 October 2018}}</ref> ||
 +
|-
 +
| 1987 || Literature || Journal ''{{w|Blood Reviews}}'' is established.<ref>{{cite web |title=Blood Reviews |url=https://www.bloodreviews.com/article/S0268-960X(13)00030-1/pdf |website=bloodreviews.com |accessdate=7 September 2018}}</ref> ||
 
|-
 
|-
| 1987 || Journal || Journal ''{{w|Blood Reviews}}'' is established.<ref>{{cite web |title=Blood Reviews |url=https://www.bloodreviews.com/article/S0268-960X(13)00030-1/pdf |website=bloodreviews.com |accessdate=7 September 2018}}</ref> ||
+
| 1990s || Field development || Recombinant factor replacement products are used to treat {{w|hemophilia}}.<ref name="What is Hematology?"/> ||
 
|-
 
|-
| 1990s || || "Recombinant factor replacement products are used to treat hemophilia."<ref name="What is Hematology?"/> ||
+
| 1990 || Field development || The {{w|Er blood group collection}} is established as a blood group.<ref>{{cite journal |last1=Cordoba |first1=Raul |last2=Poole |first2=Joyce |last3=Marais |first3=Imelda |last4=Mora |first4=Asuncion |last5=Ercoreca |first5=Luis |last6=Long |first6=Shannon |title=The second example of anti-Erb in a woman during her third pregnancy |doi=10.2450/2012.0098-12 |pmid=23114526 |url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3729140/ |pmc=3729140}}</ref> ||
 
|-
 
|-
| 1990 || Journal || Peer-reviewed medical journal [[w:Platelets (journal)|Platelets]] is first issued.<ref>{{cite web |title=Platelets: The end of an era, start of a new beginning |url=https://www.tandfonline.com/doi/pdf/10.3109/09537104.2015.993234 |website=tandfonline.com |accessdate=20 September 2018}}</ref> ||
+
| 1990 || Literature || Peer-reviewed medical journal [[w:Platelets (journal)|Platelets]] is first issued.<ref>{{cite web |title=Platelets: The end of an era, start of a new beginning |url=https://www.tandfonline.com/doi/pdf/10.3109/09537104.2015.993234 |website=tandfonline.com |accessdate=20 September 2018}}</ref> ||
 +
|-
 +
| 1991 || Field development || The {{w|Knops blood group system}} is established.<ref name="Wintrobe's Clinical Hematology, Volume 1"/> Most of the anigens of this system are common, occurring with a prevalence of >90% in most populations.<ref>{{cite book |title=Wintrobe's Clinical Hematology, Volume 1 |edition=John P. Greer |url=https://books.google.com.ar/books?id=68enzUD7BVgC&pg=PA647&lpg=PA647&dq=Knops+blood+group+system&source=bl&ots=fGGNhF-f0q&sig=r5GH2MtgiKNhuGRLp_wipkyMS3Y&hl=en&sa=X&ved=2ahUKEwisvN_KxZjeAhUhw1kKHXI7A9g4FBDoATAMegQIARAB#v=onepage&q=Knops%20blood%20group%20system&f=false}}</ref> ||
 
|-
 
|-
 
| 1992 || Organization || The {{w|International Society for Laboratory Hematology}} is founded by an international group of laboratory professionals in order to chart new directions for laboratory hematology.<ref>{{cite web |title=International Society for Laboratory Hematology |url=https://www.islh.org/web/about-islh.php |website=islh.org |accessdate=10 September 2018}}</ref> ||
 
| 1992 || Organization || The {{w|International Society for Laboratory Hematology}} is founded by an international group of laboratory professionals in order to chart new directions for laboratory hematology.<ref>{{cite web |title=International Society for Laboratory Hematology |url=https://www.islh.org/web/about-islh.php |website=islh.org |accessdate=10 September 2018}}</ref> ||
 
