Timeline of bladder cancer
This is a timeline of bladder cancer, describing especially major discoveries and advances in treatment of the disease.
Contents
Big picture
Year/period | Key developments |
---|---|
16th–17th Centuries | The first operations targeting bladder tumor are performed in these centuries.[1] |
18th Century | It is already theorized that tobacco use might be related to cancer.[2] |
19th Century | The cytoscope develops. The first cystectomy for bladder cancer is performed. |
20th Century | A major discovery is the link between bladder cancer and exposure to β-Naphthylamine. Around mid–century, aromatic amines are found to be the most important carcinogens in occupational bladder cancer. This would prompt worldwide regulatory changes to the manufacture of rubber and dyestuffs.[3] Among medical advances, urine cytology emerges as a tool to detect recurrent bladder and urinary tract cancers.[4] |
1950s | Cigarette smoking is found to be etiologic for human bladder cancer.[2] |
1970s | Cigarette smoking is linked to bladder cancer risk. The first chemotherapy drug is released for bladder cancer.[4] |
1980s | Mitomycin chemotherapy is consolidated. Surgical advances improve bladder cancer survival. First successful combination chemotherapy for advanced bladder cancer is achieved.[4] |
1990s | Surgical techniques consolidate. New chemotherapies emerge to treat bladder cancer.[4] |
2000s | New chemotherapies prove to extend survival against bladder cancer. CT scan improves bladder cancer detection.[4] |
Recent years | As of 2010, bladder cancer resulted in 170,000 deaths up from 114,000 in 1990 worldwide.[5] Current treatment options for people with bladder cancer can include surgery, intravesical therapy, chemotherapy, radiation therapy and immunotherapy.[6] Today, the incidence of occupational bladder cancer has decreased in the Western World, but is still widely reported in less developed countries. A lack of adequate data on concurrent smoking history and other risk factors is a possible limitation of actual epidemiological studies.[3] |
Full timeline
Year/period | Type of event | Event | Location |
---|---|---|---|
1551 | Scientific development | Bladder tumors are mentioned first by Lacuna.[1] | |
1761 | Scientific development | Dr. John Hill reports a relationship between tobacco use and cancer.[2] | |
1854 | Scientific development | Inverted papilloma (a tumor that may occur in the bladder and other components of the urinary tract) is first described.[7] | |
1877 | Medical development (device) | German urologist Maximilian Nitze develops the cystoscope, a device used to perform endoscopy of the urinary bladder via the urethra.[8] | |
1887 | Medical development (treatment) | The first cystectomy for bladder cancer is performed.[8] | Cologne, Germany |
1895 | Scientific development | Link between bladder cancer and environmental carcinogens is first postulated.[9] | |
1895 | Scientific development | German surgeon Ludwig Rehn, working at the Hoechst aniline factory near Frankfurt, reports 3 cases of bladder cancer in workers, labeling them aniline tumors. However, it would be hard to prove the association with the chemical at the time as chemical manufacturers begin using several other coal- and oil-based compounds.[3][2] | Germany |
1902 | Organization | The American Urological Association is founded.[10] | Linthicum, Maryland, United States |
1903 | Medical development (treatment) | Radium is first used to treat bladder tumors.[8] | United States |
1911 | Scientific development | Ferguson first first suggests association between Schistosomiasis and urinary bladder cancer.[11][2] | |
1929 | Scientific development | Researchers note that patients with tuberculosis have lower rates of cancer when examined at autopsy. This observation is among the first to link the possibility of bladder cancer treatment with BCG.[12] | |
1938 | Scientific development | Delaware-based German pathologist Wilhelm Hueper shows an increase in bladder tumors when β-Naphthylamine is administered orally to dogs. With his toxicology research funded by the chemical industry, Hueper would encounter significant resistance in publishing his findings.[3] | |
