Difference between revisions of "Timeline of Moderna"

Latest revision as of 22:26, 24 March 2024

This is a timeline of Moderna, a Cambridge, Massachusetts-based pharmaceutical and biotechnology company that focuses on RNA therapeutics, primarily mRNA vaccines. An mRNA vaccine involves providing a person with just a set of instructions on how to build specific proteins that will trigger a body’s natural defenses.^[1]

Sample questions

The following are some interesting questions that can be answered by reading this timeline:

Which diseases and conditions are target of Moderna's drug pipeline?
- Sort the full timeline by "Disease/condition (when applicable)"
- For the names of their respective candidate drugs, sort the full timeline by "Product research name (when applicable)".
What are the multiple clinical trials conducted by Moderna?
- Sort the full timeline by "Event type" and look for the group of rows with value "Clinical trial".
- You will mostly see trial launches, but also some sample or notable clinical trial results.
What are some notable collaborations started between Moderna and other organizations?
- Sort the full timeline by "Event type" and look for the group of rows with value "Partnership".
- You will see collaborations with important companies such as Merck & Co. and AstraZeneca, as well as notable research institutes, such as Pasteur Institute.
Who are some notable people having been related to Moderna over the years?
- Sort the full timeline by "Event type" and look for the group of rows with value "Team".
What are some Moderna announcements on its drug pipeline?
- Sort the full timeline by "Event type" and look for the group of rows with value "Drug pipeline".
- You will see events describing updates on Moderna's pipeline and strategy.
Other events are described under the following types: "Animal testing", "Business model", "Company launch", "Criticism", "Intellectual property", "Prelude", "Vaccine efficacy", and "Venture launch".

Big picture

Time period	Development summary	More details
2010–2012	Early years	Early period right after the founding of the company. Moderna remains largely unknown with no external funding.
2012 onwards	Jump to prominence	Moderna bursts onto the biotech scene in 2012, with its promising technology using messenger RNA (mRNA) to spur the production of human proteins within patient cells, effectively creating an in vivo factory for targeted therapies.^[2] The company starts receiving funding rounds.^[3]
2015 onwards	Unicorn status	Moderna reaches unicorn status, faster than companies like Uber, Dropbox, and Lyft.^[4]^[5]
2018 onwards	Public company	Moderna becomes a public company via the largest biotech initial public offering in history to date.
2020 onwards	COVID-19 vaccine	Amidst the COVID-19 pandemic, Moderna introduces its mRNA vaccine, and the company share price escalates after encouraging early results from clinical trial.