|-
 
|-
| 1992 || Organization || The {{w|European Hematology Association}} is founded in {{w|Brussels}}. || {{w|Belgium}}
+
| 1992 || Organization || The {{w|European Hematology Association}} is founded in {{w|Brussels}}.<ref>{{cite web |title=European Hematology Association (EHA) |url=https://www.linkedin.com/company/eha/ |website=linkedin.com |accessdate=4 October 2018}}</ref> || {{w|Belgium}}
 +
|-
 +
| 1994 || Field development || Researchers investigating the effects of {{w|lipopolysaccharide}} (LPS) stimulation on monocyte procoagulant activity, reveal that the microparticles released by stimulated human {{w|monocyte}}s possess more tissue factor activity than their parent monocytes.<ref name="=On the origin of microparticles: From “platelet dust” to mediators of intercellular communication"/> ||
 +
|-
 +
| 2002 || Field development || The {{w|GIL blood group system}} is established.<ref>{{cite book |last1=Harmening |first1=Denise M |title=Modern Blood Banking and Transfusion Practices |url=https://books.google.com.ar/books?id=QdE-AAAAQBAJ&pg=PA205&lpg=PA205&dq=chido+rodgers+blood+group+system+%22in+1900..2015%22&source=bl&ots=su9q_EoO54&sig=JLR4PR_IS8ycvJ3f_oZus1JBlNU&hl=en&sa=X&ved=2ahUKEwiZv_enw_zdAhXIIpAKHYlzBeEQ6AEwAnoECAQQAQ#v=onepage&q=chido%20rodgers%20blood%20group%20system%20%22in%201900..2015%22&f=false}}</ref> It is designated as system 29.<ref>{{cite journal |last1=Rumsey |first1=DM |last2=Mallory |first2=DA |title=GIL: a blood group system review. |pmid=24689684 |url=https://www.ncbi.nlm.nih.gov/pubmed/24689684}}</ref> ||
 +
|-
 +
| 2008 || Literature || Journal {{w|Expert Review of Hematology}} is released.<ref>{{cite web |title=Expert Review of Hematology |url=https://www.tandfonline.com/loi/ierr20?open=1&year=2008&repitition=0#vol_1_2008 |website=tandfonline.com |accessdate=8 September 2018}}</ref> ||
 
|-
 
|-
| 2008 || Journal || Journal {{w|Expert Review of Hematology}} is released.<ref>{{cite web |title=Expert Review of Hematology |url=https://www.tandfonline.com/loi/ierr20?open=1&year=2008&repitition=0#vol_1_2008 |website=tandfonline.com |accessdate=8 September 2018}}</ref> ||
+
| 2008 || Literature || The ''{{w|Open Hematology Journal}}'' is released.<ref>{{cite web |title=Effects Of Benzene on Human Hematopoiesis |url=http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.619.520&rep=rep1&type=pdf |website=citeseerx.ist.psu.edu |accessdate=30 September 2018}}</ref> ||
 
|-
 
|-
| 2008 || Journal || {{w|Open Hematology Journal}} ||
+
| 2008 || Field development || The {{w|RHAg}} (Rh-associated glycoprotein) is established as a blood group system.<ref name="The Blood Group Antigen FactsBook">{{cite book |last1=Reid |first1=Marion E. |last2=Lomas-Francis |first2=Christine |last3=Olsson |first3=Martin L. |title=The Blood Group Antigen FactsBook |url=https://books.google.com.ar/books?id=XVTc49cTw3MC&pg=PA619&lpg=PA619&dq=RHAg+system+in+1980..2017&source=bl&ots=q3Fs70yz5E&sig=8Td5bDftqsnOR22n-Ocwjgnu7Rs&hl=en&sa=X&ved=2ahUKEwjiiJjPqpbeAhUC1lkKHbTIDzwQ6AEwAHoECAIQAQ#v=onepage&q=RHAg%20system%20in%201980..2017&f=false}}</ref> ||
 
|-
 
|-
 +
| 2011 || Field development || The {{w|FORS blood group}} system is established as the 31st blood group system.<ref>{{cite book |title=Transfusion Medicine and Hemostasis: Clinical and Laboratory Aspects |edition=Beth H. Shaz, Christopher D. Hillyer, Morayma Reyes Gil |url=https://books.google.com.ar/books?id=lPdtDwAAQBAJ&pg=PA175&lpg=PA175&dq=Forssman+antigen+system+%22in+1900..2017%22&source=bl&ots=FCI6hu_hrO&sig=ME8oaZ-gQfvjAJUJ1NfdyfozGYA&hl=en&sa=X&ved=2ahUKEwjI8860wfzdAhVCFJAKHfV_BJAQ6AEwAHoECAcQAQ#v=onepage&q=Forssman%20antigen%20system%20%22in%201900..2017%22&f=false}}</ref><ref>{{cite journal |last1=Yamamoto |first1=Miyako |last2=Cid |first2=Emili |last3=Yamamoto |first3=Fumiichiro |title=Crosstalk between ABO and Forssman (FORS) blood group systems: FORS1 antigen synthesis by ABO gene-encoded glycosyltransferases |doi=10.1038/srep41632 |pmid=28134301 |url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5278553/ |pmc=5278553}}</ref> ||
 +
|-
 