1939 | Scientific development | Researchers communicate a successful attempt to induce papillary vesical lesions of benign and malignant type of bladder cancer in female dogs receiving large doses of commercial β-Naphthylamine by mouth.[13] | United States |
1940 | Scientific development | Japanese scientists claim having induced bladder papillomatosis in rabbits and rats by means of subcutaneous injection of an oily solution of o–toluidine.[13] | |
1945 | Medical development (diagnosis) | Urine cytology (a test used to diagnose urinary tract cancers) is first described.[14] | |
1950 – 1954 | Epidemiology | Incidence rate for bladder cancer per 100,000 population in the United States is reported at 14.1 for males, and 4.4 for females, during the period.[2] | United States |
1950 – 1959 | Scientific discovery | It is found that cigarette smoking is etiologic for human bladder cancer.[2] | |
1952 | Discovery | Transitional cell carcinoma in situ of the bladder is first described.[15] | |
1954 | Scientific development | Study by Case and Holster on workers in the British rubber industry demonstrate that β-Naphthylamine accounts for a 200-fold increased risk of bladder cancer with a latency period of 11-25 years. Subsequently, regulatory bodies worldwide would start prohibiting the manufacture and use of the compound.[3] | United Kingdom |
1956 | Medical development (treatment) | Early bladder removal surgery is introduced. This include surgically removing the bladder (cystectomy) and surrounding tissue where cancer is most likely to spread.[16] | |
1970 – 1974 | Epidemiology | Incidence rate for bladder cancer per 100,000 population in the United States is reported at 23.7 for males, and 6.1 for females, during the period.[2] | United States |
1970 – 1975 | Scientific development | Studies in laboratory rats link saccharin with the development of bladder cancer, especially in male rats.[17] | |
1972 | Scientific development | Researchers demonstrate a significantly decreased incidence of bladder cancer since the manufacture of dyestuffs containing β-Naphthylamine was ceased.[3] | |
1974 | Discovery | Research ties sharp increase in bladder cancer deaths among British men to the rapid rise in cigarette smoking during prior decades.[4] | United Kingdom |
1978 | Treatment | United States FDA approves the first chemotherapy drug cisplatin for bladder cancer.[18] | United States |
1980–1985 | Treatment | Reconstructive bladder surgery is found to improve quality of life. Surgeons begin to offer a neobladder to select patients needing surgery (cystectomy) for bladder cancer. This procedure provides a functional replacement for the bladder using tissue fashioned from the small bowel that allows the passage of urine through the urethra.[4] | |
1982 | Discovery | Micropapillary bladder cancer (a rare and aggressive variant of urothelial carcinoma) is first described.[19] | |
1985 | Treatment | Neoadjuvant chemotherapy combining methotrexate, vinblastine, doxorubicin, and cisplatin (MVAC) is first described. MVAC is one of the most active chemotherapy regimens for bladder cancer.[20] | |
1985–1989 | Medical development | Researchers map out the nerves surrounding the bladder and prostate and develop a new surgical technique that spares key nerves involved in male sexual function, thus preserving it.[21] | |
1987 | Treatment | Implant treats bladder cancer without surgery. The procedure involves implanting radioactive sources into cancerous tumors within the bladder.[22] | United States |
1988 | Scientific development | Intravesical chemotherapy using mitomycin is found to reduce risk of bladder cancer's return.[23] | |
1990 | Medical development (treatment) | United States FDA approved the use of live bacterium, bacillus Calmette-Guérin (BCG) for superficial bladder cancer. BCG immunotherapy helps reduce the risk of bladder cancer recurrence by stimulating an immune response that targets the bacteria as well as any bladder cancer cells.[24] | United States |