Full timeline

Year	Month and date (approximately)	Disease/condition (when applicable)	Product research name (when applicable)	Event type	Details
2010				Prelude	Canadian stem cell biologist Derrick Rossi, working at Harvard Medical School, builds upon Shinya Yamanaka's work on induced pluripotent stem cells and uses RNA to create embryonic stem cells from adult cells. This would eventually lead to the foundation of Moderna in the same year.^[6]
2010	September			Company launch	Moderna is founded in Cambridge, Massachusetts, by Derrick Rossi, Robert S. Langer, Kenneth R. Chien, and venture capitalist Noubar Afeyan.^[7]
2012	March			Recognition	A study highlights ModeRNA's program for RNA 3D structure prediction among a number of software projects deemed useful to plan a project, support the involvement of experts, and to promote higher quality and maintainability of programs.^[8]
2013	March	Cardiovascular, metabolic, and renal diseases, cancer		Partnership	Moderna and AstraZeneca sign a five-year exclusive option agreement to discover, develop, and commercialize mRNA for treatments in the therapeutic areas of cardiovascular, metabolic, and renal diseases, and selected targets for cancer.^[9]^[10]^[11]^[12]
2013	May 22			Team	John Reynders is hired by Moderna as Chief Information Officer, joining the company from AstraZeneca, where he served as Vice President of R&D Information.^[13]
2013	October 2			Financial (funding)	The United States Defense Advanced Research Projects Agency (DARPA) awards Moderna a US$24.6 million grant to develop messenger RNA therapeutics, Moderna's new treatment modality aimed to enable the in vivo production of therapeutic proteins. With the funding, DARPA expects a fast, cheap, and unusually adaptable method for fighting known contemporary and future pandemic threats.^[14]^[15]^[16]
2013	October 17			Infrastructure	Moderna announces the expansion of its headquarters to Technology Square in Cambridge, Massachusetts, with the addition of new space.^[17]^[18]^[19]
2013	November 20			Financial (funding)	Moderna raises US$110 million of equity financing.^[20]
2014	January 13	Rare diseases		Financial (funding)	AstraZeneca subsidiary Alexion Pharmaceuticals and Moderna announce an agreement for the discovery and development of messenger RNA Therapeutics to treat rare diseases. Alexion agrees to pay Moderna US$100 million to purchase 10 product options to develop and commercialize treatments for rare diseases with Moderna’s mRNA Therapeutics platform.^[21]^[22]^[23]
2014	March 6			Team	Moderna appoints biotechnology investment banking veteran Lorence Kim as Chief Financial Officer.^[24]^[25]^[26]
2015	January 5			Financial (funding)	Moderna raises US$450 million in biggest biotechnology private round to date. Funders include Viking Global Investors LP, Invus, RA Capital Management, and Wellington Management Company, LLP, AstraZeneca and Alexion Pharmaceuticals.^[27]^[28]
2015	January 13			Financial (funding)	Merck agrees to pay US$50 million to Moderna for the rights to use its mRNA technology to develop as many as five vaccines and treatments against infectious diseases over the next three years. Merck also makes a US$50 million equity investment in Moderna. Adding up these payments, Moderna raises US$500 million in private investment in the month.^[29]^[30]
2015	January			Financial (valuation)	Moderna reaches US$1 billion valuation, gaining unicorn status.^[31]
2015	February 2			Partnership	Moderna announces a long-term strategic research collaboration with Pasteur Institute for the discovery and development of drugs and vaccines using the company's mRNA platform. Moderna venture company Valera is appointed to manage the research collaboration for Moderna.^[32]
2015	March 16			Team	Tal Zaks becomes Moderna's chief medical officer, joining the company from Sanofi, where he was senior vice president and was responsible for all aspects of oncology drug discovery, development and commercialization.^[33]^[34]^[35]
2015	October 13			Team	Moderna Therapeutics' top scientist Joseph Bolen resigns from his positions as chief scientific officer and president of R&D.^[2]
2015	October 22	Cancer		Venture launch	Moderna launches a new personalized cancer vaccine venture, spinning out its messenger RNA tech into a separate entity dubbed Caperna.^[36]
2015	December	Influenza	VAL-506440	Clinical trial	Moderna initiates a Phase 1 clinical trial to evaluate the safety and immunogenicity of H10N8 Antigen mRNA in healthy adult subjects, against seasonal influenza. A total of 201 participants would be enrolled.^[37]^[38]
2016	January 11		mRNA 1440, mRNA 1851	Clinical trial	Moderna announces transition to a clinical stage company with its first Phase I study for mRNA 1440 currently underway in Europe. The company also announces having filed an investigational new drug application with the U.S. Food and Drug Administration for mRNA 1851, its second clinical program. Both mRNA 1440 and mRNA 1851 are infectious disease vaccines for undisclosed targets and indications.^[39]^[40]
2016	January 11	Cancer		Partnership	Moderna announces a new collaboration with AstraZeneca, to discover, co-develop and co-commercialize messenger RNA (mRNA) therapeutic candidates for the treatment of a range of cancers. The collaboration is in addition to the agreement announced by the companies in 2013 to develop mRNA Therapeutics against cardiovascular, metabolic and renal diseases as well as some types of cancers.^[41]^[42]
2016	January 12	HIV/AIDS		Financial (funding)	The Bill & Melinda Gates Foundation awards Moderna an initial US$20 million grant to develop a novel, affordable combination of mRNA-based antibody therapeutics to help prevent HIV infection. ^[43]^[44]
2016	February 5			Criticism	A Nature editorial criticizes Moderna for not publishing any peer reviewed papers on its technology, unlike most other emerging and established biotech companies, and compares its approach to that of the controversially failed Theranos.^[45]
2016	May 9			Team	Saqib Islam becomes Moderna's chief business officer, joining the company from Alexion Pharmaceuticals, where he was executive vice president, chief strategy and portfolio officer.^[46]^[47]^[48]
2016	May 11	Influenza	VAL-339851	Clinical trial	Moderna starts Phase 1 clinical trial with the purpose to assess the safety, tolerability and immunogenicity of biological intervention VAL-339851 in healthy subjects. A total of 156 participants would be enrolled.^[49]
2016	June 6			Partnership	Moderna announces collaboration with American pharmaceutical company Charles River Laboratories, which is expected to support Moderna to grow and advance its pipeline.^[50]^[51]
2016	June 29	Cancer		Partnership	Moderna partners with Merck & Co. to develop and commercialize novel messenger RNA (mRNA)-based personalized cancer vaccines. The partnership aims to combine Merck’s immuno-oncology know-how with Moderna’s mRNA vaccine technology and GMP manufacturing capabilities.^[52]^[53]^[54]
2016	July 6	Cystic fibrosis		Partnership	Moderna partners with Boston-based biopharmaceutical company Vertex Pharmaceuticals to discover and develop messenger ribonucleic acid (mRNA) therapeutics for cystic fibrosis. Vertex agrees to pay Moderna up to US$275 million in development and regulatory milestones, as well as undisclosed, tiered royalties on future sales.^[55]
2016	July 26		AZD8601	Clinical trial	Moderna announces the first trial from a collaboration with AstraZeneca, which was announced in 2013 to discover, develop and commercialize mRNA to treat serious cardiovascular, metabolic and renal diseases as well as cancer. The Clinical Trial Application (CTA) is to be conducted in Europe for a Phase 1 study of AZD8601, an investigational mRNA-based therapy that encodes for vascular endothelial growth factor-A (VEGF-A)^[56]^[57], a factor that induces the development of tumor-associated blood vessels and provides the way for invasion of cancer cells.^[58]
2016	August 18	Cancer	Pembrolizumab, intralesional mRNA 2752	Clinical trial	Moderna launches a pilot study with the purpose to investigate the change in the immune microenvironment of high risk ductal carcinoma in situ (DCIS) after short term exposure to pembrolizumab, a humanized antibody used in cancer immunotherapy. A total of 48 participants would be enrolled.^[59]
2016	September 7	Zika virus	mRNA-1893	Financial (funding)	Moderna announces a funding award of US$8 million with the potential of up to $125 million from the Biomedical Advanced Research and Development Authority (BARDA), a division of the Office of the Assistant Secretary for Preparedness and Response (ASPR) within the United States Department of Health and Human Services, to accelerate development of a novel Zika mRNA vaccine.^[60]^[61]
2016	September 13			Criticism	Stat publishes an article criticizing the Moderna's reputation for secrecy and the absence of scientific validation or independent peer review of its research, despite it then having the highest valuation of any U.S. private biotech company at over US$5 billion.^[9]
2016	September 21			Infrastructure	Moderna announces the lease of 200,000-square-foot facility for 15 years, for new clinical manufacturing facility in Norwood, Massachusetts.^[62] The plant is expected to cost US$ 110 million.^[63] DPS Group and Tria Architecture would be selected to provide architectural, engineering and project management services.^[64]
2016	October 17			Partnership	Moderna partners with Somerset, New Jersey-based multinational Catalent to use the latter company’s Madison, Wisconsin-based 100,000-square-foot facility for production of cancer-targeting messenger RNA vaccines. Catalent agrees to provide with its facility that boasts Catalent’s SMARTag and GPEx technology platforms, which work to optimize bioconjugates and cell lines, respectively.^[65]
2016	December 21	{Zika virus	mRNA-1325	Clinical trial	Moderna starts clinical trial with the purpose to evaluate Zika vaccine candidate mRNA-1325 in healthy adult subjects.^[66]
2017	January 4			Partnership	Moderna joins the Human Vaccines Project, a non-profit public-private partnership focused on decoding the human immune system to accelerate the development of vaccines and immunotherapies against major infectious diseases and cancer.^[67]
2017	January 9	Influenza, Zika virus, Chikungunya virus		Drug pipeline	Moderna unveils new details about its pipeline and strategy at the J.P. Morgan Healthcare Conference in San Francisco. The company announces five vaccines in clinical trials. Two are for strains of influenza with potencial to become pandemic. Another is for Zika virus, and a fourth, being developed with AstraZeneca, treats heart attacks. A fifth vaccine candidate, co-developed with Merck, is not revealed. Another vaccine, for Chikungunya virus, is reported to be ready to start trials.^[68]^[69]^[70]
2017	April 27	Influenza (H10N8)	mRNA-1440	Clinical trial (result)	Moderna shows announces positive interim data from its ongoing Phase 1 study of mRNA-1440, an mRNA infectious disease vaccine against avian H10N8 influenza, demonstrating mRNA-1440 induced high levels of immunogenicity, and was safe and well tolerated.^[71]^[72]^[73]
2017	May 16			Intellectual property	Arbutus Biopharma Corporation CEO Mark Murray comments: We have seen no evidence of a Moderna delivery system that is free of our intellectual property. Not in their publications, their presentations, or in the examples in their patent filings, (...). In our view what they are reporting as theirs appears to be dominated by our intellectual property.^[74]
2017	July 13	Zika virus	mRNA-1893	Animal testing	Moderna announces new data demonstrating that its Zika mRNA vaccine prevented Zika virus transmission from pregnant mice to their fetuses. The findings also demonstrated that Moderna’s Zika mRNA vaccine protected the placenta and fetus from Zika virus-induced injury.^[75]^[76]
2017	July 27			Partnership	Alexion Pharmaceuticals leaves Moderna, writing off a US$100 million partnership started in 2014. The pair had joined forces to use Moderna’s unproven technology to treat the rare and debilitating Crigler-Najjar syndrome, but their work would repeatedly run into safety issues, never making it into human trials.^[77]^[78]
2017	August 3			Team	Juan Andres is hired by Moderna as Senior Vice President of Late Stage Technical Development and Manufacturing, joining the company from Novartis, where he held the position of Global Head Technical Operations (manufacturing and supply).^[79]^[80]^[81]
2017	August 9	Relapsed/refractory solid tumor malignancies or lymphoma, ovarian cancer	mRNA-2416, Durvalumab	Clinical trial	Moderna starts clinical to evaluate escalating doses of mRNA-2416 alone and in combination with administered fixed doses of durvalumab in participants with relapsed/refractory solid tumor malignancies or lymphoma, as well as the objective response rate of mRNA-2416 alone or in combination with durvalumab in ovarian cancer.^[82]
2017	August 14	Cancer	mRNA-4157	Clinical trial	Moderna launches clinical trial to evaluate cancer vaccine candidate mRNA-4157 alone in participants with resected solid tumors and in combination with pembrolizumab in participants with unresectable solid tumors.^[83]