|}
 
|}
 +
 +
== Numerical and visual data  ==
 +
 +
=== Google Scholar ===
 +
 +
The following table summarizes per-year mentions on Google Scholar as of June 5, 2021.
 +
 +
{| class="sortable wikitable"
 +
! Year
 +
! hematology
 +
! hematology oncology
 +
! pediatric hematology
 +
! hematopathology
 +
|-
 +
| 1980 || 7,590 || 2,670 || 698 || 60
 +
|-
 +
| 1985 || 9,060 || 4,160 || 1,230 || 85
 +
|-
 +
| 1990 || 11,500 || 5,600 || 1,630 || 112
 +
|-
 +
| 1995 || 18,500 || 8,360 || 2,600 || 276
 +
|-
 +
| 2000 || 46,300 || 13,900 || 5,190 || 412
 +
|-
 +
| 2002 || 52,100 || 14,700 || 5,470 || 521
 +
|-
 +
| 2004 || 64,500 || 20,000 || 6,690 || 547
 +
|-
 +
| 2006 || 73,300 || 22,800 || 7,920 || 609
 +
|-
 +
| 2008 || 88,400 || 33,100 || 9,790 || 707
 +
|-
 +
| 2010 || 96,500 || 31,800 || 10,900 || 722
 +
|-
 +
| 2012 || 108,000 || 41,500 || 13,900 || 1,120 
 +
|-
 +
| 2014 || 110,000 || 40,900 || 15,300 || 1,080
 +
|-
 +
| 2016 || 107,000 || 47,000 || 17,400 || 1,310
 +
|-
 +
| 2017 || 102,000 || 48,100 || 18,200 || 1,200 
 +
|-
 +
| 2018 || 93,500 || 47,500 || 18,900 || 1,340 
 +
|-
 +
| 2019 || 83,500 || 45,000 || 19,900 || 1,520 
 +
|-
 +
| 2020 || 56,400 || 32,200 || 22,800 || 1,330 
 +
|-
 +
|}
 +
 +
[[File:Hematology tb.png|thumb|center|700px]]
 +
 +
=== Google Trends ===
 +
The comparative chart below shows {{w|Google Trends}} data for Hematology (Branch of medicine) and Hematology (Search term) from January 2004 to February 2021, when the screenshot was taken. Interest is also ranked by country and displayed on world map.<ref>{{cite web |title=Hematology |url=https://trends.google.com/trends/explore?date=all&q=%2Fm%2F0h212,Hematology |website=Google Trends |access-date=25 February 2021}}</ref>
 +
 +
[[File:Hematology gt.png|thumb|center|600px]]
 +
 +
=== Google Ngram Viewer ===
 +
The chart below shows {{w|Google Ngram Viewer}} data for Hematology from 1600 to 2019.<ref>{{cite web |title=Hematology |url=https://books.google.com/ngrams/graph?content=Hematology&year_start=1600&year_end=2019&corpus=26&smoothing=3&case_insensitive=true |website=books.google.com |access-date=25 February 2021 |language=en}}</ref>
 +
 +
[[File:Hematology ngram.png|thumb|center|700px]]
 +
 +
=== Wikipedia Views ===
 +
The chart below shows pageviews of the English Wikipedia article {{w|Hematology}}, on desktop, mobile-web, desktop-spider, mobile-web-spider and mobile app, from July 2015 to January 2021.<ref>{{cite web |title=Hematology |url=https://wikipediaviews.org/displayviewsformultiplemonths.php?page=Hematology&allmonths=allmonths-api&language=en&drilldown=all |website=wikipediaviews.org |access-date=24 February 2021}}</ref>
 +
 +
[[File:Hematology wv.jpg|thumb|center|400px]]
 +
  
 
==Meta information on the timeline==
 
==Meta information on the timeline==
Line 112: Line 335:
 
===How the timeline was built===
 
===How the timeline was built===
  
The initial version of the timeline was written by [[User:FIXME|FIXME]].
+
The initial version of the timeline was written by [[User:Sebastian]].
  