1997 | Medical development (treatment) | Introduction of combination therapy using both radiation and cisplatin chemotherapy together, is found to be a new treatment alternative for patients with advanced bladder cancer who are older or otherwise unable to undergo bladder surgery.[25] | |
2000 | Medical development (treatment) | New chemotherapy combination regimen using gemcitabine together with cisplatin is found to be comparably effective but has relatively fewer side effects than standard MVAC therapy.[26] | |
2002 | Statistics | Approximately 356,000 new bladder cancer cases worldwide are reported during the year.[27][28] | |
2003 | Scientific development | Research demonstrates that giving chemotherapy before bladder surgery improves survival for patients whose cancer has not spread significantly beyond the bladder, compared with surgery alone.[29] | |
2004 | Epidemiology | Report estimates that approximately 145,000 patients die from urinary bladder cancer annually worldwide.[28] | |
2009 | Organization | Bladder Cancer Canada is formed as a patient advocacy organization dedicated to bladder cancer issues.[30] | Canada |
2016 | Scientific development | Study suggests that alterations in the extracellular matrix (ECM) microenvironment of the bladder, especially type I collagen, may contribute to bladder cancer progression.[31] | Houston, Texas, United States |
2016 | Medical development | New technology helps doctors detect cancerous tumors in the bladder that are invisible to the naked eye.[32] | Murray, Utah, United States |
2017 (September 7) | Scientific development | Researchers develop new risk-stratification tool able to estimate mortality in patients with urothelial carcinoma of the bladder (UCB) after cystectomy. [33][34] | |
2017 (October 12) | Medical development | Researchers, working with mice and rats, develop a way to successfully deliver nano-sized, platinum-based chemotherapy drugs to treat nonmuscle-invasive bladder cancer, a type of bladder cancer which is found in the lining of the organ and has not invaded deeper into bladder tissue.[35][36][37][38] |
Numerical and visual data
Mentions on Google Scholar
The following table summarizes per-year mentions on Google Scholar as of May 20, 2021.
Year | Bladder cancer | Invasive bladder cancer | Urinary bladder cancer | Chemotherapy bladder cancer | Superficial bladder cancer | Bladder cancer intravesical | Bladder cancer recurrence |
---|---|---|---|---|---|---|---|
1980 | 3,990 | 835 | 5,820 | 2,100 | 616 | 143 | 1,820 |
1985 | 5,650 | 1,280 | 7,530 | 3,010 | 978 | 274 | 2,500 |
1990 | 7,740 | 2,000 | 9,250 | 3,710 | 1,340 | 404 | 3,110 |
1995 | 10,400 | 3,340 | 12,300 | 4,580 | 1,780 | 534 | 4,310 |
2000 | 16,300 | 6,460 | 17,500 | 7,590 | 2,950 | 838 | 7,850 |
2002 | 18,800 | 8,090 | 19,100 | 8,750 | 3,240 | 959 | 8,650 |
2004 | 25,200 | 10,000 | 21,800 | 11,500 | 4,170 | 1,180 | 11,600 |
2006 | 31,000 | 12,200 | 24,000 | 14,600 | 5,090 | 1,630 | 14,300 |
2008 | 36,400 | 16,300 | 26,700 | 17,500 | 5,980 | 1,830 | 17,000 |
2010 | 42,300 | 17,900 | 26,700 | 19,100 | 5,790 | 1,820 | 18,000 |
2012 | 56,300 | 21,100 | 31,100 | 22,100 | 7,460 | 2,370 | 20,700 |
2014 | 60,200 | 23,300 | 33,300 | 24,800 | 7,190 | 2,320 | 22,100 |
2016 | 61,000 | 26,200 | 34,400 | 27,100 | 7,620 | 2,470 | 23,800 |
2017 | 58,500 | 27,100 | 35,200 | 29,100 | 7,650 | 2,660 | 24,600 |
2018 | 55,400 | 29,600 | 36,200 | 31,200 | 7,920 | 2,820 | 25,600 |
2019 | 51,000 | 30,900 | 36,900 | 30,200 | 7,730 | 2,810 | 26,700 |
2020 | 42,800 | 33,500 | 39,700 | 31,800 | 7,960 | 3,370 | 31,200 |
Google Trends
The comparative chart below shows Google Trends data for Bladder cancer (search term and topic) from January 2004 to January 2021, when the screenshot was taken.[39]
Google Ngram Viewer
The chart below shows Google Ngram Viewer data for Bladder cancer from 1700 to 2019.[40]
Wikipedia views
The chart below shows Wikipedia views of the article bladder cancer on desktop from December 2007, and on mobile-web, desktop-spider, mobile-web-spider and mobile app, from June 2015; to January 2021.