2017	August 15	Chikungunya	mRNA-1388	Clinical trial	Moderna starts a phase 1 clinical trial to evaluate chikungunya vaccine candidate mRNA-1388 (VAL-181388) in healthy subjects. This marks the fifth prophylactic vaccine to be pushed into the clinic by the company.^[84]^[85]^[86]
2017	September 14			Business model	Moderna announces decision to set aside its venture model (i.e., names and branding) in favor of "Therapeutic Area" R&D. The company also discloses three main therapeutic areas: infectious diseases, immuno-oncology and rare diseases.^[87]^[88]
2017	October 27	Cancer	mRNA-2416	Clinical trial	Moderna announces launch of study with the purpose to assess the safety and tolerability of escalating doses of mRNA-2416 alone and in combination with administered fixed doses of durvalumab in participants with relapsed/refractory solid tumor malignancies or lymphoma, as well as the objective response rate of mRNA-2416 alone or in combination with durvalumab in ovarian cancer. The applicable dose of mRNA-2416 is to be injected directly into the participant's tumor (intratumoral) and the applicable dose of durvalumab is to be administered intravenously.^[89]^[42]
2017	November 1	Heart failure	AZD7970	Partnership	Moderna partners with AstraZeneca to codevelop a relaxin mRNA treatment for heart failure. The candidate is designed to induce the body to produce relaxin, a hormone research groups see as a way to regulate the conditions that exacerbate heart failure.^[90]^[91]
2017	November			Research	Moderna employees safely test mRNA technology in Sprague-Dawley rats and cynomolgus monkeys at the Montreal and Sherbrooke facilities of Charles River Laboratories. They find, among other things, that "mRNA is a labile biological molecule and therefore requires the use of protective delivery systems to effectively harness its potential," as the mRNA spread beyond the injection site and is found in the liver, spleen, bone marrow and heart.^[92]
2017	November 13	Cytomegalovirus	mRNA-1647	Clinical trial	Moderna begins Phase I clinical trial of its vaccine candidate mRNA-1647 against cytomegalovirus, a member of the herpes virus family. The trial is scheduled to be completed on July 2020.^[93]^[94]
2017	December 4	Human parainfluenza, human metapneumovirus	mRNA-1653	Clinical trial	Moderna begins dosing phase 1 subjects with mRNA-1653, a combination vaccine against human metapneumovirus (HMPV) and parainfluenza virus type 3 (PIV).^[95]^[96]^[97]
2018	January 8			Drug pipeline	Moderna announces pipeline update, including 19 mRNA drug candidates spanning infectious diseases, immuno-oncology, rare diseases and cardiovascular disorders, according to the company.^[95]^[98]
2018	February 1			Financial (funding)	Moderna raises US$500 million from private investors in Series G funding round, aimed at consolidating its pipeline of mRNA candidates and build out its manufacturing capabilities. Investors include Abu Dhabi Investment Authority, Julius Baer, the investment arm of the Singapore Economic Development Board and Sequoia Capital China. The series G leaves Moderna with US$1.4 billion in cash, with access to a further $250 million in grants.^[99]^[100]^[101]
2018	March 7			Team	Giuseppe Ciaramella, Moderna's CSO of the vaccines business, resigns from his position, leaving a long list of clinical programs behind.^[102]^[103]
2018	March 20	Methylmalonic acidemia, propionic acidemia		Clinical trial	Moderna starts a clinical trial with the purpose to evaluate the signs and symptoms of patients with organic acidemias.^[104]^[105]
2018	May 3	Cancer	mRNA-5671, other	Financial (funding)	Merck agrees to invest US$125 million in Moderna under a new agreement that expands the firms' 2016 partnership to develop messenger RNA (mRNA) cancer vaccines. The collaboration expansion includes partnering on cancer vaccine mRNA-5671, and other shared antigen mRNA cancer vaccines.^[106]^[107]^[108]^[109]
2018	July 17			Infrastructure	Moderna opens a $110 million 200,000 square foot facility in Norwood, Massachusetts for manufacturing, preclinical and clinical work.^[110]^[111]^[112]^[113]^[42]
2018	October 25			Recognition	The annual Science Careers Top Employers Survey recognizes Moderna as one of the global biopharmaceutical industry’s top employers in a fourth consecutive year. The annual employee survey evaluates companies in biotechnology, biopharmaceutical, pharmaceutical and other related industries in categories such as leadership in innovation, alignment between work culture and values and commitment to social responsibility. "Moderna Named a Top Employer by Science for the Fourth Consecutive Year"^[114]
2018	November 27		mRNA-2752	Clinical trial	Moderna starts a clinical trial with the purpose to assess the safety and tolerability of escalating intratumoral doses of mRNA-2752 in participants with relapsed/refractory solid tumor malignancies or lymphoma. Over 260 participants would be enrolled.^[115]
2018	December 6			Financial (Initial public offering)	Moderna becomes a public company via the largest biotech initial public offering in history to date, raising US$621 million (27 million shares at $23 per share).^[116]^[117]^[118]^[119] "Moderna: 5 things to know about the largest biotech to IPO"^[120]
2019	January 8			Drug pipeline	Moderna announces updates to several of its immuno-oncology and rare disease programs, including 21 mRNA development candidates in its pipeline, with 11 programs in clinical development.^[121]
2019	January 9			Drug pipeline	At the JP Morgan Healthcare conference, Moderna CEO Stéphane Bancel gives an update on the company R&D plans, announcing from the data generated to date from its messenger RNA program three clear readouts: the mRNAs are all well-tolerated, express the designed protein, and those proteins are active in humans. At this time, Moderna has 21 development programs spanning prophylactic vaccines, cancer vaccines, immuno-oncology, and others, with 11 already in trials.^[122]
2019	January 22	Chikungunya	mRNA-1944	Clinical trial	Moderna starts a Phase 1 first in human single-center randomized placebo controlled dose escalation study to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of chikungunya virus antibody mRNA-1944 in healthy adult subjects.^[123] On February 5 the company announces the first subject. This is the first development candidate from Moderna's systemic therapeutics modalities to start human dosing. The drug is administered via intravenous infusion in healthy adults.^[124]
2019	February 12	Human metapneumovirus, human parainfluenza	mRNA-1653	Clinical trial (result)	Moderna announces positive interim phase 1 data for first combination vaccine against the human metapneumovirus and human parainfluenza. Data show vaccination with mRNA-1653 boosted serum neutralization titers against hMPV and PIV3 at all dose levels tested and was generally well tolerated.^[125]^[126]
2019	February 20		Vascular endothelial growth factor A (VEGF-A)	Clinical trial (result)	Moderna announces the publication of a Phase 1a/b study showing the potential of mRNA encoding for vascular endothelial growth factor A (VEGF-A) as a regenerative therapeutic, an approach that aims to stimulate the growth of new blood vessels, also known as angiogenesis, to improve blood flow in tissues where it is otherwise restricted.^[127]
2019	April 2			Recognition	Moderna's clinical development manufacturing facility in Norwood, Massachusetts, wins the 2019 Facility of the Future Award, a nomination by the International Society of Pharmaceutical Engineers, whose awards program aims to recognize innovation and creativity in the pharmaceutical and biotechnology manufacturing industries.^[128]
2019	May 10	Influenza		Clinical trial (result)	Moderna announces the publication of positive results from two Phase 1 clinical studies showing that mRNA vaccines against influenza A virus subtype H10N8and and H7N9 were well-tolerated and elicited robust immune responses. In the H10N8 trial, 201 healthy volunteers 17 to 64 years of age received two doses of the vaccine or placebo three weeks apart, either intramuscularly or intradermally at two different doses. In the H7N9 trial, 156 healthy volunteers between the age of 17 and 49 years received two doses of vaccine or placebo three weeks apart at one of three doses, 10 µg, 25 µg or 50 µg. The results support the potential of mRNA-based vaccines to quickly and effectively address pandemic influenza strains.^[129]
2019	May 23	Chikungunya		Clinical trial (result)	Moderna announces the publication of preclinical data showing that its encoding antibody against chikungunya virus is 100% protective against infection in animals. The developmental vaccine candidate mRNA-1944 encodes a human monoclonal antibody against the virus delivered in a proprietary lipid nanoparticle, protecting from infection by the virus in the living body of a plant or animal.^[130]
2019	May	Methylmalonic acidemia	mRNA-3704	Clinical trial	Moderna starts a clinical trial of its candidate mRNA-3704 for treatment of patients with methylmalonic acidemia. This trial would not be completed.^[131]
2019	May 28		mRNA-3704	Clinical trial	Moderna starts a clinical trial with the purpose to evaluate mRNA-3704 in patients with methylmalonic acidemia/aciduria (MMA) due to methylmalonyl-coenzyme A mutase (MUT) deficiency between 1 to 18 years of age with elevated plasma methylmalonic acid. As of February 2022, 0 participants would be enrolled.^[132]
2019	June 26	Cancer	mRNA-5671, pembrolizumab	Clinical trial	Moderna starts clinical trial with the purpose to evaluate Phase 2 dose of V941(mRNA-5671/V941) as a monotherapy and in combination with pembrolizumab infusion.^[133]
2019	July 18	Cancer	mRNA-4157, pembrolizumab	Clinical Trial	Moderna starts a clinical trial with the purpose to assess whether postoperative adjuvant therapy with mRNA-4157 and pembrolizumab improves recurrence free survival (RFS) compared to pembrolizumab alone in participants with complete resection of cutaneous melanoma and a high risk of recurrence.^[134]
2019	July 30	Clinical trial	mRNA-1893	Clinical Trial	Moderna starts clinical trial to evaluate mRNA-1893 Zika vaccines in flavivirus seronegative and flavivirus seropositive participants.^[135]
2019	August 19	Zika virus	mRNA-1893	Drug permission	Moderna is granted Fast Track designation by the U.S. Food and Drug Administration, for its investigational Zika vaccine (mRNA-1893) at the time being evaluated in a Phase 1 study for the prevention of Zika virus infection in healthy adults.^[136]
2019	September 4			Team	Tracey Franklin is appointed as Moderna's Chief Human Resources Officer, joining the company from Merck & Co., where she worked as Chief Talent and Strategy Officer.^[137]
2019	September 12	Cytomegalovirus	mRNA-1647	Clinical trial (result)	Moderna announces positive data from the 3-month interim analysis of safety and immunogenicity of the Phase 1 clinical study of its investigational vaccine mRNA-1647, a 2-antigen vaccine designed to protect against cytomegalovirus infection. The drug combines 6 mRNAs in a proprietary lipid nanoparticle in a single vial and encodes for 2 immuno-dominant proteins of CMV.^[138]
2019	September 12	Chikungunya	mRNA-1944	Clinical trial (result)	Moderna announces positive Phase 1 results for the first systemic mRNA therapeutic against chikungunya infection encoding a secreted protein (mRNA-1944), which was successfully encoded for functional antibody (CHKV-24) in humans at all dose levels tested (0.1, 0.3 and 0.6 mg/kg). Antibody level was achieved within hours, and projected to be maintained for at least 16 weeks at the middle and high doses.^[139]
2019	October 2			Infrastructure	Moderna announces expansion of its manufacturing site in Norwood, Massachusetts, with the addition of an 85,000 square-foot technical development center aimed to support Moderna's mRNA pipeline.^[140]^[141]
2019	October 22	Propionic acidemia	mRNA-3927	Drug permission	The U.S. Food and Drug Administration grants Fast Track designation for Moderna's mRNA-3927, the company's investigational mRNA therapeutic for propionic acidemia.^[142] Fast Track is one of five FDA approaches to make new drugs available as rapidly as possible.^[143]
2019	October 24			Recognition	Moderna is named Top Employer by Science and Science Careers' 2019 annual Top Employers Survey, which polls employees in the biotechnology, biopharmaceutical, pharmaceutical, and related industries to determine the 20 best employers in these industries as well as their driving characteristics.^[144]
2019	November 4		mRNA-1653	Clinical trial	Moderna starts a clinical trial with the purpose to assess the safety and immunogenicity of 2 dose levels of mRNA-1653, a combined human metapneumovirus and human parainfluenza virus type 3 vaccine, in healthy adults (18 to 49 years of age) and 2 dose levels in children (12 to 59 months of age) with serologic evidence of prior exposure. Over 50 participants would be enrolled.^[145]