 
{{funding info}} is available.
 
{{funding info}} is available.
Line 123: Line 346:
  
 
===What the timeline is still missing===
 
===What the timeline is still missing===
 
[https://study.com/academy/lesson/what-is-hematology-definition-history.html], [http://www.hematology.org/About-ASH/50-Years.aspx], [https://pharmaceuticalintelligence.com/2014/12/05/the-history-of-hematology-and-related-sciences/]
 
  
 
===Timeline update strategy===
 
===Timeline update strategy===
  
 
==See also==
 
==See also==
 +
 +
* [[Timeline of transfusion medicine]]
 +
* [[Timeline of hemophilia]]
  
 
==External links==
 
==External links==

Latest revision as of 20:42, 12 March 2024

This is a timeline of hematology, listing important events in the development of the field. Events related to transfusion are described in the Timeline of transfusion medicine.

Big picture

Time period Development summary
Ancient history “Blood letting” instruments are used in Ancient Egypt.[1]
17th century Dutch microscopist Antonie van Leeuwenhoek, using a primitive, single-lens microscope, already observes red blood cells (erythrocytes) and compared their size with that of a grain of sand.[2]
18th century English physiologist William Hewson is considered to be the "father of hematology". Hewson manages to amplify the description of red cells and demonstrates the role of fibrin in the clotting (coagulation) of blood.[3][2]
19th century Bone marrow is recognized as the site of blood-cell formation in the 19th century, along with the first clinical descriptions of pernicious anemia, leukemia, and a number of other disorders of the blood.[2]
20th century The discovery by Karl Landsteiner of the ABO blood group system in the first quarter of the 20th century makes possible the transfusion of blood from one person to another without the serious ill effects that ensue when incompatible blood is given. The study of the blood disease anemia gains impetus from the introduction of the hematocrit, an apparatus for determining the volume of red blood cells as compared with the volume of plasma, and the introduction in 1932 of a simple method of measuring the volume and hemoglobin. After World War II, the field of hematology broadens.[2] In the 1950s, plastic intra venous tubing replaces rubber tubing.[4][1] The 1960s is the decade in which most of the modern understanding of platelet funcion is initiated.[5] In the 1970s, the combination of several observational studies identifying a possible role for prophylactic platelet transfusion in hypoproliferative thrombocytopenia and the discovery that platelets are best stored at room temperature with gentle agitation to preserve function allow for the proliferation of platelet transfusions as part of standard management of patients receiving chemotherapy.[6] In the 1980s, the emergence of HIV renews impetus for development of infection-safe blood substitutes.[7]