Meta information on the timeline
How the timeline was built
The initial version of the timeline was written by User:Sebastian.
Funding information for this timeline is available.
What the timeline is still missing
Timeline update strategy
See also
- Timeline of lung cancer
- Timeline of brain cancer
- Timeline of colorectal cancer
- Timeline of pancreatic cancer
- Timeline of cervical cancer
- Timeline of kidney cancer
References
- ↑ 1.0 1.1 Patel, Sutchin R.; Moran, Michael E.; Nakada, Stephen Y. The History of Technologic Advancements in Urology.
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 Bryan, George T. (1983). "Pathogenesis of Human Urinary Bladder Cancer". Environmental Health Perspectives: 201–207. Retrieved 13 October 2017.
- ↑ 3.0 3.1 3.2 3.3 3.4 3.5 Wanis, Michael; Hadjipavlou, Marios. "THE RISE AND FALL OF OCCUPATIONAL BLADDER CANCER IN THE WESTERN WORLD". THE JOURNAL OF UROLOGY. Retrieved 13 October 2017.
- ↑ 4.0 4.1 4.2 4.3 4.4 4.5 4.6 "Timeline". Retrieved 29 September 2016.
- ↑ Lozano, R; et al. (15 December 2012). "Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010". Lancet. 380 (9859): 2095–128. PMID 23245604. doi:10.1016/S0140-6736(12)61728-0.
- ↑ "Bladder cancer treatment". Retrieved 1 October 2016.
- ↑ Wood, JW; Casiano, RR (2012). "Inverted papillomas and benign nonneoplastic lesions of the nasal cavity". Am J Rhinol Allergy. 26: 157–63. PMC 3906506. PMID 22487294. doi:10.2500/ajra.2012.26.3732.
- ↑ 8.0 8.1 8.2 "BLADDER CANCER". Retrieved 28 September 2016.
- ↑ "Guideline for the Management of Nonmuscle Invasive Bladder Cancer: (Stages Ta, T1 and Tis: Update (2007)". Retrieved 28 September 2016.
- ↑ "History of the AUA". Retrieved 20 November 2016.
- ↑ "Bladder cancer and schistosomiasis". Journal of the Egyptian National Cancer Institute. 24: 151–159. doi:10.1016/j.jnci.2012.08.002.
- ↑ Fuge, O; Vasdev, N; Allchorne, P; Green, JS (2015). "Immunotherapy for bladder cancer". Res Rep Urol. 7: 65–79. PMC 4427258. PMID 26000263. doi:10.2147/RRU.S63447.
- ↑ 13.0 13.1 BONSER, GEORGIANA M. (January 1946). "EXPERIMENTAL CANCER OF THE BLADDER". British Medical Bulletin: 379–381. doi:10.1093/oxfordjournals.bmb.a072830.
- ↑ "Current perspectives in bladder cancer management". International Journal of Clinical Practice. 67: 435–448. doi:10.1111/ijcp.12075.
- ↑ "BCG Immunotherapy for Transitional-Cell Carcinoma in Situ of the Bladder". Retrieved 26 September 2016.
- ↑ "A technique for radical total cystectomy". Cancer. 9: 585–595. doi:10.1002/1097-0142(195605/06)9:3<585::AID-CNCR2820090325>3.0.CO;2-Z.
- ↑ "Artificial Sweeteners and Cancer". cancer.gov. Retrieved 13 October 2017.
- ↑ "The "Accidental" Cure—Platinum-based Treatment for Cancer: The Discovery of Cisplatin". Retrieved 29 September 2016.
