Timeline of SENS Research Foundation

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This is a Timeline of SENS Research Foundation, a nonprofit organization dedicated to advancing regenerative medicine approaches to aging. It documents the origins of the SENS program, key research initiatives, collaborations, funding milestones, leadership changes, and the emergence of spin-off companies and biotechnology investments aimed at developing therapies to repair age-related cellular damage.


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Year (month and date) Event type Details
2000s Scientific proposal The Strategies for engineered negligible senescence (SENS) rejuvenation approach to combating aging is articulated by Aubrey de Grey and collaborators. While some biogerontologists support the program, others criticize it as overly speculative given the state of biotechnology.[1][2]
2009 (March) Organizational development Prior to the creation of the SENS Research Foundation, the SENS research program is primarily pursued through the Methuselah Foundation, co-founded by Aubrey de Grey and David Gobel.
2009 (March) Organization founding The SENS Research Foundation is founded by Aubrey de Grey, Jeff Hall, Michael Kope, Sarah Marr, and Kevin Perrott to advance research programs and public advocacy for applying regenerative medicine approaches to aging through the SENS framework.
2010 (December 9) Donation pledge Internet entrepreneur Jason Hope pledges a $500,000 donation to the SENS Research Foundation to support research on rejuvenation biotechnology and aging damage repair.[3]
2011 Annual report publication The organization publishes its annual report documenting activities, research funding, and programs related to rejuvenation biotechnology.[4]
2011 Research collaboration SENS Research Foundation supports and participates in extramural research collaborations with multiple universities including Yale University, Harvard University, University of Cambridge, University of Texas, Rice University, and the University of Arizona.[4]
2011 Major research funding Following the death of his mother, Aubrey de Grey inherits $16.5 million and allocates $13 million to support SENS research. The donation roughly doubles the SENS Research Foundation’s annual budget to about $4 million by 2013.[5]
2016 (August 15) Investment / research collaboration The advocacy organization Fight Aging! invests in Ichor Therapeutics to support development of a SENS damage-repair therapy targeting macular degeneration under the LysoSENS research program.[6]
2016 (September 4) Scientific publication Researchers associated with the MitoSENS program demonstrate proof of concept for mitochondrial gene allotopic expression, publishing results on stable nuclear expression of the ATP8 and ATP6 genes rescuing a mitochondrial DNA Complex V null mutant in Nucleic Acids Research.[7]
2017 Organizational finance According to the SENS Research Foundation annual report, the organization reports income of $7,871,530 and expenses of $3,915,682, including spending on research, education, outreach, and administration.[8]
2017–2018 Philanthropic donation The cryptocurrency-based Pineapple Fund donates approximately $2 million to the SENS Research Foundation to support research programs focused on aging and longevity science.[9][10]
2018 Annual report publication SENS Research Foundation releases its annual report summarizing research initiatives, partnerships, and progress in regenerative medicine approaches to aging.[8]
2018 (February 2) Philanthropic donation Ethereum co-founder Vitalik Buterin donates $2.4 million in cryptocurrency to the SENS Research Foundation to support research aimed at combating aging and age-related diseases.[8][11][12][13]
2018 (October 11) Research presentation Research related to SENS-funded biotechnology efforts is presented at the University of Alberta describing selective ablation of senescent and malignant cells using apoptotic gene therapy, connected to approaches pursued by Oisin Biotechnologies.[14]