Full timeline

Year Event type Details Location
3255 BC The oldest intact red blood cells ever discovered are found in Ötzi, a natural mummy of a man who died around that time.[8]
460 BC – 377 BC Field development Greek physician Hippocrates teaches the humoral theory, a hypothetical system to explain illness in which balance equals health, and excess or deficiency equals illness.[1] Greece
1616 Field development English physician William Harvey discovers blood pathways. Since then many people try to use fluids such as beer, urine, milk, and non-human animal blood as blood substitute.[9] United Kingdom
1628 Field development English physician William Harvey publishes Exercitatio Anatomica de Motu Cordis et Sanguinis in Animalibus (Movement of the Heart and the Blood in Animals), which demonstrates the concept of blood circulation.[5] United Kingdom
1642 Scientific development Dutch scientist Antonie van Leeuwenhoek constructs a microscope and distinguishes blood cells.[1] Netherlands
1656 Field development English anatomist Christopher Wren gives the first intravenous injection in animals.[1] United Kingdom
1658 Field development Dutch biologist Jan Swammerdam first describes red blood cells by means of the use of an early microscope to study the blood of a frog.
1662 Field development J. C. Major gives the first intravenous injection in humans.[1]
1665 Field development English physician Richard Lower performs the first documented blood transfusion using dogs and notes a color difference between veins and arteries.[6][1] United Kingdom
1666 Field development Italian physician Marcello Malpighi notices that fiber filaments remain in a blood clot after it is thoroughly washed.[10] Italy
1667 Field development French physician Jean-Baptiste Denys and Richard Lower separately report giving the first human blood transfusion with blood fromlambs. Within 10 years, transfusing the blood of animals to humans becomes prohibited by law, delaying transfusion advances for about 150 years.[1] France, United Kingdom
1674 Field development Pioneer microscopist Anton van Leeuwenhoek writes his own description of human red blood cells.[11] Netherlands
1675 Field development Anton van Leeuwenhoek makes the remarkable discovery that "those sanguineous globules in a healthy body must be very flexible and pliant, if they are to pass through the small capillary veins and arteries, and that in their passage they change into an oval figure, reassuming their roundness when they come into a larger room."[11] Netherlands
1770 Field development British surgeon William Hewson describes leukocytes and some essential clottingfactors. Hewson becomes known as “the father of hematology.”[1]
1771 Literature William Hewson publishes Experimental Inquiry into the Properties of the Blood.[5] United Kingdom
1795 Field development American physician Philip Syng Physick claims to perform the first human-to-human blood transfusion, although he does not publish this information.[1]
1821 – 1902 Field development German physician Rudolf Virchow disproves a prominent view that phlebitis (inflammation of a vein) causes most diseases. Virchow demonstrates that masses in the blood vessels result from “thrombosis” (his term) and that portions of a thrombus could become detached to form an “embolus” (also his term).[12] Germany
1827 Literature Amateur British opticist Joseph Jackson Lister and fellow Quaker Dr Thomas Hodgkin publish Notice of some Microscopic Observations of the Blood and Animal Tissues.[5] United Kingdom
1830 Instrumental The gold-plated steel needle for intravenous use is invented.[4]
1840 Field development English surgeon Samuel Armstrong Lane performs the first successful whole blood transfusion to treat hemophilia.[13][14][15][16] United Kingdom
1840s Field development English anatomist George Gulliver publishes early illustrations of platelets.[5] United Kingdom
1842 Field development French microscopist Alexandre Donné identifies platelets.[17][18]
1867 Field development British surgeon Joseph Lister uses antiseptics to control infection during transfusions.[1] United Kingdom
1875 Field development Zahn reports that an injured blood vessel is eventually plugged by a fibrin-associated white thrombus. This observation leads to the discovery that platelets are responsible for contributing fibrin in the blood coagulation process.[10]
1877 Field development German-Jewish physician Paul Ehrlich develops techniques to stain blood cells to improve microscopic visualization.[19] Germany
1882 Field development Italian medical researcher Giulio Bizzozero describes blood platelets.[20][5] Italy
1897 Literature American pediatrician Luther Emmett Holt publishes The Diseases of Infancy and Childhood, which includes a 20-page chapter on diseases of the blood and is the first American pediatric medical textbook to provide significant hematologic information.[19][21] United States
1901 Field development Austrian biologist Karl Landsteiner and his associates discover the ABO blood group system, and define the different blood groups: A, B, AB, and O. Such names refer to the different kinds of antigens on the surface of the red blood cell.[22][23][24][25]
1902 Field development Alfred Decastello and Adriano Sturli add bloodtype AB to the classification system.[26]
1904 Literature Folia Haematologica is established in Germany. It is the first hematology journal in the world.[27] Germany
1906 Field development James Wright describes the bone marrow and megakaryocyte origin of platelets.[5]
1907 Field development American pathologist Ludvig Hektoen from Chicago, explains the significance of isoagglutinins in human blood and how the untoward reactions are related to them.[28][19] United States
1908 Field development American haematologist Reuben Ottenberg develops clinical methods for typing bloods.[28] United States
1910 Field development Sickle cell disease is first described.[29]
1910 Field development Duke notes that transfusions reduce the bleeding time. After this, transfusions become recognized as successful therapeutic hemostatic intervensions.[6]
1914 Field development American scientist, Richard Lewisohn, discovers that sodium citrate can be added to blood to stop it clotting.[30][25][19]