- ↑ "Micropapillary bladder cancer: a review of Léon Bérard Cancer Center experience". BMC Urology. 9. doi:10.1186/1471-2490-9-5.
- ↑ "Everything Old Is New Again! Neoadjuvant Chemotherapy in the Treatment of Muscle-Invasive Bladder Cancer". Journal of Clinical Oncology. 32: 1868–1870. doi:10.1200/JCO.2014.55.4055.
- ↑ Schlegel, PN; Walsh, PC. "Neuroanatomical approach to radical cystoprostatectomy with preservation of sexual function.". J Urol. 138: 1402–6. PMID 3682067.
- ↑ "Implant treats bladder cancer without surgery". Gainesville Sun.
- ↑ van der Meijden, AP; DeBruyne, FM. "Treatment schedule of intravesical chemotherapy with mitomycin C in superficial bladder cancer: short-term courses or maintenance therapy.". Urology. 31: 26–9. PMID 3126592.
- ↑ "Bladder Cancer". Retrieved 26 September 2016.
- ↑ "Radiotherapy with or without Chemotherapy in Muscle-Invasive Bladder Cancer". New England Journal of Medicine. 366: 1477–1488. doi:10.1056/NEJMoa1106106.
- ↑ "Gemcitabine and Cisplatin Versus Methotrexate, Vinblastine, Doxorubicin, and Cisplatin in Advanced or Metastatic Bladder Cancer: Results of a Large, Randomized, Multinational, Multicenter, Phase III Stud" (PDF). Retrieved 29 September 2016.
- ↑ Ploeg, M; Aben, KK; Kiemeney, LA (2009). "The present and future burden of urinary bladder cancer in the world". World J Urol. 27: 289–93. PMC 2694323. PMID 19219610. doi:10.1007/s00345-009-0383-3.
- ↑ 28.0 28.1 Ploeg, Martine; Aben, Katja K. H.; Kiemeney, Lambertus A. "The present and future burden of urinary bladder cancer in the world". World Journal of Urology. PMC 2694323. doi:10.1007/s00345-009-0383-3. Retrieved 13 October 2017.
- ↑ "International Phase III Trial Assessing Neoadjuvant Cisplatin, Methotrexate, and Vinblastine Chemotherapy for Muscle-Invasive Bladder Cancer: Long-Term Results of the BA06 30894 Trial". Journal of Clinical Oncology. 29: 2171–2177. doi:10.1200/JCO.2010.32.3139.
- ↑ "Bladder Cancer Canada". Retrieved 1 October 2016.
- ↑ "Bladder Cancer Progression Linked to Collagen Changes". Retrieved 29 September 2016.
- ↑ "New technology detects bladder cancer that even doctors can't see". Retrieved 29 September 2016.
- ↑ "New Tool Identifies Mortality Risk After Bladder Cancer Surgery". oncologynurseadvisor.com. Retrieved 13 October 2017.
- ↑ "New tool IDs mortality risk after bladder cancer surgery". medicalxpress.com. Retrieved 13 October 2017.
- ↑ "Experimental 'nano-chemo' particle to treat bladder cancer". sciencedaily.com. Johns Hopkins Medicine. Retrieved 13 October 2017.
- ↑ "Experimental nano-chemo particle to treat bladder cancer". europeanpharmaceuticalreview.com. Retrieved 13 October 2017.
- ↑ "Scientists develop experimental 'nano-chemo' particle to treat bladder cancer". medicalxpress.com. Retrieved 13 October 2017.
- ↑ "Johns Hopkins Scientists Develop Experimental "Nano-Chemo" Particle to Treat Bladder Cancer". newswise.com. Retrieved 13 October 2017.
- ↑ "Bladder cancer". trends.google.com. Retrieved 13 January 2021.
- ↑ "Bladder cancer". books.google.com. Retrieved 15 January 2021.