2020	January 9		mRNA-1647	Clinical trial	Moderna starts clinical study with the purpose to assess the safety and immunogenicity of 3 dose levels of mRNA-1647 cytomegalovirus vaccine in CMV-seronegative and CMV-seropositive healthy adults 18-40 years of age. Over 300 participants would be enrolled.^[146]
2020	January 23	COVID-19	mRNA-1273	Financial (funding)	Moderna announces a new collaboration with the Coalition for Epidemic Preparedness Innovations (CEPI), which agrees to fund the company to develop an mRNA vaccine against the novel coronavirus COVID-19.^[147]^[148]
2020	February 10	Methylmalonic Acidemia	mRNA-3704	Clinical trial	Moderna announces first patient enrolled in the Phase I/II trial of mRNA-3704 in methylmalonic acidemia (MMA) patients, in what is the company’s first rare disease program to enter clinical trials. The drug is administered through intravenous infusion in patients with isolated MMA due to mitochondrial enzyme methylmalonic-CoA mutase (MUT) deficiency.^[149] "Moderna enrols first patient in Phase I/II trial of mRNA-3704"^[150]
2020	March 16	COVID-19	mRNA-1273	Clinical trial	Moderna starts clinical trial designed to assess the safety, reactogenicity and immunogenicity of mRNA-1273, Moderna's COVID-19 vaccine. 120 participants would be enrolled.^[151]
2020	May 1	COVID-19		Partnership	Moderna partners with Swiss firm Lonza to manufacture up to 1 billion doses a year of the potential COVID-19 vaccine.^[152]
2020	May 29	COVID-19	mRNA-1273	Clinical trial	Moderna announces having dosed the first patients in Phase 2 Study of COVID-19 vaccine mRNA-1273. The study aims to evaluate the safety, reactogenicity and immunogenicity of two vaccinations of mRNA-1273 given 28 days apart.^[153]^[154]^[155]
2020	June 4			Team	David Meline is hired as Moderna's chief financial officer, joining the company from industrial conglomerate 3M where he also filled a CFO position.^[156]
2020	June 25	COVID-19	mRNA-1273	Partnership	Moderna partners with Catalent with the purpose to conduct large-scale, commercial fill-finish manufacturing of Moderna’s mRNA-based COVID-19 vaccine candidate (mRNA-1273) at Catalent’s biologics facility in Bloomington, Indiana.^[157]^[158]
2020	July 14	COVID-19	mRNA-1273	Research	The Moderna COVID-19 vaccine candidate is shown to be immunogenic in a Phase I trial involving 45 volunteers aged 18–55 years.^[159]
2020	July 26		mRNA-1273	Financial (funding)	Moderna receives an additional US$472 million from the U.S. Biomedical Advanced Research and Development Authority to support development of its novel COVID-19 vaccine. The additional funding aims to support Moderna's late-stage clinical development including the expanded Phase 3 study of vaccine candidate mRNA-1273.^[160]
2020	July 27	COVID-19	mRNA-1273	Clinical trial	Moderna starts clinical trial with the purpose to evaluate mRNA-1273 vaccine in adults aged 18 years and older to prevent COVID-19.^[161]
2020	August 11	COVID-19	mRNA-1273	Supply	The United States Department of Health and Human Services and the United States Department of Defense announce an agreement with Moderna to manufacture and deliver 100 million doses of the company's COVID-19 vaccine candidate. The vaccine doses would be owned by the federal government.^[162]^[163]
2020	September 16	Cystic fibrosis		Partnership	Moderna announces a three-year strategic research collaboration and licensing agreement with Vertex Pharmaceuticals, aimed at the discovery and development of lipid nanoparticles and mRNAs for the delivery of gene-editing therapies for the treatment of cystic fibrosis. The initial focus of the partnership focuses on the discovery and optimization of novel LNPs and mRNAs that can deliver gene-editing therapies to cells in the lungs, enabling functional cystic fibrosis transmembrane conductance regulator protein to be produced.^[164]^[165]^[166]
2020	September 30		mRNA-1345	Clinical trial	Moderna starts a clinical trial aimed to evaluate the tolerability and reactogenicity of a single injection of up to 5 dose levels of mRNA-1345 in younger adults, women of child-bearing potential, and older adults including Japanese older adults; of 3 injections of the middle dose level of mRNA-1345 given 56 days apart in younger adults; of a booster injection of mRNA-1345 given approximately 12 months after the primary injection in older adults; and of 3 injections of 1 of 2 dose levels of mRNA-1345 given 56 days apart in children who are RSV-seropositive.^[167]
2020	October 29	COVID-19	mRNA-1273	Supply	Takeda Pharmaceutical Company announced the import and distribution of 50 million doses of Moderna’s COVID-19 vaccine candidate, mRNA-1273, starting in the first half of 2021. The supply is arranged through a partnership with Moderna and the Government of Japan.^[168]
2020	November 17	Pulmonary arterial hypertension		Partnership	Moderna partners with Italian global pharmaceutical company Chiesi Farmaceutici with the purpose to discover and develop messenger RNA (mRNA) therapeutics to treat pulmonary arterial hypertension (PAH).^[169]
2020	November 30	COVID-19	mRNA-1273	Clinical trial (result)	Moderna announces having found a 94.1 percent vaccine efficiency against the coronavirus in a second primary analysis of its COVID-19 vaccine candidate, mRNA-1273.^[170]^[171]
2020	November 30	COVID-19	mRNA-1273	Supply	Moderna and UKsigns a deal with the Government of the United Kingdom with the purpose to supply an additional two million doses of its Covid-19 vaccine candidate, from March 2021.^[172]
2020	December 9	COVID-19	mRNA-1273	Clinical trial	Moderna starts clinical trial to primarily evaluate the safety and reactogenicity of a single dose level of mRNA-1273 vaccine administered in 2 doses 28 days apart to an adolescent population.^[173]^[174]^[175]
2020	December 18	COVID-19	mRNA-1273	Authorization	Moderna's COVID-19 vaccine mRNA-1273 becomes the second to earn authorization by the U.S. Food and Drug Administration, one week after the emergency use authorization was granted to the Pfizer–BioNTech COVID-19 vaccine.^[176]^[177]^[178]
2020	December 24	COVID-19	mRNA-1273	Supply	Moderna receives authorization for its COVID-19 vaccine from Health Canada for the immunization of individuals aged 18 years and above in the country.^[179]
2021	January 4	COVID-19	mRNA-1273	Supply	The Ministry of Health of Israel authorizes the import of Moderna COVID-19 vaccine in the country, having secured 6 million doses.^[180]
2021	January 4	COVID-19	mRNA-1273	Supply	Moderna provides a supply update for its COVID-19 vaccine mRNA-1273, increasing its base-case global production estimate from 500 to 600 million doses for 2021. The company announces continued investment and addition of staff to build up to potentially 1 billion doses for 2021.^[181]^[182]
2021	January 6	COVID-19	mRNA-1273	Authorization	The European Commission grants conditional marketing authorization (CMA) for Moderna COVID-19 vaccine, following recommendations from the European Medicines Agency to use the candidate for active immunization to prevent the coronavirus in individuals 18 years of age and older. The conditional grant allows health officials to roll out the vaccine across the EU throughout 2021, including to its 27 member states. "^[183]^[184]
2021	January 8	COVID-19	mRNA-1273	Authorization	British Prime Minister Boris Johnson approves the Moderna COVID-19 vaccine for use in the United Kingdom, being the third coronavirus vaccine to approved for use in the country. The Government of the United Kingdom pre-orders 17 million doses of the Moderna vaccine.^[185]
2021	January 11	Influenza, HIV/AIDS, Nipah virus	Flu vaccine (mRNA-1010, mRNA-1020, mRNA-1030), HIV vaccine (mRNA-1644 & mRNA-1574), Nipah virus (NiV) Vaccine (mRNA-1215)	Drug pipeline	Moderna announces development of three mRNA-based vaccines for seasonal influenza, HIV and Nipah virus, to be conducted in 2021.^[1]^[186]
2021	January 19	COVID-19	mRNA-1273	Authorization	Moderna announces approval of its mRNA-1273 COVID-19 vaccine by Swissmedic, the Swiss Agency for therapeutic products, for use in Switzerland. The authorization comes over a month after the federal government increased its confirmed order commitment of mRNA-1273 from 4.5 million to 7.5 million doses.^[187]
2021	January 19			Team	Corinne Le Goff becomes Moderna's chief commercial officer, joining the company from previous roles in Amgen, Roche, and other large-cap pharma companies.^[188]^[189]^[190]
2021	January 21	COVID-19	mRNA-1273	Clinical trial	Moderna announces having dosed the first participant in the Phase 1/2 study of vaccine candidate against COVID-19 (mRNA-1273 or TAK-919) in Japan, led by Takeda Pharmaceutical Company, which intends to enroll 200 participants aged 20 years and above in the country. The study aims to evaluate the safety and immunogenicity of two vaccinations of mRNA-1273 given 28 days apart.^[191]^[192]
2021	March 5			Team	Moderna appoints Jonathan Hoggatt as director of hematology, joining the company from his position as Harvard Stem Cell Researcher.^[193]
2021	March 8	COVID-19	mRNA-1273	Partnership	Moderna partners with health care company Baxter International to produce up to 90 million doses of the Covid-19 vaccine in the United States.^[194]^[195]^[196]
2021	March 11			Clinical trial	Moderna starts clinical trial with the purpose to evaluate the safety and reactogenicity of 3 dose levels of mRNA-1283 and 1 dose level of mRNA-1273 vaccine given to healthy adults in 2 doses, 28 days apart, and 1 dose level of mRNA-1283 administered as a single dose to healthy adults.^[197]
2021	March 29	COVID-19	mRNA-1273	Clinical trial	Moderna starts clinical trial with the purpose to evaluate mRNA-1273.351 in naïve and previously vaccinated adults.^[198]
2021	April 15	Propionic acidemia	mRNA-3927	Clinical trial	Moderna starts clinical trial with the purpose to evaluate investigational drug mRNA-3927 in participants with propionic acidemia.^[199]
2021	April 16	COVID-19	mRNA-1273	Clinical trial	Moderna starts a clinical trial to evaluate COVID-19 vaccine mRNA-1273 in adults with a kidney or liver solid organ transplant and in healthy adult participants. The primary goal of the study is to evaluate the safety of mRNA-1273 and the serum antibody (Ab) responses obtained 28 days after the last dose of mRNA-1273.^[200]
2021	April 18	COVID-19	mRNA-1273	Supply	Moderna partners with Asian pharmaceutical distributor Zuellig Pharma Corp. for mRNA-1273 vaccine distribution in the Philippines.^[201]^[202]
2021	April 19	COVID-19	mRNA-1273	Clinical trial	Moderna starts a clinical trial with the purpose to assess the comparative effectiveness and safety of approved SARS-CoV-2 vaccines in two cohorts of immunocompromised patients (HIV+ patients and transplant patients).^[203]
2021	May 3	COVID-19	mRNA-1273	Supply	Moderna signs with Gavi, the Vaccine Alliance an advance purchase agreement for 500 million doses of Covid-19 vaccine. The agreement is secured on behalf COVAX, a worldwide initiative aimed at equitable access to COVID-19 vaccines directed by the GAVI vaccine alliance, the Coalition for Epidemic Preparedness Innovations (CEPI), and the World Health Organization (WHO), alongside key delivery partner UNICEF.^[204]
2021	May 28	COVID-19	mRNA-1273	Clinical trial	Moderna starts a clinical trial with the purpose to evaluate the immunogenicity and safety of mRNA-1273.211 vaccine for COVID-19 variants.^[205]
2021	June 1	COVID-19	mRNA-1273	Partnership	Moderna partners with Thermo Fisher Scientific to scale up COVID-19 vaccine production in the United States. Under the terms, Thermo Fisher agrees to provide with its commercial manufacturing site in Greenville, North Carolina to fill/finish manufacturing services and supply packaging for hundreds of millions of doses of the vaccine.^[206]^[207]
2021	June 3			Supply	Moderna signs pact with UNICEF for Covid-19 vaccine supply. UNICEF and its procurement partners, including the Pan American Health Organization, gains access to up to 34 million doses of Moderna’s COVID-19 vaccine, to be delivered in the fourth quarter 2021, with an option for up to 466 million doses in 2022.^[208]
2021	June 8	Zika virus	mRNA-1893	Clinical trial	Moderna launches a clinical trial with the purpose to evaluate 2 dose levels of messenger RNA (mRNA)-1893 Zika vaccine in comparison to a placebo control in healthy participants who are flavivirus-seronegative and in participants who are flavivirus-seropositive.^[209]
2021	July 6			Team	Paul Burton becomes Moderna's chief marketing officer, joining the company after 16 years at Johnson & Johnson.^[210]
2021	July 6	Influenza	mRNA-1010	Clinical trial	Moderna starts a clinical trial with the purpose to evaluate mRNA-1010 seasonal influenza vaccine in healthy adults.^[211]
2021	July 7	COVID-19	mRNA-1273	Observational study	Moderna starts an observational study with the purpose to add to the ongoing active and passive safety signal detection through signal refinement and, if needed, evaluation of potential safety signals related to taking the SARS-CoV-2 mRNA-1273 vaccine.^[212]
2021	July 12			Team	Kate Cronin becomes Moderna's chief brand officer, joining the company from Ogilvy Health, part of WPP plc, where she served as Global CEO.^[213]^[214]^[215]