1918 Field development The use of blood plasma as a substitute for whole blood and for transfusion purposes is proposed by Gordon R. Ward. The use of blood plasma as a substitute for whole blood and for transfusion purposes was proposed in the same year, in the correspondence columns of the British Medical Journal. United Kingdom
1920 Field development The investigation of the role of food substances in the production of red blood cells is launched. It would lead to discovery of the beneficial effects of liver extract in treating pernicious anemia and ultimately to the discovery of vitamin B12, the anti-anemic principle of liver.[2]
1920 Literature Journal Haematologica is first published.[31][32] It is the second in the world to be released.[27] Italy
1924 Literature Pediatrics becomes the first comprehensive American publication on pediatric hematology.[19]
1925 Field development Canadian physician Alfred P. Hart introduces exsanguination ("exchange") transfusion to treat severe neonatal jaundice.[33][34][35][19]
1925 Field development American pediatrician Thomas Benton Cooley describes a Mediterranean hematologic syndrome of anemia, erythroblastosis, skeletal disorders, and splenomegaly that is later called Cooley’s anemia and now thalassemia.[19]
1927 Field development The P blood group system is discovered.[36] It is considered among the major blood group systems.[37]
1927 Organization The French Society of Hematology is formed. It is the first hematology organization in the world.[27] France
1927 Literature Journal La Sang is released in France.[27] France
1927 Field development Karl Landsteiner and Philip Levine discover the MNS antigen system, after immunizing rabbits with human red blood cells.[38] It is considered among the major blood group systems.[37]
1932 Field development A simple method of measuring the volume and hemoglobin is introduced.[2]
1933 Field development The formation of cryoprecipitate is first observed in relation to a patient with multiple myeloma.[39]
1935 Field development Danish biochemist Carl Peter Henrik Dam finds that bleeding in chicks that developed an excessive bleeding disorder in response to synthetic diets, do not occur if their synthetic chow was replaced with one fortified with a specific vitamin. Dam labels this antihemorrhagic agent “vitamin K” and establishes its essential role in normal blood coagulation.[10] Denmark
1936 Organization The World's first blood bank opens in Chicago.[40][41][25] United States
1936 Field development American hematologist John H. Lawrence of the University of California, Berkeley introduces phosphorus-32 for the treatment of leukemia.[42][43][44] United States
1937 Organization The Japanese Society of Hematology (JSH) is founded in Kyoto. It is the second hematology organization in the world.[45][27] Japan
1937 Field development Karl Landsteiner and Alexander S. Wiener identify the Rh factor (an abbreviation of "Rhesus factor") in blood.[13] The Rhesus-system is the second most important blood group system after ABO.[46]
1938 Literature Journal Acta Haematologica Japonica is established. In 1991, it would be renamed International Journal of Hematology.[27] Japan
1938 Field development American pediatricians {Louis Diamond (known as the “father of American pediatric hematology”) and Kenneth Blackfan describe the anemia still known as Diamond-Blackfan anemia.[19] United States
1941 Literature Blackfan, Diamond, and Leister publish The Atlas of the Blood of Children.[19]
1945 Field development Robin Coombs, Arthur Mourant and Rob Race describe the use of antihuman globulin (later known as the “Coombs Test”) to identify “incomplete” antibodies.[19]
1945 Field development Antigen Lua, the first in the Lutheran antigen system, is found in the serum of a patient with lupus erythematosus.[47] Antibodies against this blood group are rare and generally not considered clinically significant.[46]
1946 Literature Journal Blood is established by William Dameshek.[48]
1946–1948 Field development The Lewis blood group system is identified. It is considered among the major blood group systems.[37] Consisting in antigens Lea and Leb, the second reaches a frequency of 70 percent in Europeans.[49]
1946 Field development Austro-Hungarian biochemist Erwin Chargaff and Randolph West discover that platelet-free plasma exhibits clotting properties.[10]
1946 Field development The Kell blood group system is discovered.[50] It is considered among the major blood group systems.[37] These erythrocyte antigens are the third most potent immunogenic antigen after ABO and Rh system.[46]
1947 Field development Lerner and Watson introduce the term "cryoglobulin", demonstrating the reversibility of the phenomenon when the sera are heated to 37°C.[39]
1947 Field development Australian serologist Ruth Ann Sanger and Robert Russell Race identify the S and s genes.[26]
1950s Instrumental The “butterfly” needle and intercath are developed, making intravenous access easier and safer.[19]
1950 Organization The Society for Hematology and Stem Cells is founded by a group of scientists for the presentation and discussion of experimental hematology pre-clinical data.[51]
1950 Field development The Duffy antigen system is discovered.[38] It is considered among the major blood group systems.[37]
1951 Field development The Kidd blood group system is discovered.[52] It is considered among the major blood group systems.[37] Kidd antibodies are rare but can cause severe transfusion reactions.[46]
1952 Field development Hh blood group (also known as Oh or the Bombay blood group) is first discovered in Bombay (Mumbai), India.[53] It is a very rare histo-blood group phenotype.[54] India
1954 Field development The blood product cryoprecipitate is developed to treat bleeds in people with hemophilia.[19]
1954 Field development Peterman and Braunsteiner report cryoprecipitates of immunoglobulins with different sedimentation rates, thus introducing the concept of "mixed cryoglobulinaemia".[39]
1955 Literature The British Journal of Haematology is launched.[55][56] United Kingdom
1955 Field development The Diego antigen system is discovered.[38] It is very rare among [[w:caucasian race|Caucasians}} and Blacks, but relatively common among the South American Indians and Asians of Mongolian origin.[57] Venezuela
