Difference between revisions of "Timeline of malaria vaccine"
From Timelines
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| 1995 || || "First RTS,S clinical tests in humans begins in adults in US"<ref name="Fact s heet: T he RTS,S malaria vaccine candidate (Mosquirix TM )"/> | | 1995 || || "First RTS,S clinical tests in humans begins in adults in US"<ref name="Fact s heet: T he RTS,S malaria vaccine candidate (Mosquirix TM )"/> | ||
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| − | | 1997 || || Key proof-of-concept (PoC) study shows 6 of 7 volunteers in challenge trial are 100% protected.<ref name="Fact s heet: T he RTS,S malaria vaccine candidate (Mosquirix TM )"/> || | + | | 1997 || || "RTS,S" "Key proof-of-concept (PoC) study shows 6 of 7 volunteers in challenge trial are 100% protected."<ref name="Fact s heet: T he RTS,S malaria vaccine candidate (Mosquirix TM )"/> || |
| + | |- | ||
| + | | 1998 || Trial || "First RTS,S trials in Africa begin in Gambia".<ref name="Fact s heet: T he RTS,S malaria vaccine candidate (Mosquirix TM )"/> || | ||
| + | |- | ||
| + | | 2001 || || "GSK/MVI partnership initiated" "n January 2001, GSK and PATH’s Malaria Vaccine Initiative (PATH/MVI), with grant monies from the Bill & Melinda Gates Foundation to PATH, entered into a public-private partnership to develop RTS,S for infants and young children living in malaria-endemic regions in sub-Saharan Africa."<ref name="Fact s heet: T he RTS,S malaria vaccine candidate (Mosquirix TM )"/>|| | ||
| + | |- | ||
| + | | 2004 || || "Koy PoC study in children in the Mozambique"<ref name="Fact s heet: T he RTS,S malaria vaccine candidate (Mosquirix TM )"/> || | ||
| + | |- | ||
| + | | 2007 || || "Phase II results in African children and infants published in the LANCET and NEJM"<ref name="Fact s heet: T he RTS,S malaria vaccine candidate (Mosquirix TM )"/> || | ||
| + | |- | ||
| + | | 2009 || || "RTS,S" "Phase III study start"<ref name="Fact s heet: T he RTS,S malaria vaccine candidate (Mosquirix TM )"/> || | ||
|- | |- | ||
| 2009 || Trial || "GlaxoSmithKline Biologicals' (GSKBio) RTS,S" "A Phase III trial of the world’s most clinically advanced malaria vaccine candidate was launched in Kisumu, Kenya, in July 2009, under the auspices of the Kenya Medical Research Institute (KEMRI)/CDC Research and Public Health Collaboration."<ref>{{cite web|title=Malaria Vaccine|url=https://www.cdc.gov/malaria/features/vaccines.html|website=cdc.gov|accessdate=17 April 2017}}</ref> || | | 2009 || Trial || "GlaxoSmithKline Biologicals' (GSKBio) RTS,S" "A Phase III trial of the world’s most clinically advanced malaria vaccine candidate was launched in Kisumu, Kenya, in July 2009, under the auspices of the Kenya Medical Research Institute (KEMRI)/CDC Research and Public Health Collaboration."<ref>{{cite web|title=Malaria Vaccine|url=https://www.cdc.gov/malaria/features/vaccines.html|website=cdc.gov|accessdate=17 April 2017}}</ref> || | ||
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| 2011 || Trial || "The RTS,S vaccine was tested in Phase III trials in 11 different African countries. These trials have had some successes. The earliest results, released in October 2011, showed that in children aged 5-17 months, vaccination with RTS,S reduced the risk of clinical malaria and severe malaria by 56% and 47%, respectively.[17] However, in results released in November 2012, the vaccine was less effective in infants aged 6-12 weeks at first vaccination."<ref name="Malaria and Malaria Vaccine Candidates">{{cite web|title=Malaria and Malaria Vaccine Candidates|url=https://www.historyofvaccines.org/content/articles/malaria-and-malaria-vaccine-candidates|website=historyofvaccines.org|accessdate=17 April 2017}}</ref> | | 2011 || Trial || "The RTS,S vaccine was tested in Phase III trials in 11 different African countries. These trials have had some successes. The earliest results, released in October 2011, showed that in children aged 5-17 months, vaccination with RTS,S reduced the risk of clinical malaria and severe malaria by 56% and 47%, respectively.[17] However, in results released in November 2012, the vaccine was less effective in infants aged 6-12 weeks at first vaccination."<ref name="Malaria and Malaria Vaccine Candidates">{{cite web|title=Malaria and Malaria Vaccine Candidates|url=https://www.historyofvaccines.org/content/articles/malaria-and-malaria-vaccine-candidates|website=historyofvaccines.org|accessdate=17 April 2017}}</ref> | ||
|- | |- | ||