2021	July 14			Financial (valuation)	Moderna valuation Reaches US$100 billion.^[216]
2021	June 18	Cytomegalovirus	mRNA-1647	Clinical trial	Moderna starts a clinical trial with the purpose to evaluate the longer-term immune persistence of mRNA-1647 vaccine administered to CMV-seronegative and CMV-seropositive adults.^[217]
2021	July 20	COVID-19	mRNA-1273	Supply	Moderna partners with Takeda Pharmaceutical and the Ministry of Health, Labour and Welfare of Japan to supply additional 50 million doses of the Moderna COVID-19 vaccine and its updated variant booster vaccine candidate, if authorized, to begin delivery in 2022.^[218]
2021	July 28	Autoimmune diseases	mRNA‑6231	Clinical trial	Moderna doses the first subject in Phase I clinical trial of its therapeutic candidate, mRNA-6231, for the treatment of patients with autoimmune diseases. The dose‑escalation study aims to analyze the safety, tolerability, pharmacokinetics and pharmacodynamics of the drug, which comprises a lipid nanoparticle (LNP)‑encapsulated messenger RNA encoding for mutein human interleukin-2 and adapted for improved regulatory T cell selectivity.^[219]^[220]^[221] mRNA-6231 is Moderna's first subcutaneously administered therapeutic program.^[222]
2021	August 6			Clininal trial	Moderna starts clinical trial to evaluate mRNA-3705 in participants with isolated elevated methylmalonic acid (MMA) due to methylmalonyl-coenzyme A (CoA) mutase (MUT) deficiency.^[223] mRNA-3705 is designed to instruct the body to restore the missing or dysfunctional proteins that cause MMA and consists of mRNA encoding human MUT enzyme encapsulated within a proprietary lipid nanoparticle (LNP).^[224]
2021	August 10			Infrastructure	Moderna announces a memorandum of understanding with the government of Canada to build an mRNA vaccine manufacturing plant at an unspecified location in the country. The company says the agreement would provide Canadians with access to domestically manufactured mRNA vaccines against respiratory viruses, including COVID-19, influenza, and respiratory syncytial virus, also laying the foundation for providing vaccines in a rapid pandemic response. Moderna also announces future similar partnerships with countries around the world.^[225]^[226]
2021	August 23	Methylmalonic acidemia	mRNA-3705	Clinical trial	Moderna launches trial of mRNA vaccine for methylmalonic acidemia, announcing the first patient has been dosed in the Phase 1/2 study evaluating the safety and tolerability of mRNA-3705, its investigational mRNA therapeutic, administered via intravenous infusion in patients with isolated MMA due to MUT deficiency.^[227]
2021	August 24	COVID-19	mRNA-1273	Partnership	Moderna partners with National Football League and Major League Baseball teams to spread the message about its Covid-19 vaccine.^[228]^[229]
2021	September 1	COVID-19	mRNA-1273	Observational study	Moderna starts clinical trial to evaluate the outcomes of pregnancy in females exposed to the company's COVID-19 vaccine mRNA-1273 during pregnancy.^[230]
2021	September 8	Crigler-Najjar syndrome	mRNA-3351	Partnership	Moderna partners with the Institute for Life Changing Medicines to develop a novel messenger RNA (mRNA) therapeutic (mRNA-3351) for Crigler-Najjar Syndrome Type 1 (CN-1). The purpose of the collaboration is to make an mRNA therapy for the treatment of CN-1 available at no cost to patients.^[231]^[232] "Moderna Announces Advances Across Its Industry-Leading mRNA Pipeline and Provides Business Update"^[233]
2021	September 9	Glycogen storage disease	mRNA-3745	Authorization	Moderna's drug candidate mRNA 3745 receives orphan drug status for glycogen storage disease type I in the United States.^[234] An orphan drug is a pharmaceutical agent developed to treat medical conditions which, because they are so rare, would not be profitable to produce without government assistance.
2021	September 10	COVID-19	mRNA-1273	Observational study	Moderna starts an observational study to evaluate the immunogenicity of a third dose of mRNA-1273 SARS-CoV-2 vaccine among cancer patients receiving the recommended third vaccine dose.^[235]
2021	September 27			Partnership	As part of a collaboration with Carnegie Mellon University, Moderna establishes its own Artificial Intelligence Academy. The initiative is expected to give the company's employees at all levels the education and empowerment necessary to identify and integrate machine learning and AI solutions into the company's systems and processes.^[236]
2021	October 6			Program launch	Moderna announces the launch of the Moderna Fellowship Program, an initiative aimed to "support the next generation of scientists and healthcare professionals as they innovate in the field of mRNA research towards improving patient care and population health".^[237]
2021	October 10	HIV		Partnership	Moderna partners with scientists at Scripps Research in La Jolla to use the company’s technology to make shots against HIV, after RNA vaccine technology proved to be safe and effective against the Covid-19.^[238]
2021	October 26	Cytomegalovirus	mRNA-1647	Clinical trial	Moderna initiates Phase III trial of its cytomegalovirus vaccine candidate mRNA-1647, which merges six messenger ribonucleic acids in a single vaccine that encode for two proteins found on the cytomegalovirus surface.^[239]^[240]
2021	November 3			Partnership	Moderna partners with gene-editing company Metagenomi in a research and development collaboration focused on advancing new gene editing systems for in vivo human therapeutic applications. Metagenomi provides its novel gene editing tools, aimed at leveraging Moderna’s mRNA platform, as well as lipid nanoparticle delivery technologies, with the goal of developing curative therapies for patients with serious genetic diseases.^[241]^[242]^[243]
2021	November 5	Chikungunya	mRNA-1944	Clinical trial (shutdown)	Moderna announces interruption of its lead mRNA chikungunya candidate after phase 1, revealing it does not have plans to advance to a Phase 2 study.^[244]^[245]
2021	November 8		mRNA-1647	Clinical trial	Moderna starts a clinical trial with the purpose to evaluate the safety, reactogenicity, and immunogenicity of the mRNA-1647 vaccine administered according to a 3-study injection schedule in healthy cytomegalovirus (CMV)-seronegative and CMV-seropositive Japanese adults 18 to 40 years of age in the United States.^[246]
2021	November 9	Propionic acidemia	mRNA-3927	Clinical trial	Moderna initiates enrolment in a phase I/II Long-term extension trial of its candidate mRNA-3927 for propionic acidemia in infants, children, adolescents, adults, and the elderly) in the United States.^[247]
2021	November 12		mRNA-2752	Clinical trial (result)	Moderna announces interim data from an ongoing Phase 1 clinical study of mRNA-2752 (Triplet) in patients with accessible solid tumors and lymphomas. The data shows that the company’s mRNA Ttriplet program given in combination with durvalumab is tolerated at all dose levels tested and elicited evidence of anti-tumor activity.^[248]
2021	November 12	HIV	mRNA-1644	Clinical trial	Moderna starts a Phase 1, randomized, first-in-human, open-label clinical trial with the purpose to evaluate eOD-GT8 60mer mRNA Vaccine (mRNA-1644) and Core-g28v2 60mer mRNA Vaccine (mRNA-1644v2-Core) in HIV-1 uninfected adults in good general health.^[249] This is Moderna's clinical trial for HIV vaccine.^[250]^[251]^[252]^[253]
2021	November 16	Heart failure	AZD8601	Clinical trial (result)	Moderna and AstraZeneca announce that the Phase 2a EPICCURE study of their jointly developed mRNA therapeutic AZD8601 has met the primary endpoint of safety and tolerability in patients with heart failure. AZD8601 encodes for vascular endothelial growth factor-A (VEGF-A).^[254]
2021	November 17		mRNA-1345	Clinical trial	Moderna starts a clinical trial with the purpose to evaluate the mRNA-1345 vaccine and to demonstrate the efficacy of a single dose of mRNA-1345 vaccine in the prevention of a first episode of RSV-associated lower respiratory tract disease (RSV-LRTD) as compared with placebo from 14 days postinjection through 12 months. Over 33,000 participants would be enrolled.^[255]
2021	November 19	Respiratory syncytial virus	mRNA-1345	Clinical trial	Moderna doses the first subject in the Phase II/III trial of its respiratory syncytial virus (RSV) vaccine candidate, mRNA-1345, which encodes for a prefusion F glycoprotein, eliciting a superior neutralising antibody response. mRNA-1345 contains optimized protein and codon sequences, as well as uses lipid nanoparticle (LNP) similar to the Moderna's Covid-19 vaccine. The randomised, multicentre, placebo-controlled, observer-blind Phase II/III trial, named ConquerRSV, is planned to be conducted in many countries.^[256]
2021	December 10	COVID-19		Supply	Moderna signs an agreement with Gavi, The Vaccine Alliance, for the supply of an additional 150 million COVID-19 vaccines, to be made available to COVAX at their lowest global tiered price. This amendment means a total of up to 650 million doses of the Moderna vaccine available to COVAX participants through 2021 and 2022.^[257]
2021	December 20	COVID-19	mRNA-1273	Clinical trial (result)	Moderna releases data detailing the efficacy of its COVID-19 vaccine against the novel SARS-CoV-2 Omicron variant. Moderna's two-dose regimen is found to have relatively low levels of neutralizing antibodies effective against the variant. However, a 50 µg booster shot increases neutralizing antibody levels approximately 37-fold, while a 100 µg dose increases them approximately 83-fold.^[258]
2021	December 28	Epstein–Barr virus	mRNA-1189	Clinical trial	Mopderna starts clinical trial with the purpose to evaluate the safety and reactogenicity of mRNA-1189 against Epstein–Barr virus infection in 18- to 30-year-old healthy adults.^[259]
2021	Year round	COVID-19	mRNA-1273	Supply	Moderna ships approximately 800 million doses of its COVID-19 vaccine throughout the year.^[260]
2022		COVID-19	mRNA-1273	Vaccine efficacy	Moderna CEO Stephane Bancel announces that the efficacy of Moderna COVID-19 vaccine boosters would likely decline over time, and some people may need a fourth shot to increase their protection.^[261]
2022	January 7	Epstein-Barr Virus	mRNA-1189	Research	Moderna announces the first participant has been dosed in the Phase 1 study of Epstein-Barr Virus (EBV) vaccine candidate mRNA-1189. EBV is a common viral infection with 83% of Americans seropositive by 19 years of age.^[262]^[263]
2022	January 10	Cancer		Partnership	Moderna partners with Philadelphia cell therapy developer Carisma Therapeutics to discover, develop and commercialize potential cancer treatments, using Carisma's in vivo engineered chimeric antigen receptor monocyte (CAR-M) technology. The collaboration includes Carisma receiving an upfront payment of US$45 million by Moderna, which would also invest US$35 million in Carisma in the form of a convertible note, and in return get options for up to 12 targets for potential cancer therapies. Carisma is a pioneer in cell therapies involving macrophages.^[264]^[265]^[266]
2022	January 10			Drug pipeline	Moderna announces updates on its industry-leading mRNA pipeline, reporting 40 programs in development including 23 in ongoing clinical studies encompassing mRNA infectious disease vaccines and mRNA therapeutics spanning seven different modalities.^[267]
2022	January 17	COVID-19, influenza		Drug pipeline	Moderna announces development of a single shot that covers both flu and COVID-19, a vaccine that is not expected to be ready until the fall of 2023, and even then, it would only be available in some countries.^[268]
2022	January 27	COVID-19 (Omicron variant		Clinical trial	Moderna announces trial launch aimed at studying the power of a redesigned booster shot for SARS-CoV-2 Omicron variant.^[269]
2022	January 28	Glycogen storage disease	mRNA 3745	Clinical trial	Moderna starts mRNA 3745 Phase-I clinical trials in Glycogen storage disease type I in the United States.^[234]^[270]
2022	March 8			Program launch	Moderna reveals its "global public health strategy", and announces it will provide access to the technology to produce its mRNA COVID-19 vaccine to countries that are most in need. The company says that it would not use its patents to block manufacturing of mRNA vaccines as long as the shots are used strictly within the countries.^[271]
2022	March 10			Partnership	Researchers at the University of Queensland partner with Moderna to develop vaccines against diseases such as tuberculosis, dengue, malaria, Zika and HIV.^[272]
2022	March 24		mRNA-1230, mRNA-1287	Drug pipeline	During its Vaccines Day, Moderna announces new vaccination programs, including the development of mRNA-1230 vaccine to cover SARS-CoV-2, influenza, and respiratory syncytial virus (RSV) as well as another candidate, mRNA-1287, for endemic human coronaviruses: HCoV-229E, -NL63, -OC43 and -HKU1.^[273]
2022	March 26			Partnership	McGill University joins Moderna's mRNA Access program, which focuses on facilitating collaborative research and preclinical development to accelerate innovation on new vaccines and medicines that address existing and emerging diseases.^[274]^[275]