1958 Organization The American Society of Hematology is founded.[58][59] United States
1959 Field development Austrian-born British molecular biologist Max Perutz uses X-ray crystallography to determine the overall structure of hemoglobin.[60][61][62][63]
1959 Organization The Japanese Society of Clinical Hematology is established in Tokyo.[27] Japan
1960 Organization The British Society for Haematology is founded.[64] United Kingdom
1960 Field development The Gerbich blood group system is discovered.[65]
1961 Field development Researchers identify role of platelets in treating cancer patients.[66][25]
1962 Field development At an International Committee on Blood Clotting Factors conference in Stockholm, English hematologist Robert Gwyn Macfarlane of Oxford and American researcher Oscar Ratnoff propose that the coagulation process involves an enzyme acting on its substrate to make it an active enzyme, which subsequently acts on its own distinct substrate. This type of enzymatic activation continues down a line of substrates before coagulation is achieved.[10] Sweden
1962 Field development The Xg antigen system is discovered by Mann in the serum of a multiply transfused male.[65]
1962 Field development The first antihemophilic factor concentrate to treat coagulation disorders in hemophilia patients is developed through fractionation.[19]
1962 Field development Researchers at CSL Behring develop a new plasma fractionation method that provides significantly better yields of the valuable proteins isolated from human plasma.[67]
1962 Field development Platelet transfusion begins to be used more routinely, especially in cancer patients when the relationship between thrombocytopenia and hemorrage is noted.[6]
1965 Field development The Cromer blood group system is discovered.[65]
1965 Field development The first antibody of the Dombrock system is identified.[68]
1967 Organization The Turkish Society of Hematology is founded.[69] Turkey
1967 Field development Peter Wolf first identifies microparticles as a product of platelets.[10]
1967 Field development The Colton blood group system is identified.[70]
1968 Field development Rh immune globulin (RhIg) is first licensed as a human plasma-derived product consisting of IgG antibodies to the D antigen. It is used to prevent immunization to the D antigen in D-negative individuals and for the treatment of immune thrombocytopenia (ITP).[71]
1970 Field development Webber and Johnson find that platelet alpha granule contents are encompassed into vesicles, which come together to form a membrane complex at the surface of the platelet.[10]
1972 Literature Journal Experimental Hematology is launched by the International Society for Experimental Hematology, incorporated the same year as the continuation of the Society for Hematology and Stem Cells.[72]
1974 Literature Davis Nathan and Stuart Oski publish Hematology of Infancy and Childhood.[19]
1974 Field development The Scianna blood group system is established.[73] Composed of three antigens, the first, Sc1, a high frequency antigen, is found in greater than 99 % of most populations. The frequency of Sc2 is about 1% of Northern Europeans but the frequency is much lower in other populations. The incidence of Sc:1,2 is more common in Mennonites.[74]
1975 Literature Journal Blood Cells, Molecules and Diseases is established.[75]
1976 Literature The American Journal of Hematology is established.[76] United States
1977 Field development Kitamura first observes that mast cells are derived from hematopoietic stem cells shown by transplantation of bone marrow cells from mutant mice.[27] Japan
1977 Field development Miyake et al first purify erythropoietin.[27] Japan
1978 Field development The Duclos antigen is identified.[77]
1970s Field development Alan T. Nurden, Jacques P. Caen, David R. Phillips, and others describe the molecular basis of platelet aggregation.[20]
1980 Field development The ISBT Working Party on Terminology for Red Cell Surface Antigens is established with the goal of creating a uniform nomenclature.[65]
1980 Field development Molecular biology is applied to the study of blood groups.[78]
1981 Organization The American Society of Pediatric Hematology/Oncology is founded.[79][80] United States
1983 Field development Doctors in France and the United States discover the human immunodeficiency virus (HIV).[25] United States, France
1986 Field development Granulocyte colony-stimulating factor is cloned independently in Japan.[27] Japan
1986 Field development The Ola antigen is identified.[77] A rare blood group antigen, Only one Ola+ person was found among the 7, 151 blood donors tested.[81]
1987 Literature Journal Blood Reviews is established.[82]
1990s Field development Recombinant factor replacement products are used to treat hemophilia.[25]
1990 Field development The Er blood group collection is established as a blood group.[83]
1990 Literature Peer-reviewed medical journal Platelets is first issued.[84]
1991 Field development The Knops blood group system is established.[65] Most of the anigens of this system are common, occurring with a prevalence of >90% in most populations.[85]
1992 Organization The International Society for Laboratory Hematology is founded by an international group of laboratory professionals in order to chart new directions for laboratory hematology.[86]
1992 Organization The European Hematology Association is founded in Brussels.[87] Belgium
1994 Field development Researchers investigating the effects of lipopolysaccharide (LPS) stimulation on monocyte procoagulant activity, reveal that the microparticles released by stimulated human monocytes possess more tissue factor activity than their parent monocytes.[10]
2002 Field development The GIL blood group system is established.[88] It is designated as system 29.[89]
2008 Literature Journal Expert Review of Hematology is released.[90]
2008 Literature The Open Hematology Journal is released.[91]
2008 Field development The RHAg (Rh-associated glycoprotein) is established as a blood group system.[77]
2011 Field development The FORS blood group system is established as the 31st blood group system.[92][93]

