Timeline of hemophilia
From Timelines
This is a timeline of hemophilia.
Contents
Big picture
| Time period | Development summary. |
|---|---|
| 20th century | Until the early 1900s, there is no way to store blood for hemophiliacs so they are generally given a transfusion from a family member if they have suffered a trauma. At this point, the life expectancy for boys with hemophilia is around 13 years old. Some of the early treatments include lime, bone marrow, oxygen, thyroid gland, hydrogen peroxide or gelatin. In the 1930s, snake venom is used to help blood clotting. Hospital-based plasma transfusions are common treatments for hemophiliacs in the late 1920s and continue until the 1950s. The different factor deficiencies are distinguished in the 1950s and 1960s. By 1960, the life expectancy of a person with severe hemophilia rises to just under 20 years old. By the 1970s, freeze-dried powder formulas of factor VIII and IX become readily available, which means hemophiliacs are able to self-administer the factor in their own homes. In the 1980s, the rise of HIV and AIDS leads to many people with hemophilia dying of AIDS and becoming HIV positive through contaminated blood products. Hemophiliacs are also at a high risk of contracting hepatitis C until blood screening is introduced in 1992.[1] |
| 21st century | New recombinant factors not containing contain human or animal plasma are introduced in the early 2000s, lessening the chance of allergic reactions.[1] |
Full timeline
| Year | Event type | Details | Location |
|---|---|---|---|
| 1803 | Dr. John Conrad Otto from Philadelphia publishes a paper about a familial bleeding disorder that only affected male members.[1] | United States | |
| 1828 | "The term hemophilia comes from a student of Zurich University, Friedrich Hopff and his professor, Dr. Schonlein, who came up with the term “haemorrhaphilia” which became “haemophilia” in 1828."[1] | ||
| 1930 | Scientists learn how to separate blood into its major parts, plasma and red cells.[2] | ||
| 1947 | "Argentinian physician, Alfredo Pavlovsky discovered there were two types of hemophilia (A and B) in 1947."[1] | Argentina | |
| 1965 | Dr. Judith Graham Pool from Stanford University discovers a process of freezing and thawing plasma to get a layer of factor-rich plasma (cryoprecipitate).[2] Graham Pool discovers that the cryoprecipitate left from thawing plasma is high in factor VIII. This could be infused to control heavy bleeding allowing blood banks to produce and store large amounts for use in surgical procedures for hemophiliacs.[1] | United States | |
| 1992 | Blood screening is introduced. Prior to this, hemophiliacs were at a high risk of contracting hepatitis C and other diseases.[1] | ||
| 1995 | Prophylaxis starts being used as a preventive treatment for children.[1] | ||
| 1990s | The synthetic factor becaomes available and recombinant factors are approved by the United States Food and Drug Administration.[1] | United States |
Meta information on the timeline
How the timeline was built
The initial version of the timeline was written by FIXME.
Funding information for this timeline is available.
Feedback and comments
Feedback for the timeline can be provided at the following places:
- FIXME