Numerical and visual data

Google Trends

The chart below shows Google Trends data for Moderna (Biotechnology Company), from January 2010 to January 2022, when the screenshot was taken. Interest is also ranked by country and displayed on world map. ^[276] The first increase in early 2020 happens as COVID-19 starts spreading and Moderna announces its COVID-19 vaccine efforts. Further increases near the end of 2020 occur once Moderna succeeds in its human clinical trials of the COVID-19 vaccine. After that, interest in Moderna largely tracks the evolution of the COVID-19 pandemic.

Google Finance

The image below shows Moderna stock valuation in USD from IPO to January 14, 2022, when the screenshot was taken.^[277]

Wikipedia Views

The chart below shows pageviews of the English Wikipedia article Moderna, from July 2015 to December 2021.^[278]

Meta information on the timeline

How the timeline was built

The initial version of the timeline was written by User:Sebastian.

Funding information for this timeline is available.

Feedback and comments

Feedback for the timeline can be provided at the following places:

FIXME

What the timeline is still missing

10.1038/scibx.2010.1226
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[3]
[4]
[5]

[6]
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Check Google: "Moderna" mrna

Timeline update strategy

External links

References

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↑ Fast Track, Breakthrough Therapy, Accelerated Approval, Priority Review. [1]
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@@ Line 32: / Line 32: @@
 | 2015 onwards || [[w:Unicorn (finance)|Unicorn]] status || Moderna reaches unicorn status, faster than companies like {{w|Uber}}, {{w|Dropbox}}, and {{w|Lyft}}.<ref name="Lavishly fund">{{cite web |title=Lavishly funded Moderna hits safety problems in bold bid to revolutionize medicine |url=https://www.statnews.com/2017/01/10/moderna-trouble-mrna/ |website=STAT |access-date=3 February 2022 |date=10 January 2017}}</ref><ref>{{cite web |title=Lavishly funded Moderna hits safety problems in bold bid to revolutionize medicine |url=https://www.statnews.com/2017/01/10/moderna-trouble-mrna/ |website=STAT |access-date=3 February 2022 |date=10 January 2017}}</ref>
 |-
-| 2018 onwards || {{w|Public company}} || Moderna becomes a {{w|public company}} via the largest biotech [[w:initial public offering]] in history to date.
+| 2018 onwards || {{w|Public company}} || Moderna becomes a {{w|public company}} via the largest biotech {{w|initial public offering}} in history to date.
 |-
 | 2020 onwards || {{w|COVID-19 vaccine}} || Amidst the {{w|COVID-19 pandemic}}, Moderna introduces its {{w|mRNA vaccine}}, and the company share price escalates after encouraging early results from clinical trial.
 |-
 |}
-== Numerical and visual data  ==
-=== Google Trends  ===
-The chart below shows {{w|Google Trends}} data for Moderna (Biotechnology Company), from January 2010 to January 2022, when the screenshot was taken. Interest is also ranked by country and displayed on world map. <ref>{{cite web |title=Moderna |url=https://trends.google.com/trends/explore?date=2010-01-01%202022-01-14&q=%2Fm%2F0w2ztxm |website=Google Trends |access-date=14 January 2022}}</ref>
-[[File:Moderna gt.png|thumb|center|700px]]
-=== Google Finance ===
-The image below shows Moderna stock valuation in {{w|USD}} from {{w|IPO}} to January 14, 2022, when the screenshot was taken.<ref>{{cite web |title=Moderna |url=https://www.google.com/finance/quote/MRNA:NASDAQ?hl=en&window=MAX |website=www.google.com |access-date=14 January 2022 |language=en}}</ref>
-[[File:Moderna gf.png|thumb|center|700px]]
-=== Wikipedia Views ===
-The chart below shows pageviews of the English Wikipedia article {{w|Moderna}}, from July 2015 to December 2021.<ref>{{cite web |title=Moderna |url=https://wikipediaviews.org/displayviewsformultiplemonths.php?page=Moderna&allmonths=allmonths-api&language=en&drilldown=all |website=wikipediaviews.org |access-date=14 January 2022}}</ref>
-[[File:Moderna wv.png|thumb|center|550px]]
 ==Full timeline==
@@ Line 103: / Line 83: @@
 | 2016 || January 11 || {{w|Cancer}} || || Partnership || Moderna announces a new collaboration with {{w|AstraZeneca}}, to discover, co-develop and co-commercialize messenger RNA (mRNA) therapeutic candidates for the treatment of a range of cancers. The collaboration is in addition to the agreement announced by the companies in 2013 to develop mRNA Therapeutics against cardiovascular, metabolic and renal diseases as well as some types of cancers.<ref>{{cite web |title=AstraZeneca and Moderna Therapeutics announce new collaboration to co-develop and co-commercialise immuno-oncology mRNA therapeutics™ |url=https://www.astrazeneca.com/media-centre/press-releases/2016/AstraZeneca-and-Moderna-Therapeutics-announce-new-collaboration-to-co-develop-and-co-commercialise-immuno-oncology-mRNA-therapeutics-11012016.html#! |website=www.astrazeneca.com |access-date=10 February 2022 |language=en}}</ref><ref name="Key Milestones"/>
 |-
-| 2016 || January 12 || HIV/AIDS || || Financial (funding) || The {{w|Bill & Melinda Gates Foundation}} awards Moderna an initial US$20 million grant to develop a novel, affordable combination of mRNA-based antibody therapeutics to help prevent HIV infection. <ref>{{cite web |last1=Writer |first1=GEN Staff |title=Moderna Wins Initial $20M Grant from Gates Foundation |url=https://www.genengnews.com/topics/omics/moderna-wins-initial-20m-grant-from-gates-foundation/ |website=GEN - Genetic Engineering and Biotechnology News |access-date=1 February 2022 |date=12 January 2016}}</ref><ref>{{cite web |title=Gates Foundation Invests $20 Million to Advance HIV Care |url=https://philanthropynewsdigest.org/news/gates-foundation-invests-20-million-to-advance-hiv-care |website=philanthropynewsdigest.org |access-date=11 February 2022}}</ref>
+| 2016 || January 12 || {{w|HIV/AIDS}} || || Financial (funding) || The {{w|Bill & Melinda Gates Foundation}} awards Moderna an initial US$20 million grant to develop a novel, affordable combination of mRNA-based antibody therapeutics to help prevent HIV infection. <ref>{{cite web |last1=Writer |first1=GEN Staff |title=Moderna Wins Initial $20M Grant from Gates Foundation |url=https://www.genengnews.com/topics/omics/moderna-wins-initial-20m-grant-from-gates-foundation/ |website=GEN - Genetic Engineering and Biotechnology News |access-date=1 February 2022 |date=12 January 2016}}</ref><ref>{{cite web |title=Gates Foundation Invests $20 Million to Advance HIV Care |url=https://philanthropynewsdigest.org/news/gates-foundation-invests-20-million-to-advance-hiv-care |website=philanthropynewsdigest.org |access-date=11 February 2022}}</ref>
 |-
 | 2016 || February 5 || || || Criticism || A ''[[w:Nature (magazine)|Nature]]'' editorial criticizes Moderna for not publishing any {{w|peer review}}ed papers on its technology, unlike most other emerging and established biotech companies, and compares its approach to that of the controversially failed {{w|Theranos}}.<ref>{{cite web |title=Research not fit to print |url=https://www.nature.com/articles/nbt.3488 |website=Nature Biotechnology |access-date=19 January 2022 |pages=115–115 |language=en |doi=10.1038/nbt.3488 |date=February 2016}}</ref>
@@ Line 113: / Line 93: @@
 | 2016 || June 6 || || || Partnership || Moderna announces collaboration with American pharmaceutical company {{w|Charles River Laboratories}}, which is expected to support Moderna to grow and advance its pipeline.<ref>{{cite web |title=Moderna Therapeutics and Charles River Laboratories Announce Strategic Collaboration to Scale Moderna’s Nonclinical Development Efforts for Novel mRNA Therapeutics {{!}} Charles River Laboratories International, Inc. |url=https://ir.criver.com/news-releases/news-release-details/moderna-therapeutics-and-charles-river-laboratories-announce |website=ir.criver.com |access-date=10 February 2022 |language=en}}</ref><ref>{{cite web |title=Charles River signs up to help Moderna with mRNA pipeline |url=https://www.fiercebiotech.com/cro/charles-river-signs-up-to-help-moderna-mrna-pipeline |website=FierceBiotech |access-date=13 February 2022 |language=en}}</ref>
 |-
-| 2016 || June 29 || Cancer || || Partnership || Moderna partners with {{w|Merck & Co.}} to develop and commercialize novel messenger RNA (mRNA)-based personalized cancer vaccines. The partnership aims to combine Merck’s immuno-oncology know-how with Moderna’s mRNA vaccine technology and GMP manufacturing capabilities.<ref>{{cite web |last1=Writer |first1=GEN Staff |title=Merck, Moderna to Develop mRNA-Based Personalized Cancer Vaccines |url=https://www.genengnews.com/topics/omics/merck-moderna-to-develop-mrna-based-personalized-cancer-vaccines/ |website=GEN - Genetic Engineering and Biotechnology News |access-date=1 February 2022 |date=29 June 2016}}</ref><ref>{{cite web |title=Merck and Moderna Announce Strategic Collaboration to Advance Novel mRNA-Based Personalized Cancer Vaccines with KEYTRUDA® (pembrolizumab) for the Treatment of Multiple Types of Cancer |url=https://www.merck.com/news/merck-and-moderna-announce-strategic-collaboration-to-advance-novel-mrna-based-personalized-cancer-vaccines-with-keytruda-pembrolizumab-for-the-treatment-of-multiple-types-of-cancer/ |website=Merck.com |access-date=9 February 2022}}</ref><ref>{{cite web |title=Moderna Enters $200M+ Strategic Collaboration and License Agreement with Merck |url=https://www.goodwinlaw.com/news/2016/06/06_30_16_moderna-enters-200m-merck-strategic |website=www.goodwinlaw.com |access-date=9 February 2022 |language=en}}</ref>
+| 2016 || June 29 || {{w|Cancer}} || || Partnership || Moderna partners with {{w|Merck & Co.}} to develop and commercialize novel messenger RNA (mRNA)-based personalized cancer vaccines. The partnership aims to combine Merck’s immuno-oncology know-how with Moderna’s mRNA vaccine technology and GMP manufacturing capabilities.<ref>{{cite web |last1=Writer |first1=GEN Staff |title=Merck, Moderna to Develop mRNA-Based Personalized Cancer Vaccines |url=https://www.genengnews.com/topics/omics/merck-moderna-to-develop-mrna-based-personalized-cancer-vaccines/ |website=GEN - Genetic Engineering and Biotechnology News |access-date=1 February 2022 |date=29 June 2016}}</ref><ref>{{cite web |title=Merck and Moderna Announce Strategic Collaboration to Advance Novel mRNA-Based Personalized Cancer Vaccines with KEYTRUDA® (pembrolizumab) for the Treatment of Multiple Types of Cancer |url=https://www.merck.com/news/merck-and-moderna-announce-strategic-collaboration-to-advance-novel-mrna-based-personalized-cancer-vaccines-with-keytruda-pembrolizumab-for-the-treatment-of-multiple-types-of-cancer/ |website=Merck.com |access-date=9 February 2022}}</ref><ref>{{cite web |title=Moderna Enters $200M+ Strategic Collaboration and License Agreement with Merck |url=https://www.goodwinlaw.com/news/2016/06/06_30_16_moderna-enters-200m-merck-strategic |website=www.goodwinlaw.com |access-date=9 February 2022 |language=en}}</ref>
 |-
 | 2016 || July 6 || {{w|Cystic fibrosis}} || || Partnership || Moderna partners with {{w|Boston}}-based biopharmaceutical company {{w|Vertex Pharmaceuticals}} to discover and develop messenger ribonucleic acid (mRNA) therapeutics for {{w|cystic fibrosis}}. Vertex agrees to pay Moderna up to US$275 million in development and regulatory milestones, as well as undisclosed, tiered royalties on future sales.<ref>{{cite web |title=UPDATED: Vertex, Moderna pair to create mRNA cystic fibrosis treatment |url=https://www.fiercebiotech.com/biotech/vertex-moderna-pair-to-create-mrna-cystic-fibrosis-treatment |website=FierceBiotech |access-date=1 February 2022 |language=en}}</ref>