Numerical and visual data

Google Scholar

The following table summarizes per-year mentions on Google Scholar as of June 5, 2021.

Year hematology hematology oncology pediatric hematology hematopathology
1980 7,590 2,670 698 60
1985 9,060 4,160 1,230 85
1990 11,500 5,600 1,630 112
1995 18,500 8,360 2,600 276
2000 46,300 13,900 5,190 412
2002 52,100 14,700 5,470 521
2004 64,500 20,000 6,690 547
2006 73,300 22,800 7,920 609
2008 88,400 33,100 9,790 707
2010 96,500 31,800 10,900 722
2012 108,000 41,500 13,900 1,120
2014 110,000 40,900 15,300 1,080
2016 107,000 47,000 17,400 1,310
2017 102,000 48,100 18,200 1,200
2018 93,500 47,500 18,900 1,340
2019 83,500 45,000 19,900 1,520
2020 56,400 32,200 22,800 1,330
Hematology tb.png

Google Trends

The comparative chart below shows Google Trends data for Hematology (Branch of medicine) and Hematology (Search term) from January 2004 to February 2021, when the screenshot was taken. Interest is also ranked by country and displayed on world map.[94]

Hematology gt.png

Google Ngram Viewer

The chart below shows Google Ngram Viewer data for Hematology from 1600 to 2019.[95]

Hematology ngram.png

Wikipedia Views

The chart below shows pageviews of the English Wikipedia article Hematology, on desktop, mobile-web, desktop-spider, mobile-web-spider and mobile app, from July 2015 to January 2021.[96]

Hematology wv.jpg


Meta information on the timeline

How the timeline was built

The initial version of the timeline was written by User:Sebastian.

Funding information for this timeline is available.

Feedback and comments

Feedback for the timeline can be provided at the following places:

  • FIXME

What the timeline is still missing

Timeline update strategy

See also

External links

References

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