2019 (March 25) Research project SENS Research Foundation supports the Hebert laboratory at the Albert Einstein College of Medicine to investigate functional neuron replacement aimed at rejuvenating the neocortex as part of the RepleniSENS research program.[15]
2019 Organizational finance The foundation reports income of $2,683,611 and expenses of $4,361,258, including $2,331,364 allocated to research activities according to its annual report.[16]
2019 Annual report publication The foundation publishes its annual report reviewing research programs and organizational developments in longevity science.[17]
2020 (January 7) Startup funding Revel Pharmaceuticals receives seed funding to develop glucosepane cross-link breakers targeting advanced glycation end-product crosslinks, advancing the GlycoSENS strategy to address extracellular matrix stiffening.[18]
2020 Annual report publication SENS Research Foundation releases its annual report outlining research progress and financial activities related to rejuvenation biotechnology.[16]
2020 Philanthropic donation Oculus cofounder Michael Antonov donates $1 million to the SENS Research Foundation, including $600,000 as matching funds to support longevity research programs.[19][20]
2020 (December 17) Philanthropic donation Vitalik Buterin, Sam Bankman-Fried, and Haseeb Qureshi jointly donate $150,000 to the SENS Research Foundation through a cryptocurrency philanthropy initiative, with the recipient chosen via public voting on Twitter.[21]
2021 (June 15) Research program update The MitoSENS initiative advances mitochondrial repair strategies including engineering nuclear expression of mitochondrial genes and exploring mitochondrial transplantation to restore cellular energy production.[22]
2021 (June 16) Research project The AmyloSENS program launches a project aimed at catalyzing degradation of aggregated tau proteins associated with cognitive decline and tauopathies such as Alzheimer's disease.[23]
2021 (July) Leadership change Jim O’Neill steps down as CEO of the SENS Research Foundation shortly before an internal investigation involving founder Aubrey de Grey.[24]
2021 (August) Organizational controversy Founder Aubrey de Grey is suspended from the SENS Research Foundation following allegations that prompt an internal investigation.[24]
2021 (September 8) Regulatory milestone Underdog Pharmaceuticals, associated with SENS-related research on arterial plaque removal, receives an “Innovation Passport” from UK regulators for accelerated development of a small-molecule therapy targeting atherosclerosis.[25]
2021 (September 8) Regulatory milestone Underdog Pharmaceuticals, a startup spun out from SENS Research Foundation research programs, receives an “Innovation Passport” from the UK Medicines and Healthcare products Regulatory Agency to accelerate development of therapies targeting age-related disease.[26]
2021 (December 9) Research grant SENS Research Foundation and Underdog Pharmaceuticals jointly receive a $252,000 grant from the National Institutes of Health to further develop therapies aimed at clearing arterial plaques associated with aging and atherosclerosis.[27]
2021 Venture funding initiative Entrepreneur Michael Greve pledges €300 million to support rejuvenation biotechnology startups, reflecting growing commercial interest in therapies aligned with the SENS damage-repair paradigm.[28][29]
2023 (April 17) Leadership profile Forbes publishes an article highlighting leadership developments at SENS Research Foundation and the role of CEO Lisa Fabiny-Kiser in the longevity field.[30]
2024 (October 9) Organizational merger SENS Research Foundation and Lifespan.io (Lifespan Extension Advocacy Foundation) announce completion of a merger forming the Lifespan Research Institute. Co-founders include Lisa Fabiny-Kiser and Stephanie Dainow.[31]