@@ Line 119: / Line 99: @@
 | 2016 || July 26 || || AZD8601 || {{w|Clinical trial}} || Moderna announces the first trial from a collaboration with {{w|AstraZeneca}}, which was announced in 2013 to discover, develop and commercialize mRNA to treat serious cardiovascular, metabolic and renal diseases as well as cancer. The Clinical Trial Application (CTA) is to be conducted in Europe for a Phase 1 study of AZD8601, an investigational mRNA-based therapy that encodes for {{w|vascular endothelial growth factor}}-A (VEGF-A)<ref>{{cite web |title=Cash-rich Moderna to begin first AstraZeneca trial under collab deal |url=https://www.fiercebiotech.com/biotech/cash-rich-moderna-to-begin-first-astrazeneca-trial-under-collab-deal |website=FierceBiotech |access-date=1 February 2022 |language=en}}</ref><ref>{{cite web |title=Moderna Therapeutics Provides Mid-Year Corporate Update, Announces Continued Clinical Development Progress and Pipeline Acceleration |url=https://www.businesswire.com/news/home/20160726005747/en/Moderna-Therapeutics-Provides-Mid-Year-Corporate-Update-Announces-Continued-Clinical-Development-Progress-and-Pipeline-Acceleration |website=www.businesswire.com |access-date=2 February 2022 |language=en |date=26 July 2016}}</ref>, a factor that induces the development of tumor-associated blood vessels and provides the way for invasion of cancer cells.<ref>{{cite web |title=Vascular Endothelial Growth Factor A |url=https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/vascular-endothelial-growth-factor-a#:~:text=Vascular%20Endothelial%20Growth%20Factor%20A%20(VEGFA)%20is%20a%20factor%20that,for%20invasion%20of%20cancer%20cells. |website=sciencedirect.com |access-date=14 February 2022}}</ref>
 |-
-| 2016 || August 18 || Carcinoma || {{w|Pembrolizumab}}, intralesional mRNA 2752 || {{w|Clinical trial}} || Moderna launches a pilot study with the purpose to investigate the change in the immune microenvironment of high risk ductal carcinoma in situ (DCIS) after short term exposure to {{w|pembrolizumab}}, a humanized antibody used in cancer immunotherapy. A total of 48 participants would be enrolled.<ref>{{cite web |last1=Esserman |first1=Laura |title=Testing the Ability of Pembrolizumab and mRNA 2752 to Alter the Tumor Immune MicroEnvionment (TIME) of High Risk DCIS |url=https://clinicaltrials.gov/ct2/show/NCT02872025?spons=ModernaTX%2C+Inc.&draw=4&rank=44 |website=clinicaltrials.gov |publisher=clinicaltrials.gov |access-date=19 February 2022 |date=15 January 2022}}</ref>
+| 2016 || August 18 || {{w|Cancer}} || {{w|Pembrolizumab}}, intralesional mRNA 2752 || {{w|Clinical trial}} || Moderna launches a pilot study with the purpose to investigate the change in the immune microenvironment of high risk ductal carcinoma in situ (DCIS) after short term exposure to {{w|pembrolizumab}}, a humanized antibody used in cancer immunotherapy. A total of 48 participants would be enrolled.<ref>{{cite web |last1=Esserman |first1=Laura |title=Testing the Ability of Pembrolizumab and mRNA 2752 to Alter the Tumor Immune MicroEnvionment (TIME) of High Risk DCIS |url=https://clinicaltrials.gov/ct2/show/NCT02872025?spons=ModernaTX%2C+Inc.&draw=4&rank=44 |website=clinicaltrials.gov |publisher=clinicaltrials.gov |access-date=19 February 2022 |date=15 January 2022}}</ref>
 |-
 | 2016 || September 7 || {{w|Zika virus}} || mRNA-1893 || Financial (funding) || Moderna announces a funding award of US$8 million with the potential of up to $125 million from the {{w|Biomedical Advanced Research and Development Authority}} (BARDA), a division of the Office of the Assistant Secretary for Preparedness and Response (ASPR) within the {{w|United States Department of Health and Human Services}}, to accelerate development of a novel Zika mRNA vaccine.<ref>{{cite web |title=Moderna Announces Funding Award from BARDA for $8 Million with Potential of up to $125 Million to Accelerate Development of Zika Messenger RNA (mRNA) Vaccine |url=https://www.businesswire.com/news/home/20160907005586/en/Moderna-Announces-Funding-Award-from-BARDA-for-8-Million-with-Potential-of-up-to-125-Million-to-Accelerate-Development-of-Zika-Messenger-RNA-mRNA-Vaccine |website=www.businesswire.com |access-date=1 February 2022 |language=en |date=7 September 2016}}</ref><ref>{{cite web |last1=Writer |first1=GEN Staff |title=Moderna Wins Up to $125M from BARDA Toward Zika mRNA Vaccine |url=https://www.genengnews.com/topics/omics/moderna-wins-up-to-125m-from-barda-toward-zika-mrna-vaccine/ |website=GEN - Genetic Engineering and Biotechnology News |access-date=2 February 2022 |date=7 September 2016}}</ref>
@@ Line 129: / Line 109: @@
 | 2016 || October 17 || || || Partnership || Moderna partners with {{w|Somerset, New Jersey}}-based multinational {{w|Catalent}} to use the latter company’s {{w|Madison, Wisconsin}}-based 100,000-square-foot facility for production of cancer-targeting messenger RNA vaccines. Catalent agrees to provide with its facility that boasts Catalent’s SMARTag and GPEx technology platforms, which work to optimize bioconjugates and cell lines, respectively.<ref>{{cite web |title=Moderna taps Catalent for clinical manufacturing |url=https://www.biopharmadive.com/news/moderna-catalent-manufacturing-plant/428431/ |website=BioPharma Dive |access-date=2 February 2022}}</ref>
 |-
-| 2016 || December 21 || Zika virus || mRNA-1325 || Clinical trial || Moderna starts clinical trial with the purpose to evaluate Zika vaccine candidate mRNA-1325 in healthy adult subjects.<ref>{{cite web |title=A Phase 1, Randomized, Placebo-Controlled, Dose-Ranging Study to Evaluate the Safety and Immunogenicity of mRNA 1325 Zika Vaccine in Healthy Adults in a Non-endemic Zika Region |url=https://clinicaltrials.gov/ct2/show/NCT03014089?spons=ModernaTX%2C+Inc.&draw=5&rank=39 |website=clinicaltrials.gov |publisher=clinicaltrials.gov |access-date=19 February 2022 |date=6 December 2019}}</ref>
+| 2016 || December 21 || {{{w|Zika virus}} || mRNA-1325 || Clinical trial || Moderna starts clinical trial with the purpose to evaluate Zika vaccine candidate mRNA-1325 in healthy adult subjects.<ref>{{cite web |title=A Phase 1, Randomized, Placebo-Controlled, Dose-Ranging Study to Evaluate the Safety and Immunogenicity of mRNA 1325 Zika Vaccine in Healthy Adults in a Non-endemic Zika Region |url=https://clinicaltrials.gov/ct2/show/NCT03014089?spons=ModernaTX%2C+Inc.&draw=5&rank=39 |website=clinicaltrials.gov |publisher=clinicaltrials.gov |access-date=19 February 2022 |date=6 December 2019}}</ref>
 |-
 | 2017 || January 4 || || || Partnership || Moderna joins the Human Vaccines Project, a non-profit public-private partnership focused on decoding the human immune system to accelerate the development of vaccines and immunotherapies against major infectious diseases and cancer.<ref>{{cite web |title=Moderna Joins the Human Vaccines Project to Help Advance Fundamental Understanding of the Immune System |url=https://www.modernatx.com/sites/default/files/press_releases/moderna_human_vaccines_project_press_release_1.4.17-2.pdf |website=modernatx.com |access-date=16 February 2022}}</ref>
 |-
-| 2017 || January 9 || || || {{w|Drug pipeline}} || Moderna unveils new details about its pipeline and strategy at the J.P. Morgan Healthcare Conference in {{w|San Francisco}}. The company announces five vaccines in clinical trials. Two are for strains of influenza with potencial tp become pandemic. Another is for Zika virus, and a fourth, being developed with AstraZeneca, treats heart attacks. A fifth vaccine candidate, co-developed with {{w|Merck}}, is not revealed. Another vaccine, for Chikungunya virus, is reported to be ready to start trials.<ref>{{cite web |last1=Herper |first1=Matthew |title=Mysterious $5 Billion Biotech Firm Moderna Lays Out Drug Pipeline |url=https://www.forbes.com/sites/matthewherper/2017/01/09/mysterious-5-billion-biotech-firm-moderna-lays-out-drug-pipeline/?sh=79d7ae8a4eb5 |website=Forbes |access-date=2 February 2022 |language=en}}</ref><ref>{{cite web |title=Moderna Provides Pipeline and Full-Year Corporate Update |url=https://www.businesswire.com/news/home/20170109006270/en/Moderna-Provides-Pipeline-and-Full-Year-Corporate-Update |website=www.businesswire.com |access-date=9 February 2022 |language=en |date=9 January 2017}}</ref><ref>{{cite web |title=Moderna Provides Pipeline and Full-Year Corporate Update |url=https://www.biotech-finances.com/moderna-provides-pipeline-and-full-year-corporate-update/ |website=Biotech Finances |access-date=10 February 2022 |language=fr-FR |date=10 January 2017}}</ref>
+| 2017 || January 9 || {{w|Influenza}}, {{w|Zika virus}}, {{w|Chikungunya virus}} || || {{w|Drug pipeline}} || Moderna unveils new details about its pipeline and strategy at the J.P. Morgan Healthcare Conference in {{w|San Francisco}}. The company announces five vaccines in clinical trials. Two are for strains of influenza with potencial to become pandemic. Another is for Zika virus, and a fourth, being developed with AstraZeneca, treats heart attacks. A fifth vaccine candidate, co-developed with {{w|Merck}}, is not revealed. Another vaccine, for Chikungunya virus, is reported to be ready to start trials.<ref>{{cite web |last1=Herper |first1=Matthew |title=Mysterious $5 Billion Biotech Firm Moderna Lays Out Drug Pipeline |url=https://www.forbes.com/sites/matthewherper/2017/01/09/mysterious-5-billion-biotech-firm-moderna-lays-out-drug-pipeline/?sh=79d7ae8a4eb5 |website=Forbes |access-date=2 February 2022 |language=en}}</ref><ref>{{cite web |title=Moderna Provides Pipeline and Full-Year Corporate Update |url=https://www.businesswire.com/news/home/20170109006270/en/Moderna-Provides-Pipeline-and-Full-Year-Corporate-Update |website=www.businesswire.com |access-date=9 February 2022 |language=en |date=9 January 2017}}</ref><ref>{{cite web |title=Moderna Provides Pipeline and Full-Year Corporate Update |url=https://www.biotech-finances.com/moderna-provides-pipeline-and-full-year-corporate-update/ |website=Biotech Finances |access-date=10 February 2022 |language=fr-FR |date=10 January 2017}}</ref>
 |-
 | 2017 || April 27 || {{w|Influenza}} (H10N8) || mRNA-1440 || {{w|Clinical trial}} (result) || Moderna shows announces positive interim data from its ongoing Phase 1 study of mRNA-1440, an mRNA infectious disease vaccine against avian H10N8 influenza, demonstrating mRNA-1440 induced high levels of immunogenicity, and was safe and well tolerated.<ref>{{cite web |last1=Rockoff |first1=Jonathan D. |title=Startup Moderna Shows Promise in Vaccine Trial |url=https://www.wsj.com/articles/startup-moderna-shows-promise-in-vaccine-trial-1493308801 |website=Wall Street Journal |access-date=3 February 2022 |date=27 April 2017}}</ref><ref>{{cite web |title=Moderna Announces Positive Interim Phase 1 Clinical Data Demonstrating First mRNA Vaccine Candidate, mRNA-1440, Induces High Levels of Immunogenicity |url=https://www.modernatx.com/sites/default/files/press_releases/Moderna%20H10%20Data%20Press%20Release__FinalforBusinessWire_4.27.17_9am.pdf |website=modernatx.com |access-date=9 February 2022}}</ref><ref>{{cite web |title=Secretive Moderna reveals first-in-human data from mRNA vaccine tech |url=https://www.fiercepharma.com/vaccines/once-secretive-moderna-reveals-its-first-human-data-from-avian-flu-vaccine-trial |website=FiercePharma |access-date=2 February 2022 |language=en}}</ref>
