Timeline of immunology
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This is a timeline of immunology.
Contents
Big picture
| Time period | Development summary |
|---|
Full timeline
| Year | Event type | Details | Country/region |
|---|---|---|---|
| 430 BC | "Nevertheless, there were intimations as early as 430 B.C. that if one survived a disease, the person thereafter became "immune" to any subsequent exposures."[1] | ||
| 1700 | "Although most historical accounts credit Edward Jenner for the development of the first immunization process, a previous similar procedure had become established in China by 1700. The technique was called variolation. This was derived from the name of the infective agent—the variola virus."[1] | China | |
| 1798 | " Edward Jenner initiates smallpox vaccination."[1][2] | ||
| 1877 | "Paul Ehrlich recognizes mast cells."[1] | ||
| 1879 | " Louis Pasteur develops an attenuated chicken cholera vaccine."[1] | ||
| 1883 | Russian zoologist Ilya Ilyich Mechnikov theorizes that cells are involved in the defense of the body.[1][2] | ||
| 1891 | Robert Koch discovers delayed type hypersensitivity.[1][2] | ||
| 1900 | Paul Ehrlich theorizes about some of the events taking place in immune cells, postulating that cells interact with toxins via "side chains" that stem from protoplasm. | ||
| 1902 | Charles Richet coins the term anaphylaxis to describe the most dangerous allergic reaction.[2] | ||
| 1906 | Clemens von Pirquet coins the term allergy.[1][2] | ||
| 1907 | Svante Arrhenius coins the term immunochemistry.[2] | ||
| 1910 | Henry Dale identifies histamine, a body chemical responsible for many allergic reactions. | ||
| 1916 | Robert Cook and Albert Vander Veer demonstrate the role of heredity in allergy sufferers. | ||
| 1921 | Carl Prausnitz and Heinz Küstner discover that components in the blood can reproduce food allergy reactions.[2] | ||
| 1926 | Lloyd D. Felton isolates pure antibody preparation. | ||
| 1934 | John Marrack advances the antigen-antibody binding hypothesis. | ||
| 1937 | David Bovet synthesizes the first antihistamine. | ||
| 1938 | "John Marrack formulates antigen-antibody binding hypothesis."[1] | ||
| 1940 | Karl Landsteiner and Alexander S. Weiner identify Rh antigens. | ||
| 1941 | Albert Coons develops immunofluorescence technique. | ||
| 1942 | "Jules Freund and Katherine McDermott research adjuvants."[1] | ||
| 1948 | Astrid Fagraeus demonstrates the production of antibodies in plasma B cells. | ||
| 1949 | " Macfarlane Burnet & Frank Fenner formulate immunological tolerance hypothesis."[1] | ||
| 1957 | " Alick Isaacs & Jean Lindemann discover interferon (cytokine)."[1] | ||
| 1959 | "Niels Jerne, David Talmage, Macfarlane Burnet develop clonal selection theory."[1] | ||
| 1962 | "Rodney Porter and team discovery the structure of antibodies."[1] | ||
| 1962 | "Jaques Miller and team discover thymus involvement in cellular immunity."[1] | ||
| 1962 | "Noel Warner and team distinguish between cellular and humoral immune responses."[1] | ||
| 1968 | " Anthony Davis and team discover T cell and B cell cooperation in immune response."[1] | ||
| 1974 | "Rolf Zinkernagel and Peter Doherty explore major histocompatibility complex restriction."[1] | ||
| 1985 | " Susumu Tonegawa, Leroy Hood, and team identify immunoglobulin genes."[1] | ||
| 1985 | "Scientists begin the rapid identification of genes for immune cells that continues to the present."[1] | ||
| 1987 | " Leroy Hood and team identify genes for the T cell receptor."[1] |
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The initial version of the timeline was written by FIXME.
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