| − | | 2015 (July) || || "The Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) announced on July 24, 2015,that it has adopted a positive scientific opinion, under Article 58, for GSK’s malaria candidate vaccine Mosquirix TM, also known as RTS,S, in children aged 6 weeks to 17 months."<ref name="Fact s heet: T he RTS,S malaria vaccine candidate (Mosquirix TM )">{{cite web|title=Fact s heet: T he RTS,S malaria vaccine candidate (Mosquirix TM )|url=http://www.malariavaccine.org/ | + | | 2015 (July) || || "The Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) announced on July 24, 2015,that it has adopted a positive scientific opinion, under Article 58, for GSK’s malaria candidate vaccine Mosquirix TM, also known as RTS,S, in children aged 6 weeks to 17 months."<ref name="Fact s heet: T he RTS,S malaria vaccine candidate (Mosquirix TM )">{{cite web|title=Fact s heet: T he RTS,S malaria vaccine candidate (Mosquirix TM )|url=http://www.malariavaccine.org/sites/www.malariavaccine.org/files/content/page/files/RTSS%20vaccine%20candidate%20Factsheet_FINAL.pdf|accessdate=17 April 2017}}</ref> || |
| + | |- | ||
| + | | 2016 || || "The January 2016 WHO position paper that followed the CHMP opinion endorses the recommendations made by the WHO Strategic Advisory Group of Experts (SAGE)on Immunization and Malaria Policy Advisory Committee (MPAC) in October 2015. According to the position paper, “WHO recommends that the pilot implementations use the 4-dose schedule of the RTS,S/AS01 vaccine in 3–5 distinct epide | ||
| + | miological settings in sub-Saharan Africa, at subnational level, covering moderate-to-high transmission settings,”with three doses administered to children between 5 and 9 months of age, followed by a fourth dose 15–18 months later."<ref name="Fact s heet: T he RTS,S malaria vaccine candidate (Mosquirix TM )"/> | ||
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Revision as of 08:54, 17 April 2017
This is a timeline of malaria vaccine, attempting to describe its development.
Big picture
| Year/period | Key developments |
|---|
Full timeline
| Year/period | Type of event | Event | Location |
|---|---|---|---|
| 1984 | "GSK/WRAIR initiate collaboration"[1] | ||
| 1987 | "RTS,S is first created by combining the malaria CS protein and hepatitis B surface antigen"[1]
"The RTS,S malaria vaccine candidate is the most advanced in development globally. It was created in 1987 by scientists working at GlaxoSmithKline’s (GSK) laboratories."[1] || | ||
| 1995 | "First RTS,S clinical tests in humans begins in adults in US"[1] | ||
| 1997 | "RTS,S" "Key proof-of-concept (PoC) study shows 6 of 7 volunteers in challenge trial are 100% protected."[1] | ||
| 1998 | Trial | "First RTS,S trials in Africa begin in Gambia".[1] | |
| 2001 | "GSK/MVI partnership initiated" "n January 2001, GSK and PATH’s Malaria Vaccine Initiative (PATH/MVI), with grant monies from the Bill & Melinda Gates Foundation to PATH, entered into a public-private partnership to develop RTS,S for infants and young children living in malaria-endemic regions in sub-Saharan Africa."[1] | ||
| 2004 | "Koy PoC study in children in the Mozambique"[1] | ||
| 2007 | "Phase II results in African children and infants published in the LANCET and NEJM"[1] | ||
| 2009 | "RTS,S" "Phase III study start"[1] | ||
| 2009 | Trial | "GlaxoSmithKline Biologicals' (GSKBio) RTS,S" "A Phase III trial of the world’s most clinically advanced malaria vaccine candidate was launched in Kisumu, Kenya, in July 2009, under the auspices of the Kenya Medical Research Institute (KEMRI)/CDC Research and Public Health Collaboration."[2] | |
| 2011 | Trial | "The RTS,S vaccine was tested in Phase III trials in 11 different African countries. These trials have had some successes. The earliest results, released in October 2011, showed that in children aged 5-17 months, vaccination with RTS,S reduced the risk of clinical malaria and severe malaria by 56% and 47%, respectively.[17] However, in results released in November 2012, the vaccine was less effective in infants aged 6-12 weeks at first vaccination."[3] | |
| 2015 (July) | "The Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) announced on July 24, 2015,that it has adopted a positive scientific opinion, under Article 58, for GSK’s malaria candidate vaccine Mosquirix TM, also known as RTS,S, in children aged 6 weeks to 17 months."[1] | ||
| 2016 | "The January 2016 WHO position paper that followed the CHMP opinion endorses the recommendations made by the WHO Strategic Advisory Group of Experts (SAGE)on Immunization and Malaria Policy Advisory Committee (MPAC) in October 2015. According to the position paper, “WHO recommends that the pilot implementations use the 4-dose schedule of the RTS,S/AS01 vaccine in 3–5 distinct epide
miological settings in sub-Saharan Africa, at subnational level, covering moderate-to-high transmission settings,”with three doses administered to children between 5 and 9 months of age, followed by a fourth dose 15–18 months later."[1] |
See also
References
- ↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 "Fact s heet: T he RTS,S malaria vaccine candidate (Mosquirix TM )" (PDF). Retrieved 17 April 2017.
- ↑ "Malaria Vaccine". cdc.gov. Retrieved 17 April 2017.
- ↑ "Malaria and Malaria Vaccine Candidates". historyofvaccines.org. Retrieved 17 April 2017.