@@ Line 201: / Line 181: @@
 | 2019 || May 28 || || mRNA-3704 || {{w|Clinical trial}} || Moderna starts a clinical trial with the purpose to evaluate mRNA-3704 in patients with methylmalonic acidemia/aciduria (MMA) due to methylmalonyl-coenzyme A mutase (MUT) deficiency between 1 to 18 years of age with elevated plasma methylmalonic acid. As of February 2022, 0 participants would be enrolled.<ref>{{cite web |title=A Global, Phase 1/2, Open Label, Dose Escalation Study to Evaluate the Safety, Pharmacodynamics, and Pharmacokinetics of mRNA-3704 in Patients With Isolated Methylmalonic Acidemia Due to Methylmalonyl-CoA Mutase Deficiency |url=https://clinicaltrials.gov/ct2/show/NCT03810690?spons=ModernaTX%2C+Inc.&draw=4&rank=29 |website=clinicaltrials.gov |publisher=clinicaltrials.gov |access-date=19 February 2022 |date=10 November 2020}}</ref>
 |-
-| 2019 || June 26 || || {{w|mRNA-5671}}, {{w|pembrolizumab}} || {{w|Clinical trial}} || Moderna starts clinical trial with the purpose to evaluate Phase 2 dose of V941(mRNA-5671/V941) as a monotherapy and in combination with {{w|pembrolizumab}} infusion.<ref>{{cite web |title=A Phase 1, Open-Label, Multicenter Study to Assess the Safety and Tolerability of mRNA-5671/V941 as a Monotherapy and in Combination With Pembrolizumab in Participants With KRAS Mutant Advanced or Metastatic Non-Small Cell Lung Cancer, Colorectal Cancer or Pancreatic Adenocarcinoma |url=https://clinicaltrials.gov/ct2/show/NCT03948763 |website=clinicaltrials.gov |publisher=clinicaltrials.gov |access-date=18 February 2022 |date=9 February 2022}}</ref>
+| 2019 || June 26 || {{w|Cancer}} || {{w|mRNA-5671}}, {{w|pembrolizumab}} || {{w|Clinical trial}} || Moderna starts clinical trial with the purpose to evaluate Phase 2 dose of V941(mRNA-5671/V941) as a monotherapy and in combination with {{w|pembrolizumab}} infusion.<ref>{{cite web |title=A Phase 1, Open-Label, Multicenter Study to Assess the Safety and Tolerability of mRNA-5671/V941 as a Monotherapy and in Combination With Pembrolizumab in Participants With KRAS Mutant Advanced or Metastatic Non-Small Cell Lung Cancer, Colorectal Cancer or Pancreatic Adenocarcinoma |url=https://clinicaltrials.gov/ct2/show/NCT03948763 |website=clinicaltrials.gov |publisher=clinicaltrials.gov |access-date=18 February 2022 |date=9 February 2022}}</ref>
 |-
 | 2019 || July 18 || {{w|Cancer}} || mRNA-4157, {{w|pembrolizumab}} || {{w|Clinical Trial}} || Moderna starts a clinical trial with the purpose to assess whether postoperative adjuvant therapy with mRNA-4157 and pembrolizumab improves recurrence free survival (RFS) compared to pembrolizumab alone in participants with complete resection of cutaneous melanoma and a high risk of recurrence.<ref>{{cite web |title=A Phase 2 Randomized Study of Adjuvant Immunotherapy With the Personalized Cancer Vaccine mRNA-4157 and Pembrolizumab Versus Pembrolizumab Alone After Complete Resection of High-Risk Melanoma (KEYNOTE- 942) |url=https://clinicaltrials.gov/ct2/show/NCT03897881?spons=ModernaTX%2C+Inc.&draw=4&rank=27 |website=clinicaltrials.gov |publisher=clinicaltrials.gov |access-date=19 February 2022 |date=18 December 2021}}</ref>
@@ Line 273: / Line 253: @@
 | 2021 || January 8 || {{w|COVID-19}} || [[w:Moderna COVID-19 vaccine|mRNA-1273]] || {{w|Authorization}} || British Prime Minister {{w|Boris Johnson}} approves the {{w|Moderna COVID-19 vaccine}} for use in the {{w|United Kingdom}}, being the third coronavirus vaccine to approved for use in the country. The {{w|Government of the United Kingdom}} pre-orders 17 million doses of the Moderna vaccine.<ref>{{cite web |title=Moderna becomes third Covid vaccine approved in the UK |url=https://www.bbc.com/news/health-55586410 |website=BBC News |access-date=9 February 2022 |date=8 January 2021}}</ref>
 |-
-| 2021 || January 11 || {{w|Influenza}}, {{w|HIV}}, {{w|Nipah virus}} || Flu vaccine (mRNA-1010, mRNA-1020, mRNA-1030), HIV vaccine (mRNA-1644 & mRNA-1574), Nipah virus (NiV) Vaccine (mRNA-1215) || {{w|Drug pipeline}} || Moderna announces development of three mRNA-based vaccines for seasonal influenza, {{w|HIV}} and {{w|Nipah virus}}, to be conducted in 2021.<ref name="sdsdf">{{cite web |title=Moderna is developing three new mRNA-based vaccines for seasonal flu, HIV and Nipah virus |url=https://techcrunch.com/2021/01/11/moderna-is-developing-three-new-mrna-based-vaccines-for-seasonal-flu-hiv-and-nipah-virus/ |website=TechCrunch |access-date=19 January 2022}}</ref><ref>{{cite web |title=Moderna Provides Business Update and Announces Three New Development Programs in Infectious Disease Vaccines |url=https://investors.modernatx.com/news/news-details/2021/Moderna-Provides-Business-Update-and-Announces-Three-New-Development-Programs-in-Infectious-Disease-Vaccines-01-11-2021/default.aspx |website=investors.modernatx.com |access-date=19 January 2022}}</ref>
+| 2021 || January 11 || {{w|Influenza}}, {{w|HIV/AIDS}}, {{w|Nipah virus}} || Flu vaccine (mRNA-1010, mRNA-1020, mRNA-1030), HIV vaccine (mRNA-1644 & mRNA-1574), Nipah virus (NiV) Vaccine (mRNA-1215) || {{w|Drug pipeline}} || Moderna announces development of three mRNA-based vaccines for seasonal influenza, {{w|HIV}} and {{w|Nipah virus}}, to be conducted in 2021.<ref name="sdsdf">{{cite web |title=Moderna is developing three new mRNA-based vaccines for seasonal flu, HIV and Nipah virus |url=https://techcrunch.com/2021/01/11/moderna-is-developing-three-new-mrna-based-vaccines-for-seasonal-flu-hiv-and-nipah-virus/ |website=TechCrunch |access-date=19 January 2022}}</ref><ref>{{cite web |title=Moderna Provides Business Update and Announces Three New Development Programs in Infectious Disease Vaccines |url=https://investors.modernatx.com/news/news-details/2021/Moderna-Provides-Business-Update-and-Announces-Three-New-Development-Programs-in-Infectious-Disease-Vaccines-01-11-2021/default.aspx |website=investors.modernatx.com |access-date=19 January 2022}}</ref>
 |-
 | 2021 || January 19 || {{w|COVID-19}} || [[w:Moderna COVID-19 vaccine|mRNA-1273]] || Authorization || Moderna announces approval of its [[w:Moderna COVID-19 vaccine|mRNA-1273]] {{w|COVID-19 vaccine}} by Swissmedic, the Swiss Agency for therapeutic products, for use in Switzerland. The authorization comes over a month after the federal government increased its confirmed order commitment of mRNA-1273 from 4.5 million to 7.5 million doses.<ref>{{cite web |title=Switzerland Authorizes Moderna’s mRNA COVID-19 Vaccine |url=https://pharmanewsintel.com/news/switzerland-authorizes-modernas-mrna-covid-19-vaccine |website=PharmaNewsIntelligence |access-date=12 February 2022 |date=19 January 2021}}</ref>
@@ Line 305: / Line 285: @@
 | 2021 || June 3 || || || Supply || Moderna signs pact with {{w|UNICEF}} for {{w|Covid-19}} vaccine supply. UNICEF and its procurement partners, including the {{w|Pan American Health Organization}}, gains access to up to 34 million doses of Moderna’s COVID-19 vaccine, to be delivered in the fourth quarter 2021, with an option for up to 466 million doses in 2022.<ref>{{cite web |title=Moderna Partners with UNICEF, Lonza, Thermo Fisher for COVID-19 Vaccine |url=https://www.dcatvci.org/top-industry-news/moderna-partners-with-unicef-lonza-thermo-fisher-for-covid-vaccine/ |website=DCAT Value Chain Insights |access-date=4 February 2022 |date=3 June 2021}}</ref>
 |-
-| 2021 || June 8 || Zika || mRNA-1893 || {{w|Clinical trial}} || Moderna launches a clinical trial with the purpose to evaluate 2 dose levels of messenger RNA (mRNA)-1893 Zika vaccine in comparison to a placebo control in healthy participants who are flavivirus-seronegative and in participants who are flavivirus-seropositive.<ref>{{cite web |title=A Phase 2, Randomized, Observer-Blind, Placebo-Controlled, Dose Confirmation Study to Evaluate the Safety, Tolerability, and Immunogenicity of Zika Vaccine mRNA-1893 in Adults Aged 18 Through 65 Years and Living in Endemic and Non-Endemic Flavivirus Areas |url=https://clinicaltrials.gov/ct2/show/NCT04917861?spons=ModernaTX%2C+Inc.&draw=3&rank=13 |website=clinicaltrials.gov |publisher=clinicaltrials.gov |access-date=19 February 2022 |date=18 January 2022}}</ref>
+| 2021 || June 8 || {{w|Zika virus}} || mRNA-1893 || {{w|Clinical trial}} || Moderna launches a clinical trial with the purpose to evaluate 2 dose levels of messenger RNA (mRNA)-1893 Zika vaccine in comparison to a placebo control in healthy participants who are flavivirus-seronegative and in participants who are flavivirus-seropositive.<ref>{{cite web |title=A Phase 2, Randomized, Observer-Blind, Placebo-Controlled, Dose Confirmation Study to Evaluate the Safety, Tolerability, and Immunogenicity of Zika Vaccine mRNA-1893 in Adults Aged 18 Through 65 Years and Living in Endemic and Non-Endemic Flavivirus Areas |url=https://clinicaltrials.gov/ct2/show/NCT04917861?spons=ModernaTX%2C+Inc.&draw=3&rank=13 |website=clinicaltrials.gov |publisher=clinicaltrials.gov |access-date=19 February 2022 |date=18 January 2022}}</ref>
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 | 2021 || July 6 || || || Team || Paul Burton becomes Moderna's {{w|chief marketing officer}}, joining the company after 16 years at {{w|Johnson & Johnson}}.<ref>{{cite web |title=Moderna appoints J&J veteran Paul Burton as new CMO |url=https://www.ardent-search.com/an-ardent-view/ibt29k4tuk2prl49443s3bt041yy6d |website=Ardent Executive Search {{!}} Life Science & Healthcare Recruitment |access-date=9 February 2022}}</ref>
@@ Line 396: / Line 376: @@
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 |}
+== Numerical and visual data  ==
+=== Google Trends  ===
+The chart below shows {{w|Google Trends}} data for Moderna (Biotechnology Company), from January 2010 to January 2022, when the screenshot was taken. Interest is also ranked by country and displayed on world map. <ref>{{cite web |title=Moderna |url=https://trends.google.com/trends/explore?date=2010-01-01%202022-01-14&q=%2Fm%2F0w2ztxm |website=Google Trends |access-date=14 January 2022}}</ref> The first increase in early 2020 happens as COVID-19 starts spreading and Moderna announces its COVID-19 vaccine efforts. Further increases near the end of 2020 occur once Moderna succeeds in its human clinical trials of the COVID-19 vaccine. After that, interest in Moderna largely tracks the evolution of the COVID-19 pandemic.
+[[File:Moderna gt.png|thumb|center|700px]]
+=== Google Finance ===
+The image below shows Moderna stock valuation in {{w|USD}} from {{w|IPO}} to January 14, 2022, when the screenshot was taken.<ref>{{cite web |title=Moderna |url=https://www.google.com/finance/quote/MRNA:NASDAQ?hl=en&window=MAX |website=www.google.com |access-date=14 January 2022 |language=en}}</ref>
+[[File:Moderna gf.png|thumb|center|700px]]
+=== Wikipedia Views ===
+The chart below shows pageviews of the English Wikipedia article {{w|Moderna}}, from July 2015 to December 2021.<ref>{{cite web |title=Moderna |url=https://wikipediaviews.org/displayviewsformultiplemonths.php?page=Moderna&allmonths=allmonths-api&language=en&drilldown=all |website=wikipediaviews.org |access-date=14 January 2022}}</ref>
+[[File:Moderna wv.png|thumb|center|550px]]
 ==Meta information on the timeline==

Difference between revisions of "Timeline of Moderna"

Latest revision as of 22:26, 24 March 2024

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