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See also

References

  1. ↑ Warner H; Anderson J; Austad S; et al. (November 2005). "Science fact and the SENS agenda. What can we reasonably expect from ageing research?". EMBO Reports. 6 (11): 1006–8. doi:10.1038/sj.embor.7400555. PMC 1371037. PMID 16264422.
  2. ↑ Holliday R (April 2009). "The extreme arrogance of anti-aging medicine". Biogerontology. 10 (2): 223–8. doi:10.1007/s10522-008-9170-6. PMID 18726707. S2CID 764136.
  3. ↑ "Internet Entrepreneur Jason Hope Pledges A Donation To SENS Foundation". December 9, 2010. Retrieved 2021-03-29.
  4. ↑ 4.0 4.1 "SENS Research Foundation 2011 Annual Report" (PDF).
  5. ↑ Ben Best (2013) "Interview with Aubrey de Grey, PhD". Life Extension Magazine.
  6. ↑ "Fight Aging! Invests in Ichor Therapeutics to Support Development of a SENS Damage Repair Therapy for Macular Degeneration". Fight Aging!. 2016-08-15.
  7. ↑ Boominathan, Amutha; et al. (2016-09-04). "Stable nuclear expression of ATP8 and ATP6 genes rescues a mtDNA Complex V null mutant". Nucleic Acids Research. 44 (19): 9342–9357. doi:10.1093/nar/gkw756. PMC 5100594. PMID 27596602.
  8. ↑ 8.0 8.1 8.2 "SENS Research Foundation 2018 Annual Report" (PDF).
  9. ↑ Bitcoin Transaction 10dd3b4bb1…
  10. ↑ Bitcoin Transaction f0aa1cc5bc…
  11. ↑ "SENS Research Foundation Receives $2.4 Million Ethereum Donation From Vitalik Buterin" (Press release). SENS Research Foundation. 2018-02-02.
  12. ↑ Elena, Milova (March 20, 2018). "Vitalik Buterin: The Best Thing to Donate Money to is The Fight Against Aging". LIFE EXTENSION ADVOCACY FOUNDATION. Archived from the original on 2018-03-22. Retrieved March 21, 2018.
  13. ↑ Анна ДОБРЮХА (2018-03-20). ""Король Эфириума" Виталик Бутерин: лучшее, на что стоит жертвовать деньги — это борьба со старением" [«King of Ethereum» Vitalik Buterin: the best thing to donate money for is the fight against aging]. Kp.ru - (in русский). Komsomolskaya Pravda.
  14. ↑ Dr. John Lewis (2018-10-11). "Selective Ablation of Senescent and Malignant Cells using Apoptotic Gene Therapy" (lecture). University of Alberta.
  15. ↑ "Functional Neuron Replacement to Rejuvenate the Neocortex". 25 March 2019.
  16. ↑ 16.0 16.1 "SENS Research Foundation 2020 Annual Report" (PDF).
  17. ↑ "SENS Research Foundation 2019 Annual Report" (PDF).
  18. ↑ "Revel Pharmaceuticals Finally Seed Funded to Develop Glucosepane Cross-Link Breakers". Fight Aging!. 2020-01-07.
  19. ↑ 2020 End of Year Fundraiser
  20. ↑ Michael Antonov Foundation: SENS Research Foundation
  21. ↑ "Effective Altruism: Giving in Crypto". 2020-12-17.
  22. ↑ "Engineering New Mitochondrial Genes to Restore Mitochondrial Function (MitoSENS)". 15 June 2021.
  23. ↑ "Catalyzing Degradation of Tau Aggregates". 16 June 2021.
  24. ↑ 24.0 24.1 "Anti-aging foundation's CEO left amid probe of Aubrey de Grey". STAT. 2021-08-13. Retrieved 2021-08-15.
  25. ↑ "Kizoo portfolio company Underdog awarded 'Innovation Passport' by UK Regulators". Kizoo. 8 September 2021. Archived from the original on 2021-09-08.
  26. ↑ "Kizoo portfolio company Underdog awarded 'Innovation Passport' by UK Regulators". Kizoo. 8 September 2021. Archived from the original on 2021-09-08.
  27. ↑ "SENS Research Foundation & Underdog Pharmaceuticals jointly awarded $252,000 NIA research grant". 9 December 2021.
  28. ↑ Michael Greve Announces a New €300 Million Fund for Investment in Rejuvenation Biotechnology Startups
  29. ↑ Michael Greve, founder of Forever Healthy, commits €300 million to advance rejuvenation startups
  30. ↑ Zhavoronkov, Alex (April 17, 2023). "Women In Longevity And The Renaissance Of The SENS Research Foundation". Forbes.
  31. ↑ Garth, Eleanor (October 9, 2024). "Lifespan Research Institute: SENS and Lifespan.io merge". Longevity.Technology - Latest News, Opinions, Analysis and Research. Retrieved January 9, 2025.
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